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The map label for this gene is hisI [H]

Identifier: 83719448

GI number: 83719448

Start: 3427218

End: 3428033

Strand: Reverse

Name: hisI [H]

Synonym: BTH_I2986

Alternate gene names: 83719448

Gene position: 3428033-3427218 (Counterclockwise)

Preceding gene: 161723177

Following gene: 161723153

Centisome position: 89.99

GC content: 67.4

Gene sequence:

>816_bases
GTGCATCGTCGTCGCGATCGACGCGAAGCGCGTGTCGGCCGAAGGCGAGCCGCCGCGCTGGGAGGTCTTCACGCACGGCG
GCCGCAAGGGCACGGGCCTCGACGCGGTCGAATGGGCGCGCAAGATGGCCGAATTCGGTGCGGGCGAGATCCTGCTGACG
AGCATGGACCGCGACGGCACGAAGGCGGGCTTCGATCTCGCGCTCACGCGCGCGGTATCGGACGCGGTGCCCGTGCCCGT
GATCGCGTCGGGCGGGGTCGGCTCGCTCGAGCATCTCGCGGCGGGCATCACCGAGGGCCACGCCGACGCCGTGCTCGCCG
CGAGCATTTTCCACTACGGCGAGCACACGGTCGGCGAGGCGAAGCGCTACATGGCCGAGCGCGGCATTGCAGTGAGGTTG
TGATGAACGAAGCAGCGAAGCCGGGCGGCTGGCTCGACAAGGTCCGCTGGGATGCGAACGGCCTCGTGCCGGTGATCGCG
CAGGACGCGGCGACGAACGACGTGCTGATGTTCGCCTGGATGAACCGCGATGCGCTGGCGAGGACGATCGAGCTCAAGCG
CGCGGTGTACTACTCGCGCTCGCGGCAGCGTCTGTGGTTCAAGGGCGAGGAGTCGGGCCATGTGCAGCACGTGCACGAAG
TGCGCCTCGATTGCGACGAGGACGTCGTGCTGCTGAAGGTCGAGCAGGTCGAAGGCATCGCGTGCCACACGGGCCGGCGC
TCGTGCTTTTTCCAGAAATTCGAGGGCACCGTCGACGACGGCGAATGGGTCGCGGTCGATCCGGTGCTCAAAGATCCCGA
ACATATCTACAAATGA

Upstream 100 bases:

>100_bases
GGCGCCTGCTGAACGCCGGCGCGGACAAGGTCAGCATGAACTCGTCGGCAGTCGCCAATCCGCAGCTCGTGCGCGACGCG
GCCGACAAATACGGCTCGCA

Downstream 100 bases:

>100_bases
CGCAACCGACGATCGAAGACACGCTGCTGCGCTTGGCGGCCGTGATCGACAGCCGCAAGGGCGGCGATCCTGAGCAATCG
TACGTGTCGCGCCTCTTTCA

Product: phosphoribosyl-AMP cyclohydrolase

Products: NA

Alternate protein names: PRA-CH [H]

Number of amino acids: Translated: 271; Mature: 271

Protein sequence:

>271_residues
MHRRRDRREARVGRRRAAALGGLHARRPQGHGPRRGRMGAQDGRIRCGRDPADEHGPRRHEGGLRSRAHARGIGRGARAR
DRVGRGRLARASRGGHHRGPRRRRARREHFPLRRAHGRRGEALHGRARHCSEVVMNEAAKPGGWLDKVRWDANGLVPVIA
QDAATNDVLMFAWMNRDALARTIELKRAVYYSRSRQRLWFKGEESGHVQHVHEVRLDCDEDVVLLKVEQVEGIACHTGRR
SCFFQKFEGTVDDGEWVAVDPVLKDPEHIYK

Sequences:

>Translated_271_residues
MHRRRDRREARVGRRRAAALGGLHARRPQGHGPRRGRMGAQDGRIRCGRDPADEHGPRRHEGGLRSRAHARGIGRGARAR
DRVGRGRLARASRGGHHRGPRRRRARREHFPLRRAHGRRGEALHGRARHCSEVVMNEAAKPGGWLDKVRWDANGLVPVIA
QDAATNDVLMFAWMNRDALARTIELKRAVYYSRSRQRLWFKGEESGHVQHVHEVRLDCDEDVVLLKVEQVEGIACHTGRR
SCFFQKFEGTVDDGEWVAVDPVLKDPEHIYK
>Mature_271_residues
MHRRRDRREARVGRRRAAALGGLHARRPQGHGPRRGRMGAQDGRIRCGRDPADEHGPRRHEGGLRSRAHARGIGRGARAR
DRVGRGRLARASRGGHHRGPRRRRARREHFPLRRAHGRRGEALHGRARHCSEVVMNEAAKPGGWLDKVRWDANGLVPVIA
QDAATNDVLMFAWMNRDALARTIELKRAVYYSRSRQRLWFKGEESGHVQHVHEVRLDCDEDVVLLKVEQVEGIACHTGRR
SCFFQKFEGTVDDGEWVAVDPVLKDPEHIYK

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-CH family [H]

Homologues:

Organism=Escherichia coli, GI2367128, Length=98, Percent_Identity=41.8367346938776, Blast_Score=91, Evalue=7e-20,
Organism=Saccharomyces cerevisiae, GI6319819, Length=75, Percent_Identity=41.3333333333333, Blast_Score=69, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002496
- ProDom:   PD002610 [H]

Pfam domain/function: PF01502 PRA-CH [H]

EC number: =3.5.4.19 [H]

Molecular weight: Translated: 30978; Mature: 30978

Theoretical pI: Translated: 11.90; Mature: 11.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHRRRDRREARVGRRRAAALGGLHARRPQGHGPRRGRMGAQDGRIRCGRDPADEHGPRRH
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCHHCCCCCC
EGGLRSRAHARGIGRGARARDRVGRGRLARASRGGHHRGPRRRRARREHFPLRRAHGRRG
CCCHHHHHHHHHCCCCCHHHHHHCCCHHHHCCCCCCCCCHHHHHHHHHCCCHHHHCCCCC
EALHGRARHCSEVVMNEAAKPGGWLDKVRWDANGLVPVIAQDAATNDVLMFAWMNRDALA
CCCCCHHHHHHHHHHHHCCCCCCCHHHEEECCCCCEEEEECCCCCCCEEEEEECCCHHHH
RTIELKRAVYYSRSRQRLWFKGEESGHVQHVHEVRLDCDEDVVLLKVEQVEGIACHTGRR
HHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHCCCCCCEEEEEEECCCCEEECCCCH
SCFFQKFEGTVDDGEWVAVDPVLKDPEHIYK
HHHHHHHCCCCCCCCEEEECCCCCCHHHHCC
>Mature Secondary Structure
MHRRRDRREARVGRRRAAALGGLHARRPQGHGPRRGRMGAQDGRIRCGRDPADEHGPRRH
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCHHCCCCCC
EGGLRSRAHARGIGRGARARDRVGRGRLARASRGGHHRGPRRRRARREHFPLRRAHGRRG
CCCHHHHHHHHHCCCCCHHHHHHCCCHHHHCCCCCCCCCHHHHHHHHHCCCHHHHCCCCC
EALHGRARHCSEVVMNEAAKPGGWLDKVRWDANGLVPVIAQDAATNDVLMFAWMNRDALA
CCCCCHHHHHHHHHHHHCCCCCCCHHHEEECCCCCEEEEECCCCCCCEEEEEECCCHHHH
RTIELKRAVYYSRSRQRLWFKGEESGHVQHVHEVRLDCDEDVVLLKVEQVEGIACHTGRR
HHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHCCCCCCEEEEEEECCCCEEECCCCH
SCFFQKFEGTVDDGEWVAVDPVLKDPEHIYK
HHHHHHHCCCCCCCCEEEECCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA