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The map label for this gene is dctA [H]

Identifier: 83720161

GI number: 83720161

Start: 442791

End: 444125

Strand: Direct

Name: dctA [H]

Synonym: BTH_I0399

Alternate gene names: 83720161

Gene position: 442791-444125 (Clockwise)

Preceding gene: 83719362

Following gene: 83721206

Centisome position: 11.62

GC content: 64.64

Gene sequence:

>1335_bases
GTGACGCCGACCTGCTTCGACCCACCTTCTCTCTTCTCTGGAACCATCGTGAAGAAACCGTTCTATAAAGTCCTCTACGT
GCAGGTGATTTTCGCCATCGTCGTCGGCGTGCTCCTGGGTCACCTCTATCCGTCGCTCGCCGTCGACATGAAGCCGCTCG
GCGACGGCTTCATCAAGCTGATCAAGATGGTGATCGGCCCGATCATCTTCTGCACCGTCGTGACGGGCATCGCCGGCATG
CAGGACATGAAGAAGGTGGGCCGCGTCGGCGGCAAGGCGCTCCTGTATTTCGAAATCGTGTCGACGTTCGCGCTCGTGCT
CGGCCTCGCGGCGACGCACATCCTGCGTCCCGGCGTCGGCTTCAACATCGATCCGGCGACGCTCAACGGCAAGGAAGTCG
CGTCGTACGCGGCGAAGGCGCACGGCCAGTCGACCGTCGACTTCCTGATGCACATCATCCCGAACACGATGATCGACGCG
TTCGCGCAGGGCGAGATCCTGCAGATCCTGCTGATCGCGCTCCTGTTCGGCAGCGTGCTCGCGCATCTCGGCGAGCGCGG
CCGCGTCGTCACCGATTTCATCGACGGCATCACGCGCGTGCTGTTCGGCATCGTGCACATCGTCACGAAGCTGGCTCCGG
TCGGCGCGTTCGGCGCGATGGCGTTCACGATCGGCAAGTACGGCGTCGGCTCGCTCGTGCCGCTCCTGAAGCTGATCGGC
ACGTTCTACCTGACGTCGGTCGTGTTCGTGCTCGTCGTGCTCGGCGCGATCGCGCGCTTCACCGGCTTCTCGATCGTCCG
CTTCGTCGGCTACATCAAGGAGGAACTGCTGATCGTGCTCGGCACGAGTTCGTCGGAGGCGGCGCTGCCGCAACTGATGG
AGAAGCTCGAGAAGGCAGGCTGCTCGCGCTCGGTCGTCGGCCTCGTCGTGCCGACCGGCTACTCGTTCAACCTCGACGGC
ACGAACATCTACATGACGATGGCCGTTCTCTTCATCGCGCAGGCGACCAACATCGAACTGACGTGGATGCAGCAGCTCAC
GCTGCTCGCGGTCGCGATGCTGACGTCGAAGGGCGCGAGCGGCGTGACGGGCGCGGGTTTCATCACGCTCGCCGCGACGC
TCGCCGTCGTGCCGACGATTCCGCTGTCCGGCATGGTGCTGATCCTCGGCATCGACCGCTTCATGAGCGAATGCCGCGCG
CTGACCAACATCGTCGGCAATGGCGTCGCGACGGTTGTCGTGTCCGCGTGGGAGAAGGAGCTCGACCGCGCGAAGCTGCA
CGCGGCGCTTTCGGGCAACGGCAAGGCGGCCGCGGGCGAAGCCGCGCGGGTCTGA

Upstream 100 bases:

>100_bases
GCCCCACCCCGTCCACCTCCCTCGGATTCGCTGAGGCCATCGCTTGTTGCGGCACGGCAGCCGCGCGGGCGAGTGGCTCC
CCTGACATTCGTCCGCGCGC

Downstream 100 bases:

>100_bases
CGATGTGTGCGGAGACGGCGGGGCGCGCAGCGGCGCCCGCGCCGGGCGGGGCCGGGCCGGGCGCGTCGAAGCGCGCTTCG
CACGGCCCCGCGGCCTTTTC

Product: C4-dicarboxylate transporter DctA

Products: orotate [Cytoplasm]; fumarate [Cytoplasm]; malate [Cytoplasm]; Na (I) [Cytoplasm]; succinate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 444; Mature: 443

Protein sequence:

>444_residues
MTPTCFDPPSLFSGTIVKKPFYKVLYVQVIFAIVVGVLLGHLYPSLAVDMKPLGDGFIKLIKMVIGPIIFCTVVTGIAGM
QDMKKVGRVGGKALLYFEIVSTFALVLGLAATHILRPGVGFNIDPATLNGKEVASYAAKAHGQSTVDFLMHIIPNTMIDA
FAQGEILQILLIALLFGSVLAHLGERGRVVTDFIDGITRVLFGIVHIVTKLAPVGAFGAMAFTIGKYGVGSLVPLLKLIG
TFYLTSVVFVLVVLGAIARFTGFSIVRFVGYIKEELLIVLGTSSSEAALPQLMEKLEKAGCSRSVVGLVVPTGYSFNLDG
TNIYMTMAVLFIAQATNIELTWMQQLTLLAVAMLTSKGASGVTGAGFITLAATLAVVPTIPLSGMVLILGIDRFMSECRA
LTNIVGNGVATVVVSAWEKELDRAKLHAALSGNGKAAAGEAARV

Sequences:

>Translated_444_residues
MTPTCFDPPSLFSGTIVKKPFYKVLYVQVIFAIVVGVLLGHLYPSLAVDMKPLGDGFIKLIKMVIGPIIFCTVVTGIAGM
QDMKKVGRVGGKALLYFEIVSTFALVLGLAATHILRPGVGFNIDPATLNGKEVASYAAKAHGQSTVDFLMHIIPNTMIDA
FAQGEILQILLIALLFGSVLAHLGERGRVVTDFIDGITRVLFGIVHIVTKLAPVGAFGAMAFTIGKYGVGSLVPLLKLIG
TFYLTSVVFVLVVLGAIARFTGFSIVRFVGYIKEELLIVLGTSSSEAALPQLMEKLEKAGCSRSVVGLVVPTGYSFNLDG
TNIYMTMAVLFIAQATNIELTWMQQLTLLAVAMLTSKGASGVTGAGFITLAATLAVVPTIPLSGMVLILGIDRFMSECRA
LTNIVGNGVATVVVSAWEKELDRAKLHAALSGNGKAAAGEAARV
>Mature_443_residues
TPTCFDPPSLFSGTIVKKPFYKVLYVQVIFAIVVGVLLGHLYPSLAVDMKPLGDGFIKLIKMVIGPIIFCTVVTGIAGMQ
DMKKVGRVGGKALLYFEIVSTFALVLGLAATHILRPGVGFNIDPATLNGKEVASYAAKAHGQSTVDFLMHIIPNTMIDAF
AQGEILQILLIALLFGSVLAHLGERGRVVTDFIDGITRVLFGIVHIVTKLAPVGAFGAMAFTIGKYGVGSLVPLLKLIGT
FYLTSVVFVLVVLGAIARFTGFSIVRFVGYIKEELLIVLGTSSSEAALPQLMEKLEKAGCSRSVVGLVVPTGYSFNLDGT
NIYMTMAVLFIAQATNIELTWMQQLTLLAVAMLTSKGASGVTGAGFITLAATLAVVPTIPLSGMVLILGIDRFMSECRAL
TNIVGNGVATVVVSAWEKELDRAKLHAALSGNGKAAAGEAARV

Specific function: Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the membrane [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI169790839, Length=477, Percent_Identity=24.5283018867925, Blast_Score=119, Evalue=8e-27,
Organism=Homo sapiens, GI4827012, Length=269, Percent_Identity=31.2267657992565, Blast_Score=115, Evalue=8e-26,
Organism=Homo sapiens, GI21314632, Length=424, Percent_Identity=25.2358490566038, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI40254478, Length=468, Percent_Identity=23.7179487179487, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI66773030, Length=418, Percent_Identity=23.444976076555, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI194239697, Length=457, Percent_Identity=24.507658643326, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI5032093, Length=375, Percent_Identity=27.7333333333333, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI223468564, Length=249, Percent_Identity=30.5220883534137, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI223468566, Length=249, Percent_Identity=30.5220883534137, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI262359914, Length=418, Percent_Identity=23.444976076555, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI301601644, Length=166, Percent_Identity=29.5180722891566, Blast_Score=79, Evalue=1e-14,
Organism=Escherichia coli, GI1789947, Length=424, Percent_Identity=61.0849056603774, Blast_Score=531, Evalue=1e-152,
Organism=Escherichia coli, GI1790514, Length=413, Percent_Identity=38.9830508474576, Blast_Score=295, Evalue=3e-81,
Organism=Escherichia coli, GI1788024, Length=398, Percent_Identity=21.608040201005, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1789473, Length=323, Percent_Identity=25.3869969040248, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17537407, Length=397, Percent_Identity=27.2040302267003, Blast_Score=128, Evalue=6e-30,
Organism=Caenorhabditis elegans, GI193206505, Length=454, Percent_Identity=25.3303964757709, Blast_Score=115, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI71996953, Length=474, Percent_Identity=24.2616033755274, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI71983099, Length=486, Percent_Identity=24.6913580246914, Blast_Score=113, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI71983106, Length=486, Percent_Identity=24.6913580246914, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI193206654, Length=437, Percent_Identity=21.9679633867277, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17541374, Length=400, Percent_Identity=22.5, Blast_Score=78, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24583025, Length=425, Percent_Identity=23.2941176470588, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI17137668, Length=425, Percent_Identity=23.2941176470588, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24583023, Length=425, Percent_Identity=23.2941176470588, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI281360483, Length=497, Percent_Identity=25.1509054325956, Blast_Score=92, Evalue=9e-19,
Organism=Drosophila melanogaster, GI17137666, Length=497, Percent_Identity=25.1509054325956, Blast_Score=92, Evalue=9e-19,
Organism=Drosophila melanogaster, GI281360481, Length=499, Percent_Identity=25.0501002004008, Blast_Score=92, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 46886; Mature: 46754

Theoretical pI: Translated: 9.42; Mature: 9.42

Prosite motif: PS00713 NA_DICARBOXYL_SYMP_1 ; PS00714 NA_DICARBOXYL_SYMP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
TPTCFDPPSLFSGTIVKKPFYKVLYVQVIFAIVVGVLLGHLYPSLAVDMKPLGDGFIKL
CCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
IKMVIGPIIFCTVVTGIAGMQDMKKVGRVGGKALLYFEIVSTFALVLGLAATHILRPGVG
HHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
FNIDPATLNGKEVASYAAKAHGQSTVDFLMHIIPNTMIDAFAQGEILQILLIALLFGSVL
CCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
AHLGERGRVVTDFIDGITRVLFGIVHIVTKLAPVGAFGAMAFTIGKYGVGSLVPLLKLIG
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHH
TFYLTSVVFVLVVLGAIARFTGFSIVRFVGYIKEELLIVLGTSSSEAALPQLMEKLEKAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCHHHHHHHHHHHHHCC
CSRSVVGLVVPTGYSFNLDGTNIYMTMAVLFIAQATNIELTWMQQLTLLAVAMLTSKGAS
CCCCEEEEEEECCEEECCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCC
GVTGAGFITLAATLAVVPTIPLSGMVLILGIDRFMSECRALTNIVGNGVATVVVSAWEKE
CCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
LDRAKLHAALSGNGKAAAGEAARV
HHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: orotate [Periplasm]; fumarate [Periplasm]; malate [Periplasm]; Na (I) [Periplasm]; succinate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + orotate [Periplasm] = Na (I) [Cytoplasm] + orotate [Cytoplasm] Na (I) [Periplasm] + fumarate [Periplasm] = Na (I) [Cytoplasm] + fumarate [Cytoplasm] Na (I) [Periplasm] + malate [Periplasm] = Na (I) [Cytoplasm] + malate [Cytoplasm] Na

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA