Click here to switch to the map view.

The map label for this gene is dmlR [H]

Identifier: 83718916

GI number: 83718916

Start: 676191

End: 677123

Strand: Reverse

Name: dmlR [H]

Synonym: BTH_I0592

Alternate gene names: 83718916

Gene position: 677123-676191 (Counterclockwise)

Preceding gene: 83720439

Following gene: 83719624

Centisome position: 17.78

GC content: 68.49

Gene sequence:

>933_bases
ATGGATCGACTGGGCGACATCCGCTTGTTCGTCGAGGCAGCGGAGCTCGGCAGCCTGTCGGCCGCCGGGCGCAAGCTGAA
CCTCACGCCCGCCGCCGCGAGCGCGCGGCTCGCGAAGCTGGAGGCGCAGGTATCGACGCGCCTGTTCGAACGCTCGACGC
GGCGGCTGCGGCTCACCGACGAGGGCCGCCTGTACCTGAACTGCTGCCGGCAAGCGCTGCAGGCGCTCGACGACGCGGAC
GCGATGCTGCAGGAAGGGCGCAACGTCGTGAGCGGCAAGGTGCGGCTGTCGTCCACCGCGGATTTCGGGCGCAATCAGCT
GCTCGACTGGCTCGACGAATTCAACGCGCGCTATCCGGACGTGACGTTCTCGGTGACGGCGTCGGATTCGTCGTCGAATC
TGTGGCAGGACGAGATCGATCTCGCGATCCGTTTCGCCGCGCCGCCCGACGGCGCGCTGATCGCGCGGCCGCTCGCGGCG
AACCGGCGCGTGCTGTGCGCGTCGCCCGCGTTCGTCGACAAGTACGGCACGCCGAAGGACCCGCACGATCTGGCCCGCTT
TCCATGCAACGTGATCACGGTCGCATCGGGACCGATCAACGTCTGGCGCTTCACGCGCGGCGGCGATACGCAGACCTACA
CGGTGCCGCTCGCGAACGCGCACGAGACGAACGACGGCGGCTTCACGCGCGAATGGACGATCCGCGGCCACGGAATCGCG
CTGAAATCGATCTGGGACGTCGCCCGCGACGTTCGCGCGGGCCGGCTCAAGGTGCTGCTGCCCGAGTGGCGGCACCAGGA
CGCGCCGCTGCACGCGATCCATCACAGCAAGCGCTACATGGCGCCGCGCGTGCGGGTGCTGCTCGATTTTCTCGTCGAGC
GCTTCGCGCAAGAGGAAAAGGCGCTCGAGGATCTGTTGAACGCGTGCCGGTAA

Upstream 100 bases:

>100_bases
CGCATCAAAAGGTCAGACGAGCGCGCATTGTCCCGAATCCGAAGATTTTTGATAATTGGCGTAGCATTTGAATCATTTTC
AAAAATTTTCTGAAAATCGC

Downstream 100 bases:

>100_bases
CGACGCTCGCGCGCGGCCGCCGCCCGCCGGGGCTCGAAAAGCTATAATGGAAGGCTTTCCCGGCGACATCTTCCCGTATG
CGGCGCGTGCATCGCGCGGC

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: D-malate degradation protein R [H]

Number of amino acids: Translated: 310; Mature: 310

Protein sequence:

>310_residues
MDRLGDIRLFVEAAELGSLSAAGRKLNLTPAAASARLAKLEAQVSTRLFERSTRRLRLTDEGRLYLNCCRQALQALDDAD
AMLQEGRNVVSGKVRLSSTADFGRNQLLDWLDEFNARYPDVTFSVTASDSSSNLWQDEIDLAIRFAAPPDGALIARPLAA
NRRVLCASPAFVDKYGTPKDPHDLARFPCNVITVASGPINVWRFTRGGDTQTYTVPLANAHETNDGGFTREWTIRGHGIA
LKSIWDVARDVRAGRLKVLLPEWRHQDAPLHAIHHSKRYMAPRVRVLLDFLVERFAQEEKALEDLLNACR

Sequences:

>Translated_310_residues
MDRLGDIRLFVEAAELGSLSAAGRKLNLTPAAASARLAKLEAQVSTRLFERSTRRLRLTDEGRLYLNCCRQALQALDDAD
AMLQEGRNVVSGKVRLSSTADFGRNQLLDWLDEFNARYPDVTFSVTASDSSSNLWQDEIDLAIRFAAPPDGALIARPLAA
NRRVLCASPAFVDKYGTPKDPHDLARFPCNVITVASGPINVWRFTRGGDTQTYTVPLANAHETNDGGFTREWTIRGHGIA
LKSIWDVARDVRAGRLKVLLPEWRHQDAPLHAIHHSKRYMAPRVRVLLDFLVERFAQEEKALEDLLNACR
>Mature_310_residues
MDRLGDIRLFVEAAELGSLSAAGRKLNLTPAAASARLAKLEAQVSTRLFERSTRRLRLTDEGRLYLNCCRQALQALDDAD
AMLQEGRNVVSGKVRLSSTADFGRNQLLDWLDEFNARYPDVTFSVTASDSSSNLWQDEIDLAIRFAAPPDGALIARPLAA
NRRVLCASPAFVDKYGTPKDPHDLARFPCNVITVASGPINVWRFTRGGDTQTYTVPLANAHETNDGGFTREWTIRGHGIA
LKSIWDVARDVRAGRLKVLLPEWRHQDAPLHAIHHSKRYMAPRVRVLLDFLVERFAQEEKALEDLLNACR

Specific function: Transcriptional regulator required for the aerobic growth on D-malate as the sole carbon source. Induces the expression of dmlA in response to D-malate or L- or meso-tartrate. Negatively regulates its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87081978, Length=297, Percent_Identity=33.6700336700337, Blast_Score=165, Evalue=4e-42,
Organism=Escherichia coli, GI1789639, Length=305, Percent_Identity=27.2131147540984, Blast_Score=145, Evalue=4e-36,
Organism=Escherichia coli, GI1786401, Length=289, Percent_Identity=30.7958477508651, Blast_Score=144, Evalue=5e-36,
Organism=Escherichia coli, GI1789440, Length=289, Percent_Identity=30.1038062283737, Blast_Score=144, Evalue=7e-36,
Organism=Escherichia coli, GI145693193, Length=301, Percent_Identity=29.5681063122924, Blast_Score=128, Evalue=5e-31,
Organism=Escherichia coli, GI1787128, Length=292, Percent_Identity=25.6849315068493, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1786448, Length=260, Percent_Identity=26.1538461538462, Blast_Score=85, Evalue=7e-18,
Organism=Escherichia coli, GI1788706, Length=174, Percent_Identity=28.735632183908, Blast_Score=78, Evalue=8e-16,
Organism=Escherichia coli, GI1787589, Length=279, Percent_Identity=23.2974910394265, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1789173, Length=260, Percent_Identity=27.6923076923077, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI157672245, Length=155, Percent_Identity=30.3225806451613, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI87082132, Length=307, Percent_Identity=24.4299674267101, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1787806, Length=136, Percent_Identity=31.6176470588235, Blast_Score=65, Evalue=6e-12,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34631; Mature: 34631

Theoretical pI: Translated: 8.49; Mature: 8.49

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRLGDIRLFVEAAELGSLSAAGRKLNLTPAAASARLAKLEAQVSTRLFERSTRRLRLTD
CCCCCCEEEEEEHHHCCCHHHCCCEEECCCCHHHHHHHHHHHHHHHHHHHHCCCEEEECC
EGRLYLNCCRQALQALDDADAMLQEGRNVVSGKVRLSSTADFGRNQLLDWLDEFNARYPD
CCCHHHHHHHHHHHHHCHHHHHHHCCCCEEECEEEECCCHHCCHHHHHHHHHHHCCCCCC
VTFSVTASDSSSNLWQDEIDLAIRFAAPPDGALIARPLAANRRVLCASPAFVDKYGTPKD
EEEEEEECCCCCCCCCCCCCEEEEEECCCCCCEEECCCCCCCEEEEECCCHHHCCCCCCC
PHDLARFPCNVITVASGPINVWRFTRGGDTQTYTVPLANAHETNDGGFTREWTIRGHGIA
HHHHHHCCCCEEEEECCCEEEEEEECCCCCEEEEEECCCCCCCCCCCCEEEEEEEECCEE
LKSIWDVARDVRAGRLKVLLPEWRHQDAPLHAIHHSKRYMAPRVRVLLDFLVERFAQEEK
HHHHHHHHHHHCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALEDLLNACR
HHHHHHHHCC
>Mature Secondary Structure
MDRLGDIRLFVEAAELGSLSAAGRKLNLTPAAASARLAKLEAQVSTRLFERSTRRLRLTD
CCCCCCEEEEEEHHHCCCHHHCCCEEECCCCHHHHHHHHHHHHHHHHHHHHCCCEEEECC
EGRLYLNCCRQALQALDDADAMLQEGRNVVSGKVRLSSTADFGRNQLLDWLDEFNARYPD
CCCHHHHHHHHHHHHHCHHHHHHHCCCCEEECEEEECCCHHCCHHHHHHHHHHHCCCCCC
VTFSVTASDSSSNLWQDEIDLAIRFAAPPDGALIARPLAANRRVLCASPAFVDKYGTPKD
EEEEEEECCCCCCCCCCCCCEEEEEECCCCCCEEECCCCCCCEEEEECCCHHHCCCCCCC
PHDLARFPCNVITVASGPINVWRFTRGGDTQTYTVPLANAHETNDGGFTREWTIRGHGIA
HHHHHHCCCCEEEEECCCEEEEEEECCCCCEEEEEECCCCCCCCCCCCEEEEEEEECCEE
LKSIWDVARDVRAGRLKVLLPEWRHQDAPLHAIHHSKRYMAPRVRVLLDFLVERFAQEEK
HHHHHHHHHHHCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALEDLLNACR
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503 [H]