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The map label for this gene is relA [H]

Identifier: 83719568

GI number: 83719568

Start: 2959309

End: 2961486

Strand: Reverse

Name: relA [H]

Synonym: BTH_I2597

Alternate gene names: 83719568

Gene position: 2961486-2959309 (Counterclockwise)

Preceding gene: 83721137

Following gene: 83719712

Centisome position: 77.75

GC content: 68.09

Gene sequence:

>2178_bases
GTGCGCGAGCACGCGGGCGACGCGCGCCTGCCGTCGGGAGAGCTGCTCGCCGATCATGCGACAGGCACGTCGACGATCAT
GCAGCGGCTGAACGTCGATCCGCCCGCGACGCAGGCGGCGGCGCTTTTCGCTCTCGCGCCGTATCTGAGCGACCCCGAAA
AGCAGATTGCCGAGCGCTTCGGTGATGAGGTTGCGCACCTCGTCACCGACGTGCGCAAGCTGCTGCGTCTCGGCACCGTG
AGCCTGCGCGCCGCGCAGAGCGTGCCCGTCGACGCGGGTCGCGACGCGCAGGCGGAGCGGCGCGCGCAGATCGAGGCGCT
GCGCAAGATGCTGCTCGCGTTCGCGCAGGACATCCGCGTCGTGCTGATCAGGCTCGCATCGCGCCTGCAATCGTTGCGCC
ACTATGCTGCCGCGAAAATCGAGCCGCCGCCCGACGTCGCGCGCGAGACGCTCGAAATCTACGCGCCGCTCGCGAACCGG
CTCGGCATCTGGCAGCTGAAGTGGGAGCTCGAGGATCTTGCATTCCGCTTCGAAGATCCCGTCACCTACAAGCGCATCGC
GAAGCTGCTCGACGAGAAGCGCGTCGAGCGCGAGGCGTACGTCGCCGACGCGATCGCGCAACTGCAACGCGAACTCGCGG
CCGCGCACATCCAGGCCGAAGTGAGCGGTCGGCCGAAGCACATCTACAGCATCTGGCGCAAGATGCGCGGCAAGGAGCTC
GACTTCTCGGAGCTCTACGATGTGCGCGCGTTTCGCGTGATCGTGCCGGACATCAAGGATTGCTATACGGTGCTCGGCAT
CGTTCATCACCTTTGGCAGCCGGTGCCGAAGGAATTCGACGATTACATCTCGCGGCCGAAGCCGAACGGCTACAAATCGC
TGCATACGGTCGTGATCGGCGACGACGGCCGCGCGTTCGAGGTGCAGATCCGCACGCATGAGATGCACCGCTTCGCCGAA
TACGGCGTCGCCGCGCACTGGCGGTACAAGGAGGCGGGCGCGCGCGGCTACGGCGGCCAGTTCTCGGCCAGCGAGAAGTA
CGACGAGAAGATCGCGTGGCTGCGCCAGTTGCTTGCGTGGAAGGACGAGATCGCGGACAGCGGCGGCGCGGACGCGAGCG
GCCATGAAGCATGGGCGCAACTGCGCGAGACGACGCTCGACGACGATCACATCTACGTGCTGACGCCGCAGGCGCGCGTG
ATCGCGCTGCCGCAGGGCGCGACGCCGGTCGACTTCGCATACCACCTGCACAGCGAACTCGGTCATCGATGCCGGGGGGC
GCGCGTCGACGGTGCGATGGTGCCGCTCAACACGCCGCTCGCGAACGGCCAGACGGTCGAGATCGTCGCGGTGAAGGAGG
GCGGCCCGTCGCGCGACTGGCTCAATCCGCAGCTCGGCTATCTGAGCAGCTCGCGCGCGCGCCAGAAGGTGCGCGCGTGG
TTCAACGCGGTCGATCAGCAGGAGAACGTCGCGCACGGTCGCGCGCTCGTCGAAAAGACGCTGCAGCGCGAGGGCAAGAC
GTCGGTGAATCTCGAGCACCTCGCGGCGAAGCTCGGCTTCAAGTCGCCGGACGAGCTGTTTTCGGTCGTCGGCAAGGAAG
AGTTCAGCCTGCGCAACGTCGAGCAGGCGCTGTCCGACGCGCCGGCGCCCGAGCCCGAGCCGGAGGCACCCGCGCACTTC
GAGAAGCGCGCGAGCGGCGCGAACGTCGCGCACGGCGCGTCGACGGGCGTGCTCGTCGTCGGCGTCGATGCGCTTCTCAC
GCAGCTCGCCCGCTGCTGCCGTCCGGCGCCGCCCGATCCGATCAGCGGTTTCGTCACGCGCGGCAAGGGCATGTCGATCC
ACCGCAGCGATTGCGCGACGTTCCGCCGGATGGCCGAGCGCGCGCCCGAGCGCGTGCTGCAGACCACCTGGTCCGCCGAC
GTGCTGGGCGGGCGGGGCGCGTCCGTCTATCCGGTCGATCTGATGATCGAGGCGAGCGATCGGCAAGGGCTGTTGCGCGA
TATCTCCGAGGTATTCGCGCGCGAGAAGATGAACGTGATCGGCGTGAAGACGCAAAGCCGCCGGAACGCGGCCTTCATGC
AATTCACGGTCGAGGTGTCGAGCGCGTCGCAGGTGCAACGCGCGTGCACGCTGCTCGGCGAGGTTCAGGGGGTCGTTCGG
GCGGCCCGCAAGGCGTGA

Upstream 100 bases:

>100_bases
GCACGTTTTTTCAGGCAACTTGCAGTACCCGACGATGACAGCCGAATCCGCATCCTCCGCCACCGCCGCGGCGCCGTCGC
TTGACGACGTGCTCGCGTTC

Downstream 100 bases:

>100_bases
GCGCCCGCCGCCCAATGCCTTGCGGCAACGGCTTGCGCATTTCCCCCCAGCGAAATGCACGAAAACACTTGCCAAGACCA
AAAGAGCCCCATATAATTTC

Product: GTP pyrophosphokinase

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase; ppGpp synthase I [H]

Number of amino acids: Translated: 725; Mature: 725

Protein sequence:

>725_residues
MREHAGDARLPSGELLADHATGTSTIMQRLNVDPPATQAAALFALAPYLSDPEKQIAERFGDEVAHLVTDVRKLLRLGTV
SLRAAQSVPVDAGRDAQAERRAQIEALRKMLLAFAQDIRVVLIRLASRLQSLRHYAAAKIEPPPDVARETLEIYAPLANR
LGIWQLKWELEDLAFRFEDPVTYKRIAKLLDEKRVEREAYVADAIAQLQRELAAAHIQAEVSGRPKHIYSIWRKMRGKEL
DFSELYDVRAFRVIVPDIKDCYTVLGIVHHLWQPVPKEFDDYISRPKPNGYKSLHTVVIGDDGRAFEVQIRTHEMHRFAE
YGVAAHWRYKEAGARGYGGQFSASEKYDEKIAWLRQLLAWKDEIADSGGADASGHEAWAQLRETTLDDDHIYVLTPQARV
IALPQGATPVDFAYHLHSELGHRCRGARVDGAMVPLNTPLANGQTVEIVAVKEGGPSRDWLNPQLGYLSSSRARQKVRAW
FNAVDQQENVAHGRALVEKTLQREGKTSVNLEHLAAKLGFKSPDELFSVVGKEEFSLRNVEQALSDAPAPEPEPEAPAHF
EKRASGANVAHGASTGVLVVGVDALLTQLARCCRPAPPDPISGFVTRGKGMSIHRSDCATFRRMAERAPERVLQTTWSAD
VLGGRGASVYPVDLMIEASDRQGLLRDISEVFAREKMNVIGVKTQSRRNAAFMQFTVEVSSASQVQRACTLLGEVQGVVR
AARKA

Sequences:

>Translated_725_residues
MREHAGDARLPSGELLADHATGTSTIMQRLNVDPPATQAAALFALAPYLSDPEKQIAERFGDEVAHLVTDVRKLLRLGTV
SLRAAQSVPVDAGRDAQAERRAQIEALRKMLLAFAQDIRVVLIRLASRLQSLRHYAAAKIEPPPDVARETLEIYAPLANR
LGIWQLKWELEDLAFRFEDPVTYKRIAKLLDEKRVEREAYVADAIAQLQRELAAAHIQAEVSGRPKHIYSIWRKMRGKEL
DFSELYDVRAFRVIVPDIKDCYTVLGIVHHLWQPVPKEFDDYISRPKPNGYKSLHTVVIGDDGRAFEVQIRTHEMHRFAE
YGVAAHWRYKEAGARGYGGQFSASEKYDEKIAWLRQLLAWKDEIADSGGADASGHEAWAQLRETTLDDDHIYVLTPQARV
IALPQGATPVDFAYHLHSELGHRCRGARVDGAMVPLNTPLANGQTVEIVAVKEGGPSRDWLNPQLGYLSSSRARQKVRAW
FNAVDQQENVAHGRALVEKTLQREGKTSVNLEHLAAKLGFKSPDELFSVVGKEEFSLRNVEQALSDAPAPEPEPEAPAHF
EKRASGANVAHGASTGVLVVGVDALLTQLARCCRPAPPDPISGFVTRGKGMSIHRSDCATFRRMAERAPERVLQTTWSAD
VLGGRGASVYPVDLMIEASDRQGLLRDISEVFAREKMNVIGVKTQSRRNAAFMQFTVEVSSASQVQRACTLLGEVQGVVR
AARKA
>Mature_725_residues
MREHAGDARLPSGELLADHATGTSTIMQRLNVDPPATQAAALFALAPYLSDPEKQIAERFGDEVAHLVTDVRKLLRLGTV
SLRAAQSVPVDAGRDAQAERRAQIEALRKMLLAFAQDIRVVLIRLASRLQSLRHYAAAKIEPPPDVARETLEIYAPLANR
LGIWQLKWELEDLAFRFEDPVTYKRIAKLLDEKRVEREAYVADAIAQLQRELAAAHIQAEVSGRPKHIYSIWRKMRGKEL
DFSELYDVRAFRVIVPDIKDCYTVLGIVHHLWQPVPKEFDDYISRPKPNGYKSLHTVVIGDDGRAFEVQIRTHEMHRFAE
YGVAAHWRYKEAGARGYGGQFSASEKYDEKIAWLRQLLAWKDEIADSGGADASGHEAWAQLRETTLDDDHIYVLTPQARV
IALPQGATPVDFAYHLHSELGHRCRGARVDGAMVPLNTPLANGQTVEIVAVKEGGPSRDWLNPQLGYLSSSRARQKVRAW
FNAVDQQENVAHGRALVEKTLQREGKTSVNLEHLAAKLGFKSPDELFSVVGKEEFSLRNVEQALSDAPAPEPEPEAPAHF
EKRASGANVAHGASTGVLVVGVDALLTQLARCCRPAPPDPISGFVTRGKGMSIHRSDCATFRRMAERAPERVLQTTWSAD
VLGGRGASVYPVDLMIEASDRQGLLRDISEVFAREKMNVIGVKTQSRRNAAFMQFTVEVSSASQVQRACTLLGEVQGVVR
AARKA

Specific function: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which i

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1789147, Length=720, Percent_Identity=40.8333333333333, Blast_Score=550, Evalue=1e-158,
Organism=Escherichia coli, GI1790082, Length=700, Percent_Identity=34.8571428571429, Blast_Score=382, Evalue=1e-107,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5 [H]

Molecular weight: Translated: 80476; Mature: 80476

Theoretical pI: Translated: 7.97; Mature: 7.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MREHAGDARLPSGELLADHATGTSTIMQRLNVDPPATQAAALFALAPYLSDPEKQIAERF
CCCCCCCCCCCCCCEEECCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHH
GDEVAHLVTDVRKLLRLGTVSLRAAQSVPVDAGRDAQAERRAQIEALRKMLLAFAQDIRV
HHHHHHHHHHHHHHHHHCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VLIRLASRLQSLRHYAAAKIEPPPDVARETLEIYAPLANRLGIWQLKWELEDLAFRFEDP
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEEHHHHHHHCCCC
VTYKRIAKLLDEKRVEREAYVADAIAQLQRELAAAHIQAEVSGRPKHIYSIWRKMRGKEL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCC
DFSELYDVRAFRVIVPDIKDCYTVLGIVHHLWQPVPKEFDDYISRPKPNGYKSLHTVVIG
CHHHHHHHHHEEEECCCHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCEEEEEEC
DDGRAFEVQIRTHEMHRFAEYGVAAHWRYKEAGARGYGGQFSASEKYDEKIAWLRQLLAW
CCCCEEEEEEEHHHHHHHHHCCCHHEEEEHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
KDEIADSGGADASGHEAWAQLRETTLDDDHIYVLTPQARVIALPQGATPVDFAYHLHSEL
HHHHCCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCEEEEECCCCCCHHHHHHHHHHH
GHRCRGARVDGAMVPLNTPLANGQTVEIVAVKEGGPSRDWLNPQLGYLSSSRARQKVRAW
HHHHCCCCCCCEEEECCCCCCCCCEEEEEEEECCCCCCCCCCCCHHHCCHHHHHHHHHHH
FNAVDQQENVAHGRALVEKTLQREGKTSVNLEHLAAKLGFKSPDELFSVVGKEEFSLRNV
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCHHHHHHHHCCHHHHHHHH
EQALSDAPAPEPEPEAPAHFEKRASGANVAHGASTGVLVVGVDALLTQLARCCRPAPPDP
HHHHHCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCEEEEEHHHHHHHHHHHCCCCCCCC
ISGFVTRGKGMSIHRSDCATFRRMAERAPERVLQTTWSADVLGGRGASVYPVDLMIEASD
CCHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEEECCC
RQGLLRDISEVFAREKMNVIGVKTQSRRNAAFMQFTVEVSSASQVQRACTLLGEVQGVVR
CCCHHHHHHHHHHHHCCCEEEECCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHH
AARKA
HHHCC
>Mature Secondary Structure
MREHAGDARLPSGELLADHATGTSTIMQRLNVDPPATQAAALFALAPYLSDPEKQIAERF
CCCCCCCCCCCCCCEEECCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHH
GDEVAHLVTDVRKLLRLGTVSLRAAQSVPVDAGRDAQAERRAQIEALRKMLLAFAQDIRV
HHHHHHHHHHHHHHHHHCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VLIRLASRLQSLRHYAAAKIEPPPDVARETLEIYAPLANRLGIWQLKWELEDLAFRFEDP
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEEHHHHHHHCCCC
VTYKRIAKLLDEKRVEREAYVADAIAQLQRELAAAHIQAEVSGRPKHIYSIWRKMRGKEL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCC
DFSELYDVRAFRVIVPDIKDCYTVLGIVHHLWQPVPKEFDDYISRPKPNGYKSLHTVVIG
CHHHHHHHHHEEEECCCHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCEEEEEEC
DDGRAFEVQIRTHEMHRFAEYGVAAHWRYKEAGARGYGGQFSASEKYDEKIAWLRQLLAW
CCCCEEEEEEEHHHHHHHHHCCCHHEEEEHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
KDEIADSGGADASGHEAWAQLRETTLDDDHIYVLTPQARVIALPQGATPVDFAYHLHSEL
HHHHCCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCEEEEECCCCCCHHHHHHHHHHH
GHRCRGARVDGAMVPLNTPLANGQTVEIVAVKEGGPSRDWLNPQLGYLSSSRARQKVRAW
HHHHCCCCCCCEEEECCCCCCCCCEEEEEEEECCCCCCCCCCCCHHHCCHHHHHHHHHHH
FNAVDQQENVAHGRALVEKTLQREGKTSVNLEHLAAKLGFKSPDELFSVVGKEEFSLRNV
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCHHHHHHHHCCHHHHHHHH
EQALSDAPAPEPEPEAPAHFEKRASGANVAHGASTGVLVVGVDALLTQLARCCRPAPPDP
HHHHHCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCEEEEEHHHHHHHHHHHCCCCCCCC
ISGFVTRGKGMSIHRSDCATFRRMAERAPERVLQTTWSADVLGGRGASVYPVDLMIEASD
CCHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEEECCC
RQGLLRDISEVFAREKMNVIGVKTQSRRNAAFMQFTVEVSSASQVQRACTLLGEVQGVVR
CCCHHHHHHHHHHHHCCCEEEECCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHH
AARKA
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7928955 [H]