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The map label for this gene is thrC [H]

Identifier: 83718524

GI number: 83718524

Start: 2474297

End: 2475748

Strand: Direct

Name: thrC [H]

Synonym: BTH_I2199

Alternate gene names: 83718524

Gene position: 2474297-2475748 (Clockwise)

Preceding gene: 83721091

Following gene: 83719995

Centisome position: 64.96

GC content: 66.87

Gene sequence:

>1452_bases
ATGAATTACATCTCCACGCGCGGCGCCGGCATCGGCGAGCGCCATACGTTCTCCGACATCCTGCTCGGCGGCCTCGCGAA
GGACGGCGGGCTCTATCTGCCGAGCGAGTATCCGCAGGTGAGCGCGGACGAGCTCGCGCGCTGGCGCACGCTGCCGTACG
CGGATCTCGCGTTCGAGATCCTGTCGAAGTTCTGCGACGACATCGCCGCCGCCGACCTGCGCGCGATCACGCGCCGCACG
TACACGGCCGACGTGTACCGCCACGCGCGCCGCGGCGGGAACGCGGCCGACATCACGCCGCTCACGACGCTCGGCACCGA
GAACGGCGCGCCCGTCTCGCTGCTCGAGCTGTCGAACGGCCCGACGCTCGCGTTCAAGGACATGGCGATGCAGTTGCTCG
GCAATCTGTTCGAGTACACGCTCGCCAAGCACGGCGAAACGCTGAACATCCTCGGCGCGACGTCGGGCGACACGGGCAGC
GCGGCCGAATACGCGATGCGCGGCAAAGAGGGCGTGCGCGTGTTCATGCTGTCGCCGCACAAGAAGATGAGCGCGTTCCA
GACCGCGCAGATGTACAGCCTGCAGGACCCGAACATCTTCAACCTCGCGGTGAACGGCGTGTTCGACGACTGCCAGGACA
TCGTGAAGGCCGTGTCGAACGATCACGCGTTCAAGGCGCAGCAGAAGATCGGCACCGTCAATTCGATCAACTGGGCGCGC
GTCGTCGCGCAGGTCGTCTACTACTTCAAGGGCTACTTCGCGGCGACGCGGTCGAATGACGAGCGCGTGTCGTTCACGGT
GCCGTCGGGCAATTTCGGCAACGTCTGCGCGGGCCACATCGCGCGCATGATGGGGCTGCCGATCGAGAAGCTCGTCGTCG
CGACGAACGAGAACGACGTGCTCGACGAGTTTTTCCGCACGGGCGCGTACCGCGTGCGCAGCGCCCAGGACACGTATCAC
ACGAGCAGCCCGAGCATGGACATCTCGAAGGCGTCGAACTTCGAGCGCTTCGTGTTCGATCTGCTCGGCCGCGATCCGGC
GCGTGTCGTCCAGCTGTTTCGCGATGTCGAGCAAAAGGGCGGCTTCGATCTCGCGGCGAGCGGCGATTTCGCGCGCGTCG
CCGAGTTCGGCTTCGTGTCGGGCCGCAGCACGCACGCGGACCGGATCGCGACGATCCGCGACGTGTTCGAGCGCTACCGC
ACGATGATCGACACGCATACGGCCGACGGCCTGAAGGTCGCGCGCGAGCATCTGCGGCCGGGCGTGCCGATGGTCGTGCT
CGAGACCGCGCAGCCGATCAAGTTCGGCGAATCGATTCGCGAGGCGCTCGGGCAGGAGCCGTCGCGGCCTGCCGCGTTCG
ACGGGCTCGAGGCGCTGCCGCAGCGCTTCGAGGTCGTCGACGCGAACGCGCAGCAAGTGAAGGACTTCATCGCCGCGCAT
ACGGGCGCGTGA

Upstream 100 bases:

>100_bases
GAGAAGAACGTCAACGCGGCGATCGCGCGCATCGAGTCGCTCGCGACCGTCGTGTCGAAGGTCACGAAGCTGCGCATGGA
AGCGCTCAACTGAGGACGAC

Downstream 100 bases:

>100_bases
CGCGCCGGCGGGCGGCTCGCTCGATGTCGATGTCGAGTCGCTCGCCGCGTCTGCGGGTTCGTCCGCCGCGCGGTATCGAT
GATTCGTTCGCGATGCGCGC

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 483; Mature: 483

Protein sequence:

>483_residues
MNYISTRGAGIGERHTFSDILLGGLAKDGGLYLPSEYPQVSADELARWRTLPYADLAFEILSKFCDDIAAADLRAITRRT
YTADVYRHARRGGNAADITPLTTLGTENGAPVSLLELSNGPTLAFKDMAMQLLGNLFEYTLAKHGETLNILGATSGDTGS
AAEYAMRGKEGVRVFMLSPHKKMSAFQTAQMYSLQDPNIFNLAVNGVFDDCQDIVKAVSNDHAFKAQQKIGTVNSINWAR
VVAQVVYYFKGYFAATRSNDERVSFTVPSGNFGNVCAGHIARMMGLPIEKLVVATNENDVLDEFFRTGAYRVRSAQDTYH
TSSPSMDISKASNFERFVFDLLGRDPARVVQLFRDVEQKGGFDLAASGDFARVAEFGFVSGRSTHADRIATIRDVFERYR
TMIDTHTADGLKVAREHLRPGVPMVVLETAQPIKFGESIREALGQEPSRPAAFDGLEALPQRFEVVDANAQQVKDFIAAH
TGA

Sequences:

>Translated_483_residues
MNYISTRGAGIGERHTFSDILLGGLAKDGGLYLPSEYPQVSADELARWRTLPYADLAFEILSKFCDDIAAADLRAITRRT
YTADVYRHARRGGNAADITPLTTLGTENGAPVSLLELSNGPTLAFKDMAMQLLGNLFEYTLAKHGETLNILGATSGDTGS
AAEYAMRGKEGVRVFMLSPHKKMSAFQTAQMYSLQDPNIFNLAVNGVFDDCQDIVKAVSNDHAFKAQQKIGTVNSINWAR
VVAQVVYYFKGYFAATRSNDERVSFTVPSGNFGNVCAGHIARMMGLPIEKLVVATNENDVLDEFFRTGAYRVRSAQDTYH
TSSPSMDISKASNFERFVFDLLGRDPARVVQLFRDVEQKGGFDLAASGDFARVAEFGFVSGRSTHADRIATIRDVFERYR
TMIDTHTADGLKVAREHLRPGVPMVVLETAQPIKFGESIREALGQEPSRPAAFDGLEALPQRFEVVDANAQQVKDFIAAH
TGA
>Mature_483_residues
MNYISTRGAGIGERHTFSDILLGGLAKDGGLYLPSEYPQVSADELARWRTLPYADLAFEILSKFCDDIAAADLRAITRRT
YTADVYRHARRGGNAADITPLTTLGTENGAPVSLLELSNGPTLAFKDMAMQLLGNLFEYTLAKHGETLNILGATSGDTGS
AAEYAMRGKEGVRVFMLSPHKKMSAFQTAQMYSLQDPNIFNLAVNGVFDDCQDIVKAVSNDHAFKAQQKIGTVNSINWAR
VVAQVVYYFKGYFAATRSNDERVSFTVPSGNFGNVCAGHIARMMGLPIEKLVVATNENDVLDEFFRTGAYRVRSAQDTYH
TSSPSMDISKASNFERFVFDLLGRDPARVVQLFRDVEQKGGFDLAASGDFARVAEFGFVSGRSTHADRIATIRDVFERYR
TMIDTHTADGLKVAREHLRPGVPMVVLETAQPIKFGESIREALGQEPSRPAAFDGLEALPQRFEVVDANAQQVKDFIAAH
TGA

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI153792148, Length=451, Percent_Identity=32.5942350332594, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI149193323, Length=467, Percent_Identity=30.406852248394, Blast_Score=196, Evalue=5e-50,
Organism=Escherichia coli, GI1786185, Length=440, Percent_Identity=29.5454545454545, Blast_Score=181, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6319901, Length=472, Percent_Identity=39.8305084745763, Blast_Score=311, Evalue=1e-85,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 53002; Mature: 53002

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNYISTRGAGIGERHTFSDILLGGLAKDGGLYLPSEYPQVSADELARWRTLPYADLAFEI
CCCCCCCCCCCCCCHHHHHHHHHCCCCCCCEECCCCCCCCCHHHHHHHCCCCHHHHHHHH
LSKFCDDIAAADLRAITRRTYTADVYRHARRGGNAADITPLTTLGTENGAPVSLLELSNG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCEEEEEECCC
PTLAFKDMAMQLLGNLFEYTLAKHGETLNILGATSGDTGSAAEYAMRGKEGVRVFMLSPH
CCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHCCCCCCEEEEECCC
KKMSAFQTAQMYSLQDPNIFNLAVNGVFDDCQDIVKAVSNDHAFKAQQKIGTVNSINWAR
HHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHH
VVAQVVYYFKGYFAATRSNDERVSFTVPSGNFGNVCAGHIARMMGLPIEKLVVATNENDV
HHHHHHHHHHHHHHEECCCCCEEEEEECCCCCCCHHHHHHHHHHCCCHHHEEEECCCCHH
LDEFFRTGAYRVRSAQDTYHTSSPSMDISKASNFERFVFDLLGRDPARVVQLFRDVEQKG
HHHHHHCCCCEEECCCCCCCCCCCCCCHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHC
GFDLAASGDFARVAEFGFVSGRSTHADRIATIRDVFERYRTMIDTHTADGLKVAREHLRP
CEEEECCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCC
GVPMVVLETAQPIKFGESIREALGQEPSRPAAFDGLEALPQRFEVVDANAQQVKDFIAAH
CCCEEEECCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHC
TGA
CCC
>Mature Secondary Structure
MNYISTRGAGIGERHTFSDILLGGLAKDGGLYLPSEYPQVSADELARWRTLPYADLAFEI
CCCCCCCCCCCCCCHHHHHHHHHCCCCCCCEECCCCCCCCCHHHHHHHCCCCHHHHHHHH
LSKFCDDIAAADLRAITRRTYTADVYRHARRGGNAADITPLTTLGTENGAPVSLLELSNG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCEEEEEECCC
PTLAFKDMAMQLLGNLFEYTLAKHGETLNILGATSGDTGSAAEYAMRGKEGVRVFMLSPH
CCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHCCCCCCEEEEECCC
KKMSAFQTAQMYSLQDPNIFNLAVNGVFDDCQDIVKAVSNDHAFKAQQKIGTVNSINWAR
HHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHH
VVAQVVYYFKGYFAATRSNDERVSFTVPSGNFGNVCAGHIARMMGLPIEKLVVATNENDV
HHHHHHHHHHHHHHEECCCCCEEEEEECCCCCCCHHHHHHHHHHCCCHHHEEEECCCCHH
LDEFFRTGAYRVRSAQDTYHTSSPSMDISKASNFERFVFDLLGRDPARVVQLFRDVEQKG
HHHHHHCCCCEEECCCCCCCCCCCCCCHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHC
GFDLAASGDFARVAEFGFVSGRSTHADRIATIRDVFERYRTMIDTHTADGLKVAREHLRP
CEEEECCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCC
GVPMVVLETAQPIKFGESIREALGQEPSRPAAFDGLEALPQRFEVVDANAQQVKDFIAAH
CCCEEEECCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHC
TGA
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8117070 [H]