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The map label for this gene is ksgA [H]

Identifier: 83719203

GI number: 83719203

Start: 659713

End: 660540

Strand: Direct

Name: ksgA [H]

Synonym: BTH_I0578

Alternate gene names: 83719203

Gene position: 659713-660540 (Clockwise)

Preceding gene: 83719957

Following gene: 83720549

Centisome position: 17.32

GC content: 68.0

Gene sequence:

>828_bases
ATGTCGAACAGCAGACAGCACCAAGGGCATTTCGCGCGCAAGCGCTTCGGGCAGAACTTTCTCGTCGATCACGGCGTGAT
CGACGCGATCGTCGCGGCGATTCGTCCCGAGCGCGGCGAGCGCATGGTCGAGATCGGGCCGGGCCTCGGCGCGCTCACGG
GGCCCGTGATCGCACGGCTCGCGACGCCCGATTCGCCGCTGCACGCGGTCGAACTCGACCGCGATCTGATCGGCCGCCTC
AAGCAACGCTTCGGCGAGCTGCTCGAGCTGCACGAGGGCGATGCGCTCGCGTTCGACTTCGGCTCGCTCGCGCTGCCGGG
TGAGAAGCCGTCGCTGCGGATCATCGGCAACCTGCCGTACAACATCTCGAGCCCGCTGCTGTTCCATCTGATGTCGTTCG
CGCCCGTCGTGATCGACCAGCACTTCATGCTGCAGAACGAGGTCGTCGAGCGGATGGTGGCCGAGCCGGGCACGAAGGCG
TTCAGCCGGCTGTCGGTGATGCTCCAGTACCGCTACGTGATGGACAAGCTGATCGACGTGCCGCCCGAGTCGTTCCAGCC
GCCGCCGAAGGTCGATTCGGCGATCGTGCGGATGATCCCGCATGCGCCGCACGAACTGCCGGCCGTCGATCCGGCGGTGC
TCGGCGAAGTCGTGACGGCCGCGTTCTCGCAGCGCCGCAAGATGCTGCGCAACACGCTCGGCGGCTATCGCGATCTCGTC
GATTTCGATGCGCTCGGCTTCGATCTCGCGCGCCGCGCGGAAGACGTCGGCGTCGACGAGTACGTGCGCGTCGCGCAGGC
GGCGTGCGCGGCGCGGGCGGGACGCTGA

Upstream 100 bases:

>100_bases
GATCCGGGCAGCCTCGTCGCCGCGATCGACACCGCCGTGACGATGGCGCGCCATCAGCGCGCGGGTTGAGTTTTCGCGTC
ATCCGTTTTTCTATTTTTCG

Downstream 100 bases:

>100_bases
GGATCGCTGCGGGCCGCTGTGGACCGCACCGCCGCGGACGATACGCAGCCGAGCCGGCGGGGCGGCGGCTCGGCGCGGTA
TCGCGCTTCCGGCGCACCGC

Product: dimethyladenosine transferase

Products: NA

Alternate protein names: 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase; 16S rRNA dimethyladenosine transferase; 16S rRNA dimethylase; S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase [H]

Number of amino acids: Translated: 275; Mature: 274

Protein sequence:

>275_residues
MSNSRQHQGHFARKRFGQNFLVDHGVIDAIVAAIRPERGERMVEIGPGLGALTGPVIARLATPDSPLHAVELDRDLIGRL
KQRFGELLELHEGDALAFDFGSLALPGEKPSLRIIGNLPYNISSPLLFHLMSFAPVVIDQHFMLQNEVVERMVAEPGTKA
FSRLSVMLQYRYVMDKLIDVPPESFQPPPKVDSAIVRMIPHAPHELPAVDPAVLGEVVTAAFSQRRKMLRNTLGGYRDLV
DFDALGFDLARRAEDVGVDEYVRVAQAACAARAGR

Sequences:

>Translated_275_residues
MSNSRQHQGHFARKRFGQNFLVDHGVIDAIVAAIRPERGERMVEIGPGLGALTGPVIARLATPDSPLHAVELDRDLIGRL
KQRFGELLELHEGDALAFDFGSLALPGEKPSLRIIGNLPYNISSPLLFHLMSFAPVVIDQHFMLQNEVVERMVAEPGTKA
FSRLSVMLQYRYVMDKLIDVPPESFQPPPKVDSAIVRMIPHAPHELPAVDPAVLGEVVTAAFSQRRKMLRNTLGGYRDLV
DFDALGFDLARRAEDVGVDEYVRVAQAACAARAGR
>Mature_274_residues
SNSRQHQGHFARKRFGQNFLVDHGVIDAIVAAIRPERGERMVEIGPGLGALTGPVIARLATPDSPLHAVELDRDLIGRLK
QRFGELLELHEGDALAFDFGSLALPGEKPSLRIIGNLPYNISSPLLFHLMSFAPVVIDQHFMLQNEVVERMVAEPGTKAF
SRLSVMLQYRYVMDKLIDVPPESFQPPPKVDSAIVRMIPHAPHELPAVDPAVLGEVVTAAFSQRRKMLRNTLGGYRDLVD
FDALGFDLARRAEDVGVDEYVRVAQAACAARAGR

Specific function: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits [H]

COG id: COG0030

COG function: function code J; Dimethyladenosine transferase (rRNA methylation)

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily [H]

Homologues:

Organism=Homo sapiens, GI7657198, Length=220, Percent_Identity=32.2727272727273, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI156415992, Length=241, Percent_Identity=32.7800829875519, Blast_Score=89, Evalue=3e-18,
Organism=Escherichia coli, GI1786236, Length=266, Percent_Identity=52.2556390977444, Blast_Score=271, Evalue=2e-74,
Organism=Caenorhabditis elegans, GI25146882, Length=192, Percent_Identity=33.8541666666667, Blast_Score=101, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI25141369, Length=268, Percent_Identity=28.3582089552239, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6324989, Length=233, Percent_Identity=28.755364806867, Blast_Score=79, Evalue=8e-16,
Organism=Drosophila melanogaster, GI21358017, Length=232, Percent_Identity=33.6206896551724, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI21357273, Length=289, Percent_Identity=28.719723183391, Blast_Score=89, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023165
- InterPro:   IPR001737
- InterPro:   IPR020598
- InterPro:   IPR011530 [H]

Pfam domain/function: PF00398 RrnaAD [H]

EC number: =2.1.1.182 [H]

Molecular weight: Translated: 30345; Mature: 30214

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNSRQHQGHFARKRFGQNFLVDHGVIDAIVAAIRPERGERMVEIGPGLGALTGPVIARL
CCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHH
ATPDSPLHAVELDRDLIGRLKQRFGELLELHEGDALAFDFGSLALPGEKPSLRIIGNLPY
CCCCCCCHHHHHCHHHHHHHHHHHHHHHHHCCCCEEEEECCCEECCCCCCCEEEEECCCC
NISSPLLFHLMSFAPVVIDQHFMLQNEVVERMVAEPGTKAFSRLSVMLQYRYVMDKLIDV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCC
PPESFQPPPKVDSAIVRMIPHAPHELPAVDPAVLGEVVTAAFSQRRKMLRNTLGGYRDLV
CCCCCCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DFDALGFDLARRAEDVGVDEYVRVAQAACAARAGR
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SNSRQHQGHFARKRFGQNFLVDHGVIDAIVAAIRPERGERMVEIGPGLGALTGPVIARL
CCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHH
ATPDSPLHAVELDRDLIGRLKQRFGELLELHEGDALAFDFGSLALPGEKPSLRIIGNLPY
CCCCCCCHHHHHCHHHHHHHHHHHHHHHHHCCCCEEEEECCCEECCCCCCCEEEEECCCC
NISSPLLFHLMSFAPVVIDQHFMLQNEVVERMVAEPGTKAFSRLSVMLQYRYVMDKLIDV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCC
PPESFQPPPKVDSAIVRMIPHAPHELPAVDPAVLGEVVTAAFSQRRKMLRNTLGGYRDLV
CCCCCCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DFDALGFDLARRAEDVGVDEYVRVAQAACAARAGR
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA