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The map label for this gene is hisM [H]

Identifier: 83721356

GI number: 83721356

Start: 1014448

End: 1015161

Strand: Reverse

Name: hisM [H]

Synonym: BTH_I0888

Alternate gene names: 83721356

Gene position: 1015161-1014448 (Counterclockwise)

Preceding gene: 83720821

Following gene: 83718977

Centisome position: 26.65

GC content: 64.01

Gene sequence:

>714_bases
ATGATCGAACTGATCCAAGAATACTGGCGCAATTACCTGTATACGGACGGGTATCGCTTCACCGGCCTCGCGATCACGCT
GTGGCTGCTCGTCGTGTCGATCGGGATCGGCTTCTGTCTTTCGGTGCCGCTCGCGGTCGCGCGCGTGTCGAAGAAGAAAT
GGCTCGCGGGCGCCGTCTGGCTCTATACGTACGTGTTCCGCGGCACGCCGCTCTACGTGCAGCTGCTCCTCTGCTACACG
GGCCTCTATAGCCTGCAGGCCGTGCGCGGCACGCCGATGCTCGACGCGTTCTTCCGCGACGGGATGAACTGCACGCTGCT
CGCGTTCACGCTGAACACCTGCGCGTACACGACCGAGATCTTCGCGGGCGCGATCAAGTCGACGTCGTACGGCGAGATCG
AGGCGGCCCGGGCTTACGGGATGTCGACCTTCACGCTGTATCGCCGGATCGTGCTGCCGTCGGCGCTGCGCCGCGCGCTG
CCGCTCTACAGCAACGAAGTGATCCTGATGCTGCACGCGACGACGGTCGCGTTCACGGCGACCGTGCCCGATATCCTGAA
GATCGCGCGCGACGTCAATTCGGCGACCTACATGTCGTTCCATGCGTTCGGCATCGCCGCCCTCCTCTATCTCGCGATCT
CGTTTACGCTCGTGTGGCTGTTCCGCCGCGCCGAGCGCCGCTGGCTCGCGTATCTGCGCCCGCAAGGCAAATGA

Upstream 100 bases:

>100_bases
TGCTTGCGGGCGCGATCTATCTCGCGATCACGACGATCTCGAACTTCGTGCTGATGTGGCTCGAGAAGCGTTATTCGACG
GGCGTACGCAAGGCTGACCT

Downstream 100 bases:

>100_bases
GTTTCGCCCGGACATGCCTCAGATGAACACCCAGATGCACAAGCTCTTCGTCGACGATCTCCACAAGCGCTACGGCAACA
ACGAAGTTTTGAAGGGCGTC

Product: amino acid ABC transporter permease

Products: ADP; phosphate; L-histidine [Cytoplasm]; ADP; L-ornithine [Cytoplasm]; L-arginine [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 237; Mature: 237

Protein sequence:

>237_residues
MIELIQEYWRNYLYTDGYRFTGLAITLWLLVVSIGIGFCLSVPLAVARVSKKKWLAGAVWLYTYVFRGTPLYVQLLLCYT
GLYSLQAVRGTPMLDAFFRDGMNCTLLAFTLNTCAYTTEIFAGAIKSTSYGEIEAARAYGMSTFTLYRRIVLPSALRRAL
PLYSNEVILMLHATTVAFTATVPDILKIARDVNSATYMSFHAFGIAALLYLAISFTLVWLFRRAERRWLAYLRPQGK

Sequences:

>Translated_237_residues
MIELIQEYWRNYLYTDGYRFTGLAITLWLLVVSIGIGFCLSVPLAVARVSKKKWLAGAVWLYTYVFRGTPLYVQLLLCYT
GLYSLQAVRGTPMLDAFFRDGMNCTLLAFTLNTCAYTTEIFAGAIKSTSYGEIEAARAYGMSTFTLYRRIVLPSALRRAL
PLYSNEVILMLHATTVAFTATVPDILKIARDVNSATYMSFHAFGIAALLYLAISFTLVWLFRRAERRWLAYLRPQGK
>Mature_237_residues
MIELIQEYWRNYLYTDGYRFTGLAITLWLLVVSIGIGFCLSVPLAVARVSKKKWLAGAVWLYTYVFRGTPLYVQLLLCYT
GLYSLQAVRGTPMLDAFFRDGMNCTLLAFTLNTCAYTTEIFAGAIKSTSYGEIEAARAYGMSTFTLYRRIVLPSALRRAL
PLYSNEVILMLHATTVAFTATVPDILKIARDVNSATYMSFHAFGIAALLYLAISFTLVWLFRRAERRWLAYLRPQGK

Specific function: Part of the binding-protein-dependent transport system for histidine; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG4160

COG function: function code E; ABC-type arginine/histidine transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1788645, Length=236, Percent_Identity=67.3728813559322, Blast_Score=337, Evalue=5e-94,
Organism=Escherichia coli, GI1787086, Length=212, Percent_Identity=33.4905660377358, Blast_Score=104, Evalue=4e-24,
Organism=Escherichia coli, GI1788226, Length=209, Percent_Identity=32.0574162679426, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI1787030, Length=208, Percent_Identity=29.8076923076923, Blast_Score=88, Evalue=6e-19,
Organism=Escherichia coli, GI1786873, Length=224, Percent_Identity=29.9107142857143, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1788646, Length=218, Percent_Identity=27.0642201834862, Blast_Score=71, Evalue=5e-14,
Organism=Escherichia coli, GI1787087, Length=218, Percent_Identity=24.7706422018349, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI48994930, Length=184, Percent_Identity=26.6304347826087, Blast_Score=61, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010065
- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 26881; Mature: 26881

Theoretical pI: Translated: 9.80; Mature: 9.80

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIELIQEYWRNYLYTDGYRFTGLAITLWLLVVSIGIGFCLSVPLAVARVSKKKWLAGAVW
CHHHHHHHHHHCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LYTYVFRGTPLYVQLLLCYTGLYSLQAVRGTPMLDAFFRDGMNCTLLAFTLNTCAYTTEI
HHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCEEEEEEEHHHHHHHHHH
FAGAIKSTSYGEIEAARAYGMSTFTLYRRIVLPSALRRALPLYSNEVILMLHATTVAFTA
HHHHHCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEHHHHHHH
TVPDILKIARDVNSATYMSFHAFGIAALLYLAISFTLVWLFRRAERRWLAYLRPQGK
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MIELIQEYWRNYLYTDGYRFTGLAITLWLLVVSIGIGFCLSVPLAVARVSKKKWLAGAVW
CHHHHHHHHHHCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LYTYVFRGTPLYVQLLLCYTGLYSLQAVRGTPMLDAFFRDGMNCTLLAFTLNTCAYTTEI
HHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCEEEEEEEHHHHHHHHHH
FAGAIKSTSYGEIEAARAYGMSTFTLYRRIVLPSALRRALPLYSNEVILMLHATTVAFTA
HHHHHCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEHHHHHHH
TVPDILKIARDVNSATYMSFHAFGIAALLYLAISFTLVWLFRRAERRWLAYLRPQGK
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-histidine [Periplasm]; H2O; ATP; L-ornithine [Periplasm]; L-arginine [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: ATP + L-histidine [Periplasm] + H2O = ADP + phosphate + L-histidine [Cytoplasm] ATP + L-ornithine [Periplasm] + H2O = ADP + phosphate + L-ornithine [Cytoplasm] ATP + L-arginine [Periplasm] + H2O = ADP + phosphate + L-arginine [Cytoplasm] ATP + L-lysine [P

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]