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The map label for this gene is fadA [H]

Identifier: 83720390

GI number: 83720390

Start: 66869

End: 68371

Strand: Direct

Name: fadA [H]

Synonym: BTH_I0061

Alternate gene names: 83720390

Gene position: 66869-68371 (Clockwise)

Preceding gene: 83721003

Following gene: 83719271

Centisome position: 1.76

GC content: 72.06

Gene sequence:

>1503_bases
TTGCCGAGCCGCGTCCGCGATCGAAATCGGCCGCGCCGATCGAAGATCGCACCGGGCGAACGCGCGGCCCGCCTCGCGGC
CGATGAGCGCTTCGGCAAGCGGCGTCTCGCCGGCGGGCGAGAAGAGAAGACGCGTGGGCAGCACGCAGGAACGCGCCGAT
CGGCCCACCCAAGCGGCGGAACCGGCGGAACCCGACGAGCGCCGGGCCGGCCGGCGGGGCGACGCGGCCGGCCCGATCGG
CGGCCGCCGCATCCGGCCGTCCCGACCGGCCATCTCCATCAACCGAAGGAACGATTCATGGAAGCCTACATTTTCGACGC
CGTGCGCACGCCGCGCGGCAAAGGCAAGAAGGACGGCAGCCTGCACGGCGTCACGCCGCTCGCGCTCGCCGCAACCGCGC
TGCGCGCGATTCGCGATCGCAACGGCCTCGACACGAGCGCCGTCGACGACGTCGTGCTCGGCTGCGTCGAGCCCGTCGGC
GAGCAGGGCGCGTGCATCGGCCGCATCGCGGTGCTCGCGGCCGGCTACGCGGAAACCACGGCCGGCGTGCAGATCAACCG
CTTCTGCGCGTCGGGCCTCGAGGCGTGCAACATGGCCGCCGCGCAGGTGATGTCCGGCCAGTCGGACATGGCGATCGGCG
GCGGCGTCGAGAGCATGTCGCGCGTGCCGATGGGCGCGAGCGGCGGCGCGTGGCCCGTCGATCCGGCGATCGCGATTCCG
AGCTACTTCGTGCCGCAGGGCGTGTCGGCCGACACGATCGCGACGAAGTGGGGCTACAGCCGAGCCGACGTCGACGCGTA
CGCAGCCGAGAGCCACCGCCGCGCGCACGCGGCGACGCAGGCCGGCTGGTTCGCGCGCTCGATCGTGCCGGTGCGCGACG
CGAACGGCCTGACGATCCTCGATCGCGACGAAACGATCCGCCCGCAGACGACACCCGAGACGCTCGCGACGCTCAAGCCG
TCGTTCGCCGAACTGGGCGAGATGTACGGCTTCGACGCGGTGATCCGCCAGCGCTATCCGGAGCTCGAGCGCATCGAGCA
CGTGCATCACGCGGGCAACAGCTCGGGGATCGTCGACGGCGCGGCGGCCGTGCTGATCGGCTCGCTCGAGGCAGGCAAGC
GCGCGGGCCTCGCGCCGCGCGCGCGGGTCCGCTCGTTCGCGAGCGTCGGCTCGGAGCCGTCGATGATGCTGACGGGGCCG
GCCTACGCGGCCGAGAAGGCATTGAAGCGTGCCGGCATGCGCGCGGCCGACATCGATCTGTACGAGCTGAACGAAGCGTT
CGCATCGGTCGTGCTGCGCTTCATGGACGCGATGGCGATTGCGCACGACAGGATCAACGTGAACGGCGGCGCGATCGCGA
TGGGCCACCCGCTCGGCGCGACGGGCGCGATGATCCTCGGCACGCTGCTCGACGAACTCGAGCGGCGCGGCGCGGCCACG
GGCCTCGCAACGCTGTGCGTCGGCGCCGGCATGGGCACGGCGACCATCATCGAACGGATTTGA

Upstream 100 bases:

>100_bases
AGGTCGGATCGATTTTTCGCGCCGCACGCGAATCGGCTCGCCGAGCGGGCCGCCGTGCCTCGCCGAGCCGACGCCAACGC
CGACGCCAACGCCGAACGGC

Downstream 100 bases:

>100_bases
CGGGGGACGACCATGATCGATTACACGCTCGATGACGACGGCATCGCGGCCTTGAGCTGGAATCTGCCCGGGCGCAGCCA
GAACGTGCTGAACGGCGAGA

Product: acetyl-CoA acetyltransferase

Products: CoA; oxoacyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 500; Mature: 499

Protein sequence:

>500_residues
MPSRVRDRNRPRRSKIAPGERAARLAADERFGKRRLAGGREEKTRGQHAGTRRSAHPSGGTGGTRRAPGRPAGRRGRPDR
RPPHPAVPTGHLHQPKERFMEAYIFDAVRTPRGKGKKDGSLHGVTPLALAATALRAIRDRNGLDTSAVDDVVLGCVEPVG
EQGACIGRIAVLAAGYAETTAGVQINRFCASGLEACNMAAAQVMSGQSDMAIGGGVESMSRVPMGASGGAWPVDPAIAIP
SYFVPQGVSADTIATKWGYSRADVDAYAAESHRRAHAATQAGWFARSIVPVRDANGLTILDRDETIRPQTTPETLATLKP
SFAELGEMYGFDAVIRQRYPELERIEHVHHAGNSSGIVDGAAAVLIGSLEAGKRAGLAPRARVRSFASVGSEPSMMLTGP
AYAAEKALKRAGMRAADIDLYELNEAFASVVLRFMDAMAIAHDRINVNGGAIAMGHPLGATGAMILGTLLDELERRGAAT
GLATLCVGAGMGTATIIERI

Sequences:

>Translated_500_residues
MPSRVRDRNRPRRSKIAPGERAARLAADERFGKRRLAGGREEKTRGQHAGTRRSAHPSGGTGGTRRAPGRPAGRRGRPDR
RPPHPAVPTGHLHQPKERFMEAYIFDAVRTPRGKGKKDGSLHGVTPLALAATALRAIRDRNGLDTSAVDDVVLGCVEPVG
EQGACIGRIAVLAAGYAETTAGVQINRFCASGLEACNMAAAQVMSGQSDMAIGGGVESMSRVPMGASGGAWPVDPAIAIP
SYFVPQGVSADTIATKWGYSRADVDAYAAESHRRAHAATQAGWFARSIVPVRDANGLTILDRDETIRPQTTPETLATLKP
SFAELGEMYGFDAVIRQRYPELERIEHVHHAGNSSGIVDGAAAVLIGSLEAGKRAGLAPRARVRSFASVGSEPSMMLTGP
AYAAEKALKRAGMRAADIDLYELNEAFASVVLRFMDAMAIAHDRINVNGGAIAMGHPLGATGAMILGTLLDELERRGAAT
GLATLCVGAGMGTATIIERI
>Mature_499_residues
PSRVRDRNRPRRSKIAPGERAARLAADERFGKRRLAGGREEKTRGQHAGTRRSAHPSGGTGGTRRAPGRPAGRRGRPDRR
PPHPAVPTGHLHQPKERFMEAYIFDAVRTPRGKGKKDGSLHGVTPLALAATALRAIRDRNGLDTSAVDDVVLGCVEPVGE
QGACIGRIAVLAAGYAETTAGVQINRFCASGLEACNMAAAQVMSGQSDMAIGGGVESMSRVPMGASGGAWPVDPAIAIPS
YFVPQGVSADTIATKWGYSRADVDAYAAESHRRAHAATQAGWFARSIVPVRDANGLTILDRDETIRPQTTPETLATLKPS
FAELGEMYGFDAVIRQRYPELERIEHVHHAGNSSGIVDGAAAVLIGSLEAGKRAGLAPRARVRSFASVGSEPSMMLTGPA
YAAEKALKRAGMRAADIDLYELNEAFASVVLRFMDAMAIAHDRINVNGGAIAMGHPLGATGAMILGTLLDELERRGAATG
LATLCVGAGMGTATIIERI

Specific function: Subunit Of The Multifunctional Enzyme Complex Of The Fatty Acid Degradation Cycle. [C]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4501853, Length=389, Percent_Identity=35.2185089974293, Blast_Score=204, Evalue=1e-52,
Organism=Homo sapiens, GI148539872, Length=399, Percent_Identity=35.3383458646617, Blast_Score=199, Evalue=7e-51,
Organism=Homo sapiens, GI167614485, Length=410, Percent_Identity=32.4390243902439, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI4557237, Length=423, Percent_Identity=31.4420803782506, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI4504327, Length=467, Percent_Identity=29.9785867237687, Blast_Score=156, Evalue=4e-38,
Organism=Homo sapiens, GI194353979, Length=115, Percent_Identity=40.8695652173913, Blast_Score=90, Evalue=6e-18,
Organism=Escherichia coli, GI48994986, Length=408, Percent_Identity=40.9313725490196, Blast_Score=265, Evalue=3e-72,
Organism=Escherichia coli, GI1787663, Length=422, Percent_Identity=38.3886255924171, Blast_Score=244, Evalue=6e-66,
Organism=Escherichia coli, GI87082165, Length=415, Percent_Identity=38.5542168674699, Blast_Score=237, Evalue=2e-63,
Organism=Escherichia coli, GI1788554, Length=416, Percent_Identity=37.5, Blast_Score=224, Evalue=1e-59,
Organism=Escherichia coli, GI1788683, Length=427, Percent_Identity=28.5714285714286, Blast_Score=134, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI133906874, Length=412, Percent_Identity=32.0388349514563, Blast_Score=198, Evalue=6e-51,
Organism=Caenorhabditis elegans, GI25147385, Length=413, Percent_Identity=30.7506053268765, Blast_Score=184, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI17535921, Length=413, Percent_Identity=30.2663438256659, Blast_Score=165, Evalue=5e-41,
Organism=Caenorhabditis elegans, GI17551802, Length=454, Percent_Identity=26.8722466960352, Blast_Score=125, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI17535917, Length=411, Percent_Identity=27.7372262773723, Blast_Score=121, Evalue=9e-28,
Organism=Saccharomyces cerevisiae, GI6322031, Length=365, Percent_Identity=34.5205479452055, Blast_Score=198, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6325229, Length=414, Percent_Identity=30.4347826086957, Blast_Score=159, Evalue=1e-39,
Organism=Drosophila melanogaster, GI24655093, Length=414, Percent_Identity=35.2657004830918, Blast_Score=221, Evalue=6e-58,
Organism=Drosophila melanogaster, GI17648125, Length=413, Percent_Identity=33.6561743341404, Blast_Score=195, Evalue=6e-50,
Organism=Drosophila melanogaster, GI24640423, Length=415, Percent_Identity=30.3614457831325, Blast_Score=172, Evalue=3e-43,
Organism=Drosophila melanogaster, GI17137578, Length=454, Percent_Identity=29.9559471365639, Blast_Score=166, Evalue=3e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: 2.3.1.16 [C]

Molecular weight: Translated: 52722; Mature: 52590

Theoretical pI: Translated: 10.24; Mature: 10.24

Prosite motif: PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSRVRDRNRPRRSKIAPGERAARLAADERFGKRRLAGGREEKTRGQHAGTRRSAHPSGG
CCCCCCCCCCCCHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHCCHHCCCCCCCCCCCC
TGGTRRAPGRPAGRRGRPDRRPPHPAVPTGHLHQPKERFMEAYIFDAVRTPRGKGKKDGS
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCC
LHGVTPLALAATALRAIRDRNGLDTSAVDDVVLGCVEPVGEQGACIGRIAVLAAGYAETT
CCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHH
AGVQINRFCASGLEACNMAAAQVMSGQSDMAIGGGVESMSRVPMGASGGAWPVDPAIAIP
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCHHHHHHCCCCCCCCCCCCCCHHHCC
SYFVPQGVSADTIATKWGYSRADVDAYAAESHRRAHAATQAGWFARSIVPVRDANGLTIL
CHHCCCCCCCCHHHHHCCCCHHCHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCEEE
DRDETIRPQTTPETLATLKPSFAELGEMYGFDAVIRQRYPELERIEHVHHAGNSSGIVDG
CCCCCCCCCCCHHHHHHCCCCHHHHHHHHCHHHHHHHHCCHHHHHHHHHHCCCCCCCHHH
AAAVLIGSLEAGKRAGLAPRARVRSFASVGSEPSMMLTGPAYAAEKALKRAGMRAADIDL
HHHHHHHCHHHCCCCCCCHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHCCCCCCCCHH
YELNEAFASVVLRFMDAMAIAHDRINVNGGAIAMGHPLGATGAMILGTLLDELERRGAAT
HHHHHHHHHHHHHHHHHHHHHHHCEECCCCEEEECCCCCCHHHHHHHHHHHHHHHCCCHH
GLATLCVGAGMGTATIIERI
HHHHHHHHCCCCHHHHHHCC
>Mature Secondary Structure 
PSRVRDRNRPRRSKIAPGERAARLAADERFGKRRLAGGREEKTRGQHAGTRRSAHPSGG
CCCCCCCCCCCHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHCCHHCCCCCCCCCCCC
TGGTRRAPGRPAGRRGRPDRRPPHPAVPTGHLHQPKERFMEAYIFDAVRTPRGKGKKDGS
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCC
LHGVTPLALAATALRAIRDRNGLDTSAVDDVVLGCVEPVGEQGACIGRIAVLAAGYAETT
CCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHH
AGVQINRFCASGLEACNMAAAQVMSGQSDMAIGGGVESMSRVPMGASGGAWPVDPAIAIP
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCHHHHHHCCCCCCCCCCCCCCHHHCC
SYFVPQGVSADTIATKWGYSRADVDAYAAESHRRAHAATQAGWFARSIVPVRDANGLTIL
CHHCCCCCCCCHHHHHCCCCHHCHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCEEE
DRDETIRPQTTPETLATLKPSFAELGEMYGFDAVIRQRYPELERIEHVHHAGNSSGIVDG
CCCCCCCCCCCHHHHHHCCCCHHHHHHHHCHHHHHHHHCCHHHHHHHHHHCCCCCCCHHH
AAAVLIGSLEAGKRAGLAPRARVRSFASVGSEPSMMLTGPAYAAEKALKRAGMRAADIDL
HHHHHHHCHHHCCCCCCCHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHCCCCCCCCHH
YELNEAFASVVLRFMDAMAIAHDRINVNGGAIAMGHPLGATGAMILGTLLDELERRGAAT
HHHHHHHHHHHHHHHHHHHHHHHCEECCCCEEEECCCCCCHHHHHHHHHHHHHHHCCCHH
GLATLCVGAGMGTATIIERI
HHHHHHHHCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Acyl-CoA; acetyl-CoA [C]

Specific reaction: Acyl-CoA + acetyl-CoA = CoA + oxoacyl-CoA [C]

General reaction: Acyl group transfer; Claisen condensation [C]

Inhibitor: Tris (hydroxy methyl) aminomethane [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230 [H]