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The map label for this gene is gyaR [H]

Identifier: 83718903

GI number: 83718903

Start: 150585

End: 151601

Strand: Reverse

Name: gyaR [H]

Synonym: BTH_I0123

Alternate gene names: 83718903

Gene position: 151601-150585 (Counterclockwise)

Preceding gene: 284159405

Following gene: 83719727

Centisome position: 3.98

GC content: 65.49

Gene sequence:

>1017_bases
ATGAAAATTGCCATTCTCGACGACTACCAGGACGCCGTCCGCAAGCTCAACTGCTTCGAGATGCTTGCCGACCATGAAGT
GAAGATCTTCAACAACACGGTGCGCGGCCTCGGGCAGCTCGCGAGCCGCCTGGCGGAAGTCGAAGCGCTCGTGCTGATTC
GCGAGCGCACCCACATCACGTCGCAGTTGCTCGGCAAGCTTCCGCATCTGCGCATGATCAGCCAGACGGGCCGCGTGTCG
ACTCATATCGATCTCGACGCGTGCACGGAGCGCGGCATCGCCGTGCTCGAGGGCGCGGGCTCGCCGATCGCCCCTGCCGA
GCTGACCTGGGCGCTCATCATGGCCGCGCAGCGCCGCATCCCGCAGTACGTTGCGAACCTGAAGCAGGGCGCGTGGCAGC
AGTCGGGCCTCAAGACGTCGGCGATGCCGCCGAATTTCGGGCTCGGCCAGGTGCTGCGCGGGCAGACGCTCGGCATCTGG
GGCTACGGCAAGATCGGCCGGCTCGTCGCCGGCTACGGCAAGGCATTCGGGATGAACGTGCTGGTCTGGGGGCGCGAGCA
CTCGCTCGAAGCGGCGCGCGCCGACGGCCACGCGACCGCCGAGAGCCGCGAGGCGTTCTTCGAGCAGGCCGACGTGCTGT
CGCTACACCTGCGCCTGCACGACGACACGCGCGGCATCGTCAAGCTCGACGACCTGCTGCGAATGAAGCCGACGTCGCTC
CTCGTCAACACGAGTCGCGCGGAACTGCTCGAAGAAAACGCGCTCGTTTCCGCACTGGCGCGCAACCGGCCAGGGATGGT
CGCGATCGACGTCTATGAAAGCGAACCGATCCTGCAGGGCTACAGCCTGCTGCGAATGGAGAACGTGATCTGCACGCCGC
ACATCGGCTATGTCGAGCGTGAAAGCTACGAGCTCTACTTCGGCGCGGCGTTCAAGAACATACTCGCATTCGATGCGGGC
GATCTGTCGAGCGTCGCGAATCCCGAGGCGCTCAATCAGGGGCGGGTTCGCCGCTGA

Upstream 100 bases:

>100_bases
AGGATCATTACGGCCCTCAAACCGGGCCGGACCGGCGCGCGACGCCGCGCGGCGGCCACCACCTCACATCGCTCATCCCG
CGCGAATCCCGAAACACGCC

Downstream 100 bases:

>100_bases
ACGGCGGCAGCGAGCGCGGCGCGCGAGCGGCCCCTTGCCGCCTGCCGCGCCTCACGCACCAAGCGCCTGAGCACGACGAT
CCGCCGCCCCCACTTCTCGC

Product: glyoxylate reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MKIAILDDYQDAVRKLNCFEMLADHEVKIFNNTVRGLGQLASRLAEVEALVLIRERTHITSQLLGKLPHLRMISQTGRVS
THIDLDACTERGIAVLEGAGSPIAPAELTWALIMAAQRRIPQYVANLKQGAWQQSGLKTSAMPPNFGLGQVLRGQTLGIW
GYGKIGRLVAGYGKAFGMNVLVWGREHSLEAARADGHATAESREAFFEQADVLSLHLRLHDDTRGIVKLDDLLRMKPTSL
LVNTSRAELLEENALVSALARNRPGMVAIDVYESEPILQGYSLLRMENVICTPHIGYVERESYELYFGAAFKNILAFDAG
DLSSVANPEALNQGRVRR

Sequences:

>Translated_338_residues
MKIAILDDYQDAVRKLNCFEMLADHEVKIFNNTVRGLGQLASRLAEVEALVLIRERTHITSQLLGKLPHLRMISQTGRVS
THIDLDACTERGIAVLEGAGSPIAPAELTWALIMAAQRRIPQYVANLKQGAWQQSGLKTSAMPPNFGLGQVLRGQTLGIW
GYGKIGRLVAGYGKAFGMNVLVWGREHSLEAARADGHATAESREAFFEQADVLSLHLRLHDDTRGIVKLDDLLRMKPTSL
LVNTSRAELLEENALVSALARNRPGMVAIDVYESEPILQGYSLLRMENVICTPHIGYVERESYELYFGAAFKNILAFDAG
DLSSVANPEALNQGRVRR
>Mature_338_residues
MKIAILDDYQDAVRKLNCFEMLADHEVKIFNNTVRGLGQLASRLAEVEALVLIRERTHITSQLLGKLPHLRMISQTGRVS
THIDLDACTERGIAVLEGAGSPIAPAELTWALIMAAQRRIPQYVANLKQGAWQQSGLKTSAMPPNFGLGQVLRGQTLGIW
GYGKIGRLVAGYGKAFGMNVLVWGREHSLEAARADGHATAESREAFFEQADVLSLHLRLHDDTRGIVKLDDLLRMKPTSL
LVNTSRAELLEENALVSALARNRPGMVAIDVYESEPILQGYSLLRMENVICTPHIGYVERESYELYFGAAFKNILAFDAG
DLSSVANPEALNQGRVRR

Specific function: Unknown

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=302, Percent_Identity=28.8079470198675, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI61743967, Length=255, Percent_Identity=32.5490196078431, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI4557497, Length=255, Percent_Identity=32.5490196078431, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI6912396, Length=252, Percent_Identity=28.968253968254, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI145580578, Length=255, Percent_Identity=30.5882352941176, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI4557499, Length=255, Percent_Identity=30.5882352941176, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI145580575, Length=256, Percent_Identity=31.640625, Blast_Score=92, Evalue=5e-19,
Organism=Escherichia coli, GI87082289, Length=293, Percent_Identity=28.3276450511945, Blast_Score=111, Evalue=7e-26,
Organism=Escherichia coli, GI1789279, Length=284, Percent_Identity=30.2816901408451, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI1787645, Length=196, Percent_Identity=30.1020408163265, Blast_Score=77, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17532191, Length=334, Percent_Identity=27.5449101796407, Blast_Score=108, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI25147481, Length=276, Percent_Identity=30.0724637681159, Blast_Score=92, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6320925, Length=275, Percent_Identity=27.6363636363636, Blast_Score=94, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6324055, Length=228, Percent_Identity=28.0701754385965, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6322116, Length=275, Percent_Identity=26.1818181818182, Blast_Score=84, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6324964, Length=254, Percent_Identity=24.4094488188976, Blast_Score=67, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24646446, Length=247, Percent_Identity=31.5789473684211, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI24646448, Length=247, Percent_Identity=31.5789473684211, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI24646452, Length=247, Percent_Identity=31.5789473684211, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI24646450, Length=247, Percent_Identity=31.5789473684211, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI62472511, Length=250, Percent_Identity=31.6, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI28574286, Length=259, Percent_Identity=27.7992277992278, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI19921140, Length=296, Percent_Identity=27.3648648648649, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI45552429, Length=259, Percent_Identity=26.6409266409266, Blast_Score=92, Evalue=7e-19,
Organism=Drosophila melanogaster, GI45551003, Length=259, Percent_Identity=26.6409266409266, Blast_Score=92, Evalue=7e-19,
Organism=Drosophila melanogaster, GI24585514, Length=259, Percent_Identity=26.6409266409266, Blast_Score=92, Evalue=7e-19,
Organism=Drosophila melanogaster, GI28574282, Length=259, Percent_Identity=26.6409266409266, Blast_Score=92, Evalue=7e-19,
Organism=Drosophila melanogaster, GI28571528, Length=265, Percent_Identity=27.1698113207547, Blast_Score=91, Evalue=8e-19,
Organism=Drosophila melanogaster, GI28574284, Length=259, Percent_Identity=26.6409266409266, Blast_Score=91, Evalue=9e-19,
Organism=Drosophila melanogaster, GI24585516, Length=231, Percent_Identity=24.6753246753247, Blast_Score=69, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 37313; Mature: 37313

Theoretical pI: Translated: 7.30; Mature: 7.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIAILDDYQDAVRKLNCFEMLADHEVKIFNNTVRGLGQLASRLAEVEALVLIRERTHIT
CEEEEECCHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SQLLGKLPHLRMISQTGRVSTHIDLDACTERGIAVLEGAGSPIAPAELTWALIMAAQRRI
HHHHHCCCCHHHHHHCCCEEEEEEHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHH
PQYVANLKQGAWQQSGLKTSAMPPNFGLGQVLRGQTLGIWGYGKIGRLVAGYGKAFGMNV
HHHHHHHHHCCHHHCCCCCCCCCCCCCHHHHHCCCEEEEECCCHHHHHHHHCCHHCCCEE
LVWGREHSLEAARADGHATAESREAFFEQADVLSLHLRLHDDTRGIVKLDDLLRMKPTSL
EEECCCCCCHHHCCCCCCCHHHHHHHHHHHCEEEEEEEEECCCCCEEEHHHHHHCCCCCE
LVNTSRAELLEENALVSALARNRPGMVAIDVYESEPILQGYSLLRMENVICTPHIGYVER
EEECHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHCCEEECCCCCCEEC
ESYELYFGAAFKNILAFDAGDLSSVANPEALNQGRVRR
CCEEEEEHHHHHHHHHCCCCCCCCCCCCHHHCCCCCCC
>Mature Secondary Structure
MKIAILDDYQDAVRKLNCFEMLADHEVKIFNNTVRGLGQLASRLAEVEALVLIRERTHIT
CEEEEECCHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SQLLGKLPHLRMISQTGRVSTHIDLDACTERGIAVLEGAGSPIAPAELTWALIMAAQRRI
HHHHHCCCCHHHHHHCCCEEEEEEHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHH
PQYVANLKQGAWQQSGLKTSAMPPNFGLGQVLRGQTLGIWGYGKIGRLVAGYGKAFGMNV
HHHHHHHHHCCHHHCCCCCCCCCCCCCHHHHHCCCEEEEECCCHHHHHHHHCCHHCCCEE
LVWGREHSLEAARADGHATAESREAFFEQADVLSLHLRLHDDTRGIVKLDDLLRMKPTSL
EEECCCCCCHHHCCCCCCCHHHHHHHHHHHCEEEEEEEEECCCCCEEEHHHHHHCCCCCE
LVNTSRAELLEENALVSALARNRPGMVAIDVYESEPILQGYSLLRMENVICTPHIGYVER
EEECHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHCCEEECCCCCCEEC
ESYELYFGAAFKNILAFDAGDLSSVANPEALNQGRVRR
CCEEEEEHHHHHHHHHCCCCCCCCCCCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10382966 [H]