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The map label for this gene is hutU [H]

Identifier: 83720912

GI number: 83720912

Start: 2045813

End: 2047501

Strand: Direct

Name: hutU [H]

Synonym: BTH_I1822

Alternate gene names: 83720912

Gene position: 2045813-2047501 (Clockwise)

Preceding gene: 83720225

Following gene: 83718757

Centisome position: 53.71

GC content: 67.61

Gene sequence:

>1689_bases
ATGAACCACCCGAAACACATCGATCCGCGCCTCGATCCGACCCGCGTGATCCGCGCGCCGCGCGGCGGCGAGAAGACCTG
CAAGAACTGGCTCGCCGAGGCTGCGTACCGGATGATCCAGAACAATCTCGATCCGGAGGTCGCCGAGCATCCGCACGCGC
TCGTCGTCTACGGCGGCATCGGCCGCGCGGCGCGCAACTGGGATTGCTTCGACCAGATTCTCGCGTCGCTGAAGGACCTG
AACGACGACGAGACGCTGCTCGTGCAATCGGGCAAGCCGGTGGGCGTGTTCCGCACGCACGAGAACGCGCCGCGCGTGCT
GATCGCGAACTCGAACCTCGTGCCGCACTGGGCGACGTGGGACCACTTCAACGAGCTCGACCGCAAGGGCCTGATGATGT
ACGGCCAGATGACGGCGGGCAGCTGGATCTACATCGGCAGCCAGGGGATCGTGCAGGGCACGTACGAGACGTTCTTCGCG
GTCGCGAACCAGCACTTCAACGGCGATCCTGCCGGGCGCTGGATTCTGACGGGCGGGCTCGGCGGCATGGGCGGCGCGCA
GCCGCTCGCCGCGACGATGGCGGGCTTCTCGATGATCGCGGTCGAATGCGACGAATCGCGAATCGACTTCCGCCTGAAGA
CGCGCTACGTCGACAAGAAGGCGAAGACGCTCGACGAAGCGCTCGCGATGATCGACGAAGCGAAGCGCGCGGGCAAGCCG
GTGTCGGTCGGCCTGCTCGGCAACGCGGCCGACGTGTTCTCGGAGATCGTCGCGCGCGGCATCACGCCGGACTGCGTGAC
CGACCAGACGAGCGCGCACGATCCGATCAACGGCTACCTGCCGCAGGGCTGGAGCGTCGAGCAGTGGCGCGAGGCACAGA
AGGTCGATCCGCAGAGCATCGTGAAGGCCGCGAAGCAATCGATGGCCGTGCAGGTGCGCGCGATGCTCGCGCTGCAGGAG
CGCGGCGCGGCGACGCTCGACTACGGCAACAACATCCGCCAGATGGCGCTGGAGATGGGCGTCGACAATGCGTTCGACTT
CCCGGGTTTCGTGCCCGCGTACATCCGGCCGCTCTTCTGCGAAGGCAAGGGGCCGTTCCGCTGGGTCGCGCTGTCGGGCG
ATCCGGAGGACATCTACAAGACCGATGCGAAGGTCAAGGAGCTGATCCCCGACGATGCGCACCTGCACAACTGGCTCGAC
ATGGCGCGCGAGCGCATCGCGTTCCAGGGCCTGCCGGCGCGCATTTGCTGGGTCGGCGTGAAGGATCGCTATCGCCTCGG
CCAGGCGTTCAACGAGATGGTGAGGACGGGCGAGCTGAAGGCGCCGATCGTGATCGGCCGCGACCACCTCGACACCGGCT
CGGTCGCAAGCCCGAACCGCGAGACGGAAGCGATGAAGGACGGATCGGACGCGGTGAGCGACTGGCCGCTGCTGAACGCG
CTGCTGAATACCGCGGGCGGCGCGTCATGGGTGTCGCTGCATCACGGCGGCGGCGTCGGCATGGGCTTCTCGCAGCATGC
GGGCGTCGTGATCGTCGCCGACGGCACCGACGCCGCGCACGAGCGCTTGGGCCGCGTCCTCTTCAACGATCCGGCCACGG
GCGTGATGCGTCACGCGGATGCCGGCTACGAGCTCGCGCAGCGCACCGCGAAGGAAGCGGGCCTGAAGCTGCCGATGCTC
GGACGCTGA

Upstream 100 bases:

>100_bases
ATCGGTCGTGAACCTCTGGCACCCGGGCAGCCGCTATCGCTTCACCGGCCATTTCTGAACGCTTGACGAACCTTCACATC
CTTTTCCGGGAGCAGTTGCG

Downstream 100 bases:

>100_bases
TGCGGGCCGCGTCGTCCACGATGCGCGCGACGCTGATCCGCTCGGACGCGCTCGTCGCGTCGCCGTGGAAGAACGGCGGC
GGCGTGACGCGCGAGATCGC

Product: urocanate hydratase

Products: NA

Alternate protein names: Urocanase; Imidazolonepropionate hydrolase [H]

Number of amino acids: Translated: 562; Mature: 562

Protein sequence:

>562_residues
MNHPKHIDPRLDPTRVIRAPRGGEKTCKNWLAEAAYRMIQNNLDPEVAEHPHALVVYGGIGRAARNWDCFDQILASLKDL
NDDETLLVQSGKPVGVFRTHENAPRVLIANSNLVPHWATWDHFNELDRKGLMMYGQMTAGSWIYIGSQGIVQGTYETFFA
VANQHFNGDPAGRWILTGGLGGMGGAQPLAATMAGFSMIAVECDESRIDFRLKTRYVDKKAKTLDEALAMIDEAKRAGKP
VSVGLLGNAADVFSEIVARGITPDCVTDQTSAHDPINGYLPQGWSVEQWREAQKVDPQSIVKAAKQSMAVQVRAMLALQE
RGAATLDYGNNIRQMALEMGVDNAFDFPGFVPAYIRPLFCEGKGPFRWVALSGDPEDIYKTDAKVKELIPDDAHLHNWLD
MARERIAFQGLPARICWVGVKDRYRLGQAFNEMVRTGELKAPIVIGRDHLDTGSVASPNRETEAMKDGSDAVSDWPLLNA
LLNTAGGASWVSLHHGGGVGMGFSQHAGVVIVADGTDAAHERLGRVLFNDPATGVMRHADAGYELAQRTAKEAGLKLPML
GR

Sequences:

>Translated_562_residues
MNHPKHIDPRLDPTRVIRAPRGGEKTCKNWLAEAAYRMIQNNLDPEVAEHPHALVVYGGIGRAARNWDCFDQILASLKDL
NDDETLLVQSGKPVGVFRTHENAPRVLIANSNLVPHWATWDHFNELDRKGLMMYGQMTAGSWIYIGSQGIVQGTYETFFA
VANQHFNGDPAGRWILTGGLGGMGGAQPLAATMAGFSMIAVECDESRIDFRLKTRYVDKKAKTLDEALAMIDEAKRAGKP
VSVGLLGNAADVFSEIVARGITPDCVTDQTSAHDPINGYLPQGWSVEQWREAQKVDPQSIVKAAKQSMAVQVRAMLALQE
RGAATLDYGNNIRQMALEMGVDNAFDFPGFVPAYIRPLFCEGKGPFRWVALSGDPEDIYKTDAKVKELIPDDAHLHNWLD
MARERIAFQGLPARICWVGVKDRYRLGQAFNEMVRTGELKAPIVIGRDHLDTGSVASPNRETEAMKDGSDAVSDWPLLNA
LLNTAGGASWVSLHHGGGVGMGFSQHAGVVIVADGTDAAHERLGRVLFNDPATGVMRHADAGYELAQRTAKEAGLKLPML
GR
>Mature_562_residues
MNHPKHIDPRLDPTRVIRAPRGGEKTCKNWLAEAAYRMIQNNLDPEVAEHPHALVVYGGIGRAARNWDCFDQILASLKDL
NDDETLLVQSGKPVGVFRTHENAPRVLIANSNLVPHWATWDHFNELDRKGLMMYGQMTAGSWIYIGSQGIVQGTYETFFA
VANQHFNGDPAGRWILTGGLGGMGGAQPLAATMAGFSMIAVECDESRIDFRLKTRYVDKKAKTLDEALAMIDEAKRAGKP
VSVGLLGNAADVFSEIVARGITPDCVTDQTSAHDPINGYLPQGWSVEQWREAQKVDPQSIVKAAKQSMAVQVRAMLALQE
RGAATLDYGNNIRQMALEMGVDNAFDFPGFVPAYIRPLFCEGKGPFRWVALSGDPEDIYKTDAKVKELIPDDAHLHNWLD
MARERIAFQGLPARICWVGVKDRYRLGQAFNEMVRTGELKAPIVIGRDHLDTGSVASPNRETEAMKDGSDAVSDWPLLNA
LLNTAGGASWVSLHHGGGVGMGFSQHAGVVIVADGTDAAHERLGRVLFNDPATGVMRHADAGYELAQRTAKEAGLKLPML
GR

Specific function: Unknown

COG id: COG2987

COG function: function code E; Urocanate hydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the urocanase family [H]

Homologues:

Organism=Homo sapiens, GI21389467, Length=576, Percent_Identity=34.0277777777778, Blast_Score=305, Evalue=1e-82,
Organism=Homo sapiens, GI260306182, Length=636, Percent_Identity=30.9748427672956, Blast_Score=274, Evalue=1e-73,
Organism=Caenorhabditis elegans, GI71997891, Length=571, Percent_Identity=34.1506129597198, Blast_Score=310, Evalue=2e-84,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000193 [H]

Pfam domain/function: PF01175 Urocanase [H]

EC number: =4.2.1.49 [H]

Molecular weight: Translated: 61469; Mature: 61469

Theoretical pI: Translated: 6.47; Mature: 6.47

Prosite motif: PS01233 UROCANASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNHPKHIDPRLDPTRVIRAPRGGEKTCKNWLAEAAYRMIQNNLDPEVAEHPHALVVYGGI
CCCCCCCCCCCCHHHEEECCCCCHHHHHHHHHHHHHHHHHCCCCCHHHCCCCEEEEECCC
GRAARNWDCFDQILASLKDLNDDETLLVQSGKPVGVFRTHENAPRVLIANSNLVPHWATW
CCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCEEEEEECCCCCEEEEECCCCCCCCCCH
DHFNELDRKGLMMYGQMTAGSWIYIGSQGIVQGTYETFFAVANQHFNGDPAGRWILTGGL
HHHHHHCCCCEEEEEEECCCCEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEECCC
GGMGGAQPLAATMAGFSMIAVECDESRIDFRLKTRYVDKKAKTLDEALAMIDEAKRAGKP
CCCCCCHHHHHHHHCCEEEEEEECCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCC
VSVGLLGNAADVFSEIVARGITPDCVTDQTSAHDPINGYLPQGWSVEQWREAQKVDPQSI
EEEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCHHHH
VKAAKQSMAVQVRAMLALQERGAATLDYGNNIRQMALEMGVDNAFDFPGFVPAYIRPLFC
HHHHHHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHCCCCCCCCCCCCHHHHCEEEE
EGKGPFRWVALSGDPEDIYKTDAKVKELIPDDAHLHNWLDMARERIAFQGLPARICWVGV
CCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECC
KDRYRLGQAFNEMVRTGELKAPIVIGRDHLDTGSVASPNRETEAMKDGSDAVSDWPLLNA
HHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHH
LLNTAGGASWVSLHHGGGVGMGFSQHAGVVIVADGTDAAHERLGRVLFNDPATGVMRHAD
HHHCCCCCEEEEEECCCCCCCCCCCCCCEEEEECCCHHHHHHHCHHHCCCCCHHHHHHCC
AGYELAQRTAKEAGLKLPMLGR
CCHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MNHPKHIDPRLDPTRVIRAPRGGEKTCKNWLAEAAYRMIQNNLDPEVAEHPHALVVYGGI
CCCCCCCCCCCCHHHEEECCCCCHHHHHHHHHHHHHHHHHCCCCCHHHCCCCEEEEECCC
GRAARNWDCFDQILASLKDLNDDETLLVQSGKPVGVFRTHENAPRVLIANSNLVPHWATW
CCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCEEEEEECCCCCEEEEECCCCCCCCCCH
DHFNELDRKGLMMYGQMTAGSWIYIGSQGIVQGTYETFFAVANQHFNGDPAGRWILTGGL
HHHHHHCCCCEEEEEEECCCCEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEECCC
GGMGGAQPLAATMAGFSMIAVECDESRIDFRLKTRYVDKKAKTLDEALAMIDEAKRAGKP
CCCCCCHHHHHHHHCCEEEEEEECCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCC
VSVGLLGNAADVFSEIVARGITPDCVTDQTSAHDPINGYLPQGWSVEQWREAQKVDPQSI
EEEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCHHHH
VKAAKQSMAVQVRAMLALQERGAATLDYGNNIRQMALEMGVDNAFDFPGFVPAYIRPLFC
HHHHHHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHCCCCCCCCCCCCHHHHCEEEE
EGKGPFRWVALSGDPEDIYKTDAKVKELIPDDAHLHNWLDMARERIAFQGLPARICWVGV
CCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECC
KDRYRLGQAFNEMVRTGELKAPIVIGRDHLDTGSVASPNRETEAMKDGSDAVSDWPLLNA
HHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHH
LLNTAGGASWVSLHHGGGVGMGFSQHAGVVIVADGTDAAHERLGRVLFNDPATGVMRHAD
HHHCCCCCEEEEEECCCCCCCCCCCCCCEEEEECCCHHHHHHHCHHHCCCCCHHHHHHCC
AGYELAQRTAKEAGLKLPMLGR
CCHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14500782 [H]