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The map label for this gene is cusR [H]

Identifier: 83719535

GI number: 83719535

Start: 307684

End: 308502

Strand: Direct

Name: cusR [H]

Synonym: BTH_I0274

Alternate gene names: 83719535

Gene position: 307684-308502 (Clockwise)

Preceding gene: 83721441

Following gene: 83720967

Centisome position: 8.08

GC content: 65.93

Gene sequence:

>819_bases
GTGCGTCGCGGCTCGCGCCGCGGTGCACGGCGGCCACGTTCCGAAGAGCTGATACCGAATATGGCAACATGTATGCCTGC
AAACAACCCGTCGTGCCCGCCGCGCACGGTGGTCCCATCCGTCGCGGCGCCCGATACGCTCATGTCGCGAGTGCTCACAA
TCGAAGATGACGAAATCACGGCGAATGAAATCGTCGGCGAATTGAAAAGCCGCGGCTTTACCGTCGATTGGGTCGCGAAC
GGCCGCGACGGCATGGCGCGCGCGATCAGCGACGATTACGACGTGATCACGCTCGACCGCATGCTGCCCGGCGTCGACGG
CCTCACGATCCTGACCACGATGCGCAGCATCGGCGTGCGCACGCCGGTGCTGATGCTGAGCGCGCTCGGCGACGTCGACG
AGCGCGTGCGCGGCCTGCGCGCGGGCGGCGACGACTACCTGACGAAACCGTTCGATACCGAGGAAATGACGGCGAGGCTC
GAGGTGCTGCTGCGGCGCAGCCAAGCGTCGCCCGCGCCGTTCGAGACGACGCTCGCCGTTGGTCCGCTGACGCTCGATCT
GATCTCGCGGAAGGTCTATCGCGACGGCGCGGAGATCGCGCTGCTGCCGACCGAGTACCGCGTGCTCGAGTTCATGATGC
GTCATGCCGGGCAGACGATCACGCGGATGATGCTGTTCGAGGCCGTATGGGGCTACCACTTCGACCCCGGCACCAACCTG
ATCGACGTGCACATGGGCCGCCTGCGCAAGAAGATCGATCCGCCGGATGCGACGCCGATGATCCGGACCGTGCGCGGCGC
GGGCTACATCCTTTCGTAA

Upstream 100 bases:

>100_bases
GCGGCGGCGCGCGCCGTGGGGCCGAAGATTAAATAATTTTTCATGAAGCCGACGGCGCGCTTTCACGCGCGCGCGTGTAG
TCTGCTCTCGATCGCCGGCC

Downstream 100 bases:

>100_bases
GCGGATTTTTCCGATGGACGCTTCACGCCATGCGCCCGCCGCGCCGGGACGTCGGTGGTATTCGACGACGTTCCGTCTGC
TCACCGTCTATGCGGCGACG

Product: DNA-binding response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 272; Mature: 272

Protein sequence:

>272_residues
MRRGSRRGARRPRSEELIPNMATCMPANNPSCPPRTVVPSVAAPDTLMSRVLTIEDDEITANEIVGELKSRGFTVDWVAN
GRDGMARAISDDYDVITLDRMLPGVDGLTILTTMRSIGVRTPVLMLSALGDVDERVRGLRAGGDDYLTKPFDTEEMTARL
EVLLRRSQASPAPFETTLAVGPLTLDLISRKVYRDGAEIALLPTEYRVLEFMMRHAGQTITRMMLFEAVWGYHFDPGTNL
IDVHMGRLRKKIDPPDATPMIRTVRGAGYILS

Sequences:

>Translated_272_residues
MRRGSRRGARRPRSEELIPNMATCMPANNPSCPPRTVVPSVAAPDTLMSRVLTIEDDEITANEIVGELKSRGFTVDWVAN
GRDGMARAISDDYDVITLDRMLPGVDGLTILTTMRSIGVRTPVLMLSALGDVDERVRGLRAGGDDYLTKPFDTEEMTARL
EVLLRRSQASPAPFETTLAVGPLTLDLISRKVYRDGAEIALLPTEYRVLEFMMRHAGQTITRMMLFEAVWGYHFDPGTNL
IDVHMGRLRKKIDPPDATPMIRTVRGAGYILS
>Mature_272_residues
MRRGSRRGARRPRSEELIPNMATCMPANNPSCPPRTVVPSVAAPDTLMSRVLTIEDDEITANEIVGELKSRGFTVDWVAN
GRDGMARAISDDYDVITLDRMLPGVDGLTILTTMRSIGVRTPVLMLSALGDVDERVRGLRAGGDDYLTKPFDTEEMTARL
EVLLRRSQASPAPFETTLAVGPLTLDLISRKVYRDGAEIALLPTEYRVLEFMMRHAGQTITRMMLFEAVWGYHFDPGTNL
IDVHMGRLRKKIDPPDATPMIRTVRGAGYILS

Specific function: Member of the two-component regulatory system CusS/CusR. Activates the expression of cusCFBA in response to increasing levels of copper ions, and probably silver ions [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=223, Percent_Identity=43.4977578475336, Blast_Score=182, Evalue=2e-47,
Organism=Escherichia coli, GI87082012, Length=220, Percent_Identity=41.3636363636364, Blast_Score=173, Evalue=1e-44,
Organism=Escherichia coli, GI1789402, Length=223, Percent_Identity=39.9103139013453, Blast_Score=152, Evalue=3e-38,
Organism=Escherichia coli, GI1790552, Length=222, Percent_Identity=35.5855855855856, Blast_Score=137, Evalue=7e-34,
Organism=Escherichia coli, GI1786599, Length=227, Percent_Identity=35.2422907488987, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI1789809, Length=228, Percent_Identity=32.4561403508772, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1786911, Length=223, Percent_Identity=33.1838565022422, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1787375, Length=223, Percent_Identity=31.390134529148, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI2367329, Length=230, Percent_Identity=34.3478260869565, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1790860, Length=225, Percent_Identity=30.6666666666667, Blast_Score=101, Evalue=7e-23,
Organism=Escherichia coli, GI1788394, Length=221, Percent_Identity=28.9592760180996, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI1790863, Length=228, Percent_Identity=27.6315789473684, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI145693140, Length=238, Percent_Identity=28.1512605042017, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1787229, Length=229, Percent_Identity=26.2008733624454, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1788550, Length=112, Percent_Identity=32.1428571428571, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1790299, Length=134, Percent_Identity=30.5970149253731, Blast_Score=61, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 30188; Mature: 30188

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
5.5 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
5.5 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRGSRRGARRPRSEELIPNMATCMPANNPSCPPRTVVPSVAAPDTLMSRVLTIEDDEIT
CCCCCCCCCCCCCCHHHCCCHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHEECCCCCCC
ANEIVGELKSRGFTVDWVANGRDGMARAISDDYDVITLDRMLPGVDGLTILTTMRSIGVR
HHHHHHHHHHCCEEEEEEECCCCCHHHHHCCCCCEEEHHHHCCCCCCHHHHHHHHHHCCC
TPVLMLSALGDVDERVRGLRAGGDDYLTKPFDTEEMTARLEVLLRRSQASPAPFETTLAV
HHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEE
GPLTLDLISRKVYRDGAEIALLPTEYRVLEFMMRHAGQTITRMMLFEAVWGYHFDPGTNL
CCHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
IDVHMGRLRKKIDPPDATPMIRTVRGAGYILS
HHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCC
>Mature Secondary Structure
MRRGSRRGARRPRSEELIPNMATCMPANNPSCPPRTVVPSVAAPDTLMSRVLTIEDDEIT
CCCCCCCCCCCCCCHHHCCCHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHEECCCCCCC
ANEIVGELKSRGFTVDWVANGRDGMARAISDDYDVITLDRMLPGVDGLTILTTMRSIGVR
HHHHHHHHHHCCEEEEEEECCCCCHHHHHCCCCCEEEHHHHCCCCCCHHHHHHHHHHCCC
TPVLMLSALGDVDERVRGLRAGGDDYLTKPFDTEEMTARLEVLLRRSQASPAPFETTLAV
HHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEE
GPLTLDLISRKVYRDGAEIALLPTEYRVLEFMMRHAGQTITRMMLFEAVWGYHFDPGTNL
CCHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
IDVHMGRLRKKIDPPDATPMIRTVRGAGYILS
HHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]