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The map label for this gene is lon [H]

Identifier: 83719045

GI number: 83719045

Start: 248079

End: 249059

Strand: Direct

Name: lon [H]

Synonym: BTH_I0216

Alternate gene names: 83719045

Gene position: 248079-249059 (Clockwise)

Preceding gene: 83719978

Following gene: 83721063

Centisome position: 6.51

GC content: 66.97

Gene sequence:

>981_bases
ATGACGACGGCGATGGTGAAACAGGAATTGGCGGTGGCTTCGTTCAGCACGGTCTACGATATCGAGCGAGTCGAGACGGC
GCTGGGCGATCTGAATGAGGGCGCGAGCGATGCGCTGCGCGCGACTTACGAGAAGATGCTGAAGACGGGCAACCTGCGCT
TTTGCGTGAAACCGACGCGCATGCCCGCGTTCGATTCGCTCGCGGAGGAATTGCCGAACTTCGCTGAGCCGCTCGACGAC
GTGCGCAAGCAGGTGGCGCTGTGCCTCGAAACCGACGACCGCCTCGAATTGATGCCGATCCTGCTGCTCGGCGAGCCGGG
CATCGGCAAGACGCATTTCGCGAAGGCGCTCGCGAAGATGCTCGGGACCGCTTATCACTACGTGCCGATGAGCTCGCTGA
CGGCGGGCTGGGTGCTCTCGGGCGCGTCGTCGCAGTGGAAGAACGCGAAGCCGGGCAAGGTGTTCGATGCGCTCGTCAAC
GGCTGCTACTCGAATCCCGTGATCGCGATCGACGAGATCGACAAGGCGGGCAGCGACGCGCAGTACGATCCGCTCGGCGC
GCTGTATGCGCTCCTCGAGCACGACACCGCGTGTGCGTTCGTCGACGAATTCGCCGAGGTGCCGATCGACGCGGGCAACG
TGATCTGGATCGCGACCGCGAACGACGCGAGCGCGATTCCCGAGCCGATCATGAACCGGATGAACGTGTACGAGATCGAG
CCGCCCGACGCGTCGGGCGCGCGCCGCATCGCGCAGACGATCTACGGCGAGATCCGCAACGCGCACGCATGGGGGCAGCG
CTTTCCCGGCGCGCTCGGCGACGACGCGCTCGACGTGCTCGCCGCGATGCCGCCGCGCACGATGCGCCGCGTGCTGCTGC
ACGCGTTCGGCGCGGCGCGGCTCGACGGGCGGGACGCGATCGCGCCGCGCGACATCCGCACCGACGAAAGCGCGGGACGC
CGCCGTCCGATCGGCTTTTGA

Upstream 100 bases:

>100_bases
CAGCAGACCCCGGCGGCTGCTTGCTTGCGCGGGATTTCGGGCTCGCTACACTGAAATCGACGGGGTCTGATGGATGGGCG
GTAGCAAGGCGAGGTGGGCG

Downstream 100 bases:

>100_bases
CGGCCGCCACGCGCACGCGCCGCGCGACGTACAATCGAAGGCCCTGTCTTCGAAGCGTGAGCGAAGCGAATGACGATGGA
GCGGATTGACTGTGTGGTGA

Product: ATP-dependent protease domain-containing protein

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 326; Mature: 325

Protein sequence:

>326_residues
MTTAMVKQELAVASFSTVYDIERVETALGDLNEGASDALRATYEKMLKTGNLRFCVKPTRMPAFDSLAEELPNFAEPLDD
VRKQVALCLETDDRLELMPILLLGEPGIGKTHFAKALAKMLGTAYHYVPMSSLTAGWVLSGASSQWKNAKPGKVFDALVN
GCYSNPVIAIDEIDKAGSDAQYDPLGALYALLEHDTACAFVDEFAEVPIDAGNVIWIATANDASAIPEPIMNRMNVYEIE
PPDASGARRIAQTIYGEIRNAHAWGQRFPGALGDDALDVLAAMPPRTMRRVLLHAFGAARLDGRDAIAPRDIRTDESAGR
RRPIGF

Sequences:

>Translated_326_residues
MTTAMVKQELAVASFSTVYDIERVETALGDLNEGASDALRATYEKMLKTGNLRFCVKPTRMPAFDSLAEELPNFAEPLDD
VRKQVALCLETDDRLELMPILLLGEPGIGKTHFAKALAKMLGTAYHYVPMSSLTAGWVLSGASSQWKNAKPGKVFDALVN
GCYSNPVIAIDEIDKAGSDAQYDPLGALYALLEHDTACAFVDEFAEVPIDAGNVIWIATANDASAIPEPIMNRMNVYEIE
PPDASGARRIAQTIYGEIRNAHAWGQRFPGALGDDALDVLAAMPPRTMRRVLLHAFGAARLDGRDAIAPRDIRTDESAGR
RRPIGF
>Mature_325_residues
TTAMVKQELAVASFSTVYDIERVETALGDLNEGASDALRATYEKMLKTGNLRFCVKPTRMPAFDSLAEELPNFAEPLDDV
RKQVALCLETDDRLELMPILLLGEPGIGKTHFAKALAKMLGTAYHYVPMSSLTAGWVLSGASSQWKNAKPGKVFDALVNG
CYSNPVIAIDEIDKAGSDAQYDPLGALYALLEHDTACAFVDEFAEVPIDAGNVIWIATANDASAIPEPIMNRMNVYEIEP
PDASGARRIAQTIYGEIRNAHAWGQRFPGALGDDALDVLAAMPPRTMRRVLLHAFGAARLDGRDAIAPRDIRTDESAGRR
RPIGF

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI21396489, Length=140, Percent_Identity=35, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI31377667, Length=142, Percent_Identity=32.3943661971831, Blast_Score=97, Evalue=3e-20,
Organism=Escherichia coli, GI1786643, Length=142, Percent_Identity=33.8028169014084, Blast_Score=90, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17556486, Length=168, Percent_Identity=31.547619047619, Blast_Score=95, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI17505831, Length=137, Percent_Identity=35.036496350365, Blast_Score=92, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6319449, Length=154, Percent_Identity=33.7662337662338, Blast_Score=97, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24666867, Length=136, Percent_Identity=36.7647058823529, Blast_Score=100, Evalue=9e-22,
Organism=Drosophila melanogaster, GI221513036, Length=136, Percent_Identity=36.7647058823529, Blast_Score=100, Evalue=1e-21,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 35455; Mature: 35324

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTAMVKQELAVASFSTVYDIERVETALGDLNEGASDALRATYEKMLKTGNLRFCVKPTR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCEEEEECCCC
MPAFDSLAEELPNFAEPLDDVRKQVALCLETDDRLELMPILLLGEPGIGKTHFAKALAKM
CCHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCHHHHHHHHHHH
LGTAYHYVPMSSLTAGWVLSGASSQWKNAKPGKVFDALVNGCYSNPVIAIDEIDKAGSDA
HHHHHHHCCHHHHHHHHEECCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCC
QYDPLGALYALLEHDTACAFVDEFAEVPIDAGNVIWIATANDASAIPEPIMNRMNVYEIE
CCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCHHHHCCCCEEEEC
PPDASGARRIAQTIYGEIRNAHAWGQRFPGALGDDALDVLAAMPPRTMRRVLLHAFGAAR
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCC
LDGRDAIAPRDIRTDESAGRRRPIGF
CCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TTAMVKQELAVASFSTVYDIERVETALGDLNEGASDALRATYEKMLKTGNLRFCVKPTR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCEEEEECCCC
MPAFDSLAEELPNFAEPLDDVRKQVALCLETDDRLELMPILLLGEPGIGKTHFAKALAKM
CCHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCHHHHHHHHHHH
LGTAYHYVPMSSLTAGWVLSGASSQWKNAKPGKVFDALVNGCYSNPVIAIDEIDKAGSDA
HHHHHHHCCHHHHHHHHEECCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCC
QYDPLGALYALLEHDTACAFVDEFAEVPIDAGNVIWIATANDASAIPEPIMNRMNVYEIE
CCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCHHHHCCCCEEEEC
PPDASGARRIAQTIYGEIRNAHAWGQRFPGALGDDALDVLAAMPPRTMRRVLLHAFGAAR
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCC
LDGRDAIAPRDIRTDESAGRRRPIGF
CCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA