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The map label for this gene is pheP [H]

Identifier: 83719298

GI number: 83719298

Start: 879781

End: 881160

Strand: Direct

Name: pheP [H]

Synonym: BTH_I0764

Alternate gene names: 83719298

Gene position: 879781-881160 (Clockwise)

Preceding gene: 83720277

Following gene: 83718397

Centisome position: 23.1

GC content: 66.88

Gene sequence:

>1380_bases
GTGACACAAGAACAAAGAACGTTCGACTCGATCGTCGAGCGCGAAAAGGGGCTGCGGCGCGGGCTCTCGTCGGGGCAGAT
GGCGATGATCGCGATTGGAGGCGCGATTGGGACGGGGCTCTTTCTGGGCAGCGGTTTCGCGATCGGGCTCGCGGGGCCGG
GCGTGCTGGTGTCGTATGCGATCGGCGCGCTGATCGCGCTGCTGCTGATGGGCGCGCTGGCGGAGATGACGGTCGCGCAT
CCGACGTCCGGCTCGTTCGGCGCGTATGCCGAGCATTACGTCGGCCCGCTCGCGGGTTTTCTCGTGCGCTACGCGTACTG
GTCGGCCGTCGTGTTCGCGGTCGGCACCGAGGTGAGCGCGATCGCCGTCTTCATGAAGTACTGGTATCCGGGCGTGCCGG
GCTGGTATTGGGTCGTCGGCTTTTCGGCCGCGCTGATTGCGGTGAACATGACGAGCGTCACGCTCTACGGCGTCGTCGAG
TATGTGTTCTCGATGCTGAAGATCGCCGCGATCGTCGTGTTCATCGCGCTTGGCGCGTACTTCGTCGCGACGGCGCCCGC
GTCGTCCGGCATCGGCTTCGCGAACTATTCGGCGCACGGCGGCTTTCTCCCGAAAGGCTTCTCGGGCGTGTGGGTCGCGG
TGATCGTCGCCATCTTCAGCTATATGAGCATCGAAACGGTCGCGATCGCGGCGGGCGAAGCGCGCGATCCGCAGCGTGCG
GTATCGCGCGCGTTTCGATCGACCGTGTTCCGCCTCGTGCTGTTTTATCTGCTCACGCTCGCGCTGATGCTCGCGATCGT
GCCGTGGACGCAGGCCGGCACCGACGAGAGCCCGTTCGTCAAGGTGATGGCCGCGACGCACGTGCCGTATGCGGCGGGCG
TCATCAACTTCGTCGTGCTCGTTGCCGCGCTGTCCGCGATGAACAGCCAGTTGTACGTGACGACGCGGATGATGTTCAGC
CTGTCGCGCGCGCGGCTCGCGCCCGCGATGTTCGGGCGCGTCGGGGCGAACGGCGTGCCGCTGGCGGCGCTCGTCGTGTC
GTCGAGCGGCGTCGCGGTCGCGGCCGTGCTGGTCGCGCTGTATCCGGAGGCCGCGTTCACGCTGTTGATGGCGATCGCGA
TGTTCGGCGCGCTGTTCACCTGGCTGATGATCTTCGTCACGCATCTGTGCTTCCGCGCGCGCTATCGCGGCCCCACCCCC
GCGTTCCGGATGTGGCTGCATCCGGCGGGCAGCCTGACGGGCGCGGCGCTCGTGGGCGCGGTGCTCGTGACGACCGCGTT
TACGCGCGAGTTCAGAATGACGATGATGGTCGGCGTTGCGTTCGTCGTGCTGCTGACGCTCGCTTACCGGCTGCATTACC
GCGCGCGGCACGCGCGTTAG

Upstream 100 bases:

>100_bases
GCCGCAGGTCCAAAATGTTTCGCATGAACGGCGCGGGAGGTCTTCCGCGCCGTTTCGTTTTATTCGCGGCAGATACACGG
TATTGAAGCAGGAGTCTGGT

Downstream 100 bases:

>100_bases
TTCGCGCGGCGTGAGGCGCGTGAATCGCATCGCGATCGTGATGCGACGCGAGTTCGCGACGGCGCAGCGAGTAAGTCGAC
ACATCTGGCGGGAGGCCGCA

Product: amino acid permease

Products: Proton [Cytoplasm]; L-phenylalanine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 459; Mature: 458

Protein sequence:

>459_residues
MTQEQRTFDSIVEREKGLRRGLSSGQMAMIAIGGAIGTGLFLGSGFAIGLAGPGVLVSYAIGALIALLLMGALAEMTVAH
PTSGSFGAYAEHYVGPLAGFLVRYAYWSAVVFAVGTEVSAIAVFMKYWYPGVPGWYWVVGFSAALIAVNMTSVTLYGVVE
YVFSMLKIAAIVVFIALGAYFVATAPASSGIGFANYSAHGGFLPKGFSGVWVAVIVAIFSYMSIETVAIAAGEARDPQRA
VSRAFRSTVFRLVLFYLLTLALMLAIVPWTQAGTDESPFVKVMAATHVPYAAGVINFVVLVAALSAMNSQLYVTTRMMFS
LSRARLAPAMFGRVGANGVPLAALVVSSSGVAVAAVLVALYPEAAFTLLMAIAMFGALFTWLMIFVTHLCFRARYRGPTP
AFRMWLHPAGSLTGAALVGAVLVTTAFTREFRMTMMVGVAFVVLLTLAYRLHYRARHAR

Sequences:

>Translated_459_residues
MTQEQRTFDSIVEREKGLRRGLSSGQMAMIAIGGAIGTGLFLGSGFAIGLAGPGVLVSYAIGALIALLLMGALAEMTVAH
PTSGSFGAYAEHYVGPLAGFLVRYAYWSAVVFAVGTEVSAIAVFMKYWYPGVPGWYWVVGFSAALIAVNMTSVTLYGVVE
YVFSMLKIAAIVVFIALGAYFVATAPASSGIGFANYSAHGGFLPKGFSGVWVAVIVAIFSYMSIETVAIAAGEARDPQRA
VSRAFRSTVFRLVLFYLLTLALMLAIVPWTQAGTDESPFVKVMAATHVPYAAGVINFVVLVAALSAMNSQLYVTTRMMFS
LSRARLAPAMFGRVGANGVPLAALVVSSSGVAVAAVLVALYPEAAFTLLMAIAMFGALFTWLMIFVTHLCFRARYRGPTP
AFRMWLHPAGSLTGAALVGAVLVTTAFTREFRMTMMVGVAFVVLLTLAYRLHYRARHAR
>Mature_458_residues
TQEQRTFDSIVEREKGLRRGLSSGQMAMIAIGGAIGTGLFLGSGFAIGLAGPGVLVSYAIGALIALLLMGALAEMTVAHP
TSGSFGAYAEHYVGPLAGFLVRYAYWSAVVFAVGTEVSAIAVFMKYWYPGVPGWYWVVGFSAALIAVNMTSVTLYGVVEY
VFSMLKIAAIVVFIALGAYFVATAPASSGIGFANYSAHGGFLPKGFSGVWVAVIVAIFSYMSIETVAIAAGEARDPQRAV
SRAFRSTVFRLVLFYLLTLALMLAIVPWTQAGTDESPFVKVMAATHVPYAAGVINFVVLVAALSAMNSQLYVTTRMMFSL
SRARLAPAMFGRVGANGVPLAALVVSSSGVAVAAVLVALYPEAAFTLLMAIAMFGALFTWLMIFVTHLCFRARYRGPTPA
FRMWLHPAGSLTGAALVGAVLVTTAFTREFRMTMMVGVAFVVLLTLAYRLHYRARHAR

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of phenylalanine [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI181337167, Length=420, Percent_Identity=24.5238095238095, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI1786789, Length=448, Percent_Identity=37.0535714285714, Blast_Score=313, Evalue=1e-86,
Organism=Escherichia coli, GI1786302, Length=448, Percent_Identity=34.1517857142857, Blast_Score=280, Evalue=1e-76,
Organism=Escherichia coli, GI87081708, Length=457, Percent_Identity=36.3238512035011, Blast_Score=278, Evalue=5e-76,
Organism=Escherichia coli, GI48994972, Length=454, Percent_Identity=33.2599118942731, Blast_Score=265, Evalue=5e-72,
Organism=Escherichia coli, GI1786602, Length=453, Percent_Identity=33.3333333333333, Blast_Score=265, Evalue=5e-72,
Organism=Escherichia coli, GI1790653, Length=399, Percent_Identity=33.0827067669173, Blast_Score=247, Evalue=1e-66,
Organism=Escherichia coli, GI1789017, Length=393, Percent_Identity=35.6234096692112, Blast_Score=234, Evalue=6e-63,
Organism=Escherichia coli, GI87081915, Length=383, Percent_Identity=33.420365535248, Blast_Score=224, Evalue=7e-60,
Organism=Escherichia coli, GI1788480, Length=411, Percent_Identity=33.8199513381995, Blast_Score=209, Evalue=3e-55,
Organism=Escherichia coli, GI87081869, Length=246, Percent_Identity=25.609756097561, Blast_Score=67, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6324553, Length=402, Percent_Identity=32.089552238806, Blast_Score=182, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6324061, Length=473, Percent_Identity=29.1754756871036, Blast_Score=178, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6320772, Length=455, Percent_Identity=28.7912087912088, Blast_Score=177, Evalue=3e-45,
Organism=Saccharomyces cerevisiae, GI6324059, Length=419, Percent_Identity=31.980906921241, Blast_Score=164, Evalue=4e-41,
Organism=Saccharomyces cerevisiae, GI6324924, Length=455, Percent_Identity=27.4725274725275, Blast_Score=161, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6324990, Length=412, Percent_Identity=30.0970873786408, Blast_Score=160, Evalue=3e-40,
Organism=Saccharomyces cerevisiae, GI6322892, Length=402, Percent_Identity=31.3432835820896, Blast_Score=159, Evalue=7e-40,
Organism=Saccharomyces cerevisiae, GI6320251, Length=397, Percent_Identity=28.9672544080605, Blast_Score=157, Evalue=4e-39,
Organism=Saccharomyces cerevisiae, GI6319824, Length=395, Percent_Identity=29.873417721519, Blast_Score=151, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6321629, Length=405, Percent_Identity=26.9135802469136, Blast_Score=151, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6320717, Length=405, Percent_Identity=27.6543209876543, Blast_Score=149, Evalue=8e-37,
Organism=Saccharomyces cerevisiae, GI6319543, Length=402, Percent_Identity=27.8606965174129, Blast_Score=147, Evalue=4e-36,
Organism=Saccharomyces cerevisiae, GI6319542, Length=399, Percent_Identity=27.5689223057644, Blast_Score=140, Evalue=6e-34,
Organism=Saccharomyces cerevisiae, GI6321053, Length=389, Percent_Identity=26.9922879177378, Blast_Score=139, Evalue=8e-34,
Organism=Saccharomyces cerevisiae, GI6322967, Length=420, Percent_Identity=27.1428571428571, Blast_Score=125, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6319608, Length=451, Percent_Identity=25.0554323725055, Blast_Score=117, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6324981, Length=396, Percent_Identity=28.2828282828283, Blast_Score=114, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6320364, Length=458, Percent_Identity=22.9257641921397, Blast_Score=84, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24667468, Length=415, Percent_Identity=22.6506024096386, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI161077963, Length=403, Percent_Identity=21.3399503722084, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 48882; Mature: 48750

Theoretical pI: Translated: 10.18; Mature: 10.18

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TQEQRTFDSIVEREKGLRRGLSSGQMAMIAIGGAIGTGLFLGSGFAIGLAGPGVLVSYA
CCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECHHHHHHHHHCCCCEEECCCHHHHHHHH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HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-phenylalanine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-phenylalanine [Periplasm] = Proton [Cytoplasm] + L-phenylalanine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1711024; 8905232; 9278503; 8626334 [H]