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The map label for this gene is hutC [H]

Identifier: 83720225

GI number: 83720225

Start: 2045075

End: 2045770

Strand: Direct

Name: hutC [H]

Synonym: BTH_I1821

Alternate gene names: 83720225

Gene position: 2045075-2045770 (Clockwise)

Preceding gene: 83719164

Following gene: 83720912

Centisome position: 53.69

GC content: 67.1

Gene sequence:

>696_bases
ATGAGCACGCCCGCCTATCAGGAAATCAAGGATTTCATCCTCGCGCGCATTCACGCCGGCGAATGGGCGGAAGGCGATCA
GGTGCCGTCCGAGAACGAGCTCGCGCGCGACTTCAAGGTCGCGCGGATGACCGTCAACCGCGCGCTGCGCGAGCTGACGG
CCGAGCAGGTGCTCACGCGCATCCAGGGGGCGGGCACCTTCGTCGCGCGGCCGAAGTACGAATCGACGCTCGTCGCGATC
CGCAGCATCTCCGACGAAGTCGCCGCGCGCGGCCACAAGCATCACGCGCGCGTGCTCGACCTCGTCACGATGAAAGCCGA
CGAGGCGCTCGCCGACGAGATGCAGGTGCCGCTCCACACGAAGCTCTTCCGCTCGGTGATGCTGCACTACGAGAACGACG
AGCCCGTGCAGATCGAGGAACGCTGGGTCAATCCCGCCGTCGCCGCGGATTACGCGGATCAGGACTTCTCGGCGATCACG
CCGAACCAGTACCTGATGCGCGTCGCGCCGCTGCAGCGCGTCGAGTACCGGATCGAGGCGGCGATGCCCGATCGCGCGAT
GCGCGAGGAGCTCGAGATGAGCGACGCCGAGCCGTGCCTCGTGCTGCATCGGCGCACGTGGTCGCAGGGCGTCGTCGCAT
CGGTCGTGAACCTCTGGCACCCGGGCAGCCGCTATCGCTTCACCGGCCATTTCTGA

Upstream 100 bases:

>100_bases
CATTACTTCGCGCCCGACATCGCGGTGGTCGCGCAGCGCGTGCGCGAGCGCGCGTTCGCGACGCTGAGCCCGCTGTCGTT
CGAATCGGAACAATAAGACG

Downstream 100 bases:

>100_bases
ACGCTTGACGAACCTTCACATCCTTTTCCGGGAGCAGTTGCGATGAACCACCCGAAACACATCGATCCGCGCCTCGATCC
GACCCGCGTGATCCGCGCGC

Product: histidine utilization repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 231; Mature: 230

Protein sequence:

>231_residues
MSTPAYQEIKDFILARIHAGEWAEGDQVPSENELARDFKVARMTVNRALRELTAEQVLTRIQGAGTFVARPKYESTLVAI
RSISDEVAARGHKHHARVLDLVTMKADEALADEMQVPLHTKLFRSVMLHYENDEPVQIEERWVNPAVAADYADQDFSAIT
PNQYLMRVAPLQRVEYRIEAAMPDRAMREELEMSDAEPCLVLHRRTWSQGVVASVVNLWHPGSRYRFTGHF

Sequences:

>Translated_231_residues
MSTPAYQEIKDFILARIHAGEWAEGDQVPSENELARDFKVARMTVNRALRELTAEQVLTRIQGAGTFVARPKYESTLVAI
RSISDEVAARGHKHHARVLDLVTMKADEALADEMQVPLHTKLFRSVMLHYENDEPVQIEERWVNPAVAADYADQDFSAIT
PNQYLMRVAPLQRVEYRIEAAMPDRAMREELEMSDAEPCLVLHRRTWSQGVVASVVNLWHPGSRYRFTGHF
>Mature_230_residues
STPAYQEIKDFILARIHAGEWAEGDQVPSENELARDFKVARMTVNRALRELTAEQVLTRIQGAGTFVARPKYESTLVAIR
SISDEVAARGHKHHARVLDLVTMKADEALADEMQVPLHTKLFRSVMLHYENDEPVQIEERWVNPAVAADYADQDFSAITP
NQYLMRVAPLQRVEYRIEAAMPDRAMREELEMSDAEPCLVLHRRTWSQGVVASVVNLWHPGSRYRFTGHF

Specific function: Repressor which binds to the hutP region in the histidine utilization (hut) operon. It blocks the expression of all the hut genes in the absence of inducer [H]

COG id: COG2188

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786950, Length=201, Percent_Identity=28.3582089552239, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI87082252, Length=138, Percent_Identity=28.9855072463768, Blast_Score=83, Evalue=1e-17,
Organism=Escherichia coli, GI1788418, Length=210, Percent_Identity=27.6190476190476, Blast_Score=78, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010248
- InterPro:   IPR000524
- InterPro:   IPR011663
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00392 GntR; PF07702 UTRA [H]

EC number: NA

Molecular weight: Translated: 26398; Mature: 26267

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTPAYQEIKDFILARIHAGEWAEGDQVPSENELARDFKVARMTVNRALRELTAEQVLTR
CCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IQGAGTFVARPKYESTLVAIRSISDEVAARGHKHHARVLDLVTMKADEALADEMQVPLHT
HHCCCCEEECCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHH
KLFRSVMLHYENDEPVQIEERWVNPAVAADYADQDFSAITPNQYLMRVAPLQRVEYRIEA
HHHHHHHHHCCCCCCEEHHHHHCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
AMPDRAMREELEMSDAEPCLVLHRRTWSQGVVASVVNLWHPGSRYRFTGHF
CCCCHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHCCCCCCCEEECCC
>Mature Secondary Structure 
STPAYQEIKDFILARIHAGEWAEGDQVPSENELARDFKVARMTVNRALRELTAEQVLTR
CCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IQGAGTFVARPKYESTLVAIRSISDEVAARGHKHHARVLDLVTMKADEALADEMQVPLHT
HHCCCCEEECCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHH
KLFRSVMLHYENDEPVQIEERWVNPAVAADYADQDFSAITPNQYLMRVAPLQRVEYRIEA
HHHHHHHHHCCCCCCEEHHHHHCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
AMPDRAMREELEMSDAEPCLVLHRRTWSQGVVASVVNLWHPGSRYRFTGHF
CCCCHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHCCCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]