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The map label for this gene is hom [H]

Identifier: 83721091

GI number: 83721091

Start: 2472961

End: 2474289

Strand: Direct

Name: hom [H]

Synonym: BTH_I2198

Alternate gene names: 83721091

Gene position: 2472961-2474289 (Clockwise)

Preceding gene: 83721092

Following gene: 83718524

Centisome position: 64.92

GC content: 68.02

Gene sequence:

>1329_bases
ATGGAACCGATCAAAGTAGGCCTGTTGGGCTTCGGCACGGTGGGCGGCGGCACCTTCAAGGTGCTGCGCCGCAACCAGGA
GGAAATCAAGCGGCGCGCCGGGCGCGGCATCGAGATCACGCGCGTCGCGGTGCGCAATCCCGCGAAGGCGCTCGCCGCGC
TCGACGGCGATGCGAACGGCGTGTCGATCGGCGACGATTTCAACGCGGTCGTCGACGACCCGTCGATCGCGATCGTCGCC
GAGATGATCGGCGGCACCGGCCTCGCGCGCGAGCTCGTGCTGCGCGCGATCGCGAACGGCAAGCACGTCGTGACCGCGAA
CAAGGCGCTGCTCGCGGTGCACGGCACCGAGATCTTCGAGGCCGCGCGCGAGAAGGGCGTGATGGTCGCGTTCGAGGCGG
CCGTCGCGGGCGGCATCCCGATCATCAAGGCGCTGCGCGAAGGGCTGACCGCGAACCGGATTCAGTACATCGCCGGCATC
ATCAACGGCACGACGAACTACATCCTGTCGGAGATGCGCGAGCACGGCCTCGATTTCGCGACGGCGCTCAAGGCCGCGCA
GGAGCTCGGCTACGCGGAAGCCGATCCGACCTTCGACATCGAGGGCATCGACGCCGCGCACAAGGCGACGATCATGAGCG
CGATCGCGTTCGGCGTGCCGGTGCAGTTCGAGCGTGCGTACGTCGAAGGGATCAGCAAGCTCGCCGCGACCGATATCCGC
TACGCGGAAGAGCTCGGCTACCGGATCAAGCTGCTCGGCATCACGCGGCGCACCGAGCGCGGCATCGAGCTGCGCGTGCA
CCCGACGCTGATTCCCGCGAAGCGCCTGCTCGCGAACGTCGAGGGCGCGATGAACGCGGTCGTCGTGCACGGCGACGCGG
TGGGCACGACGCTTTACTACGGCAAGGGCGCGGGCGCGGAGCCGACGGCGTCGGCCGTCGTCGCCGATCTCGTCGACGTC
ACGCGCCTGCACACGGCGGACCCCGAGCACCGCGTGCCGCACCTCGCGTTCCAGCCGGACAGCCTGTCGAACACGCCGAT
CCTGCCGATCGAAGAGGTGACGAGCGGCTACTACCTGCGCCTGCGCGTCGCCGACGAGACGGGCGTGCTCGCCGACATCA
CGCGCATCCTCGCCGATTCGGGGATCTCGATCGACGCGCTGTTGCAGAAGGAGTCGGAGCAGGTCGACGACGCGAACGGC
GAGACCGACATCATCCTGATCACGCACGAGACGATCGAGAAGAACGTCAACGCGGCGATCGCGCGCATCGAGTCGCTCGC
GACCGTCGTGTCGAAGGTCACGAAGCTGCGCATGGAAGCGCTCAACTGA

Upstream 100 bases:

>100_bases
CGATCGAGCGGATCGCGCGCTTCCTCGACGGCTACCGCAAGCGCCACTCGGCCTGACCGGGCGAGTCTCACCTTTTTCAT
TCAATAAGATCACACGCAGC

Downstream 100 bases:

>100_bases
GGACGACATGAATTACATCTCCACGCGCGGCGCCGGCATCGGCGAGCGCCATACGTTCTCCGACATCCTGCTCGGCGGCC
TCGCGAAGGACGGCGGGCTC

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 442; Mature: 442

Protein sequence:

>442_residues
MEPIKVGLLGFGTVGGGTFKVLRRNQEEIKRRAGRGIEITRVAVRNPAKALAALDGDANGVSIGDDFNAVVDDPSIAIVA
EMIGGTGLARELVLRAIANGKHVVTANKALLAVHGTEIFEAAREKGVMVAFEAAVAGGIPIIKALREGLTANRIQYIAGI
INGTTNYILSEMREHGLDFATALKAAQELGYAEADPTFDIEGIDAAHKATIMSAIAFGVPVQFERAYVEGISKLAATDIR
YAEELGYRIKLLGITRRTERGIELRVHPTLIPAKRLLANVEGAMNAVVVHGDAVGTTLYYGKGAGAEPTASAVVADLVDV
TRLHTADPEHRVPHLAFQPDSLSNTPILPIEEVTSGYYLRLRVADETGVLADITRILADSGISIDALLQKESEQVDDANG
ETDIILITHETIEKNVNAAIARIESLATVVSKVTKLRMEALN

Sequences:

>Translated_442_residues
MEPIKVGLLGFGTVGGGTFKVLRRNQEEIKRRAGRGIEITRVAVRNPAKALAALDGDANGVSIGDDFNAVVDDPSIAIVA
EMIGGTGLARELVLRAIANGKHVVTANKALLAVHGTEIFEAAREKGVMVAFEAAVAGGIPIIKALREGLTANRIQYIAGI
INGTTNYILSEMREHGLDFATALKAAQELGYAEADPTFDIEGIDAAHKATIMSAIAFGVPVQFERAYVEGISKLAATDIR
YAEELGYRIKLLGITRRTERGIELRVHPTLIPAKRLLANVEGAMNAVVVHGDAVGTTLYYGKGAGAEPTASAVVADLVDV
TRLHTADPEHRVPHLAFQPDSLSNTPILPIEEVTSGYYLRLRVADETGVLADITRILADSGISIDALLQKESEQVDDANG
ETDIILITHETIEKNVNAAIARIESLATVVSKVTKLRMEALN
>Mature_442_residues
MEPIKVGLLGFGTVGGGTFKVLRRNQEEIKRRAGRGIEITRVAVRNPAKALAALDGDANGVSIGDDFNAVVDDPSIAIVA
EMIGGTGLARELVLRAIANGKHVVTANKALLAVHGTEIFEAAREKGVMVAFEAAVAGGIPIIKALREGLTANRIQYIAGI
INGTTNYILSEMREHGLDFATALKAAQELGYAEADPTFDIEGIDAAHKATIMSAIAFGVPVQFERAYVEGISKLAATDIR
YAEELGYRIKLLGITRRTERGIELRVHPTLIPAKRLLANVEGAMNAVVVHGDAVGTTLYYGKGAGAEPTASAVVADLVDV
TRLHTADPEHRVPHLAFQPDSLSNTPILPIEEVTSGYYLRLRVADETGVLADITRILADSGISIDALLQKESEQVDDANG
ETDIILITHETIEKNVNAAIARIESLATVVSKVTKLRMEALN

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=253, Percent_Identity=27.2727272727273, Blast_Score=65, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322599, Length=159, Percent_Identity=31.4465408805031, Blast_Score=72, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 47102; Mature: 47102

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEPIKVGLLGFGTVGGGTFKVLRRNQEEIKRRAGRGIEITRVAVRNPAKALAALDGDANG
CCCEEEEEEEEECCCCCHHHHHHCCHHHHHHHCCCCEEEEEEECCCCHHHHHHCCCCCCC
VSIGDDFNAVVDDPSIAIVAEMIGGTGLARELVLRAIANGKHVVTANKALLAVHGTEIFE
EEECCCCCEEECCCCCEEHHHHHCCCHHHHHHHHHHHCCCCEEEEECCEEEEEECHHHHH
AAREKGVMVAFEAAVAGGIPIIKALREGLTANRIQYIAGIINGTTNYILSEMREHGLDFA
HHHHCCEEEEEEHHHHCCCHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCHHH
TALKAAQELGYAEADPTFDIEGIDAAHKATIMSAIAFGVPVQFERAYVEGISKLAATDIR
HHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
YAEELGYRIKLLGITRRTERGIELRVHPTLIPAKRLLANVEGAMNAVVVHGDAVGTTLYY
HHHHCCCEEEEEEEEECCCCCCEEEECCCHHHHHHHHHHHCCCCEEEEEECCCCCCEEEE
GKGAGAEPTASAVVADLVDVTRLHTADPEHRVPHLAFQPDSLSNTPILPIEEVTSGYYLR
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCCHHHHCCCEEEE
LRVADETGVLADITRILADSGISIDALLQKESEQVDDANGETDIILITHETIEKNVNAAI
EEEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCEEEEEEEHHHHHHHHHHHH
ARIESLATVVSKVTKLRMEALN
HHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEPIKVGLLGFGTVGGGTFKVLRRNQEEIKRRAGRGIEITRVAVRNPAKALAALDGDANG
CCCEEEEEEEEECCCCCHHHHHHCCHHHHHHHCCCCEEEEEEECCCCHHHHHHCCCCCCC
VSIGDDFNAVVDDPSIAIVAEMIGGTGLARELVLRAIANGKHVVTANKALLAVHGTEIFE
EEECCCCCEEECCCCCEEHHHHHCCCHHHHHHHHHHHCCCCEEEEECCEEEEEECHHHHH
AAREKGVMVAFEAAVAGGIPIIKALREGLTANRIQYIAGIINGTTNYILSEMREHGLDFA
HHHHCCEEEEEEHHHHCCCHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCHHH
TALKAAQELGYAEADPTFDIEGIDAAHKATIMSAIAFGVPVQFERAYVEGISKLAATDIR
HHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
YAEELGYRIKLLGITRRTERGIELRVHPTLIPAKRLLANVEGAMNAVVVHGDAVGTTLYY
HHHHCCCEEEEEEEEECCCCCCEEEECCCHHHHHHHHHHHCCCCEEEEEECCCCCCEEEE
GKGAGAEPTASAVVADLVDVTRLHTADPEHRVPHLAFQPDSLSNTPILPIEEVTSGYYLR
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCCHHHHCCCEEEE
LRVADETGVLADITRILADSGISIDALLQKESEQVDDANGETDIILITHETIEKNVNAAI
EEEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCEEEEEEEHHHHHHHHHHHH
ARIESLATVVSKVTKLRMEALN
HHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1333566; 10984043 [H]