| Definition | Burkholderia thailandensis E264 chromosome chromosome I, complete sequence. |
|---|---|
| Accession | NC_007651 |
| Length | 3,809,201 |
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The map label for this gene is topB [H]
Identifier: 284159405
GI number: 284159405
Start: 153323
End: 155998
Strand: Reverse
Name: topB [H]
Synonym: BTH_I0125
Alternate gene names: 284159405
Gene position: 155998-153323 (Counterclockwise)
Preceding gene: 83718599
Following gene: 83718903
Centisome position: 4.1
GC content: 64.5
Gene sequence:
>2676_bases GTGTGCTATAAAGCCGTCGTAAAAGGGCCCGCATCGGGCTCGCCCGGTCCATCAATACACACTGTCATGTCGAAAGCACT CATCATTGCGGAAAAGCCTTCTGTCGCGAACGACATCGCGCGTGCTTTGGGCGGCTTTACCAAGCATGACGAATACTACG AGAGCGACGAATACGTACTGTCGTCGGCGGTCGGCCACCTGCTCGAAATCGCCGCGCCGGAGGAATACGAGGTCAAGCGC GGCAAGTGGAGCTTCGCGCATCTGCCCGTCATTCCCCCCCATTTCGATCTGAATCCGATCGCGAAAAGCGAGTCGCGCCT AAAGGTGCTGACGAAGCTGATCAAGCGCAAGGACGTCGACCGCCTGATCAACGCATGCGACGCGGGGCGCGAGGGCGAGT TGATCTTCCGCCTGATCGCGCAGCACGCGAAGGCGAAGCAGCCGGTCCAGCGCCTGTGGCTGCAGTCGATGACGCCCGCC GCGATCCGCGACGGCTTCGCGCACCTGCGCACCGACGTGGACATGCAGCCGCTCGCCGATGCCGCGCGTTGCCGCTCGGA AGCCGACTGGCTCGTCGGCATCAACGGCACGCGCGCGATGACGGCGTTCAACAGCAAGGGCGGCGGCTTCTTCCTGACGA CCGTCGGCCGCGTGCAGACGCCGACGCTGTCGATCGTCGTCGAGCGCGAGGAGAAGATTCGCCGCTTCGTGCCGCGCGAC TACTGGGAAGTGCGCGCGGAATTCGTCTGCGCGGGCGGCTTCTACGAAGGCCGCTGGTTCGATCCGAAATTCAAGAAGGA CGAGTTCGACCCCGAAAAGCGCGATTCACGCCTCTGGAGCCTGCCCGCGGCGGAGACGATCGTCGCCGCGTGTCGTGACC AGCTCGGCACCGTCACCGAGGAATCGAAGCCGTCGACGCAGCTCTCGCCGCTGCTGTACGACCTGACGAGCCTGCAGCGC GAGGCGAACAGCCGCTTCGGCTTCTCCGCGAAGAACACGCTCGGCCTGGCGCAGGCGCTGTACGAAAAGCACAAGGTGCT CACCTACCCGCGTACCGACGCTCGCGCCTTGCCGGAGGACTACCTCGGCACGGTGAAGTCGACGCTCGAGATGCTCAAGG AGAGCAACAACTACCTGCCGCACGCGAAGCAGGTGCTCGACAAGAACTGGGTGAAGCCGAACAAGCGGATCTTCGACAAC TCGAAGATCAGCGATCACTTCGCGATCATCCCGACGCTGCAGGCGCCGAAATCGCTGTCCGAGCCGGAGCAGAAGCTCTA CGACCTCGTCGTCAAGCGCTTCCTCGCCGTGTTCTTCCCGGCCGCCGAATTCAAGGTGACGACCCGGATCACCGAGGTCG CGGGCCATCACTTCAAGACGGAAGGCAAGGTGCTCGTCGAACCGGGCTGGCTGCAGGTCTACGGCCGGGACGCGGAGGGC GCCGACGCGAATCTCGTGCCGGTGCAGAAGGACGAGAAGGTCAAGACCGACAAGATCGCCGCACACGGCCTGACGACGAA GCCGCCCGCGCGCTATTCGGAAGCGACGCTGCTCTCGGCGATGGAAGGCGCGGGCAAGCTCGTCGAAGACGACGAGCTGC GCGAAGCGATGGCCGCGAAGGGCCTCGGCACGCCGGCCACGCGCGCGGCGATCATCGAAGGCCTGCTTGGCGAGAAGTAC CTCCTGCGCGAAGGCCGCGAGCTGATTCCGACCGCGAAGGCGTTCCAGCTGATGACGCTGTTGCGCGGCCTCGGCGTGAA GGAGCTGACCGCGCCCGAGTTGACGGGCGAATGGGAATACAAGCTGTCGCAGATGGAGCGCGGCAACCTGCAGCGCGACG CGTTCATGCAGGAAATCGCGCGGATGACGCAGACGATCGTCAAGCGCGCGAAGGAATACGATTCCGACACGATCCCGGGC GACTACGCGACGCTCGAAACGCCGTGCCCGAACTGCGGCGGCCAGGTGAAGGAGAACTACCGGCGCTTCGCGTGCACGAA GTGCGACTTCTCGATCTCGAAGATCCCGGGCAGCCGGCAATTCGAGATCGCCGAAGTCGAGGAACTGTTGCAGAAGAAGG AAATCGGGCCGCTGTCGGGCTTTCGCAGCAAGATGGGCCGGCCGTTCTCCGCGATCCTCAAGCTCACGTTCGACGACGAG ACGAAGAACTACAAGCTCGAATTCGACTTCGGCCAGGAGCAAGGCGGCGAAGAAGGCGAGGCGCCCGACTTCTCCGCGCA AGAGCCGGTCGGCGCGTGCCCGAAGTGCAAGGGCCGCGTGTTCGAGCACGGCATGAGCTACGTCTGCGAGCATGCGGTCG CGAACCCGAAGACCTGCGACTTCCGCTCCGGCAAGGTGATCCTGCAGCAGGAGATCACCCGCGAGCAGATGGCGAAGCTC CTCGAGAACGGCCGCACCGATCTGCTGCCGAACTTCAAGTCGTCGCGCACCGGGCGCAACTTCAAGGCGTATCTCGTCAA GCAGGCGGACGGCAAGATCGGCTTCGAGTTCGAGAAGAAGGAGCCGAAGCCCGCGGCCGCGAAGAAGACGGCGTCCAAAT CGACGGCTGCGGCCGCCGATGCCGCTGCCGACAGCGACGACAAGGCTGAAAAGAAGACAGCGCCCGCCCGCAAGACGGCC GCGCGCAAGACGCCGGCACGCAAGACGGGCTCTTGA
Upstream 100 bases:
>100_bases CGCTCGTTTACGCGAGAGGGCGTGCGACAGGCTTGCCGCCGCCCTTGCCCACACTTATGATGACCCGCTTTTTGCTCGCG CCGGCCGCCGTTTGGGCGCC
Downstream 100 bases:
>100_bases CGGGCGCAATGCCGGCCCCGCGAATGCGCGGCGTGCCGGCGCTTCGCCGAGCGGCGTCCGCGATGCCGCGCAGCCCGGGC CCGGCGGCCGCCGGCACTAC
Product: DNA topoisomerase III
Products: NA
Alternate protein names: DNA topoisomerase III [H]
Number of amino acids: Translated: 891; Mature: 891
Protein sequence:
>891_residues MCYKAVVKGPASGSPGPSIHTVMSKALIIAEKPSVANDIARALGGFTKHDEYYESDEYVLSSAVGHLLEIAAPEEYEVKR GKWSFAHLPVIPPHFDLNPIAKSESRLKVLTKLIKRKDVDRLINACDAGREGELIFRLIAQHAKAKQPVQRLWLQSMTPA AIRDGFAHLRTDVDMQPLADAARCRSEADWLVGINGTRAMTAFNSKGGGFFLTTVGRVQTPTLSIVVEREEKIRRFVPRD YWEVRAEFVCAGGFYEGRWFDPKFKKDEFDPEKRDSRLWSLPAAETIVAACRDQLGTVTEESKPSTQLSPLLYDLTSLQR EANSRFGFSAKNTLGLAQALYEKHKVLTYPRTDARALPEDYLGTVKSTLEMLKESNNYLPHAKQVLDKNWVKPNKRIFDN SKISDHFAIIPTLQAPKSLSEPEQKLYDLVVKRFLAVFFPAAEFKVTTRITEVAGHHFKTEGKVLVEPGWLQVYGRDAEG ADANLVPVQKDEKVKTDKIAAHGLTTKPPARYSEATLLSAMEGAGKLVEDDELREAMAAKGLGTPATRAAIIEGLLGEKY LLREGRELIPTAKAFQLMTLLRGLGVKELTAPELTGEWEYKLSQMERGNLQRDAFMQEIARMTQTIVKRAKEYDSDTIPG DYATLETPCPNCGGQVKENYRRFACTKCDFSISKIPGSRQFEIAEVEELLQKKEIGPLSGFRSKMGRPFSAILKLTFDDE TKNYKLEFDFGQEQGGEEGEAPDFSAQEPVGACPKCKGRVFEHGMSYVCEHAVANPKTCDFRSGKVILQQEITREQMAKL LENGRTDLLPNFKSSRTGRNFKAYLVKQADGKIGFEFEKKEPKPAAAKKTASKSTAAAADAAADSDDKAEKKTAPARKTA ARKTPARKTGS
Sequences:
>Translated_891_residues MCYKAVVKGPASGSPGPSIHTVMSKALIIAEKPSVANDIARALGGFTKHDEYYESDEYVLSSAVGHLLEIAAPEEYEVKR GKWSFAHLPVIPPHFDLNPIAKSESRLKVLTKLIKRKDVDRLINACDAGREGELIFRLIAQHAKAKQPVQRLWLQSMTPA AIRDGFAHLRTDVDMQPLADAARCRSEADWLVGINGTRAMTAFNSKGGGFFLTTVGRVQTPTLSIVVEREEKIRRFVPRD YWEVRAEFVCAGGFYEGRWFDPKFKKDEFDPEKRDSRLWSLPAAETIVAACRDQLGTVTEESKPSTQLSPLLYDLTSLQR EANSRFGFSAKNTLGLAQALYEKHKVLTYPRTDARALPEDYLGTVKSTLEMLKESNNYLPHAKQVLDKNWVKPNKRIFDN SKISDHFAIIPTLQAPKSLSEPEQKLYDLVVKRFLAVFFPAAEFKVTTRITEVAGHHFKTEGKVLVEPGWLQVYGRDAEG ADANLVPVQKDEKVKTDKIAAHGLTTKPPARYSEATLLSAMEGAGKLVEDDELREAMAAKGLGTPATRAAIIEGLLGEKY LLREGRELIPTAKAFQLMTLLRGLGVKELTAPELTGEWEYKLSQMERGNLQRDAFMQEIARMTQTIVKRAKEYDSDTIPG DYATLETPCPNCGGQVKENYRRFACTKCDFSISKIPGSRQFEIAEVEELLQKKEIGPLSGFRSKMGRPFSAILKLTFDDE TKNYKLEFDFGQEQGGEEGEAPDFSAQEPVGACPKCKGRVFEHGMSYVCEHAVANPKTCDFRSGKVILQQEITREQMAKL LENGRTDLLPNFKSSRTGRNFKAYLVKQADGKIGFEFEKKEPKPAAAKKTASKSTAAAADAAADSDDKAEKKTAPARKTA ARKTPARKTGS >Mature_891_residues MCYKAVVKGPASGSPGPSIHTVMSKALIIAEKPSVANDIARALGGFTKHDEYYESDEYVLSSAVGHLLEIAAPEEYEVKR GKWSFAHLPVIPPHFDLNPIAKSESRLKVLTKLIKRKDVDRLINACDAGREGELIFRLIAQHAKAKQPVQRLWLQSMTPA AIRDGFAHLRTDVDMQPLADAARCRSEADWLVGINGTRAMTAFNSKGGGFFLTTVGRVQTPTLSIVVEREEKIRRFVPRD YWEVRAEFVCAGGFYEGRWFDPKFKKDEFDPEKRDSRLWSLPAAETIVAACRDQLGTVTEESKPSTQLSPLLYDLTSLQR EANSRFGFSAKNTLGLAQALYEKHKVLTYPRTDARALPEDYLGTVKSTLEMLKESNNYLPHAKQVLDKNWVKPNKRIFDN SKISDHFAIIPTLQAPKSLSEPEQKLYDLVVKRFLAVFFPAAEFKVTTRITEVAGHHFKTEGKVLVEPGWLQVYGRDAEG ADANLVPVQKDEKVKTDKIAAHGLTTKPPARYSEATLLSAMEGAGKLVEDDELREAMAAKGLGTPATRAAIIEGLLGEKY LLREGRELIPTAKAFQLMTLLRGLGVKELTAPELTGEWEYKLSQMERGNLQRDAFMQEIARMTQTIVKRAKEYDSDTIPG DYATLETPCPNCGGQVKENYRRFACTKCDFSISKIPGSRQFEIAEVEELLQKKEIGPLSGFRSKMGRPFSAILKLTFDDE TKNYKLEFDFGQEQGGEEGEAPDFSAQEPVGACPKCKGRVFEHGMSYVCEHAVANPKTCDFRSGKVILQQEITREQMAKL LENGRTDLLPNFKSSRTGRNFKAYLVKQADGKIGFEFEKKEPKPAAAKKTASKSTAAAADAAADSDDKAEKKTAPARKTA ARKTPARKTGS
Specific function: The reaction catalyzed by topoisomerases leads to the conversion of one topological isomer of DNA to another. TOP3 is a potent decatenase [H]
COG id: COG0550
COG function: function code L; Topoisomerase IA
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 Toprim domain [H]
Homologues:
Organism=Homo sapiens, GI10835218, Length=649, Percent_Identity=25.8859784283513, Blast_Score=141, Evalue=3e-33, Organism=Homo sapiens, GI4507635, Length=698, Percent_Identity=22.9226361031519, Blast_Score=111, Evalue=3e-24, Organism=Escherichia coli, GI1788061, Length=619, Percent_Identity=33.6025848142165, Blast_Score=322, Evalue=7e-89, Organism=Escherichia coli, GI1787529, Length=667, Percent_Identity=25.3373313343328, Blast_Score=149, Evalue=8e-37, Organism=Caenorhabditis elegans, GI32563869, Length=626, Percent_Identity=25.0798722044728, Blast_Score=122, Evalue=6e-28, Organism=Caenorhabditis elegans, GI17555378, Length=635, Percent_Identity=24.251968503937, Blast_Score=106, Evalue=5e-23, Organism=Saccharomyces cerevisiae, GI6323263, Length=670, Percent_Identity=25.5223880597015, Blast_Score=110, Evalue=1e-24, Organism=Drosophila melanogaster, GI24585251, Length=668, Percent_Identity=25.8982035928144, Blast_Score=115, Evalue=1e-25, Organism=Drosophila melanogaster, GI24640096, Length=640, Percent_Identity=22.03125, Blast_Score=101, Evalue=3e-21,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR003601 - InterPro: IPR013497 - InterPro: IPR013824 - InterPro: IPR013825 - InterPro: IPR000380 - InterPro: IPR003602 - InterPro: IPR005738 - InterPro: IPR006171 [H]
Pfam domain/function: PF01131 Topoisom_bac; PF01751 Toprim [H]
EC number: =5.99.1.2 [H]
Molecular weight: Translated: 99110; Mature: 99110
Theoretical pI: Translated: 8.96; Mature: 8.96
Prosite motif: PS00396 TOPOISOMERASE_I_PROK
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.5 %Cys (Translated Protein) 1.7 %Met (Translated Protein) 3.1 %Cys+Met (Translated Protein) 1.5 %Cys (Mature Protein) 1.7 %Met (Mature Protein) 3.1 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MCYKAVVKGPASGSPGPSIHTVMSKALIIAEKPSVANDIARALGGFTKHDEYYESDEYVL CCCHHHCCCCCCCCCCCHHHHHHHHHHEEECCCCHHHHHHHHHCCCCCCCHHHCCHHHHH SSAVGHLLEIAAPEEYEVKRGKWSFAHLPVIPPHFDLNPIAKSESRLKVLTKLIKRKDVD HHHHHHHHHHCCCCCCHHCCCCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH RLINACDAGREGELIFRLIAQHAKAKQPVQRLWLQSMTPAAIRDGFAHLRTDVDMQPLAD HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHH AARCRSEADWLVGINGTRAMTAFNSKGGGFFLTTVGRVQTPTLSIVVEREEKIRRFVPRD HHHHCCCCCEEEECCCCEEEEEECCCCCCEEEEECCCCCCCEEEEEECCHHHHHHHCCCH YWEVRAEFVCAGGFYEGRWFDPKFKKDEFDPEKRDSRLWSLPAAETIVAACRDQLGTVTE HHHHHHHEEEECCCCCCCCCCCCCCCCCCCCHHHCCCEECCCHHHHHHHHHHHHHCCCCC ESKPSTQLSPLLYDLTSLQREANSRFGFSAKNTLGLAQALYEKHKVLTYPRTDARALPED CCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCEEECCCCCHHCCCHH YLGTVKSTLEMLKESNNYLPHAKQVLDKNWVKPNKRIFDNSKISDHFAIIPTLQAPKSLS HHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCC EPEQKLYDLVVKRFLAVFFPAAEFKVTTRITEVAGHHFKTEGKVLVEPGWLQVYGRDAEG CHHHHHHHHHHHHHHHHHCCCHHEEHHHHHHHHHCCCCCCCCEEEECCCEEEEEECCCCC ADANLVPVQKDEKVKTDKIAAHGLTTKPPARYSEATLLSAMEGAGKLVEDDELREAMAAK CCCCEECCCCCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHC GLGTPATRAAIIEGLLGEKYLLREGRELIPTAKAFQLMTLLRGLGVKELTAPELTGEWEY CCCCCHHHHHHHHHHHCCHHHHHCCHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHH KLSQMERGNLQRDAFMQEIARMTQTIVKRAKEYDSDTIPGDYATLETPCPNCGGQVKENY HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEECCCCCCCCCHHHHHH RRFACTKCDFSISKIPGSRQFEIAEVEELLQKKEIGPLSGFRSKMGRPFSAILKLTFDDE HHHHHCCCCCCHHCCCCCCCEEHHHHHHHHHHHCCCCHHHHHHHHCCCHHHEEEEEECCC TKNYKLEFDFGQEQGGEEGEAPDFSAQEPVGACPKCKGRVFEHGMSYVCEHAVANPKTCD CCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCC FRSGKVILQQEITREQMAKLLENGRTDLLPNFKSSRTGRNFKAYLVKQADGKIGFEFEKK CCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCEEECCC EPKPAAAKKTASKSTAAAADAAADSDDKAEKKTAPARKTAARKTPARKTGS CCCCCHHHHHCCHHHHHHHHHCCCCCHHHHHHCCCHHHHHHHCCCCCCCCC >Mature Secondary Structure MCYKAVVKGPASGSPGPSIHTVMSKALIIAEKPSVANDIARALGGFTKHDEYYESDEYVL CCCHHHCCCCCCCCCCCHHHHHHHHHHEEECCCCHHHHHHHHHCCCCCCCHHHCCHHHHH SSAVGHLLEIAAPEEYEVKRGKWSFAHLPVIPPHFDLNPIAKSESRLKVLTKLIKRKDVD HHHHHHHHHHCCCCCCHHCCCCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH RLINACDAGREGELIFRLIAQHAKAKQPVQRLWLQSMTPAAIRDGFAHLRTDVDMQPLAD HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHH AARCRSEADWLVGINGTRAMTAFNSKGGGFFLTTVGRVQTPTLSIVVEREEKIRRFVPRD HHHHCCCCCEEEECCCCEEEEEECCCCCCEEEEECCCCCCCEEEEEECCHHHHHHHCCCH YWEVRAEFVCAGGFYEGRWFDPKFKKDEFDPEKRDSRLWSLPAAETIVAACRDQLGTVTE HHHHHHHEEEECCCCCCCCCCCCCCCCCCCCHHHCCCEECCCHHHHHHHHHHHHHCCCCC ESKPSTQLSPLLYDLTSLQREANSRFGFSAKNTLGLAQALYEKHKVLTYPRTDARALPED CCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCEEECCCCCHHCCCHH YLGTVKSTLEMLKESNNYLPHAKQVLDKNWVKPNKRIFDNSKISDHFAIIPTLQAPKSLS HHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCC EPEQKLYDLVVKRFLAVFFPAAEFKVTTRITEVAGHHFKTEGKVLVEPGWLQVYGRDAEG CHHHHHHHHHHHHHHHHHCCCHHEEHHHHHHHHHCCCCCCCCEEEECCCEEEEEECCCCC ADANLVPVQKDEKVKTDKIAAHGLTTKPPARYSEATLLSAMEGAGKLVEDDELREAMAAK CCCCEECCCCCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHC GLGTPATRAAIIEGLLGEKYLLREGRELIPTAKAFQLMTLLRGLGVKELTAPELTGEWEY CCCCCHHHHHHHHHHHCCHHHHHCCHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHH KLSQMERGNLQRDAFMQEIARMTQTIVKRAKEYDSDTIPGDYATLETPCPNCGGQVKENY HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEECCCCCCCCCHHHHHH RRFACTKCDFSISKIPGSRQFEIAEVEELLQKKEIGPLSGFRSKMGRPFSAILKLTFDDE HHHHHCCCCCCHHCCCCCCCEEHHHHHHHHHHHCCCCHHHHHHHHCCCHHHEEEEEECCC TKNYKLEFDFGQEQGGEEGEAPDFSAQEPVGACPKCKGRVFEHGMSYVCEHAVANPKTCD CCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCC FRSGKVILQQEITREQMAKLLENGRTDLLPNFKSSRTGRNFKAYLVKQADGKIGFEFEKK CCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCEEECCC EPKPAAAKKTASKSTAAAADAAADSDDKAEKKTAPARKTAARKTPARKTGS CCCCCHHHHHCCHHHHHHHHHCCCCCHHHHHHCCCHHHHHHHCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: NA