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The map label for this gene is dctA [H]

Identifier: 83719924

GI number: 83719924

Start: 2850581

End: 2851993

Strand: Direct

Name: dctA [H]

Synonym: BTH_I2493

Alternate gene names: 83719924

Gene position: 2850581-2851993 (Clockwise)

Preceding gene: 83719165

Following gene: 83721523

Centisome position: 74.83

GC content: 64.26

Gene sequence:

>1413_bases
GTGCGTGCCGTACCGGAAGGCGCGCGAACAGCTCAGGTTGTCAGTCCACTGCTTGCACGCCGGCGAGCCGCGCCGTCATT
TGCAATACCTGCCGTGCAATTTGGACTCCTCATGAAGAAAAGACGCAACATCACCTCGTACATCGTGATTGCGATGATCC
TCGGCATCGCGGTCGGCTATGGTTGCCACAGTGCGTTTCCGGACCCGGCGATCGCGAAGGAAATCGCCGGCTACGTCTCG
CTGCTGTCCGACGTGTTCCTGCGTCTCATCAAGATGATCATCGCGCCGCTCGTGTTCGCGACGCTGACGGTCGGCATCGC
GCACATGGGCGACACCGGAGCGGTCGGCCGGGTCGGCGTGAAGGCACTCGGCTGGTTCTTCATCGCGTCGTTCACGTCGC
TGCTGCTCGGCCTGCTGGCCGCAACGGTCCTGCAGCCGGGCAGTCATCTGAGCCTGCCGCTGCCCGCCACCGATGCCGCC
GTCAATCTGAAGACCAGCTCGTTCACGCTGAAGGACTTCGTGATCCACCTGGTGCCGAAGTCGATCGCCGAGGCAATGGC
GAACAACGAGATCCTGCAGATCGTCGTGTTCTCGATCTTCTTCGGCACCGCGCTGTCCGCGCTCGGCGACGCCGGCAAAC
GGCTGACCGGCGTGATCGAGGATCTCGCGCAAGTGATGCTGAAGGTCACGGGCGCCGTGATGTGGTTCGCGCCCGTCGCG
GTGTTCGCGGCGCTCGCGTCGACGATCACGACGGAAGGGCTCGGCATCCTGCTCACGTTCGCGAAGTTCATGGGCAGCTT
CTATATCGCACTTGCGCTGCTGTGGGGCGTGCTCACGCTCGCCGGCATCGTGTTTCTCGGCAAGCGCACGTTCACGCTGA
TCCGCCTGATCCGCGAGCCGTTCCTGCTGTCGTTCGCGACCGCAAGCTCGGAGGCCGCGTATCCGAAGCTGCTCGACGCG
CTCGACCGCTTCGGCGTGAACCGCAAGATTTCGAGCTTCGTGCTGCCGATCGGCTATTCGTTCAACCTCGACGGCTCGAT
GATGTACTGCACGTTCGCGGTGCTGTTCATCGCGCAGGTATACGGCGTCCACTTGCCGCTCGGCACGCAGATCACGATGC
TGCTTCTGCTGATGCTGACGTCGAAGGGCATGGCCGGCGTGCCGCGCGCGTCGCTCGTCGTGATCGCGGCGACGCTCAAC
CAGTTCCACCTGCCCGAAGCAGGCCTGCTGCTGATCATGGGCGTCGACATGTTCCTCGACATGGGCCGATCGGCGACCAA
TGCTGTCGGCAATTCGATCGCGGCCGCCGTCGTCGCGAAGTGGGAAGGCCAGCTCGACGACCCGCGCGACGATGCCGACC
CCGACAGCGGCCACGCGTCGCGCGAATCGCCGCAAATCACGGAGCGCGTGTAG

Upstream 100 bases:

>100_bases
GCTTTCATTTTTGAAAGCGCCCCGGTCAATTGAGGTAACATAGGGCCCGCTTGCGTCGAGCGGCCGCCTCCTGCCGCCCG
TCTCCCGCGAGCGTTGTCTG

Downstream 100 bases:

>100_bases
CGCGCGCACTCGCACAGGCCGGGCCGCTCCCGATCGTCCGCGCCAAGCCGGCGGCGGCACGCCCGGCCCGCGACGCCCGA
TGGCCGCCTTGCGGTAAAAT

Product: sodium:dicarboxylate symporter family protein

Products: orotate [Cytoplasm]; fumarate [Cytoplasm]; malate [Cytoplasm]; Na (I) [Cytoplasm]; succinate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 470; Mature: 470

Protein sequence:

>470_residues
MRAVPEGARTAQVVSPLLARRRAAPSFAIPAVQFGLLMKKRRNITSYIVIAMILGIAVGYGCHSAFPDPAIAKEIAGYVS
LLSDVFLRLIKMIIAPLVFATLTVGIAHMGDTGAVGRVGVKALGWFFIASFTSLLLGLLAATVLQPGSHLSLPLPATDAA
VNLKTSSFTLKDFVIHLVPKSIAEAMANNEILQIVVFSIFFGTALSALGDAGKRLTGVIEDLAQVMLKVTGAVMWFAPVA
VFAALASTITTEGLGILLTFAKFMGSFYIALALLWGVLTLAGIVFLGKRTFTLIRLIREPFLLSFATASSEAAYPKLLDA
LDRFGVNRKISSFVLPIGYSFNLDGSMMYCTFAVLFIAQVYGVHLPLGTQITMLLLLMLTSKGMAGVPRASLVVIAATLN
QFHLPEAGLLLIMGVDMFLDMGRSATNAVGNSIAAAVVAKWEGQLDDPRDDADPDSGHASRESPQITERV

Sequences:

>Translated_470_residues
MRAVPEGARTAQVVSPLLARRRAAPSFAIPAVQFGLLMKKRRNITSYIVIAMILGIAVGYGCHSAFPDPAIAKEIAGYVS
LLSDVFLRLIKMIIAPLVFATLTVGIAHMGDTGAVGRVGVKALGWFFIASFTSLLLGLLAATVLQPGSHLSLPLPATDAA
VNLKTSSFTLKDFVIHLVPKSIAEAMANNEILQIVVFSIFFGTALSALGDAGKRLTGVIEDLAQVMLKVTGAVMWFAPVA
VFAALASTITTEGLGILLTFAKFMGSFYIALALLWGVLTLAGIVFLGKRTFTLIRLIREPFLLSFATASSEAAYPKLLDA
LDRFGVNRKISSFVLPIGYSFNLDGSMMYCTFAVLFIAQVYGVHLPLGTQITMLLLLMLTSKGMAGVPRASLVVIAATLN
QFHLPEAGLLLIMGVDMFLDMGRSATNAVGNSIAAAVVAKWEGQLDDPRDDADPDSGHASRESPQITERV
>Mature_470_residues
MRAVPEGARTAQVVSPLLARRRAAPSFAIPAVQFGLLMKKRRNITSYIVIAMILGIAVGYGCHSAFPDPAIAKEIAGYVS
LLSDVFLRLIKMIIAPLVFATLTVGIAHMGDTGAVGRVGVKALGWFFIASFTSLLLGLLAATVLQPGSHLSLPLPATDAA
VNLKTSSFTLKDFVIHLVPKSIAEAMANNEILQIVVFSIFFGTALSALGDAGKRLTGVIEDLAQVMLKVTGAVMWFAPVA
VFAALASTITTEGLGILLTFAKFMGSFYIALALLWGVLTLAGIVFLGKRTFTLIRLIREPFLLSFATASSEAAYPKLLDA
LDRFGVNRKISSFVLPIGYSFNLDGSMMYCTFAVLFIAQVYGVHLPLGTQITMLLLLMLTSKGMAGVPRASLVVIAATLN
QFHLPEAGLLLIMGVDMFLDMGRSATNAVGNSIAAAVVAKWEGQLDDPRDDADPDSGHASRESPQITERV

Specific function: Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the membrane [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI21314632, Length=441, Percent_Identity=27.891156462585, Blast_Score=145, Evalue=8e-35,
Organism=Homo sapiens, GI169790839, Length=485, Percent_Identity=25.7731958762887, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI40254478, Length=480, Percent_Identity=25, Blast_Score=128, Evalue=9e-30,
Organism=Homo sapiens, GI4827012, Length=256, Percent_Identity=33.59375, Blast_Score=126, Evalue=4e-29,
Organism=Homo sapiens, GI5032093, Length=384, Percent_Identity=28.6458333333333, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI194239697, Length=283, Percent_Identity=29.6819787985866, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI223468566, Length=309, Percent_Identity=27.5080906148867, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI223468564, Length=282, Percent_Identity=29.4326241134752, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI66773030, Length=415, Percent_Identity=25.0602409638554, Blast_Score=109, Evalue=6e-24,
Organism=Homo sapiens, GI262359914, Length=417, Percent_Identity=23.9808153477218, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI301601644, Length=196, Percent_Identity=29.5918367346939, Blast_Score=88, Evalue=1e-17,
Organism=Escherichia coli, GI1789947, Length=394, Percent_Identity=40.8629441624365, Blast_Score=275, Evalue=3e-75,
Organism=Escherichia coli, GI1790514, Length=412, Percent_Identity=38.8349514563107, Blast_Score=275, Evalue=6e-75,
Organism=Escherichia coli, GI1788024, Length=421, Percent_Identity=24.4655581947743, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1789473, Length=289, Percent_Identity=23.1833910034602, Blast_Score=69, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17537407, Length=448, Percent_Identity=25.8928571428571, Blast_Score=151, Evalue=6e-37,
Organism=Caenorhabditis elegans, GI71996953, Length=463, Percent_Identity=27.645788336933, Blast_Score=147, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI71983099, Length=420, Percent_Identity=25.7142857142857, Blast_Score=141, Evalue=9e-34,
Organism=Caenorhabditis elegans, GI71983106, Length=420, Percent_Identity=25.7142857142857, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI193206505, Length=466, Percent_Identity=25.5364806866953, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI193206654, Length=465, Percent_Identity=21.7204301075269, Blast_Score=115, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17541374, Length=451, Percent_Identity=22.6164079822616, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24583025, Length=433, Percent_Identity=26.3279445727483, Blast_Score=145, Evalue=4e-35,
Organism=Drosophila melanogaster, GI17137668, Length=433, Percent_Identity=26.3279445727483, Blast_Score=145, Evalue=4e-35,
Organism=Drosophila melanogaster, GI24583023, Length=433, Percent_Identity=26.3279445727483, Blast_Score=145, Evalue=4e-35,
Organism=Drosophila melanogaster, GI281360481, Length=432, Percent_Identity=26.8518518518519, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI281360483, Length=432, Percent_Identity=26.8518518518519, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI17137666, Length=432, Percent_Identity=26.8518518518519, Blast_Score=101, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 50037; Mature: 50037

Theoretical pI: Translated: 9.66; Mature: 9.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHCCC
>Mature Secondary Structure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CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: orotate [Periplasm]; fumarate [Periplasm]; malate [Periplasm]; Na (I) [Periplasm]; succinate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + orotate [Periplasm] = Na (I) [Cytoplasm] + orotate [Cytoplasm] Na (I) [Periplasm] + fumarate [Periplasm] = Na (I) [Cytoplasm] + fumarate [Cytoplasm] Na (I) [Periplasm] + malate [Periplasm] = Na (I) [Cytoplasm] + malate [Cytoplasm] Na

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA