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The map label for this gene is argG

Identifier: 83591106

GI number: 83591106

Start: 2396761

End: 2397987

Strand: Reverse

Name: argG

Synonym: Moth_2285

Alternate gene names: 83591106

Gene position: 2397987-2396761 (Counterclockwise)

Preceding gene: 83591107

Following gene: 83591105

Centisome position: 91.22

GC content: 58.03

Gene sequence:

>1227_bases
ATGAAAGGAGTCTTTACTGTGGCCGAAAAGGTAGTTCTCGCCTATTCCGGCGGGCTGGATACCTCCATTATTATCCCCTG
GCTCAAGGAAACCTATGGTTATGAGGTTATCGCCGTGGCCGTCGATGTCGGCCAGGGAGAAGAGCTGGAACCCCTGGAGG
AAAAGGCTATAAAGAGCGGGGCCAGCAAGATCTATATTCTGGATAAAAAGAAGGAGTTTGTGGAGGAGTACATCTGGCCC
ACCCTCAAGGCCGGCGCTGTTTACGAGGGCAAGTACCTCCTGGGCACCTCCTTCGCCCGGCCCCTCATTGCCAAATGCCT
GGTGGAGGTCGCCGCACAGGAAGGGGCCACGGCCGTGGCCCACGGAGCCACCGGCAAGGGCAACGACCAGGTGCGTTTCG
AACTGGGGGTTAAGGCCTTAAATCCCCAGCTAAAGGTCATCGCTCCCTGGCGGATCTGGAACATCCGCTCCCGGGAAGAG
GCCATGGACTACGCCGCCGCCCGGGGCATCCCGGTGCCGGTGACTAAAGACCGGCCCTACAGCATGGACCGTAACCTCTG
GCACTTGAGCCACGAGGGAGGCGATCTCGAGGATCCCTGGAATGCACCCGGGGACGACCTTTACCTGATAATCACCCCGC
CGGAACAGGCCCCGGATAAACCGACTTATGTAACCATCGACTTTGAAAAGGGTATTCCGGTAGCCGTGGACGGGGAAAAA
CTGGACGCCGTCGCCCTGGTGGAGAAGCTCAATGACCTGGCGGCGGCCAACGGTGTGGGCATAGTTGACATTGTAGAAAA
TCGCCTGGTTGGTATGAAGTCCCGGGGCGTTTATGAAACCCCCGGGGGGACGATCCTCTATACAGCCCACCGGGAACTGG
AGTACCTCACCCTGGACCGCATGACCATGCATTTCAAAGAAATGGTGGCCGCCAAGTACGCCGAGCTGGTTTACGACGGC
AACTGGTTCTCACCCTTGAAAAAAGCCCTGGACGCCTTTGTGGACAGCACCCAGGAGACGGTGACGGGCACGGTGCGTCT
AAAACTCTATAAAGGCAGCTGCACCCCGGCCGGGGTCAAATCACCTTATTCCATCTACAACGAGGACCTGGTCACCTTCG
GTGCCGGCGGTGACTACGACCATAAGGACGCCACCGGTTTCATCAACCTCTTCGGCCTGCCCTTGAAGGTACGGGCGCTG
ATGGAACAAAAAACTGGACTGAGATAG

Upstream 100 bases:

>100_bases
GTTGAAGATGTCTCAGCCCGCAGCCATCTTTGCCGATCCGGTCTCCTGCACCGGGACGCAGTATGTTTCCGGTCCATGGG
GCCAGGTAAACATTTTGGAT

Downstream 100 bases:

>100_bases
GAGTATTTCTATGAAACTCTGGGGCGGACGTTTTACCAGGACAACCGACCGGCTGGTGGAGGATTTCCACTCCTCCATCA
GCTTTGACCAGCGCCTCTAT

Product: argininosuccinate synthase

Products: NA

Alternate protein names: Citrulline--aspartate ligase

Number of amino acids: Translated: 408; Mature: 408

Protein sequence:

>408_residues
MKGVFTVAEKVVLAYSGGLDTSIIIPWLKETYGYEVIAVAVDVGQGEELEPLEEKAIKSGASKIYILDKKKEFVEEYIWP
TLKAGAVYEGKYLLGTSFARPLIAKCLVEVAAQEGATAVAHGATGKGNDQVRFELGVKALNPQLKVIAPWRIWNIRSREE
AMDYAAARGIPVPVTKDRPYSMDRNLWHLSHEGGDLEDPWNAPGDDLYLIITPPEQAPDKPTYVTIDFEKGIPVAVDGEK
LDAVALVEKLNDLAAANGVGIVDIVENRLVGMKSRGVYETPGGTILYTAHRELEYLTLDRMTMHFKEMVAAKYAELVYDG
NWFSPLKKALDAFVDSTQETVTGTVRLKLYKGSCTPAGVKSPYSIYNEDLVTFGAGGDYDHKDATGFINLFGLPLKVRAL
MEQKTGLR

Sequences:

>Translated_408_residues
MKGVFTVAEKVVLAYSGGLDTSIIIPWLKETYGYEVIAVAVDVGQGEELEPLEEKAIKSGASKIYILDKKKEFVEEYIWP
TLKAGAVYEGKYLLGTSFARPLIAKCLVEVAAQEGATAVAHGATGKGNDQVRFELGVKALNPQLKVIAPWRIWNIRSREE
AMDYAAARGIPVPVTKDRPYSMDRNLWHLSHEGGDLEDPWNAPGDDLYLIITPPEQAPDKPTYVTIDFEKGIPVAVDGEK
LDAVALVEKLNDLAAANGVGIVDIVENRLVGMKSRGVYETPGGTILYTAHRELEYLTLDRMTMHFKEMVAAKYAELVYDG
NWFSPLKKALDAFVDSTQETVTGTVRLKLYKGSCTPAGVKSPYSIYNEDLVTFGAGGDYDHKDATGFINLFGLPLKVRAL
MEQKTGLR
>Mature_408_residues
MKGVFTVAEKVVLAYSGGLDTSIIIPWLKETYGYEVIAVAVDVGQGEELEPLEEKAIKSGASKIYILDKKKEFVEEYIWP
TLKAGAVYEGKYLLGTSFARPLIAKCLVEVAAQEGATAVAHGATGKGNDQVRFELGVKALNPQLKVIAPWRIWNIRSREE
AMDYAAARGIPVPVTKDRPYSMDRNLWHLSHEGGDLEDPWNAPGDDLYLIITPPEQAPDKPTYVTIDFEKGIPVAVDGEK
LDAVALVEKLNDLAAANGVGIVDIVENRLVGMKSRGVYETPGGTILYTAHRELEYLTLDRMTMHFKEMVAAKYAELVYDG
NWFSPLKKALDAFVDSTQETVTGTVRLKLYKGSCTPAGVKSPYSIYNEDLVTFGAGGDYDHKDATGFINLFGLPLKVRAL
MEQKTGLR

Specific function: Arginine biosynthesis; seventh step. [C]

COG id: COG0137

COG function: function code E; Argininosuccinate synthase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the argininosuccinate synthase family. Type 1 subfamily

Homologues:

Organism=Homo sapiens, GI53759107, Length=403, Percent_Identity=50.1240694789082, Blast_Score=379, Evalue=1e-105,
Organism=Homo sapiens, GI16950633, Length=403, Percent_Identity=50.1240694789082, Blast_Score=379, Evalue=1e-105,
Organism=Escherichia coli, GI1789563, Length=388, Percent_Identity=28.6082474226804, Blast_Score=139, Evalue=4e-34,
Organism=Saccharomyces cerevisiae, GI6324514, Length=402, Percent_Identity=43.0348258706468, Blast_Score=321, Evalue=1e-88,
Organism=Drosophila melanogaster, GI21358151, Length=407, Percent_Identity=44.4717444717445, Blast_Score=335, Evalue=5e-92,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ASSY_MOOTA (Q2RG67)

Other databases:

- EMBL:   CP000232
- RefSeq:   YP_431115.1
- HSSP:   Q9X2A1
- ProteinModelPortal:   Q2RG67
- SMR:   Q2RG67
- STRING:   Q2RG67
- GeneID:   3831317
- GenomeReviews:   CP000232_GR
- KEGG:   mta:Moth_2285
- NMPDR:   fig|264732.9.peg.2322
- eggNOG:   COG0137
- HOGENOM:   HBG335267
- OMA:   VAVDVGQ
- PhylomeDB:   Q2RG67
- BioCyc:   MTHE264732:MOTH_2285-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00005
- InterPro:   IPR001518
- InterPro:   IPR018223
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR11587
- TIGRFAMs:   TIGR00032

Pfam domain/function: PF00764 Arginosuc_synth

EC number: =6.3.4.5

Molecular weight: Translated: 44871; Mature: 44871

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: PS00564 ARGININOSUCCIN_SYN_1; PS00565 ARGININOSUCCIN_SYN_2

Important sites: BINDING 92-92 BINDING 97-97 BINDING 122-122 BINDING 124-124 BINDING 128-128 BINDING 128-128 BINDING 129-129 BINDING 132-132 BINDING 181-181 BINDING 190-190 BINDING 266-266 BINDING 278-278

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGVFTVAEKVVLAYSGGLDTSIIIPWLKETYGYEVIAVAVDVGQGEELEPLEEKAIKSG
CCCHHHHHHHEEEEECCCCCCEEEEEHHHHHCCEEEEEEEEECCCCCCCCHHHHHHHHCC
ASKIYILDKKKEFVEEYIWPTLKAGAVYEGKYLLGTSFARPLIAKCLVEVAAQEGATAVA
CCEEEEEECHHHHHHHHHCCCCCCCEEECCCEEECCHHHHHHHHHHHHHHHHHCCCEEEE
HGATGKGNDQVRFELGVKALNPQLKVIAPWRIWNIRSREEAMDYAAARGIPVPVTKDRPY
ECCCCCCCCEEEEEECCEECCCCEEEEECEEEECCCCHHHHHHHHHHCCCCCCCCCCCCC
SMDRNLWHLSHEGGDLEDPWNAPGDDLYLIITPPEQAPDKPTYVTIDFEKGIPVAVDGEK
CCCCCEEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCEEEEEECCCCCEEECCCC
LDAVALVEKLNDLAAANGVGIVDIVENRLVGMKSRGVYETPGGTILYTAHRELEYLTLDR
HHHHHHHHHHHHHHHCCCCEEEEEHHHHHCCCCCCCCEECCCCEEEEEECCCEEEEEHHH
MTMHFKEMVAAKYAELVYDGNWFSPLKKALDAFVDSTQETVTGTVRLKLYKGSCTPAGVK
HHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHCCCHHHEEEEEEEEEEECCCCCCCCC
SPYSIYNEDLVTFGAGGDYDHKDATGFINLFGLPLKVRALMEQKTGLR
CCHHHHCCCEEEECCCCCCCCCCCCCEEEEECCCHHHHHHHHHHCCCC
>Mature Secondary Structure
MKGVFTVAEKVVLAYSGGLDTSIIIPWLKETYGYEVIAVAVDVGQGEELEPLEEKAIKSG
CCCHHHHHHHEEEEECCCCCCEEEEEHHHHHCCEEEEEEEEECCCCCCCCHHHHHHHHCC
ASKIYILDKKKEFVEEYIWPTLKAGAVYEGKYLLGTSFARPLIAKCLVEVAAQEGATAVA
CCEEEEEECHHHHHHHHHCCCCCCCEEECCCEEECCHHHHHHHHHHHHHHHHHCCCEEEE
HGATGKGNDQVRFELGVKALNPQLKVIAPWRIWNIRSREEAMDYAAARGIPVPVTKDRPY
ECCCCCCCCEEEEEECCEECCCCEEEEECEEEECCCCHHHHHHHHHHCCCCCCCCCCCCC
SMDRNLWHLSHEGGDLEDPWNAPGDDLYLIITPPEQAPDKPTYVTIDFEKGIPVAVDGEK
CCCCCEEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCEEEEEECCCCCEEECCCC
LDAVALVEKLNDLAAANGVGIVDIVENRLVGMKSRGVYETPGGTILYTAHRELEYLTLDR
HHHHHHHHHHHHHHHCCCCEEEEEHHHHHCCCCCCCCEECCCCEEEEEECCCEEEEEHHH
MTMHFKEMVAAKYAELVYDGNWFSPLKKALDAFVDSTQETVTGTVRLKLYKGSCTPAGVK
HHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHCCCHHHEEEEEEEEEEECCCCCCCCC
SPYSIYNEDLVTFGAGGDYDHKDATGFINLFGLPLKVRALMEQKTGLR
CCHHHHCCCEEEECCCCCCCCCCCCCEEEEECCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA