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The map label for this gene is clpA [H]

Identifier: 83720277

GI number: 83720277

Start: 877381

End: 879681

Strand: Direct

Name: clpA [H]

Synonym: BTH_I0763

Alternate gene names: 83720277

Gene position: 877381-879681 (Clockwise)

Preceding gene: 83721401

Following gene: 83719298

Centisome position: 23.03

GC content: 64.88

Gene sequence:

>2301_bases
ATGATTGCCCAGGAATTGGAAGTCAGCCTGCACATGGCGTTCATGGAAGCGCGCCAGGCGCGGCATGAGTTCATTACGGT
CGAGCATCTTTTGTTGGCCCTGCTGGATAACCCGACGGCAGCCGAGGTGCTGCGCGCGTGCGCGGCGAACATCGAGGATC
TGCGTCAGAACCTGCGCAACTTCATCCACGACAACACGCCTACCGTTCCCGGCACCGACGATGTCGACACGCAGCCGACG
CTCGGCTTCCAGCGCGTGATCCAGCGCGCCATCATGCACGTGCAGTCGACGTCGAACGGCAAGAAGGAAGTCACGGGCGC
GAACGTGCTCGTCGCGATCTTCGGAGAGAAGGATTCGCACGCGGTCTACTACCTGCAGCAGCAGGGGGTGACGCGCCTCG
ACGTCGTCAACTTCATTTCGCACGGCATCGCGAAGACGAGCGGCGGCGAAGCCGCGAAGCCCGCCGACGCGAACGCGGAA
GGCGAGGACGCGAGCGCGCAGAAGGAAACGCCGCTCGCGCAGTTCACGCAGAACCTGAACCAGATGGCGAAGGACGGCCG
CATCGATCCGCTGATCGGGCGCGAGTCGGAGGTCGAGCGCGTCGTGCAGGTGCTCTGCCGCCGCCGCAAGAACAATCCGC
TCCTCGTCGGCGAGGCGGGCGTCGGCAAGACGGCGATCGCCGAAGGCCTCGCGTACCGGATCACGCGCGGCGAGGTGCCG
GACATCCTCGCGAACGCGCAGGTGTATTCGCTCGACATGGGCGCGCTCCTGGCGGGCACGAAGTACCGCGGCGATTTCGA
GCAGCGTCTGAAGACGGTGCTGAAGGAACTGAAGGAGCGGCCGCACGCGATTCTCTTCATCGACGAGATCCACACGCTGA
TCGGCGCGGGCGCCGCATCGGGCGGCACGCTCGACGCGTCGAACCTGCTGAAGCCGGCGCTGTCGTCGGGCACGCTCAAG
TGCATCGGCGCCACGACGTTCACCGAATATCGCGGGATCTTCGAAAAGGATGCGGCGCTGTCGCGGCGCTTCCAGAAGGT
CGACGTGACCGAGCCGACCGTCGAGCAGACGGTTGCGATCCTGCGCGGCCTGAAGTCGCGCTTCGAGGAGCATCACGGCG
TCAAGTATTCGTCGGGCGCGCTGTCGGCGGCCGCCGAGTTGTCGGCGCGCTTCATCACCGACCGTCATCTGCCCGACAAG
GCGATCGACGTGATCGACGAGGCGGGCGCCGCGCAGCGCGTGCTGCCGAAATCGAAGCAGAAGAAGACGATCGGCAAGAG
CGAGATCGAGGAAATCATCTCGAAGATCGCGCGCGTTCCGCCGCAGAGCGTGTCGCAGGACGACCGCAGCAAGCTGCAGA
CGCTCGATCGCGATCTGAAGAGCGTCGTGTTCGGCCAGGACCCGGCGATCGACGCGCTCGCGGCCTCGATCAAGATGGCG
CGTGCGGGCCTCGGCAAGATGGACAAGCCGATCGGCGCGTTCCTGTTCTCCGGCCCGACGGGTGTCGGCAAGACCGAAGT
GGCGCGCCAGCTCGCGTTCACGCTCGGCATCGAGCTGATCCGCTTCGACATGTCGGAATACATGGAGCGTCACGCGGTGA
GCCGCCTGATCGGCGCGCCGCCCGGATACGTCGGGTTCGACCAGGGCGGCTTGCTGACCGAGGCCGTCACGAAGAAGCCG
CACTGCGTGCTGCTGCTCGACGAAATCGAGAAGGCGCATCCGGACATCTTCAACGTGCTGCTGCAGGTGATGGATCACGG
CACGCTGACGGACAACAACGGGCGCAAGGCGGATTTCCGCAACGTCATCATCATCATGACGACGAACGCGGGCGCGGAAT
CGATGCAGAAGGCGACGATCGGTTTCACGACGCGGCGCGAAGTCGGCGACGAGATGGCGGACATCAAGCGCCTGTTCACG
CCCGAGTTCCGCAACCGGCTCGATGCGACGATCAGCTTCCGTGCGCTCGATGAGGAAATCATCATGCGGGTGGTCGACAA
GTTCCTGATCCAGCTGGAGGAGCAACTGCACGAGAAGAAGGTCGACGCGCTCTTCACCGACGCGTTGCGCAAGCATCTCG
CGAAGCACGGCTTCGATCCGCTGATGGGCGCGCGGCCGATGCAGCGGCTGATCCAGGACACGATCCGGCGTGCGCTTGCC
GACGAGCTGCTGTTCGGCAAGCTCGTGAACGGCGGCCACGTGACGGTCGACGTCGACGAGAACGACAAGGTGCTGCTGTC
GTTCGACAAGACGGCGACGCCGCCGAGCAAGCCGAATGAAGAGGCGGTGGAAGTCGAATAG

Upstream 100 bases:

>100_bases
GTGGGGTCTATACGCGAGACATCGCGTCGACCAAAGTCGAGCAAGTCGTTACCCATGCGCGGCAGGCCGGGCATCCGCTG
CAGTGCGTGATGGAGGAAGC

Downstream 100 bases:

>100_bases
CCGCAGGTCCAAAATGTTTCGCATGAACGGCGCGGGAGGTCTTCCGCGCCGTTTCGTTTTATTCGCGGCAGATACACGGT
ATTGAAGCAGGAGTCTGGTG

Product: ATP-dependent Clp protease, ATP-binding subunit ClpA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 766; Mature: 766

Protein sequence:

>766_residues
MIAQELEVSLHMAFMEARQARHEFITVEHLLLALLDNPTAAEVLRACAANIEDLRQNLRNFIHDNTPTVPGTDDVDTQPT
LGFQRVIQRAIMHVQSTSNGKKEVTGANVLVAIFGEKDSHAVYYLQQQGVTRLDVVNFISHGIAKTSGGEAAKPADANAE
GEDASAQKETPLAQFTQNLNQMAKDGRIDPLIGRESEVERVVQVLCRRRKNNPLLVGEAGVGKTAIAEGLAYRITRGEVP
DILANAQVYSLDMGALLAGTKYRGDFEQRLKTVLKELKERPHAILFIDEIHTLIGAGAASGGTLDASNLLKPALSSGTLK
CIGATTFTEYRGIFEKDAALSRRFQKVDVTEPTVEQTVAILRGLKSRFEEHHGVKYSSGALSAAAELSARFITDRHLPDK
AIDVIDEAGAAQRVLPKSKQKKTIGKSEIEEIISKIARVPPQSVSQDDRSKLQTLDRDLKSVVFGQDPAIDALAASIKMA
RAGLGKMDKPIGAFLFSGPTGVGKTEVARQLAFTLGIELIRFDMSEYMERHAVSRLIGAPPGYVGFDQGGLLTEAVTKKP
HCVLLLDEIEKAHPDIFNVLLQVMDHGTLTDNNGRKADFRNVIIIMTTNAGAESMQKATIGFTTRREVGDEMADIKRLFT
PEFRNRLDATISFRALDEEIIMRVVDKFLIQLEEQLHEKKVDALFTDALRKHLAKHGFDPLMGARPMQRLIQDTIRRALA
DELLFGKLVNGGHVTVDVDENDKVLLSFDKTATPPSKPNEEAVEVE

Sequences:

>Translated_766_residues
MIAQELEVSLHMAFMEARQARHEFITVEHLLLALLDNPTAAEVLRACAANIEDLRQNLRNFIHDNTPTVPGTDDVDTQPT
LGFQRVIQRAIMHVQSTSNGKKEVTGANVLVAIFGEKDSHAVYYLQQQGVTRLDVVNFISHGIAKTSGGEAAKPADANAE
GEDASAQKETPLAQFTQNLNQMAKDGRIDPLIGRESEVERVVQVLCRRRKNNPLLVGEAGVGKTAIAEGLAYRITRGEVP
DILANAQVYSLDMGALLAGTKYRGDFEQRLKTVLKELKERPHAILFIDEIHTLIGAGAASGGTLDASNLLKPALSSGTLK
CIGATTFTEYRGIFEKDAALSRRFQKVDVTEPTVEQTVAILRGLKSRFEEHHGVKYSSGALSAAAELSARFITDRHLPDK
AIDVIDEAGAAQRVLPKSKQKKTIGKSEIEEIISKIARVPPQSVSQDDRSKLQTLDRDLKSVVFGQDPAIDALAASIKMA
RAGLGKMDKPIGAFLFSGPTGVGKTEVARQLAFTLGIELIRFDMSEYMERHAVSRLIGAPPGYVGFDQGGLLTEAVTKKP
HCVLLLDEIEKAHPDIFNVLLQVMDHGTLTDNNGRKADFRNVIIIMTTNAGAESMQKATIGFTTRREVGDEMADIKRLFT
PEFRNRLDATISFRALDEEIIMRVVDKFLIQLEEQLHEKKVDALFTDALRKHLAKHGFDPLMGARPMQRLIQDTIRRALA
DELLFGKLVNGGHVTVDVDENDKVLLSFDKTATPPSKPNEEAVEVE
>Mature_766_residues
MIAQELEVSLHMAFMEARQARHEFITVEHLLLALLDNPTAAEVLRACAANIEDLRQNLRNFIHDNTPTVPGTDDVDTQPT
LGFQRVIQRAIMHVQSTSNGKKEVTGANVLVAIFGEKDSHAVYYLQQQGVTRLDVVNFISHGIAKTSGGEAAKPADANAE
GEDASAQKETPLAQFTQNLNQMAKDGRIDPLIGRESEVERVVQVLCRRRKNNPLLVGEAGVGKTAIAEGLAYRITRGEVP
DILANAQVYSLDMGALLAGTKYRGDFEQRLKTVLKELKERPHAILFIDEIHTLIGAGAASGGTLDASNLLKPALSSGTLK
CIGATTFTEYRGIFEKDAALSRRFQKVDVTEPTVEQTVAILRGLKSRFEEHHGVKYSSGALSAAAELSARFITDRHLPDK
AIDVIDEAGAAQRVLPKSKQKKTIGKSEIEEIISKIARVPPQSVSQDDRSKLQTLDRDLKSVVFGQDPAIDALAASIKMA
RAGLGKMDKPIGAFLFSGPTGVGKTEVARQLAFTLGIELIRFDMSEYMERHAVSRLIGAPPGYVGFDQGGLLTEAVTKKP
HCVLLLDEIEKAHPDIFNVLLQVMDHGTLTDNNGRKADFRNVIIIMTTNAGAESMQKATIGFTTRREVGDEMADIKRLFT
PEFRNRLDATISFRALDEEIIMRVVDKFLIQLEEQLHEKKVDALFTDALRKHLAKHGFDPLMGARPMQRLIQDTIRRALA
DELLFGKLVNGGHVTVDVDENDKVLLSFDKTATPPSKPNEEAVEVE

Specific function: ATP-dependent specificity component of the ClpP protease. It directs the protease to specific substrates. The primary function of the ClpA-ClpP complex appears to be the degradation of unfolded or abnormal proteins [H]

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=332, Percent_Identity=28.6144578313253, Blast_Score=155, Evalue=1e-37,
Organism=Escherichia coli, GI1787109, Length=741, Percent_Identity=61.6734143049933, Blast_Score=955, Evalue=0.0,
Organism=Escherichia coli, GI1788943, Length=401, Percent_Identity=45.8852867830424, Blast_Score=309, Evalue=4e-85,
Organism=Saccharomyces cerevisiae, GI6320464, Length=259, Percent_Identity=55.5984555984556, Blast_Score=286, Evalue=6e-78,
Organism=Saccharomyces cerevisiae, GI6323002, Length=296, Percent_Identity=47.6351351351351, Blast_Score=263, Evalue=9e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR013461
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 84132; Mature: 84132

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIAQELEVSLHMAFMEARQARHEFITVEHLLLALLDNPTAAEVLRACAANIEDLRQNLRN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHH
FIHDNTPTVPGTDDVDTQPTLGFQRVIQRAIMHVQSTSNGKKEVTGANVLVAIFGEKDSH
HHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCC
AVYYLQQQGVTRLDVVNFISHGIAKTSGGEAAKPADANAEGEDASAQKETPLAQFTQNLN
EEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHCCCHHHHHHHHH
QMAKDGRIDPLIGRESEVERVVQVLCRRRKNNPLLVGEAGVGKTAIAEGLAYRITRGEVP
HHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHEECCCCCC
DILANAQVYSLDMGALLAGTKYRGDFEQRLKTVLKELKERPHAILFIDEIHTLIGAGAAS
HHHHCCEEEEECHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHCCCCC
GGTLDASNLLKPALSSGTLKCIGATTFTEYRGIFEKDAALSRRFQKVDVTEPTVEQTVAI
CCCCCHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
LRGLKSRFEEHHGVKYSSGALSAAAELSARFITDRHLPDKAIDVIDEAGAAQRVLPKSKQ
HHHHHHHHHHHCCCEECCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHCCCCHH
KKTIGKSEIEEIISKIARVPPQSVSQDDRSKLQTLDRDLKSVVFGQDPAIDALAASIKMA
HHCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
RAGLGKMDKPIGAFLFSGPTGVGKTEVARQLAFTLGIELIRFDMSEYMERHAVSRLIGAP
HHCCCCCCCCHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PGYVGFDQGGLLTEAVTKKPHCVLLLDEIEKAHPDIFNVLLQVMDHGTLTDNNGRKADFR
CCCCCCCCCCCHHHHHCCCCCEEEEHHHHHHHCHHHHHHHHHHHCCCCCCCCCCCCCCCC
NVIIIMTTNAGAESMQKATIGFTTRREVGDEMADIKRLFTPEFRNRLDATISFRALDEEI
CEEEEEECCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHCHHHHHHHCCEEEEHHHHHHH
IMRVVDKFLIQLEEQLHEKKVDALFTDALRKHLAKHGFDPLMGARPMQRLIQDTIRRALA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHH
DELLFGKLVNGGHVTVDVDENDKVLLSFDKTATPPSKPNEEAVEVE
HHHHHHHHCCCCEEEEEECCCCCEEEEECCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MIAQELEVSLHMAFMEARQARHEFITVEHLLLALLDNPTAAEVLRACAANIEDLRQNLRN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHH
FIHDNTPTVPGTDDVDTQPTLGFQRVIQRAIMHVQSTSNGKKEVTGANVLVAIFGEKDSH
HHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCC
AVYYLQQQGVTRLDVVNFISHGIAKTSGGEAAKPADANAEGEDASAQKETPLAQFTQNLN
EEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHCCCHHHHHHHHH
QMAKDGRIDPLIGRESEVERVVQVLCRRRKNNPLLVGEAGVGKTAIAEGLAYRITRGEVP
HHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHEECCCCCC
DILANAQVYSLDMGALLAGTKYRGDFEQRLKTVLKELKERPHAILFIDEIHTLIGAGAAS
HHHHCCEEEEECHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHCCCCC
GGTLDASNLLKPALSSGTLKCIGATTFTEYRGIFEKDAALSRRFQKVDVTEPTVEQTVAI
CCCCCHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
LRGLKSRFEEHHGVKYSSGALSAAAELSARFITDRHLPDKAIDVIDEAGAAQRVLPKSKQ
HHHHHHHHHHHCCCEECCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHCCCCHH
KKTIGKSEIEEIISKIARVPPQSVSQDDRSKLQTLDRDLKSVVFGQDPAIDALAASIKMA
HHCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
RAGLGKMDKPIGAFLFSGPTGVGKTEVARQLAFTLGIELIRFDMSEYMERHAVSRLIGAP
HHCCCCCCCCHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PGYVGFDQGGLLTEAVTKKPHCVLLLDEIEKAHPDIFNVLLQVMDHGTLTDNNGRKADFR
CCCCCCCCCCCHHHHHCCCCCEEEEHHHHHHHCHHHHHHHHHHHCCCCCCCCCCCCCCCC
NVIIIMTTNAGAESMQKATIGFTTRREVGDEMADIKRLFTPEFRNRLDATISFRALDEEI
CEEEEEECCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHCHHHHHHHCCEEEEHHHHHHH
IMRVVDKFLIQLEEQLHEKKVDALFTDALRKHLAKHGFDPLMGARPMQRLIQDTIRRALA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHH
DELLFGKLVNGGHVTVDVDENDKVLLSFDKTATPPSKPNEEAVEVE
HHHHHHHHCCCCEEEEEECCCCCEEEEECCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]