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The map label for this gene is argH [H]

Identifier: 83720476

GI number: 83720476

Start: 982797

End: 984206

Strand: Reverse

Name: argH [H]

Synonym: BTH_I0864

Alternate gene names: 83720476

Gene position: 984206-982797 (Counterclockwise)

Preceding gene: 83718580

Following gene: 83721583

Centisome position: 25.84

GC content: 68.01

Gene sequence:

>1410_bases
ATGACGTCCCAACTGCACAAAAAGGGCGAGGCCTGGTCGGCCCGCTTTTCGGAACCGATGTCCGAGCTCGTCAAGCGCTA
CACGTCGTCGGTTTTCTTCGACAAGCGGCTCGCGCTCGTCGACATCGCCGGCTCGCTCGCGCACGCGGGCATGCTCGCCG
CGCAGAAGATCATCAGCGCCGACGACCTCGCCGCGATCGAGCACGGGATGGCGCAAATCAAGGGCGAGATCGAGCGCGGC
GAATTCGAATGGCAGCTCGATCTCGAAGACGTGCACCTGAACATCGAGGCGCGCCTGACCGCGCTCATCGGCGACGCGGG
CAAGCGCCTGCACACGGGCCGCTCGCGCAACGACCAGGTCGCGACCGACATCCGCCTGTGGCTGCGCGGCGAGATCGACC
GGATCGGCGGCCTGCTGAACGACCTGCGCGGCGCGCTGATCGATCTCGCCGAACAGAACGCGGACACGATCCTGCCGGGC
TTCACGCACCTGCAGGTCGCGCAGCCCGTCACGTTCGGCCATCACCTGCTCGCGTACGTCGAGATGTTCTCGCGCGACGC
CGAGCGCATGCGCGACTGCCGCGCGCGCGTGAACCGCCTGCCGCTCGGCGCGGCGGCGCTCGCGGGCACGAGCTATCCGA
TCGACCGCCATGCGGTGGCGAAGACGCTCGGCTTCGACGGCATCTGCGCGAACTCGCTCGACGCGGTGTCCGATCGCGAC
TTCGCGATCGAATTCACGGCCGCGGCCGCGCTGGTCATGACGCACGTGTCGCGCTTCTCGGAAGAACTCGTGCTGTGGAT
GAGCCCGCGCGTCGGCTTCATCGACATCGCCGACCGCTTCTGCACCGGCAGCTCGATCATGCCGCAGAAGAAGAACCCGG
ACGTGCCCGAGCTCGCGCGCGGCAAGACGGGCCGCGTGAACGGCCACCTGATGGCGCTCCTCACGCTGATGAAGGGCCAG
CCGCTCGCGTACAACAAGGACAACCAGGAAGACAAGGAACCGCTGTTCGACACGGTCGACACCGTCGCCGACACGCTGCG
GATCTTCGCGGAGATGGTCGCGGGCATCACCGTGAAGCCGGACGCGATGCGCGCGGCCGCGCTGCAGGGCTTCTCGACCG
CGACGGATCTCGCCGACTATCTGGTCAAGCGCGGGCTGCCGTTCCGCGACGCGCACGAAGCGGTCGCGCACGCGGTGAAG
ATCTGCGACGCGCGCGGCATCGATCTCGCGGACCTGACGCTCGACGAAATGAAGCAGGAACTGCCGAACGTCGCGCATCT
GATCGGCAGCGACGTGTTCGACTATCTGACACTCGAAGGCTCGGTTGCGAGCCGCAGCCATCCGGGCGGCACCGCGCCTG
ACCAGGTGCGCGCGGCGGCGAAGGCGGCGCGCGCGGCGCTCGGCAAGTAA

Upstream 100 bases:

>100_bases
GCCGCGGCCCTGCCTGCGGCGGCCGGCCGCCCGTCGAATGCTAGAATCCGCGTTGTCCGTTCGCGGCGCGCGCCGCTCCA
CTCCCCTTCTAAGAATCGCC

Downstream 100 bases:

>100_bases
GCCGCCGCAGCGCCCGCCTCACGGACAGCCCCATGTTTTCAGCGGCGATCTTCGATATGGACGGCCTGCTCGTCGATTCC
GAGCGGACCATCATGAACGC

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase [H]

Number of amino acids: Translated: 469; Mature: 468

Protein sequence:

>469_residues
MTSQLHKKGEAWSARFSEPMSELVKRYTSSVFFDKRLALVDIAGSLAHAGMLAAQKIISADDLAAIEHGMAQIKGEIERG
EFEWQLDLEDVHLNIEARLTALIGDAGKRLHTGRSRNDQVATDIRLWLRGEIDRIGGLLNDLRGALIDLAEQNADTILPG
FTHLQVAQPVTFGHHLLAYVEMFSRDAERMRDCRARVNRLPLGAAALAGTSYPIDRHAVAKTLGFDGICANSLDAVSDRD
FAIEFTAAAALVMTHVSRFSEELVLWMSPRVGFIDIADRFCTGSSIMPQKKNPDVPELARGKTGRVNGHLMALLTLMKGQ
PLAYNKDNQEDKEPLFDTVDTVADTLRIFAEMVAGITVKPDAMRAAALQGFSTATDLADYLVKRGLPFRDAHEAVAHAVK
ICDARGIDLADLTLDEMKQELPNVAHLIGSDVFDYLTLEGSVASRSHPGGTAPDQVRAAAKAARAALGK

Sequences:

>Translated_469_residues
MTSQLHKKGEAWSARFSEPMSELVKRYTSSVFFDKRLALVDIAGSLAHAGMLAAQKIISADDLAAIEHGMAQIKGEIERG
EFEWQLDLEDVHLNIEARLTALIGDAGKRLHTGRSRNDQVATDIRLWLRGEIDRIGGLLNDLRGALIDLAEQNADTILPG
FTHLQVAQPVTFGHHLLAYVEMFSRDAERMRDCRARVNRLPLGAAALAGTSYPIDRHAVAKTLGFDGICANSLDAVSDRD
FAIEFTAAAALVMTHVSRFSEELVLWMSPRVGFIDIADRFCTGSSIMPQKKNPDVPELARGKTGRVNGHLMALLTLMKGQ
PLAYNKDNQEDKEPLFDTVDTVADTLRIFAEMVAGITVKPDAMRAAALQGFSTATDLADYLVKRGLPFRDAHEAVAHAVK
ICDARGIDLADLTLDEMKQELPNVAHLIGSDVFDYLTLEGSVASRSHPGGTAPDQVRAAAKAARAALGK
>Mature_468_residues
TSQLHKKGEAWSARFSEPMSELVKRYTSSVFFDKRLALVDIAGSLAHAGMLAAQKIISADDLAAIEHGMAQIKGEIERGE
FEWQLDLEDVHLNIEARLTALIGDAGKRLHTGRSRNDQVATDIRLWLRGEIDRIGGLLNDLRGALIDLAEQNADTILPGF
THLQVAQPVTFGHHLLAYVEMFSRDAERMRDCRARVNRLPLGAAALAGTSYPIDRHAVAKTLGFDGICANSLDAVSDRDF
AIEFTAAAALVMTHVSRFSEELVLWMSPRVGFIDIADRFCTGSSIMPQKKNPDVPELARGKTGRVNGHLMALLTLMKGQP
LAYNKDNQEDKEPLFDTVDTVADTLRIFAEMVAGITVKPDAMRAAALQGFSTATDLADYLVKRGLPFRDAHEAVAHAVKI
CDARGIDLADLTLDEMKQELPNVAHLIGSDVFDYLTLEGSVASRSHPGGTAPDQVRAAAKAARAALGK

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=461, Percent_Identity=39.9132321041215, Blast_Score=352, Evalue=6e-97,
Organism=Homo sapiens, GI68303542, Length=461, Percent_Identity=39.9132321041215, Blast_Score=352, Evalue=6e-97,
Organism=Homo sapiens, GI68303547, Length=461, Percent_Identity=37.7440347071584, Blast_Score=322, Evalue=6e-88,
Organism=Homo sapiens, GI68303549, Length=461, Percent_Identity=37.527114967462, Blast_Score=313, Evalue=3e-85,
Organism=Escherichia coli, GI1790398, Length=458, Percent_Identity=44.7598253275109, Blast_Score=397, Evalue=1e-111,
Organism=Saccharomyces cerevisiae, GI6321806, Length=448, Percent_Identity=41.0714285714286, Blast_Score=334, Evalue=2e-92,
Organism=Drosophila melanogaster, GI221473854, Length=457, Percent_Identity=38.074398249453, Blast_Score=305, Evalue=3e-83,
Organism=Drosophila melanogaster, GI78706858, Length=457, Percent_Identity=38.074398249453, Blast_Score=305, Evalue=3e-83,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 51100; Mature: 50969

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSQLHKKGEAWSARFSEPMSELVKRYTSSVFFDKRLALVDIAGSLAHAGMLAAQKIISA
CCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH
DDLAAIEHGMAQIKGEIERGEFEWQLDLEDVHLNIEARLTALIGDAGKRLHTGRSRNDQV
HHHHHHHHHHHHHHCCCCCCCEEEEEEHHHEEEEHHHHHHHHHHHHHHHHHCCCCCCCCH
ATDIRLWLRGEIDRIGGLLNDLRGALIDLAEQNADTILPGFTHLQVAQPVTFGHHLLAYV
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCHHHHHHHHHHH
EMFSRDAERMRDCRARVNRLPLGAAALAGTSYPIDRHAVAKTLGFDGICANSLDAVSDRD
HHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCHHHHHHHHHCCCCCCCCCHHCCCCCC
FAIEFTAAAALVMTHVSRFSEELVLWMSPRVGFIDIADRFCTGSSIMPQKKNPDVPELAR
EEEEHHHHHHHHHHHHHHHHHHEEEEECCCCCEEEHHHHHCCCCCCCCCCCCCCCCHHHC
GKTGRVNGHLMALLTLMKGQPLAYNKDNQEDKEPLFDTVDTVADTLRIFAEMVAGITVKP
CCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
DAMRAAALQGFSTATDLADYLVKRGLPFRDAHEAVAHAVKICDARGIDLADLTLDEMKQE
HHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHHCCHHHHHHH
LPNVAHLIGSDVFDYLTLEGSVASRSHPGGTAPDQVRAAAKAARAALGK
HHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TSQLHKKGEAWSARFSEPMSELVKRYTSSVFFDKRLALVDIAGSLAHAGMLAAQKIISA
CCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH
DDLAAIEHGMAQIKGEIERGEFEWQLDLEDVHLNIEARLTALIGDAGKRLHTGRSRNDQV
HHHHHHHHHHHHHHCCCCCCCEEEEEEHHHEEEEHHHHHHHHHHHHHHHHHCCCCCCCCH
ATDIRLWLRGEIDRIGGLLNDLRGALIDLAEQNADTILPGFTHLQVAQPVTFGHHLLAYV
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCHHHHHHHHHHH
EMFSRDAERMRDCRARVNRLPLGAAALAGTSYPIDRHAVAKTLGFDGICANSLDAVSDRD
HHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCHHHHHHHHHCCCCCCCCCHHCCCCCC
FAIEFTAAAALVMTHVSRFSEELVLWMSPRVGFIDIADRFCTGSSIMPQKKNPDVPELAR
EEEEHHHHHHHHHHHHHHHHHHEEEEECCCCCEEEHHHHHCCCCCCCCCCCCCCCCHHHC
GKTGRVNGHLMALLTLMKGQPLAYNKDNQEDKEPLFDTVDTVADTLRIFAEMVAGITVKP
CCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
DAMRAAALQGFSTATDLADYLVKRGLPFRDAHEAVAHAVKICDARGIDLADLTLDEMKQE
HHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHHCCHHHHHHH
LPNVAHLIGSDVFDYLTLEGSVASRSHPGGTAPDQVRAAAKAARAALGK
HHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA