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The map label for this gene is gor [H]

Identifier: 83721441

GI number: 83721441

Start: 305194

End: 306555

Strand: Direct

Name: gor [H]

Synonym: BTH_I0272

Alternate gene names: 83721441

Gene position: 305194-306555 (Clockwise)

Preceding gene: 83719015

Following gene: 83719535

Centisome position: 8.01

GC content: 70.04

Gene sequence:

>1362_bases
ATGGAATTCGACTACGATCTCTTTGTCATCGGCGCGGGCTCGGGCGGCGTGCGCCTGAGCCGGGTCGCGGCGTCCTACGG
CGCGCGCGTCGGCATCGCCGAGGAAGAACGGATCGGCGGCACCTGCGTGCTGCGCGGCTGCATTCCGAAGAAGCTGCTCG
TCTATGCATCGCATTACGGCCACGATGTCGAGGATGCCGCGGGCTTCGGCTGGACCTTCGACATCGGCCTCTTCTCGTGG
CCGGCGCTCATCGAGGCGAAGGACCGCGAGATCGCGCGCCTGAGCGGCATTTACGGCGATCTGCTGAACAAGTCGGGCGT
CGAGATCCACGCGGGGCGCGCGACGCTCGTGGACGCGCATACGGTCGACGTCGCGGGACGGCGCATCACCGCACGGCACA
TCGGCGTCGCGACCGGCTCGCGGCCGGTGCTGCCGCCGATTCCCGGCATCGAGCACGCGATCACGTCGCGCGAGGCGCTC
GACTTGCCCGAACTGCCCAGGCGGATCGCGATCGTCGGCGGCGGCTACATCGCGGTCGAGTTCGCCGGCATCTTCAACGG
TCTGGGCGCCGACGTCGACCTGTTCTATCGCGGCGCGCAGATCCTGCGCGGCTTCGACGACGACGTGCGGCGCGCGCTGC
ACGGCGAGATGACGAAGCACGGCATCGCCATCCATACGCACGCCGGGATCGACGCGATCGAGCGCGGCGCCGACGGCGCG
CTGACGCTCAGGCTCGCGCAAGGCGCGTACGGGCCGTACGATGCGGTGCTGTACGCAACGGGGCGCGTCGCGAATGGCGA
CGGGCTCGGGCTCGAAGCGGTCGGCGTCGCGCGCGACGCGCGCGGCGCGATCGAGGTCGATGCATATTCGACGACGACGG
TGCCGTCGATCCACGCGATCGGCGACGTCACCGCACGCCCGCAACTCACGCCCGTCGCCACGCGCGACGGCATGCTGCTC
GCGGCGAACCTGTTCGGCGGCAAGCGGATCGCGGCCGATCATCGCTACATTCCTTCCGCGGTGTTCAGCCAGCCGGAGAT
CGCGACGGTCGGCCTCACCGAGGCGGATGCGCGCGCCGAGCTCGGCGCGCTCGACATCTACAAGACGTCGTTCCGCGCGC
TGCGGCACACGTTGTCCGGCCGCGACGAGAAGACGTTCATGAAGCTCGTCGTCGCGCGCGACAGCCAGCGCGTCGTCGGC
GCGCACATGGTCGGGCGCGACGCGGCGGAGATCATTCAGGGCATCGCGATCGCGATCCGCGCGGGCGCGACGAAGGCGCA
GTTCGACGAGACGGTCGGCATCCACCCGACCGCCGCGGAGGAATTCGTCACGCTGCGGCAGAAGGAGCCGGACGACGCGT
GA

Upstream 100 bases:

>100_bases
CGCTGATGATTGCGCTGCATGACAGTGCGCACGCACCGCGCCGCATGAAATTCGAAAACTTGCTATCGTCCGGTCATCGA
GGCTTCGATCAGGCGGCGCT

Downstream 100 bases:

>100_bases
CGCGCGCCGACGATATGCCCGCGCCGCGCCGCGCCGTGTCGGGTTGACGGCGTGCCCCGCCGCATGCGCCGCCGTCAGTT
GCCGTTCGACGCGATCGAGC

Product: glutathione-disulfide reductase

Products: NA

Alternate protein names: GR; GRase [H]

Number of amino acids: Translated: 453; Mature: 453

Protein sequence:

>453_residues
MEFDYDLFVIGAGSGGVRLSRVAASYGARVGIAEEERIGGTCVLRGCIPKKLLVYASHYGHDVEDAAGFGWTFDIGLFSW
PALIEAKDREIARLSGIYGDLLNKSGVEIHAGRATLVDAHTVDVAGRRITARHIGVATGSRPVLPPIPGIEHAITSREAL
DLPELPRRIAIVGGGYIAVEFAGIFNGLGADVDLFYRGAQILRGFDDDVRRALHGEMTKHGIAIHTHAGIDAIERGADGA
LTLRLAQGAYGPYDAVLYATGRVANGDGLGLEAVGVARDARGAIEVDAYSTTTVPSIHAIGDVTARPQLTPVATRDGMLL
AANLFGGKRIAADHRYIPSAVFSQPEIATVGLTEADARAELGALDIYKTSFRALRHTLSGRDEKTFMKLVVARDSQRVVG
AHMVGRDAAEIIQGIAIAIRAGATKAQFDETVGIHPTAAEEFVTLRQKEPDDA

Sequences:

>Translated_453_residues
MEFDYDLFVIGAGSGGVRLSRVAASYGARVGIAEEERIGGTCVLRGCIPKKLLVYASHYGHDVEDAAGFGWTFDIGLFSW
PALIEAKDREIARLSGIYGDLLNKSGVEIHAGRATLVDAHTVDVAGRRITARHIGVATGSRPVLPPIPGIEHAITSREAL
DLPELPRRIAIVGGGYIAVEFAGIFNGLGADVDLFYRGAQILRGFDDDVRRALHGEMTKHGIAIHTHAGIDAIERGADGA
LTLRLAQGAYGPYDAVLYATGRVANGDGLGLEAVGVARDARGAIEVDAYSTTTVPSIHAIGDVTARPQLTPVATRDGMLL
AANLFGGKRIAADHRYIPSAVFSQPEIATVGLTEADARAELGALDIYKTSFRALRHTLSGRDEKTFMKLVVARDSQRVVG
AHMVGRDAAEIIQGIAIAIRAGATKAQFDETVGIHPTAAEEFVTLRQKEPDDA
>Mature_453_residues
MEFDYDLFVIGAGSGGVRLSRVAASYGARVGIAEEERIGGTCVLRGCIPKKLLVYASHYGHDVEDAAGFGWTFDIGLFSW
PALIEAKDREIARLSGIYGDLLNKSGVEIHAGRATLVDAHTVDVAGRRITARHIGVATGSRPVLPPIPGIEHAITSREAL
DLPELPRRIAIVGGGYIAVEFAGIFNGLGADVDLFYRGAQILRGFDDDVRRALHGEMTKHGIAIHTHAGIDAIERGADGA
LTLRLAQGAYGPYDAVLYATGRVANGDGLGLEAVGVARDARGAIEVDAYSTTTVPSIHAIGDVTARPQLTPVATRDGMLL
AANLFGGKRIAADHRYIPSAVFSQPEIATVGLTEADARAELGALDIYKTSFRALRHTLSGRDEKTFMKLVVARDSQRVVG
AHMVGRDAAEIIQGIAIAIRAGATKAQFDETVGIHPTAAEEFVTLRQKEPDDA

Specific function: Maintains High Levels Of Reduced Glutathione In The Cytosol. [C]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=459, Percent_Identity=40.3050108932462, Blast_Score=306, Evalue=3e-83,
Organism=Homo sapiens, GI148277065, Length=474, Percent_Identity=35.2320675105485, Blast_Score=243, Evalue=2e-64,
Organism=Homo sapiens, GI33519430, Length=474, Percent_Identity=35.2320675105485, Blast_Score=243, Evalue=3e-64,
Organism=Homo sapiens, GI33519428, Length=474, Percent_Identity=35.2320675105485, Blast_Score=243, Evalue=3e-64,
Organism=Homo sapiens, GI33519426, Length=474, Percent_Identity=35.2320675105485, Blast_Score=243, Evalue=3e-64,
Organism=Homo sapiens, GI148277071, Length=474, Percent_Identity=35.2320675105485, Blast_Score=243, Evalue=3e-64,
Organism=Homo sapiens, GI22035672, Length=472, Percent_Identity=36.864406779661, Blast_Score=238, Evalue=1e-62,
Organism=Homo sapiens, GI291045266, Length=476, Percent_Identity=34.2436974789916, Blast_Score=236, Evalue=3e-62,
Organism=Homo sapiens, GI291045268, Length=474, Percent_Identity=32.7004219409283, Blast_Score=206, Evalue=3e-53,
Organism=Homo sapiens, GI91199540, Length=459, Percent_Identity=29.8474945533769, Blast_Score=185, Evalue=9e-47,
Organism=Escherichia coli, GI1789915, Length=434, Percent_Identity=42.3963133640553, Blast_Score=329, Evalue=2e-91,
Organism=Escherichia coli, GI87082354, Length=452, Percent_Identity=29.8672566371681, Blast_Score=180, Evalue=2e-46,
Organism=Escherichia coli, GI1786307, Length=449, Percent_Identity=30.0668151447661, Blast_Score=179, Evalue=2e-46,
Organism=Escherichia coli, GI87081717, Length=452, Percent_Identity=28.9823008849558, Blast_Score=152, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI71983419, Length=450, Percent_Identity=40.2222222222222, Blast_Score=292, Evalue=2e-79,
Organism=Caenorhabditis elegans, GI71983429, Length=450, Percent_Identity=40.2222222222222, Blast_Score=292, Evalue=2e-79,
Organism=Caenorhabditis elegans, GI17557007, Length=470, Percent_Identity=32.5531914893617, Blast_Score=243, Evalue=1e-64,
Organism=Caenorhabditis elegans, GI71982272, Length=487, Percent_Identity=33.4702258726899, Blast_Score=228, Evalue=6e-60,
Organism=Caenorhabditis elegans, GI32565766, Length=458, Percent_Identity=31.2227074235808, Blast_Score=195, Evalue=5e-50,
Organism=Saccharomyces cerevisiae, GI6325166, Length=461, Percent_Identity=37.3101952277657, Blast_Score=293, Evalue=4e-80,
Organism=Saccharomyces cerevisiae, GI6321091, Length=463, Percent_Identity=28.2937365010799, Blast_Score=159, Evalue=8e-40,
Organism=Saccharomyces cerevisiae, GI6325240, Length=465, Percent_Identity=27.741935483871, Blast_Score=153, Evalue=4e-38,
Organism=Drosophila melanogaster, GI24640549, Length=469, Percent_Identity=35.6076759061834, Blast_Score=247, Evalue=1e-65,
Organism=Drosophila melanogaster, GI24640553, Length=469, Percent_Identity=35.6076759061834, Blast_Score=247, Evalue=1e-65,
Organism=Drosophila melanogaster, GI24640551, Length=469, Percent_Identity=35.6076759061834, Blast_Score=246, Evalue=2e-65,
Organism=Drosophila melanogaster, GI17737741, Length=471, Percent_Identity=35.244161358811, Blast_Score=234, Evalue=7e-62,
Organism=Drosophila melanogaster, GI21358499, Length=455, Percent_Identity=30.5494505494506, Blast_Score=194, Evalue=1e-49,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006324
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.7 [H]

Molecular weight: Translated: 48086; Mature: 48086

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFDYDLFVIGAGSGGVRLSRVAASYGARVGIAEEERIGGTCVLRGCIPKKLLVYASHYG
CCCCEEEEEEECCCCCEEHHHHHHHHCCEECCCHHHCCCCEEEEECCCCHHHHEEHHHCC
HDVEDAAGFGWTFDIGLFSWPALIEAKDREIARLSGIYGDLLNKSGVEIHAGRATLVDAH
CCHHHHCCCCEEEECHHHCCCHHEECCCCHHHHHHHHHHHHHCCCCCEEECCCEEEEEEE
TVDVAGRRITARHIGVATGSRPVLPPIPGIEHAITSREALDLPELPRRIAIVGGGYIAVE
EEECCCCEEEEEEEEEECCCCCCCCCCCCCHHHHCCCCCCCCCCCCCEEEEEECCEEEEE
FAGIFNGLGADVDLFYRGAQILRGFDDDVRRALHGEMTKHGIAIHTHAGIDAIERGADGA
EEHHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHHCCHHHCCEEEEECCCHHHHHCCCCCE
LTLRLAQGAYGPYDAVLYATGRVANGDGLGLEAVGVARDARGAIEVDAYSTTTVPSIHAI
EEEEEECCCCCCCCEEEEEECEEECCCCCCEEEEEECCCCCCCEEEECCCCCCCCCCCCC
GDVTARPQLTPVATRDGMLLAANLFGGKRIAADHRYIPSAVFSQPEIATVGLTEADARAE
CCCCCCCCCCEEECCCCEEEEEECCCCCEEECCCCCCCHHHCCCCCEEEEECCCCCCHHC
LGALDIYKTSFRALRHTLSGRDEKTFMKLVVARDSQRVVGAHMVGRDAAEIIQGIAIAIR
CCCHHHHHHHHHHHHHHHCCCCHHHEEEEEEECCCCCEEEHHHHCCCHHHHHHHHEEEEE
AGATKAQFDETVGIHPTAAEEFVTLRQKEPDDA
CCCCHHHCCCCCCCCCCCHHHHHHHHCCCCCCC
>Mature Secondary Structure
MEFDYDLFVIGAGSGGVRLSRVAASYGARVGIAEEERIGGTCVLRGCIPKKLLVYASHYG
CCCCEEEEEEECCCCCEEHHHHHHHHCCEECCCHHHCCCCEEEEECCCCHHHHEEHHHCC
HDVEDAAGFGWTFDIGLFSWPALIEAKDREIARLSGIYGDLLNKSGVEIHAGRATLVDAH
CCHHHHCCCCEEEECHHHCCCHHEECCCCHHHHHHHHHHHHHCCCCCEEECCCEEEEEEE
TVDVAGRRITARHIGVATGSRPVLPPIPGIEHAITSREALDLPELPRRIAIVGGGYIAVE
EEECCCCEEEEEEEEEECCCCCCCCCCCCCHHHHCCCCCCCCCCCCCEEEEEECCEEEEE
FAGIFNGLGADVDLFYRGAQILRGFDDDVRRALHGEMTKHGIAIHTHAGIDAIERGADGA
EEHHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHHCCHHHCCEEEEECCCHHHHHCCCCCE
LTLRLAQGAYGPYDAVLYATGRVANGDGLGLEAVGVARDARGAIEVDAYSTTTVPSIHAI
EEEEEECCCCCCCCEEEEEECEEECCCCCCEEEEEECCCCCCCEEEECCCCCCCCCCCCC
GDVTARPQLTPVATRDGMLLAANLFGGKRIAADHRYIPSAVFSQPEIATVGLTEADARAE
CCCCCCCCCCEEECCCCEEEEEECCCCCEEECCCCCCCHHHCCCCCEEEEECCCCCCHHC
LGALDIYKTSFRALRHTLSGRDEKTFMKLVVARDSQRVVGAHMVGRDAAEIIQGIAIAIR
CCCHHHHHHHHHHHHHHHCCCCHHHEEEEEEECCCCCEEEHHHHCCCHHHHHHHHEEEEE
AGATKAQFDETVGIHPTAAEEFVTLRQKEPDDA
CCCCHHHCCCCCCCCCCCHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7538273 [H]