Click here to switch to the map view.

The map label for this gene is gutB [H]

Identifier: 83719883

GI number: 83719883

Start: 2781966

End: 2783057

Strand: Reverse

Name: gutB [H]

Synonym: BTH_I2432

Alternate gene names: 83719883

Gene position: 2783057-2781966 (Counterclockwise)

Preceding gene: 83720324

Following gene: 83719138

Centisome position: 73.06

GC content: 67.58

Gene sequence:

>1092_bases
ATGACGAATCGAAACGACGACACGCAGCAGATGACGGCGATCGTCTGCCACGCCCCCGAGGACTATCGCGTCGAGCGCGT
CGCGAAGCCGCGCGCGAACGCGCGCGAGCTCGTGATCCGCATCGGCGCGTGCGGAATCTGCGCGAGCGACTGCAAGTGCC
ATTCCGGCGCGAAGATGTTCTGGGGCGGCCCGAGCCCGTGGGTCAAGGCGCCCGTGATTCCCGGCCACGAGTTCTTCGGC
CATGTCGAGGAACTGGGCGAGGGCGCGGCCGAGCACTTCGGCGTCGCGCTCGGCGATCGCGTGATCGCCGAGCAGATCGT
GCCGTGCGGCAATTGCCGCTACTGCAAGTCGGGCCAGTACTGGATGTGCGAGGTCCACAACATCTTCGGCTTCCAGCGAG
AAGTCGCCGACGGCGGGATGGCCGAGTACATGCGGATTCCGTCCACCGCGATCGTCCACCGGATTCCGCTCGGCATCTCG
CTCGAGGACGCGGCGATCATCGAGCCGCTCGCGTGCGCGATCCACACGGTCAATCGCGGCGACATCCAGCTCGACGACGT
CGTCGTGATCGCGGGCGCGGGGCCGCTCGGCCTGATGATGACGCAGGTCGCGAAGCTGAAGACGCCGAAGCGGCTCGTCG
TGATCGATCCCGTCGGCGAACGGCTCGCGCTCGCGCGCGAATACGGCGCGGACGTGACGATCGACCCGACGCGCGAGGAC
GCGCTCGCGATCGTGCACGAGCTGACGGGCGGCTACGGCTGCGACGTCTACATCGAGACGACCGGCGTGCCGGCGGGCGT
CACGCAGGGGATGAGCCTGATCCGCAAGCTCGGCCGCTTCGTCGAGTTCTCGGTGTTCGGCAAGGACACGGCGCTCGACT
GGTCGATCATCGGCGATCGCAAGGAGCTCGACGTGCGCGGCGCGCATCTCGGCCCGTATTGCTATCCTGTCGCGATCGAT
CTGCTCGCGCGCGGGCTCGTCACGTCGAAGGGCATCGTCACGCACGGCTTCTCGCTCGAAGAATGGGACGAGGCGATCCG
GGTCGCGAACTCGCTCGGCTCGATCAAGGTGCTGATGAAGCCGCGCGGCTGA

Upstream 100 bases:

>100_bases
CGCGGCGTCGCGGCGAGCGGCGGCCCGCCCGGCGCGTTCGCCCGCCCGCCGCTTCATCCGGCATTTCATTTCTTCGAACC
CAGCCAGGCAAACCGAAACC

Downstream 100 bases:

>100_bases
GTGCGCCGCTCATCGAAACGCGGAGGCGATATGGCATGCGTGATTGGTGTCGACATCGGCACCCAGAGCACGAAGGCGGT
CCTCGTCGGCATCGACGGCG

Product: zinc-binding dehydrogenase family oxidoreductase

Products: NA

Alternate protein names: Glucitol dehydrogenase; L-iditol 2-dehydrogenase [H]

Number of amino acids: Translated: 363; Mature: 362

Protein sequence:

>363_residues
MTNRNDDTQQMTAIVCHAPEDYRVERVAKPRANARELVIRIGACGICASDCKCHSGAKMFWGGPSPWVKAPVIPGHEFFG
HVEELGEGAAEHFGVALGDRVIAEQIVPCGNCRYCKSGQYWMCEVHNIFGFQREVADGGMAEYMRIPSTAIVHRIPLGIS
LEDAAIIEPLACAIHTVNRGDIQLDDVVVIAGAGPLGLMMTQVAKLKTPKRLVVIDPVGERLALAREYGADVTIDPTRED
ALAIVHELTGGYGCDVYIETTGVPAGVTQGMSLIRKLGRFVEFSVFGKDTALDWSIIGDRKELDVRGAHLGPYCYPVAID
LLARGLVTSKGIVTHGFSLEEWDEAIRVANSLGSIKVLMKPRG

Sequences:

>Translated_363_residues
MTNRNDDTQQMTAIVCHAPEDYRVERVAKPRANARELVIRIGACGICASDCKCHSGAKMFWGGPSPWVKAPVIPGHEFFG
HVEELGEGAAEHFGVALGDRVIAEQIVPCGNCRYCKSGQYWMCEVHNIFGFQREVADGGMAEYMRIPSTAIVHRIPLGIS
LEDAAIIEPLACAIHTVNRGDIQLDDVVVIAGAGPLGLMMTQVAKLKTPKRLVVIDPVGERLALAREYGADVTIDPTRED
ALAIVHELTGGYGCDVYIETTGVPAGVTQGMSLIRKLGRFVEFSVFGKDTALDWSIIGDRKELDVRGAHLGPYCYPVAID
LLARGLVTSKGIVTHGFSLEEWDEAIRVANSLGSIKVLMKPRG
>Mature_362_residues
TNRNDDTQQMTAIVCHAPEDYRVERVAKPRANARELVIRIGACGICASDCKCHSGAKMFWGGPSPWVKAPVIPGHEFFGH
VEELGEGAAEHFGVALGDRVIAEQIVPCGNCRYCKSGQYWMCEVHNIFGFQREVADGGMAEYMRIPSTAIVHRIPLGISL
EDAAIIEPLACAIHTVNRGDIQLDDVVVIAGAGPLGLMMTQVAKLKTPKRLVVIDPVGERLALAREYGADVTIDPTREDA
LAIVHELTGGYGCDVYIETTGVPAGVTQGMSLIRKLGRFVEFSVFGKDTALDWSIIGDRKELDVRGAHLGPYCYPVAIDL
LARGLVTSKGIVTHGFSLEEWDEAIRVANSLGSIKVLMKPRG

Specific function: Reduces glucitol to fructose [H]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=350, Percent_Identity=31.1428571428571, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI4501929, Length=378, Percent_Identity=24.6031746031746, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI71565154, Length=282, Percent_Identity=26.9503546099291, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI34577061, Length=275, Percent_Identity=26.1818181818182, Blast_Score=65, Evalue=9e-11,
Organism=Homo sapiens, GI4501933, Length=275, Percent_Identity=26.1818181818182, Blast_Score=65, Evalue=9e-11,
Organism=Escherichia coli, GI1787863, Length=340, Percent_Identity=28.8235294117647, Blast_Score=144, Evalue=9e-36,
Organism=Escherichia coli, GI1788073, Length=351, Percent_Identity=28.2051282051282, Blast_Score=132, Evalue=4e-32,
Organism=Escherichia coli, GI1790045, Length=346, Percent_Identity=30.0578034682081, Blast_Score=131, Evalue=7e-32,
Organism=Escherichia coli, GI1788075, Length=364, Percent_Identity=28.8461538461538, Blast_Score=122, Evalue=4e-29,
Organism=Escherichia coli, GI1788407, Length=336, Percent_Identity=28.2738095238095, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI226510992, Length=335, Percent_Identity=27.1641791044776, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI1786825, Length=291, Percent_Identity=29.2096219931272, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI87082125, Length=284, Percent_Identity=31.3380281690141, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1790718, Length=325, Percent_Identity=27.3846153846154, Blast_Score=101, Evalue=9e-23,
Organism=Escherichia coli, GI87081918, Length=221, Percent_Identity=33.4841628959276, Blast_Score=77, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17562876, Length=359, Percent_Identity=30.9192200557103, Blast_Score=161, Evalue=6e-40,
Organism=Caenorhabditis elegans, GI17562878, Length=357, Percent_Identity=29.6918767507003, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI71997431, Length=238, Percent_Identity=26.890756302521, Blast_Score=65, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6323099, Length=364, Percent_Identity=27.1978021978022, Blast_Score=115, Evalue=8e-27,
Organism=Saccharomyces cerevisiae, GI6322619, Length=342, Percent_Identity=28.0701754385965, Blast_Score=113, Evalue=4e-26,
Organism=Saccharomyces cerevisiae, GI6319955, Length=342, Percent_Identity=28.0701754385965, Blast_Score=113, Evalue=5e-26,
Organism=Saccharomyces cerevisiae, GI6319257, Length=278, Percent_Identity=28.4172661870504, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6319258, Length=274, Percent_Identity=24.4525547445255, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6324486, Length=334, Percent_Identity=28.7425149700599, Blast_Score=71, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6320033, Length=284, Percent_Identity=26.056338028169, Blast_Score=70, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6323729, Length=317, Percent_Identity=25.8675078864353, Blast_Score=66, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6319520, Length=159, Percent_Identity=30.8176100628931, Blast_Score=66, Evalue=7e-12,
Organism=Drosophila melanogaster, GI17137530, Length=363, Percent_Identity=29.7520661157025, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI17737897, Length=365, Percent_Identity=29.8630136986301, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI45550770, Length=371, Percent_Identity=25.0673854447439, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI45551930, Length=371, Percent_Identity=25.0673854447439, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI221457811, Length=371, Percent_Identity=25.0673854447439, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI17737895, Length=243, Percent_Identity=26.7489711934156, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.14 [H]

Molecular weight: Translated: 39366; Mature: 39235

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
3.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNRNDDTQQMTAIVCHAPEDYRVERVAKPRANARELVIRIGACGICASDCKCHSGAKMF
CCCCCCCHHEEEEEEEECCCCCCHHHHHCCCCCCEEEEEEECCCCEECCCCCCCCCCEEE
WGGPSPWVKAPVIPGHEFFGHVEELGEGAAEHFGVALGDRVIAEQIVPCGNCRYCKSGQY
ECCCCCCEECCCCCCHHHHHHHHHHCCHHHHHHCHHHHHHHHHHHCCCCCCCCEECCCCE
WMCEVHNIFGFQREVADGGMAEYMRIPSTAIVHRIPLGISLEDAAIIEPLACAIHTVNRG
EEEEEHHHHCHHHHHHCCCHHHHHHCCCHHHHEECCCCCEECCHHHHHHHHHHHEECCCC
DIQLDDVVVIAGAGPLGLMMTQVAKLKTPKRLVVIDPVGERLALAREYGADVTIDPTRED
CEEECCEEEEECCCHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCCEEECCCCHH
ALAIVHELTGGYGCDVYIETTGVPAGVTQGMSLIRKLGRFVEFSVFGKDTALDWSIIGDR
HHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHEEEEEECCCCCEEEEEECCC
KELDVRGAHLGPYCYPVAIDLLARGLVTSKGIVTHGFSLEEWDEAIRVANSLGSIKVLMK
CCCEECCCCCCCHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHCCCCEEEEEE
PRG
CCC
>Mature Secondary Structure 
TNRNDDTQQMTAIVCHAPEDYRVERVAKPRANARELVIRIGACGICASDCKCHSGAKMF
CCCCCCHHEEEEEEEECCCCCCHHHHHCCCCCCEEEEEEECCCCEECCCCCCCCCCEEE
WGGPSPWVKAPVIPGHEFFGHVEELGEGAAEHFGVALGDRVIAEQIVPCGNCRYCKSGQY
ECCCCCCEECCCCCCHHHHHHHHHHCCHHHHHHCHHHHHHHHHHHCCCCCCCCEECCCCE
WMCEVHNIFGFQREVADGGMAEYMRIPSTAIVHRIPLGISLEDAAIIEPLACAIHTVNRG
EEEEEHHHHCHHHHHHCCCHHHHHHCCCHHHHEECCCCCEECCHHHHHHHHHHHEECCCC
DIQLDDVVVIAGAGPLGLMMTQVAKLKTPKRLVVIDPVGERLALAREYGADVTIDPTRED
CEEECCEEEEECCCHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCCEEECCCCHH
ALAIVHELTGGYGCDVYIETTGVPAGVTQGMSLIRKLGRFVEFSVFGKDTALDWSIIGDR
HHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHEEEEEECCCCCEEEEEECCC
KELDVRGAHLGPYCYPVAIDLLARGLVTSKGIVTHGFSLEEWDEAIRVANSLGSIKVLMK
CCCEECCCCCCCHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHCCCCEEEEEE
PRG
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10086842; 11058132 [H]