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The map label for this gene is fadJ [H]

Identifier: 83719271

GI number: 83719271

Start: 68384

End: 70507

Strand: Direct

Name: fadJ [H]

Synonym: BTH_I0062

Alternate gene names: 83719271

Gene position: 68384-70507 (Clockwise)

Preceding gene: 83720390

Following gene: 83718526

Centisome position: 1.8

GC content: 70.72

Gene sequence:

>2124_bases
ATGATCGATTACACGCTCGATGACGACGGCATCGCGGCCTTGAGCTGGAATCTGCCCGGGCGCAGCCAGAACGTGCTGAA
CGGCGAGAGCTGCGCGGCGTTCTTCGCGGCGGCGTCGCGCGCGCTTCAGGATGCGGCGGTGAAGGGGATACTCGTCACGT
CGGCGAAGCCCGACTTCATCGCGGGCGGCGACCTCGAATGGCTGCAGGCGAGCGACGACGCCGAGACGCTCTTCGCGCGC
ACGTGCGAGCTGCACCGTGCGCTGCGCGCGCTCGAAACAGGCGGCAAGCCGGTGGCGATCGCGATGCCGGGCTCGGCGCT
CGGCGGCGGGCTCGAGATCGCGCTCGCGGGTCACTACCGGGTTGCGGCCGACAATCCGAAGGCGCGCTTCGGCCTGCCCG
AAGTGACGCTCGGCCTGCTGCCGGGCGGCGGCGGCACGCAGCGCCTGCCGCGCCTCGTCGGCATTCAGGCGTCGCTGCCG
CTGTTGCTCGAAGGCAAGCGGCTGAAGGCGGCCGACGCGCTGGCCGCCGGCATCCTGCACGCGGTCGTGCCGGCGGGCGA
GGAGATCGCGGCCGCGCGCGCGTGGCTGCTCGACGCGAGCCGCCGCACCGCGACGCAGCCGTGGGACGTGAAGGGCTTCC
GGATTCCGGGCGGCGCGCTCACGCATCCGTCCGTCCAGCAGGTGTTCATGGCGGCGAACGCGCTCGCGCGACAGAAGACG
TACGGCAACTATCCGGCCGTCGCGAGCATCCTGTCGTGCGTGTACGAAGGGCTGCTGACCGATCTCGACACGGGCCTGAA
GACCGAGGCGCGCTATTTCGTGAAGGCGGTGCTGTCGCCGCAAGCGAAGGCGATGATCCGCACGCTGTTCTTCGGGATGA
ACGAAGCGAACAAGCTCGCCGCGCGGCCGGCCGGCGTGCCGACGCAGCGCTACCGGAAGATCGGCGTGCTCGGCGCGGGG
ATGATGGGCGCGGGCATCGCGTACGTGAGCGCGAAGGCGGGGCTCGACGTCGTGCTGATCGACACGAGCGAAGAGGCGGC
CGCGCGCGGCAAGGACTACTCGCGCAAGCTCGTCGACAAACAGGTGCAGCGCGGCCGGCTCACGCGGGAAAAGGCCGATG
CATTGCTTGCGAAGATCGTGCCGACGACCGATTACGCGCGGCTCGACGGCGCGGAGCTCGTGATCGAGGCGGTGTTCGAG
GATCGCGCGATCAAGGCCGACGTCACGCGCAGGAGCGAAACGGTGCTCGCGCCCGACGCGCTCTTCGCGTCGAACACGTC
GACGCTGCCGATCACGGGCCTCGCGCAGGCGAGCGCGCGGCCGGCGAACTTCATCGGCCTGCATTTCTTCTCGCCCGTCG
ACAAGATGCCGCTCGTCGAAGTGATCGTCGGCCGCGACACGAGCGAGGCGACGCTCGCGCGCGCGCTCGACTACGTGAAG
ACGATCGGCATGACGCCGATCGTCGTCAACGATTCGCGCGGCTTCTACACGAGCCGCGTGTTCTCGACTTACGTGCTCGA
AGGGCTCGCGATGCTTGCCGAGGGCGTCGCGCCCGCGCTGATCGAGAACGCCGGGCTGCTCGCCGGGATGCCGGTGGGCC
CGCTCGCGCTGACCGACGAGGTGTCGAGCGAGTTGATCCACAAGATCACGAAGCAGACGCGCGCCGATCTCGGCGACGCG
TACGTCGCGCGCCCCGGCGAGGACGTGGCCGCGCGCATGGTCGAGCTCGGCCGGCTCGGCCGCAAGGCGGGGCTCGGCTA
TTACGACTATCCGGCGAACGGCGGCAAGAAGGCGCTGTGGCCGGGGCTCGCGCAAGCGTTTCCCGTCGCGGCCGAGCAGC
CGGACGTGGCGGCGCTGATCGAGCGGCTCGTGACGGTGCAGGCGGTCGAGACCGCGCGCTGCCTCGAAGAGCGCGTGCTG
ACGACGGCGCGCGACGCGGACGTCGGCGCGATTCTCGGCTGGGGCTTCCCGGCGTTCCGCGGCGGGCCGGTGTCGTACAT
TCACGGCGTCGGGGTGGACGCGTTCGTCGCGACGTGCGATCGTCTTGCCGCGCGGTACGGCGCGCGCTTCGCCGCGCCGG
GGCTGCTGCGCGAGATGGCCGCGCAGGGGCGAAGCTTCTACTGA

Upstream 100 bases:

>100_bases
ACTCGAGCGGCGCGGCGCGGCCACGGGCCTCGCAACGCTGTGCGTCGGCGCCGGCATGGGCACGGCGACCATCATCGAAC
GGATTTGACGGGGGACGACC

Downstream 100 bases:

>100_bases
GCGCGAAGCGTGTCGAGGCGCGCGGCGATTGCGGCGCGGCGCGCGTCGGGCCGCGCGCGCAAACGCATCGCGTGCCGCGC
GTGAGGCCGTGTGTCGTATC

Product: fatty oxidation complex subunit alpha

Products: NA

Alternate protein names: Enoyl-CoA hydratase/3-hydroxybutyryl-CoA epimerase; 3-hydroxyacyl-CoA dehydrogenase [H]

Number of amino acids: Translated: 707; Mature: 707

Protein sequence:

>707_residues
MIDYTLDDDGIAALSWNLPGRSQNVLNGESCAAFFAAASRALQDAAVKGILVTSAKPDFIAGGDLEWLQASDDAETLFAR
TCELHRALRALETGGKPVAIAMPGSALGGGLEIALAGHYRVAADNPKARFGLPEVTLGLLPGGGGTQRLPRLVGIQASLP
LLLEGKRLKAADALAAGILHAVVPAGEEIAAARAWLLDASRRTATQPWDVKGFRIPGGALTHPSVQQVFMAANALARQKT
YGNYPAVASILSCVYEGLLTDLDTGLKTEARYFVKAVLSPQAKAMIRTLFFGMNEANKLAARPAGVPTQRYRKIGVLGAG
MMGAGIAYVSAKAGLDVVLIDTSEEAAARGKDYSRKLVDKQVQRGRLTREKADALLAKIVPTTDYARLDGAELVIEAVFE
DRAIKADVTRRSETVLAPDALFASNTSTLPITGLAQASARPANFIGLHFFSPVDKMPLVEVIVGRDTSEATLARALDYVK
TIGMTPIVVNDSRGFYTSRVFSTYVLEGLAMLAEGVAPALIENAGLLAGMPVGPLALTDEVSSELIHKITKQTRADLGDA
YVARPGEDVAARMVELGRLGRKAGLGYYDYPANGGKKALWPGLAQAFPVAAEQPDVAALIERLVTVQAVETARCLEERVL
TTARDADVGAILGWGFPAFRGGPVSYIHGVGVDAFVATCDRLAARYGARFAAPGLLREMAAQGRSFY

Sequences:

>Translated_707_residues
MIDYTLDDDGIAALSWNLPGRSQNVLNGESCAAFFAAASRALQDAAVKGILVTSAKPDFIAGGDLEWLQASDDAETLFAR
TCELHRALRALETGGKPVAIAMPGSALGGGLEIALAGHYRVAADNPKARFGLPEVTLGLLPGGGGTQRLPRLVGIQASLP
LLLEGKRLKAADALAAGILHAVVPAGEEIAAARAWLLDASRRTATQPWDVKGFRIPGGALTHPSVQQVFMAANALARQKT
YGNYPAVASILSCVYEGLLTDLDTGLKTEARYFVKAVLSPQAKAMIRTLFFGMNEANKLAARPAGVPTQRYRKIGVLGAG
MMGAGIAYVSAKAGLDVVLIDTSEEAAARGKDYSRKLVDKQVQRGRLTREKADALLAKIVPTTDYARLDGAELVIEAVFE
DRAIKADVTRRSETVLAPDALFASNTSTLPITGLAQASARPANFIGLHFFSPVDKMPLVEVIVGRDTSEATLARALDYVK
TIGMTPIVVNDSRGFYTSRVFSTYVLEGLAMLAEGVAPALIENAGLLAGMPVGPLALTDEVSSELIHKITKQTRADLGDA
YVARPGEDVAARMVELGRLGRKAGLGYYDYPANGGKKALWPGLAQAFPVAAEQPDVAALIERLVTVQAVETARCLEERVL
TTARDADVGAILGWGFPAFRGGPVSYIHGVGVDAFVATCDRLAARYGARFAAPGLLREMAAQGRSFY
>Mature_707_residues
MIDYTLDDDGIAALSWNLPGRSQNVLNGESCAAFFAAASRALQDAAVKGILVTSAKPDFIAGGDLEWLQASDDAETLFAR
TCELHRALRALETGGKPVAIAMPGSALGGGLEIALAGHYRVAADNPKARFGLPEVTLGLLPGGGGTQRLPRLVGIQASLP
LLLEGKRLKAADALAAGILHAVVPAGEEIAAARAWLLDASRRTATQPWDVKGFRIPGGALTHPSVQQVFMAANALARQKT
YGNYPAVASILSCVYEGLLTDLDTGLKTEARYFVKAVLSPQAKAMIRTLFFGMNEANKLAARPAGVPTQRYRKIGVLGAG
MMGAGIAYVSAKAGLDVVLIDTSEEAAARGKDYSRKLVDKQVQRGRLTREKADALLAKIVPTTDYARLDGAELVIEAVFE
DRAIKADVTRRSETVLAPDALFASNTSTLPITGLAQASARPANFIGLHFFSPVDKMPLVEVIVGRDTSEATLARALDYVK
TIGMTPIVVNDSRGFYTSRVFSTYVLEGLAMLAEGVAPALIENAGLLAGMPVGPLALTDEVSSELIHKITKQTRADLGDA
YVARPGEDVAARMVELGRLGRKAGLGYYDYPANGGKKALWPGLAQAFPVAAEQPDVAALIERLVTVQAVETARCLEERVL
TTARDADVGAILGWGFPAFRGGPVSYIHGVGVDAFVATCDRLAARYGARFAAPGLLREMAAQGRSFY

Specific function: Catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities [H]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the central section; belongs to the 3-hydroxyacyl- CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI20127408, Length=736, Percent_Identity=34.2391304347826, Blast_Score=370, Evalue=1e-102,
Organism=Homo sapiens, GI68989263, Length=698, Percent_Identity=29.6561604584527, Blast_Score=246, Evalue=6e-65,
Organism=Homo sapiens, GI261878539, Length=631, Percent_Identity=29.9524564183835, Blast_Score=228, Evalue=2e-59,
Organism=Homo sapiens, GI296179429, Length=287, Percent_Identity=33.7979094076655, Blast_Score=147, Evalue=3e-35,
Organism=Homo sapiens, GI296179427, Length=304, Percent_Identity=31.25, Blast_Score=142, Evalue=1e-33,
Organism=Homo sapiens, GI194097323, Length=145, Percent_Identity=35.8620689655172, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI213417737, Length=199, Percent_Identity=29.1457286432161, Blast_Score=68, Evalue=3e-11,
Organism=Homo sapiens, GI157694516, Length=199, Percent_Identity=29.1457286432161, Blast_Score=68, Evalue=3e-11,
Organism=Escherichia coli, GI1788682, Length=715, Percent_Identity=38.8811188811189, Blast_Score=409, Evalue=1e-115,
Organism=Escherichia coli, GI1790281, Length=720, Percent_Identity=31.8055555555556, Blast_Score=293, Evalue=3e-80,
Organism=Escherichia coli, GI1787661, Length=284, Percent_Identity=35.2112676056338, Blast_Score=153, Evalue=4e-38,
Organism=Escherichia coli, GI1787659, Length=172, Percent_Identity=37.2093023255814, Blast_Score=89, Evalue=7e-19,
Organism=Escherichia coli, GI221142681, Length=111, Percent_Identity=40.5405405405405, Blast_Score=74, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17558304, Length=725, Percent_Identity=35.7241379310345, Blast_Score=382, Evalue=1e-106,
Organism=Caenorhabditis elegans, GI17508951, Length=727, Percent_Identity=35.3507565337001, Blast_Score=365, Evalue=1e-101,
Organism=Caenorhabditis elegans, GI17508953, Length=727, Percent_Identity=35.3507565337001, Blast_Score=364, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI25144276, Length=601, Percent_Identity=36.2728785357737, Blast_Score=317, Evalue=2e-86,
Organism=Caenorhabditis elegans, GI71985923, Length=403, Percent_Identity=27.0471464019851, Blast_Score=166, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI71985930, Length=368, Percent_Identity=24.7282608695652, Blast_Score=149, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI17549919, Length=298, Percent_Identity=32.8859060402685, Blast_Score=135, Evalue=6e-32,
Organism=Caenorhabditis elegans, GI17553560, Length=296, Percent_Identity=30.4054054054054, Blast_Score=129, Evalue=7e-30,
Organism=Caenorhabditis elegans, GI17563036, Length=290, Percent_Identity=29.6551724137931, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17540714, Length=182, Percent_Identity=34.0659340659341, Blast_Score=82, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17554946, Length=195, Percent_Identity=30.7692307692308, Blast_Score=81, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI25145438, Length=185, Percent_Identity=31.8918918918919, Blast_Score=79, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17560910, Length=171, Percent_Identity=28.0701754385965, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI19921000, Length=730, Percent_Identity=33.972602739726, Blast_Score=334, Evalue=1e-91,
Organism=Drosophila melanogaster, GI24583077, Length=730, Percent_Identity=33.972602739726, Blast_Score=334, Evalue=1e-91,
Organism=Drosophila melanogaster, GI24583079, Length=730, Percent_Identity=33.972602739726, Blast_Score=334, Evalue=1e-91,
Organism=Drosophila melanogaster, GI20129971, Length=185, Percent_Identity=31.8918918918919, Blast_Score=83, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24653477, Length=185, Percent_Identity=31.8918918918919, Blast_Score=83, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24653139, Length=185, Percent_Identity=34.0540540540541, Blast_Score=76, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR001753
- InterPro:   IPR013328
- InterPro:   IPR012802
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N; PF00378 ECH [H]

EC number: =4.2.1.17; =5.1.2.3; =1.1.1.35 [H]

Molecular weight: Translated: 74742; Mature: 74742

Theoretical pI: Translated: 8.17; Mature: 8.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDYTLDDDGIAALSWNLPGRSQNVLNGESCAAFFAAASRALQDAAVKGILVTSAKPDFI
CCCEEECCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCEEEEECCCCCCE
AGGDLEWLQASDDAETLFARTCELHRALRALETGGKPVAIAMPGSALGGGLEIALAGHYR
ECCCCCEEECCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCEEEEEECCEE
VAADNPKARFGLPEVTLGLLPGGGGTQRLPRLVGIQASLPLLLEGKRLKAADALAAGILH
EECCCCCCCCCCCCEEEEEECCCCCHHHHHHHHCCCCCCCEEECCCCCHHHHHHHHHHHH
AVVPAGEEIAAARAWLLDASRRTATQPWDVKGFRIPGGALTHPSVQQVFMAANALARQKT
HHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHC
YGNYPAVASILSCVYEGLLTDLDTGLKTEARYFVKAVLSPQAKAMIRTLFFGMNEANKLA
CCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCHHHHHHHHHHHHCCCCHHHHH
ARPAGVPTQRYRKIGVLGAGMMGAGIAYVSAKAGLDVVLIDTSEEAAARGKDYSRKLVDK
CCCCCCCHHHHHHHHHCCCCHHHCCHHEEECCCCCEEEEEECCHHHHHCCCHHHHHHHHH
QVQRGRLTREKADALLAKIVPTTDYARLDGAELVIEAVFEDRAIKADVTRRSETVLAPDA
HHHHCCCHHHHHHHHHHHHCCCCCHHHCCHHHHHHHHHHHCCCHHHHHHCCCCEEECCCH
LFASNTSTLPITGLAQASARPANFIGLHFFSPVDKMPLVEVIVGRDTSEATLARALDYVK
HCCCCCCCCCEECCHHCCCCCCCEEEEEECCCCCCCCHHHHEECCCCCHHHHHHHHHHHH
TIGMTPIVVNDSRGFYTSRVFSTYVLEGLAMLAEGVAPALIENAGLLAGMPVGPLALTDE
HCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCEECCCCCCCHHHHH
VSSELIHKITKQTRADLGDAYVARPGEDVAARMVELGRLGRKAGLGYYDYPANGGKKALW
HHHHHHHHHHHHHHHHCCCHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
PGLAQAFPVAAEQPDVAALIERLVTVQAVETARCLEERVLTTARDADVGAILGWGFPAFR
CCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCC
GGPVSYIHGVGVDAFVATCDRLAARYGARFAAPGLLREMAAQGRSFY
CCCHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCC
>Mature Secondary Structure
MIDYTLDDDGIAALSWNLPGRSQNVLNGESCAAFFAAASRALQDAAVKGILVTSAKPDFI
CCCEEECCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCEEEEECCCCCCE
AGGDLEWLQASDDAETLFARTCELHRALRALETGGKPVAIAMPGSALGGGLEIALAGHYR
ECCCCCEEECCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCEEEEEECCEE
VAADNPKARFGLPEVTLGLLPGGGGTQRLPRLVGIQASLPLLLEGKRLKAADALAAGILH
EECCCCCCCCCCCCEEEEEECCCCCHHHHHHHHCCCCCCCEEECCCCCHHHHHHHHHHHH
AVVPAGEEIAAARAWLLDASRRTATQPWDVKGFRIPGGALTHPSVQQVFMAANALARQKT
HHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHC
YGNYPAVASILSCVYEGLLTDLDTGLKTEARYFVKAVLSPQAKAMIRTLFFGMNEANKLA
CCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCHHHHHHHHHHHHCCCCHHHHH
ARPAGVPTQRYRKIGVLGAGMMGAGIAYVSAKAGLDVVLIDTSEEAAARGKDYSRKLVDK
CCCCCCCHHHHHHHHHCCCCHHHCCHHEEECCCCCEEEEEECCHHHHHCCCHHHHHHHHH
QVQRGRLTREKADALLAKIVPTTDYARLDGAELVIEAVFEDRAIKADVTRRSETVLAPDA
HHHHCCCHHHHHHHHHHHHCCCCCHHHCCHHHHHHHHHHHCCCHHHHHHCCCCEEECCCH
LFASNTSTLPITGLAQASARPANFIGLHFFSPVDKMPLVEVIVGRDTSEATLARALDYVK
HCCCCCCCCCEECCHHCCCCCCCEEEEEECCCCCCCCHHHHEECCCCCHHHHHHHHHHHH
TIGMTPIVVNDSRGFYTSRVFSTYVLEGLAMLAEGVAPALIENAGLLAGMPVGPLALTDE
HCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCEECCCCCCCHHHHH
VSSELIHKITKQTRADLGDAYVARPGEDVAARMVELGRLGRKAGLGYYDYPANGGKKALW
HHHHHHHHHHHHHHHHCCCHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
PGLAQAFPVAAEQPDVAALIERLVTVQAVETARCLEERVLTTARDADVGAILGWGFPAFR
CCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCC
GGPVSYIHGVGVDAFVATCDRLAARYGARFAAPGLLREMAAQGRSFY
CCCHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA