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The map label for this gene is ahcY [H]

Identifier: 83719843

GI number: 83719843

Start: 3608822

End: 3610243

Strand: Reverse

Name: ahcY [H]

Synonym: BTH_I3165

Alternate gene names: 83719843

Gene position: 3610243-3608822 (Counterclockwise)

Preceding gene: 83719422

Following gene: 83718543

Centisome position: 94.78

GC content: 64.14

Gene sequence:

>1422_bases
ATGAACGCCGCTGTCATCGATTCCAATTCCGCACAAGATTACGTCGTCGCCGATATCGCGCTGGCCGGCTGGGGCCGCAA
GGAACTGAACATCGCCGAGACCGAGATGCCCGGCCTCGTGCAGATCCGCGACGAATACAAGGCGCAGCAGCCGCTGAAAG
GCGCGCGCATCGCCGGCTCGCTGCACATGACGATCCAGACGGGCGTGCTGATCGAGACGCTCAAGGCGCTCGGCGCGGAC
GTTCGCTGGGCGTCGTGCAACATCTTCTCGACGCAGGATCACGCGGCCGCCGCGATCGTCGAAGCCGGCACGCCCGTCTT
CGCGTTCAAGGGCGAATCGCTCGACGAATACTGGGAGTTCTCGCACCGCATCTTCGAATGGCCGAACGGCGAGTTCGCGA
ACATGATCCTCGACGACGGCGGCGACGCAACGCTGCTCCTCATCCTCGGCTCGAAGGCCGAGAAGGACCGCTCGGTGATC
GCGAAGCCGACCAACGAGGAAGAAGTCGCGCTCTTCAAGTCGATCGAGCGCCACCTCGAAATCGACGGCAGCTGGTACTC
GAAGCGCCTCGCGCACATCAAGGGCGTGACCGAAGAGACGACGACGGGCGTGCACCGCCTGTACCAGATGGAAAAGGACG
GCCGCCTGCCGTTCCCGGCGTTCAACGTCAACGATTCGGTGACGAAATCGAAGTTCGACAACCTGTACGGCTGCCGCGAG
TCGCTCGTCGACGGCATCAAGCGCGCGACCGACGTGATGATCGCGGGCAAGATCGCGGTTGTCGCGGGCTACGGCGACGT
GGGCAAGGGCTGCGCGCAATCGCTGCGCGGCCTCGGCGCGACCGTCTGGGTGACGGAAATCGATCCGATCTGCGCGCTGC
AGGCGGCGATGGAAGGCTACCGCGTGGTGACGATGGAATACGCGGCCGACAAGGCCGACATCTTCGTGACGGCGACGGGC
AACTACCACGTGATCAACCACGATCACATGAAGGCGATGCGCCACAACGCGATCGTCTGCAACATCGGCCACTTCGATTC
GGAAATCGACGTCGCGTCGACCCGCCAGTACCAGTGGGAAAACATCAAGCCGCAGGTCGACCACATCATCTTCCCGGACG
GCAAGCGCGTGATCCTGCTGGCGGAAGGCCGCCTCGTGAACCTCGGCTGCGCGACGGGCCACCCGTCGTTCGTGATGTCG
AACTCGTTCACGAACCAGACCCTCGCGCAGATCGAGCTGTTCACGCGCGGCGGCGAGTACGCCAACAAGGTGTACGTGCT
GCCGAAGCACCTCGACGAAAAGGTCGCGCGCCTGCACCTCGCGCGCATCGGCGCGCAGCTCTCCGAGCTGTCGGACGATC
AGGCGGCGTACATCGGCGTGCCGAAGGCGGGCCCGTTCAAGCCGGATCACTATCGTTACTGA

Upstream 100 bases:

>100_bases
CATCGTCGCATAGCGGCGATCGTTTCCGCCGATGCCGGCCGCTTACTTGAACGGCGCTCACGTCACAATTTTCTAGAACT
TTTTTAGAAAGGAGGGCGTG

Downstream 100 bases:

>100_bases
TATCTTGATCCGTACCCGGCGCGCGGGCGCCGGGCGGCCCGCCGCCTGACGCCCGCCGTGCGCGGCGCGCGGGCGGCAAA
GCAAGCCGCCCGCCGCGCCG

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase [H]

Number of amino acids: Translated: 473; Mature: 473

Protein sequence:

>473_residues
MNAAVIDSNSAQDYVVADIALAGWGRKELNIAETEMPGLVQIRDEYKAQQPLKGARIAGSLHMTIQTGVLIETLKALGAD
VRWASCNIFSTQDHAAAAIVEAGTPVFAFKGESLDEYWEFSHRIFEWPNGEFANMILDDGGDATLLLILGSKAEKDRSVI
AKPTNEEEVALFKSIERHLEIDGSWYSKRLAHIKGVTEETTTGVHRLYQMEKDGRLPFPAFNVNDSVTKSKFDNLYGCRE
SLVDGIKRATDVMIAGKIAVVAGYGDVGKGCAQSLRGLGATVWVTEIDPICALQAAMEGYRVVTMEYAADKADIFVTATG
NYHVINHDHMKAMRHNAIVCNIGHFDSEIDVASTRQYQWENIKPQVDHIIFPDGKRVILLAEGRLVNLGCATGHPSFVMS
NSFTNQTLAQIELFTRGGEYANKVYVLPKHLDEKVARLHLARIGAQLSELSDDQAAYIGVPKAGPFKPDHYRY

Sequences:

>Translated_473_residues
MNAAVIDSNSAQDYVVADIALAGWGRKELNIAETEMPGLVQIRDEYKAQQPLKGARIAGSLHMTIQTGVLIETLKALGAD
VRWASCNIFSTQDHAAAAIVEAGTPVFAFKGESLDEYWEFSHRIFEWPNGEFANMILDDGGDATLLLILGSKAEKDRSVI
AKPTNEEEVALFKSIERHLEIDGSWYSKRLAHIKGVTEETTTGVHRLYQMEKDGRLPFPAFNVNDSVTKSKFDNLYGCRE
SLVDGIKRATDVMIAGKIAVVAGYGDVGKGCAQSLRGLGATVWVTEIDPICALQAAMEGYRVVTMEYAADKADIFVTATG
NYHVINHDHMKAMRHNAIVCNIGHFDSEIDVASTRQYQWENIKPQVDHIIFPDGKRVILLAEGRLVNLGCATGHPSFVMS
NSFTNQTLAQIELFTRGGEYANKVYVLPKHLDEKVARLHLARIGAQLSELSDDQAAYIGVPKAGPFKPDHYRY
>Mature_473_residues
MNAAVIDSNSAQDYVVADIALAGWGRKELNIAETEMPGLVQIRDEYKAQQPLKGARIAGSLHMTIQTGVLIETLKALGAD
VRWASCNIFSTQDHAAAAIVEAGTPVFAFKGESLDEYWEFSHRIFEWPNGEFANMILDDGGDATLLLILGSKAEKDRSVI
AKPTNEEEVALFKSIERHLEIDGSWYSKRLAHIKGVTEETTTGVHRLYQMEKDGRLPFPAFNVNDSVTKSKFDNLYGCRE
SLVDGIKRATDVMIAGKIAVVAGYGDVGKGCAQSLRGLGATVWVTEIDPICALQAAMEGYRVVTMEYAADKADIFVTATG
NYHVINHDHMKAMRHNAIVCNIGHFDSEIDVASTRQYQWENIKPQVDHIIFPDGKRVILLAEGRLVNLGCATGHPSFVMS
NSFTNQTLAQIELFTRGGEYANKVYVLPKHLDEKVARLHLARIGAQLSELSDDQAAYIGVPKAGPFKPDHYRY

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine [H]

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family [H]

Homologues:

Organism=Homo sapiens, GI9951915, Length=462, Percent_Identity=59.5238095238095, Blast_Score=524, Evalue=1e-149,
Organism=Homo sapiens, GI239937451, Length=440, Percent_Identity=58.8636363636364, Blast_Score=493, Evalue=1e-139,
Organism=Homo sapiens, GI298286489, Length=470, Percent_Identity=49.7872340425532, Blast_Score=472, Evalue=1e-133,
Organism=Homo sapiens, GI195539337, Length=470, Percent_Identity=49.7872340425532, Blast_Score=471, Evalue=1e-133,
Organism=Homo sapiens, GI24308043, Length=470, Percent_Identity=49.7872340425532, Blast_Score=471, Evalue=1e-133,
Organism=Homo sapiens, GI195539349, Length=470, Percent_Identity=49.7872340425532, Blast_Score=470, Evalue=1e-132,
Organism=Homo sapiens, GI21361647, Length=470, Percent_Identity=50, Blast_Score=457, Evalue=1e-128,
Organism=Caenorhabditis elegans, GI17506425, Length=471, Percent_Identity=59.8726114649682, Blast_Score=537, Evalue=1e-153,
Organism=Saccharomyces cerevisiae, GI6320882, Length=483, Percent_Identity=58.1780538302277, Blast_Score=522, Evalue=1e-149,
Organism=Drosophila melanogaster, GI24642172, Length=466, Percent_Identity=59.656652360515, Blast_Score=535, Evalue=1e-152,
Organism=Drosophila melanogaster, GI24656245, Length=471, Percent_Identity=50.1061571125265, Blast_Score=466, Evalue=1e-131,
Organism=Drosophila melanogaster, GI45553387, Length=469, Percent_Identity=49.4669509594883, Blast_Score=450, Evalue=1e-126,
Organism=Drosophila melanogaster, GI45553385, Length=468, Percent_Identity=49.3589743589744, Blast_Score=448, Evalue=1e-126,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082 [H]

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD [H]

EC number: =3.3.1.1 [H]

Molecular weight: Translated: 52161; Mature: 52161

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: PS00738 ADOHCYASE_1 ; PS00739 ADOHCYASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAAVIDSNSAQDYVVADIALAGWGRKELNIAETEMPGLVQIRDEYKAQQPLKGARIAGS
CCCEEECCCCCCCEEEEEEEEECCCCCCCEEECCCCCCEEEEHHHHCCCCCCCCCEEECE
LHMTIQTGVLIETLKALGADVRWASCNIFSTQDHAAAAIVEAGTPVFAFKGESLDEYWEF
EEEEEECCHHHHHHHHHCCCCEEEEEEEECCCCCCEEEEEECCCEEEEEECCCHHHHHHH
SHRIFEWPNGEFANMILDDGGDATLLLILGSKAEKDRSVIAKPTNEEEVALFKSIERHLE
HHHEEECCCCCEEEEEEECCCCEEEEEEECCCCCCCCCEEECCCCCHHHHHHHHHHHHEE
IDGSWYSKRLAHIKGVTEETTTGVHRLYQMEKDGRLPFPAFNVNDSVTKSKFDNLYGCRE
CCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCEECCCCCHHHHHHHHHHHHHH
SLVDGIKRATDVMIAGKIAVVAGYGDVGKGCAQSLRGLGATVWVTEIDPICALQAAMEGY
HHHHHHHHHHHEEEECEEEEEECCCCCCHHHHHHHHHCCCEEEEEECCHHHHHHHHHCCE
RVVTMEYAADKADIFVTATGNYHVINHDHMKAMRHNAIVCNIGHFDSEIDVASTRQYQWE
EEEEEEECCCCCCEEEEECCCEEEEECHHHHHHHCCEEEEEECCCCCCCCCCCCCCEECC
NIKPQVDHIIFPDGKRVILLAEGRLVNLGCATGHPSFVMSNSFTNQTLAQIELFTRGGEY
CCCCCCCEEECCCCCEEEEEECCEEEEEEECCCCCCEEEECCCCCCEEEEEEEEECCCCC
ANKVYVLPKHLDEKVARLHLARIGAQLSELSDDQAAYIGVPKAGPFKPDHYRY
CCEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCC
>Mature Secondary Structure
MNAAVIDSNSAQDYVVADIALAGWGRKELNIAETEMPGLVQIRDEYKAQQPLKGARIAGS
CCCEEECCCCCCCEEEEEEEEECCCCCCCEEECCCCCCEEEEHHHHCCCCCCCCCEEECE
LHMTIQTGVLIETLKALGADVRWASCNIFSTQDHAAAAIVEAGTPVFAFKGESLDEYWEF
EEEEEECCHHHHHHHHHCCCCEEEEEEEECCCCCCEEEEEECCCEEEEEECCCHHHHHHH
SHRIFEWPNGEFANMILDDGGDATLLLILGSKAEKDRSVIAKPTNEEEVALFKSIERHLE
HHHEEECCCCCEEEEEEECCCCEEEEEEECCCCCCCCCEEECCCCCHHHHHHHHHHHHEE
IDGSWYSKRLAHIKGVTEETTTGVHRLYQMEKDGRLPFPAFNVNDSVTKSKFDNLYGCRE
CCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCEECCCCCHHHHHHHHHHHHHH
SLVDGIKRATDVMIAGKIAVVAGYGDVGKGCAQSLRGLGATVWVTEIDPICALQAAMEGY
HHHHHHHHHHHEEEECEEEEEECCCCCCHHHHHHHHHCCCEEEEEECCHHHHHHHHHCCE
RVVTMEYAADKADIFVTATGNYHVINHDHMKAMRHNAIVCNIGHFDSEIDVASTRQYQWE
EEEEEEECCCCCCEEEEECCCEEEEECHHHHHHHCCEEEEEECCCCCCCCCCCCCCEECC
NIKPQVDHIIFPDGKRVILLAEGRLVNLGCATGHPSFVMSNSFTNQTLAQIELFTRGGEY
CCCCCCCEEECCCCCEEEEEECCEEEEEEECCCCCCEEEECCCCCCEEEEEEEEECCCCC
ANKVYVLPKHLDEKVARLHLARIGAQLSELSDDQAAYIGVPKAGPFKPDHYRY
CCEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA