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The map label for this gene is phbA [H]

Identifier: 83719964

GI number: 83719964

Start: 2538455

End: 2539636

Strand: Direct

Name: phbA [H]

Synonym: BTH_I2256

Alternate gene names: 83719964

Gene position: 2538455-2539636 (Clockwise)

Preceding gene: 83720440

Following gene: 83719268

Centisome position: 66.64

GC content: 69.12

Gene sequence:

>1182_bases
ATGACTGACGTAGTGATCGTATCGGCCGCGCGCACCGCGGTCGGCAAGTTCGGCGGCTCGCTCGCGAAGATCGCCGCGCC
GGAGCTCGGCGCGACCGTGATCCGCGCGGTGCTCGAGCGTGCGGGCGTGAAGCCCGAGCAGGTCAGCGAAGTGATTCTCG
GCCAGGTGCTGACGGCGGGCTCGGGCCAGAATCCGGCGCGTCAGGCGCTCATCGCGGCGGGGCTGCCGAACGCCGTGCCG
GGCATGACGATCAACAAGGTGTGCGGCTCCGGCCTGAAGGCCGTGATGCTCGCCGCGAACGCGATCGTCGCGGGCGACGC
GGAGATCGTCGTTGCGGGCGGGCAGGAGAACATGAGCGCCGCGCCGCACGTGCTGCCGGGCTCGCGCGACGGCTTCCGGA
TGGGCGATGCGAAGCTTGTCGACAGCATGATCGTCGACGGCCTGTGGGACGTCTACAACAAGTACCACATGGGCGTCACG
GCGGAGAACGTCGCGAAGGAGTACGGGATCACGCGCGAAGCGCAGGACCAGTTCGCGGCGCTGTCGCAGAACAAGGCGGA
AGCCGCGCAGAAAGCCGGCCGTTTCGACGACGAGATCGTGCCGATCGAGATCCCGCAGCGAAAGGGCGAGCCGCTTCGCT
TCGCGACCGACGAGTTCGTGCGCTACGGCGTGACGGCCGAGTCGCTCGCGAGCCTGAAGCCCGCGTTCGCGAAGGACGGC
ACGGTGACGGCCGCGAACGCGTCCGGCATCAACGACGGCGCGGCCGCGGTGCTCGTGATGTCTGCGAAGAAGGCCGAGGC
GCTCGGTCTCGAGCCGCTCGCGCGGATCAAGGCGTACGCGAACGCGGGCGTCGATCCGAGCGTGATGGGCATGGGCCCCG
TTCCGGCATCGCGCCGCTGTCTCGAACGCGCGGGCTGGTCGGTGGGCGACCTCGACCTGATGGAGATCAACGAGGCGTTC
GCCGCGCAGGCGCTCGCGGTCCACAAGCAGATGGGCTGGGATACGTCGAAGGTCAACGTGAACGGCGGCGCGATCGCGAT
CGGCCATCCGATCGGCGCGTCGGGCTGCCGGATTCTCGTCACGCTGCTGCACGAAATGCAAAAGCGCGATGCGAAACGCG
GCCTCGCGTCGCTTTGCATCGGCGGCGGAATGGGCGTCGCGCTCGCGCTCGAGCGCCCGTAA

Upstream 100 bases:

>100_bases
TTGACGAACGACGGAAGGCGGAGCACGCTTTGCGTCGCTACCGATTTTTAACAGGGCGGTTCGCGGCGCGCCGTGCCGCG
TTCGCTCGGAGGATAGTGAA

Downstream 100 bases:

>100_bases
CGCGAGTCAGGAGGCACCCGAGCGGGCCGTGCCGACAGGCGCGGCCCGGCGTCGGGCGAAAAGGCAGGCGGGCGACGGAG
AGGTTGCCGCTCGGCGCTTC

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 393; Mature: 392

Protein sequence:

>393_residues
MTDVVIVSAARTAVGKFGGSLAKIAAPELGATVIRAVLERAGVKPEQVSEVILGQVLTAGSGQNPARQALIAAGLPNAVP
GMTINKVCGSGLKAVMLAANAIVAGDAEIVVAGGQENMSAAPHVLPGSRDGFRMGDAKLVDSMIVDGLWDVYNKYHMGVT
AENVAKEYGITREAQDQFAALSQNKAEAAQKAGRFDDEIVPIEIPQRKGEPLRFATDEFVRYGVTAESLASLKPAFAKDG
TVTAANASGINDGAAAVLVMSAKKAEALGLEPLARIKAYANAGVDPSVMGMGPVPASRRCLERAGWSVGDLDLMEINEAF
AAQALAVHKQMGWDTSKVNVNGGAIAIGHPIGASGCRILVTLLHEMQKRDAKRGLASLCIGGGMGVALALERP

Sequences:

>Translated_393_residues
MTDVVIVSAARTAVGKFGGSLAKIAAPELGATVIRAVLERAGVKPEQVSEVILGQVLTAGSGQNPARQALIAAGLPNAVP
GMTINKVCGSGLKAVMLAANAIVAGDAEIVVAGGQENMSAAPHVLPGSRDGFRMGDAKLVDSMIVDGLWDVYNKYHMGVT
AENVAKEYGITREAQDQFAALSQNKAEAAQKAGRFDDEIVPIEIPQRKGEPLRFATDEFVRYGVTAESLASLKPAFAKDG
TVTAANASGINDGAAAVLVMSAKKAEALGLEPLARIKAYANAGVDPSVMGMGPVPASRRCLERAGWSVGDLDLMEINEAF
AAQALAVHKQMGWDTSKVNVNGGAIAIGHPIGASGCRILVTLLHEMQKRDAKRGLASLCIGGGMGVALALERP
>Mature_392_residues
TDVVIVSAARTAVGKFGGSLAKIAAPELGATVIRAVLERAGVKPEQVSEVILGQVLTAGSGQNPARQALIAAGLPNAVPG
MTINKVCGSGLKAVMLAANAIVAGDAEIVVAGGQENMSAAPHVLPGSRDGFRMGDAKLVDSMIVDGLWDVYNKYHMGVTA
ENVAKEYGITREAQDQFAALSQNKAEAAQKAGRFDDEIVPIEIPQRKGEPLRFATDEFVRYGVTAESLASLKPAFAKDGT
VTAANASGINDGAAAVLVMSAKKAEALGLEPLARIKAYANAGVDPSVMGMGPVPASRRCLERAGWSVGDLDLMEINEAFA
AQALAVHKQMGWDTSKVNVNGGAIAIGHPIGASGCRILVTLLHEMQKRDAKRGLASLCIGGGMGVALALERP

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=391, Percent_Identity=56.5217391304348, Blast_Score=446, Evalue=1e-125,
Organism=Homo sapiens, GI167614485, Length=390, Percent_Identity=44.6153846153846, Blast_Score=322, Evalue=3e-88,
Organism=Homo sapiens, GI4557237, Length=393, Percent_Identity=44.0203562340967, Blast_Score=317, Evalue=2e-86,
Organism=Homo sapiens, GI4501853, Length=397, Percent_Identity=42.3173803526448, Blast_Score=276, Evalue=2e-74,
Organism=Homo sapiens, GI4504327, Length=424, Percent_Identity=30.8962264150943, Blast_Score=188, Evalue=1e-47,
Organism=Homo sapiens, GI194353979, Length=394, Percent_Identity=30.7106598984772, Blast_Score=158, Evalue=7e-39,
Organism=Escherichia coli, GI87082165, Length=392, Percent_Identity=62.7551020408163, Blast_Score=493, Evalue=1e-140,
Organism=Escherichia coli, GI1788554, Length=393, Percent_Identity=60.559796437659, Blast_Score=451, Evalue=1e-128,
Organism=Escherichia coli, GI1787663, Length=404, Percent_Identity=45.049504950495, Blast_Score=317, Evalue=8e-88,
Organism=Escherichia coli, GI48994986, Length=399, Percent_Identity=42.3558897243108, Blast_Score=276, Evalue=2e-75,
Organism=Escherichia coli, GI1788683, Length=423, Percent_Identity=34.0425531914894, Blast_Score=194, Evalue=9e-51,
Organism=Caenorhabditis elegans, GI133906874, Length=390, Percent_Identity=46.6666666666667, Blast_Score=338, Evalue=3e-93,
Organism=Caenorhabditis elegans, GI25147385, Length=387, Percent_Identity=43.1524547803618, Blast_Score=306, Evalue=1e-83,
Organism=Caenorhabditis elegans, GI17535921, Length=396, Percent_Identity=41.4141414141414, Blast_Score=280, Evalue=1e-75,
Organism=Caenorhabditis elegans, GI17535917, Length=394, Percent_Identity=33.502538071066, Blast_Score=193, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI17551802, Length=428, Percent_Identity=31.7757009345794, Blast_Score=189, Evalue=3e-48,
Organism=Saccharomyces cerevisiae, GI6325229, Length=397, Percent_Identity=44.080604534005, Blast_Score=304, Evalue=1e-83,
Organism=Saccharomyces cerevisiae, GI6322031, Length=399, Percent_Identity=40.8521303258145, Blast_Score=244, Evalue=2e-65,
Organism=Drosophila melanogaster, GI24655093, Length=392, Percent_Identity=57.3979591836735, Blast_Score=451, Evalue=1e-127,
Organism=Drosophila melanogaster, GI24640423, Length=393, Percent_Identity=46.0559796437659, Blast_Score=325, Evalue=2e-89,
Organism=Drosophila melanogaster, GI17648125, Length=390, Percent_Identity=46.1538461538462, Blast_Score=321, Evalue=7e-88,
Organism=Drosophila melanogaster, GI17137578, Length=425, Percent_Identity=31.2941176470588, Blast_Score=184, Evalue=7e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 40585; Mature: 40454

Theoretical pI: Translated: 7.04; Mature: 7.04

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDVVIVSAARTAVGKFGGSLAKIAAPELGATVIRAVLERAGVKPEQVSEVILGQVLTAG
CCCEEEEEHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC
SGQNPARQALIAAGLPNAVPGMTINKVCGSGLKAVMLAANAIVAGDAEIVVAGGQENMSA
CCCCHHHHHHHHCCCCCCCCCCCHHHHHCCCHHHHHHHHHHEEECCCEEEEECCCCCCCC
APHVLPGSRDGFRMGDAKLVDSMIVDGLWDVYNKYHMGVTAENVAKEYGITREAQDQFAA
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHH
LSQNKAEAAQKAGRFDDEIVPIEIPQRKGEPLRFATDEFVRYGVTAESLASLKPAFAKDG
HHCHHHHHHHHCCCCCCCEEEEECCCCCCCCCEEHHHHHHHHCCCHHHHHHCCCCCCCCC
TVTAANASGINDGAAAVLVMSAKKAEALGLEPLARIKAYANAGVDPSVMGMGPVPASRRC
CEEECCCCCCCCCCEEEEEEECCHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHH
LERAGWSVGDLDLMEINEAFAAQALAVHKQMGWDTSKVNVNGGAIAIGHPIGASGCRILV
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCEEEECCCCCCCHHHHHH
TLLHEMQKRDAKRGLASLCIGGGMGVALALERP
HHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCC
>Mature Secondary Structure 
TDVVIVSAARTAVGKFGGSLAKIAAPELGATVIRAVLERAGVKPEQVSEVILGQVLTAG
CCEEEEEHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC
SGQNPARQALIAAGLPNAVPGMTINKVCGSGLKAVMLAANAIVAGDAEIVVAGGQENMSA
CCCCHHHHHHHHCCCCCCCCCCCHHHHHCCCHHHHHHHHHHEEECCCEEEEECCCCCCCC
APHVLPGSRDGFRMGDAKLVDSMIVDGLWDVYNKYHMGVTAENVAKEYGITREAQDQFAA
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHH
LSQNKAEAAQKAGRFDDEIVPIEIPQRKGEPLRFATDEFVRYGVTAESLASLKPAFAKDG
HHCHHHHHHHHCCCCCCCEEEEECCCCCCCCCEEHHHHHHHHCCCHHHHHHCCCCCCCCC
TVTAANASGINDGAAAVLVMSAKKAEALGLEPLARIKAYANAGVDPSVMGMGPVPASRRC
CEEECCCCCCCCCCEEEEEEECCHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHH
LERAGWSVGDLDLMEINEAFAAQALAVHKQMGWDTSKVNVNGGAIAIGHPIGASGCRILV
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCEEEECCCCCCCHHHHHH
TLLHEMQKRDAKRGLASLCIGGGMGVALALERP
HHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2670935; 2670936 [H]