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The map label for this gene is uvrD [H]

Identifier: 83720350

GI number: 83720350

Start: 2997141

End: 2999504

Strand: Reverse

Name: uvrD [H]

Synonym: BTH_I2632

Alternate gene names: 83720350

Gene position: 2999504-2997141 (Counterclockwise)

Preceding gene: 83720948

Following gene: 83719445

Centisome position: 78.74

GC content: 68.36

Gene sequence:

>2364_bases
ATGCCCGATCTGCTCGCGAATCTGAACCCCGAACAACTCGCCGCCGTCACGTTGCCGAACGAGCCGGCGCTGATCCTCGC
CGGGGCGGGCAGCGGCAAGACCCGCGTGCTCATCACGCGTATCGCGTGGCTGATCCAGCAGGGCTATGCGTCGCCCGCCA
CCGTGCTCGCCGTCACGTTCACGAACAAGGCCGCGCGCGAGATGATGGCGCGCCTGTCCGCGATGATGCCGATCGACACG
CGCGGGATGTGGATCGGCACGTTCCACGGCCTGTGCAACCGGATGCTGCGCGCGCACTTCCGCGACGCGGGGCTGCCGCA
GACGTTCCAGATCCTCGACACCGCCGACCAGCTCTCCGCGATCAAGCGGCTGATGAAGGCGGCCAACGTCGACGACGAGA
AGTACCCGCCGAAGAACGTCCAGTACTTCATCAACAACGCGAAGGAGCAGGGGCTGCGTCCCGACAAGGTCGACGCGACC
GACAGCTTCAACCGCAAGTTCGTCGAGCTGTACCAGGCGTACGACCAGCAATGCCAGCGCGAGGGCGTCGTCGATTTCCC
CGAGCTGCTGTTGCGCTGCTACGAGCTGCTCGCGCACAATCCGCCGCTGCGCGCGCACTACCAGGCGCGCTTCAAGCACA
TCCTCGTCGACGAGTTCCAGGACACGAACAAGCTGCAGTACGCGTGGCTCAAGCTTCTCGCGGGCGGCCACAACGCGATC
TTCGCGGTCGGCGACGACGACCAGTCGATCTACGCGTTCCGCGGCGCGAACGTCGGCAACATGCGCGACTTCGAGAACGA
ATTCCGCGTGCGCAACCTGATCAAGCTCGAGCAGAACTACCGGTCGCACGGCAACATCCTCGATGCGGCGAACCACCTGA
TCGCGAACAACGCGCACCGGCTCGGCAAGAACCTGCGCACCGACGCGGGCCACGGCGAGCCCGTGCGCGTCTACGAGGCG
GCCACCGACGCGCAGGAAGCCGCGTGGATCGTCGAGGAGATCCGCTCGCTCGTGAATTCGGGCCTCGCGCGCAGCGAGGT
CGCGGTGCTGTACCGGAGCAACGCGCAGTCGCGCTCGATCGAGCACACGCTGATGACGGCGGGCATTGCGTACCGCGTGT
ACGGCGGCTTGCGCTTCTTCGAGCGCCAGGAAGTGAAGCACGCGCTCGCGTATCTGCGCCTCATCGACAACCCGAACGAC
GACACCGCGTTCGCGCGCGTCGTCAACTTCCCGACGCGCGGCATCGGCGCGCGTTCGATCGAGCAGCTCGCCGATGCCGC
GCGCCTGTACGATTGCTCGATGGCGGCCGCGATCCCGTACGTGGCGGGCAAGGCGGGCTCGAGCCTCGCGTCGTTCGCGA
ACCTGATCGCGAAGATGCGCGCGGAAACCGCGCAGATGAGCTTGCCCGAGACGGTCGAGCACGTCGTGCGCGCGAGCGGC
CTTGCGGATTTCTATCAAGGCGAGCGCGAAGGGCAGGATCGTCTCGAGAACCTGCAGGAACTGGTGAACGCGGCCACCGC
GTTCGTCTCCGAGGAAGGCTACGGGCTCGACACGCCCGCGCGTTCGATTCCGCTGCATGCGCGCGCGAGCGCGGCGCCGG
AGCTCGCCGCGGGCGGCGCCGACCCGGCCGACGCGGTGCTCGCGCCCGCGAACCTCGCCGATCCCGCGCAGAACCCGGAT
GCGATGACGCCGCTCGCCGGCTTCCTGTCGCACGCGTCGCTCGAGGCGGGCGACAACCAGGCGCAGGCGGGCCAGGACGC
GGTGCAGTTGATGACGGTCCATGCGGCGAAGGGGCTCGAGTTCGCCGCGGTGTTCATCACCGGGCTCGAAGAGGGGCTCT
TCCCGCACGAGAACAGCGCGCTCGAATCCGACGGCCTGGAGGAGGAGCGCCGGCTGATGTACGTCGCGATCACGCGTGCG
AAGGAGCGGCTCTATCTGTCGTTCGCGCAGAGCCGGATGCTGCACGGCCAGACCCGCTACAACATCCGCTCGCGCTTCTT
CGACGAGCTGCCGCAGCACGTGCTCAAGTGGCTCACGCCGAAGGTCGAGGCGGGCGCGCGCTGGGGCGGCCGCTCGGACA
ACGCCGGTTGGGGCCGCGACTGGTTCGCGCGGCCGGGCGGCGGCGCGCGGGAGAGCGTGGTCGACGCGGCGGTGTCCGCG
CCGCTGCCCGCGTTCGCAAACCAGCAGCGCGAGGCGCAGAACGGCTTGCGGATCGGCCAGCAGGTGTTCCACACGAAGTT
CGGCGAAGGCACGGTGACCGCGCTCGAAGGCAGCGGCACCGACGCGAAGGCGCAAGTCAAATTCAAGCGGCACGGCGAGA
AGTGGCTCGCGCTGGCGGTCGCGAAACTGCAGGCGGTCGAATGA

Upstream 100 bases:

>100_bases
ACCTTCGATTATAAATGGATGCGCATCCGCCCGGGCGGCGCGGGCCGCGCGCGATTTATAATGTCAGGCCCGCGTCCACC
CGCTCGACTGTTTTCTCTCC

Downstream 100 bases:

>100_bases
ATCAGCAGACGTCTTTCGACCGGCCGCTCGGCATCCTTGCCGCGCTGCCGGAGGAGTTGGGCGACCTCGTCGCCGCGATG
CGCGCCGACGGGCCCGTCGA

Product: DNA helicase II

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 787; Mature: 786

Protein sequence:

>787_residues
MPDLLANLNPEQLAAVTLPNEPALILAGAGSGKTRVLITRIAWLIQQGYASPATVLAVTFTNKAAREMMARLSAMMPIDT
RGMWIGTFHGLCNRMLRAHFRDAGLPQTFQILDTADQLSAIKRLMKAANVDDEKYPPKNVQYFINNAKEQGLRPDKVDAT
DSFNRKFVELYQAYDQQCQREGVVDFPELLLRCYELLAHNPPLRAHYQARFKHILVDEFQDTNKLQYAWLKLLAGGHNAI
FAVGDDDQSIYAFRGANVGNMRDFENEFRVRNLIKLEQNYRSHGNILDAANHLIANNAHRLGKNLRTDAGHGEPVRVYEA
ATDAQEAAWIVEEIRSLVNSGLARSEVAVLYRSNAQSRSIEHTLMTAGIAYRVYGGLRFFERQEVKHALAYLRLIDNPND
DTAFARVVNFPTRGIGARSIEQLADAARLYDCSMAAAIPYVAGKAGSSLASFANLIAKMRAETAQMSLPETVEHVVRASG
LADFYQGEREGQDRLENLQELVNAATAFVSEEGYGLDTPARSIPLHARASAAPELAAGGADPADAVLAPANLADPAQNPD
AMTPLAGFLSHASLEAGDNQAQAGQDAVQLMTVHAAKGLEFAAVFITGLEEGLFPHENSALESDGLEEERRLMYVAITRA
KERLYLSFAQSRMLHGQTRYNIRSRFFDELPQHVLKWLTPKVEAGARWGGRSDNAGWGRDWFARPGGGARESVVDAAVSA
PLPAFANQQREAQNGLRIGQQVFHTKFGEGTVTALEGSGTDAKAQVKFKRHGEKWLALAVAKLQAVE

Sequences:

>Translated_787_residues
MPDLLANLNPEQLAAVTLPNEPALILAGAGSGKTRVLITRIAWLIQQGYASPATVLAVTFTNKAAREMMARLSAMMPIDT
RGMWIGTFHGLCNRMLRAHFRDAGLPQTFQILDTADQLSAIKRLMKAANVDDEKYPPKNVQYFINNAKEQGLRPDKVDAT
DSFNRKFVELYQAYDQQCQREGVVDFPELLLRCYELLAHNPPLRAHYQARFKHILVDEFQDTNKLQYAWLKLLAGGHNAI
FAVGDDDQSIYAFRGANVGNMRDFENEFRVRNLIKLEQNYRSHGNILDAANHLIANNAHRLGKNLRTDAGHGEPVRVYEA
ATDAQEAAWIVEEIRSLVNSGLARSEVAVLYRSNAQSRSIEHTLMTAGIAYRVYGGLRFFERQEVKHALAYLRLIDNPND
DTAFARVVNFPTRGIGARSIEQLADAARLYDCSMAAAIPYVAGKAGSSLASFANLIAKMRAETAQMSLPETVEHVVRASG
LADFYQGEREGQDRLENLQELVNAATAFVSEEGYGLDTPARSIPLHARASAAPELAAGGADPADAVLAPANLADPAQNPD
AMTPLAGFLSHASLEAGDNQAQAGQDAVQLMTVHAAKGLEFAAVFITGLEEGLFPHENSALESDGLEEERRLMYVAITRA
KERLYLSFAQSRMLHGQTRYNIRSRFFDELPQHVLKWLTPKVEAGARWGGRSDNAGWGRDWFARPGGGARESVVDAAVSA
PLPAFANQQREAQNGLRIGQQVFHTKFGEGTVTALEGSGTDAKAQVKFKRHGEKWLALAVAKLQAVE
>Mature_786_residues
PDLLANLNPEQLAAVTLPNEPALILAGAGSGKTRVLITRIAWLIQQGYASPATVLAVTFTNKAAREMMARLSAMMPIDTR
GMWIGTFHGLCNRMLRAHFRDAGLPQTFQILDTADQLSAIKRLMKAANVDDEKYPPKNVQYFINNAKEQGLRPDKVDATD
SFNRKFVELYQAYDQQCQREGVVDFPELLLRCYELLAHNPPLRAHYQARFKHILVDEFQDTNKLQYAWLKLLAGGHNAIF
AVGDDDQSIYAFRGANVGNMRDFENEFRVRNLIKLEQNYRSHGNILDAANHLIANNAHRLGKNLRTDAGHGEPVRVYEAA
TDAQEAAWIVEEIRSLVNSGLARSEVAVLYRSNAQSRSIEHTLMTAGIAYRVYGGLRFFERQEVKHALAYLRLIDNPNDD
TAFARVVNFPTRGIGARSIEQLADAARLYDCSMAAAIPYVAGKAGSSLASFANLIAKMRAETAQMSLPETVEHVVRASGL
ADFYQGEREGQDRLENLQELVNAATAFVSEEGYGLDTPARSIPLHARASAAPELAAGGADPADAVLAPANLADPAQNPDA
MTPLAGFLSHASLEAGDNQAQAGQDAVQLMTVHAAKGLEFAAVFITGLEEGLFPHENSALESDGLEEERRLMYVAITRAK
ERLYLSFAQSRMLHGQTRYNIRSRFFDELPQHVLKWLTPKVEAGARWGGRSDNAGWGRDWFARPGGGARESVVDAAVSAP
LPAFANQQREAQNGLRIGQQVFHTKFGEGTVTALEGSGTDAKAQVKFKRHGEKWLALAVAKLQAVE

Specific function: Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide exc

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI2367296, Length=794, Percent_Identity=45.2141057934509, Blast_Score=657, Evalue=0.0,
Organism=Escherichia coli, GI48994965, Length=684, Percent_Identity=35.5263157894737, Blast_Score=360, Evalue=1e-100,
Organism=Escherichia coli, GI1787196, Length=340, Percent_Identity=28.2352941176471, Blast_Score=103, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6322369, Length=766, Percent_Identity=28.0678851174935, Blast_Score=221, Evalue=4e-58,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005753
- InterPro:   IPR013986
- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 86574; Mature: 86443

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDLLANLNPEQLAAVTLPNEPALILAGAGSGKTRVLITRIAWLIQQGYASPATVLAVTF
CCCCCCCCCHHHEEEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEE
TNKAAREMMARLSAMMPIDTRGMWIGTFHGLCNRMLRAHFRDAGLPQTFQILDTADQLSA
CCHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
IKRLMKAANVDDEKYPPKNVQYFINNAKEQGLRPDKVDATDSFNRKFVELYQAYDQQCQR
HHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
EGVVDFPELLLRCYELLAHNPPLRAHYQARFKHILVDEFQDTNKLQYAWLKLLAGGHNAI
CCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEE
FAVGDDDQSIYAFRGANVGNMRDFENEFRVRNLIKLEQNYRSHGNILDAANHLIANNAHR
EEECCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHH
LGKNLRTDAGHGEPVRVYEAATDAQEAAWIVEEIRSLVNSGLARSEVAVLYRSNAQSRSI
HCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCHHHHHEEEECCCCHHHH
EHTLMTAGIAYRVYGGLRFFERQEVKHALAYLRLIDNPNDDTAFARVVNFPTRGIGARSI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCHHHH
EQLADAARLYDCSMAAAIPYVAGKAGSSLASFANLIAKMRAETAQMSLPETVEHVVRASG
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHC
LADFYQGEREGQDRLENLQELVNAATAFVSEEGYGLDTPARSIPLHARASAAPELAAGGA
CHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCC
DPADAVLAPANLADPAQNPDAMTPLAGFLSHASLEAGDNQAQAGQDAVQLMTVHAAKGLE
CCHHHEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCH
FAAVFITGLEEGLFPHENSALESDGLEEERRLMYVAITRAKERLYLSFAQSRMLHGQTRY
HHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHEEEEEEHHHHHHHHHHHHHHHHHCCCHHH
NIRSRFFDELPQHVLKWLTPKVEAGARWGGRSDNAGWGRDWFARPGGGARESVVDAAVSA
HHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHC
PLPAFANQQREAQNGLRIGQQVFHTKFGEGTVTALEGSGTDAKAQVKFKRHGEKWLALAV
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEEHHHHCCHHHHHHHH
AKLQAVE
HHHHHCC
>Mature Secondary Structure 
PDLLANLNPEQLAAVTLPNEPALILAGAGSGKTRVLITRIAWLIQQGYASPATVLAVTF
CCCCCCCCHHHEEEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEE
TNKAAREMMARLSAMMPIDTRGMWIGTFHGLCNRMLRAHFRDAGLPQTFQILDTADQLSA
CCHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
IKRLMKAANVDDEKYPPKNVQYFINNAKEQGLRPDKVDATDSFNRKFVELYQAYDQQCQR
HHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
EGVVDFPELLLRCYELLAHNPPLRAHYQARFKHILVDEFQDTNKLQYAWLKLLAGGHNAI
CCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEE
FAVGDDDQSIYAFRGANVGNMRDFENEFRVRNLIKLEQNYRSHGNILDAANHLIANNAHR
EEECCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHH
LGKNLRTDAGHGEPVRVYEAATDAQEAAWIVEEIRSLVNSGLARSEVAVLYRSNAQSRSI
HCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCHHHHHEEEECCCCHHHH
EHTLMTAGIAYRVYGGLRFFERQEVKHALAYLRLIDNPNDDTAFARVVNFPTRGIGARSI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCHHHH
EQLADAARLYDCSMAAAIPYVAGKAGSSLASFANLIAKMRAETAQMSLPETVEHVVRASG
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHC
LADFYQGEREGQDRLENLQELVNAATAFVSEEGYGLDTPARSIPLHARASAAPELAAGGA
CHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCC
DPADAVLAPANLADPAQNPDAMTPLAGFLSHASLEAGDNQAQAGQDAVQLMTVHAAKGLE
CCHHHEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCH
FAAVFITGLEEGLFPHENSALESDGLEEERRLMYVAITRAKERLYLSFAQSRMLHGQTRY
HHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHEEEEEEHHHHHHHHHHHHHHHHHCCCHHH
NIRSRFFDELPQHVLKWLTPKVEAGARWGGRSDNAGWGRDWFARPGGGARESVVDAAVSA
HHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHC
PLPAFANQQREAQNGLRIGQQVFHTKFGEGTVTALEGSGTDAKAQVKFKRHGEKWLALAV
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEEHHHHCCHHHHHHHH
AKLQAVE
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6379604; 2943729; 1379743; 9278503; 6324092; 2254268; 8419285 [H]