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The map label for this gene is argF [H]

Identifier: 83591107

GI number: 83591107

Start: 2398083

End: 2399027

Strand: Reverse

Name: argF [H]

Synonym: Moth_2286

Alternate gene names: 83591107

Gene position: 2399027-2398083 (Counterclockwise)

Preceding gene: 83591108

Following gene: 83591106

Centisome position: 91.26

GC content: 59.05

Gene sequence:

>945_bases
ATGAATGACCTGGCGGGGAGCCTGAAAGGCCGTGATTTTCTCTCCCTGAAGGATTTTTCGAGGGAAGAGATTTTTTACCT
GCTGGATCTGGCGGACGATCTCAAGGCCAAACTCAAAAAAAGGGAACCCCATCCCCTGCTGGCGGGTAAAACCCTGGGAA
TGATCTTTACCAAACGATCCACCCGCACCCGGGTCTCCTTTGAAGTTGGCATGTACCAGCTGGGTGGGTACCCCCTTTTC
CTAACCAAAGACGACCTGCAACTGGGCCGGGGAGAGACCATTGCCGACACTGCCCGGGTCCTTTCCCGCTACCTGGACGG
GATTATGATCCGGACCTATTCCCACCGGGAGGTTGAGGAGCTGGCGGAATACGCCTCCATCCCGGTCATTAACGGCCTGA
CGGATTTCCTCCATCCCACCCAGGCCCTGGCGGATATCATGACCATCCGCGAGTGGAAGGGAAAACTGCAAGGCCTCAAC
CTTACCTTTATCGGTGACGGCAACAACGTGGCCCACTCCCTCATGTACGGGGGCGCCAAGGTGGGGCTCAACGTCACCAT
TGCCTGCCCCTCCGGTTATGAGCCCATGCCCCAGGTGGTCGAGGAGGCCAGGCGCATAGCTGCCGGCAACGGTTGCCAGA
TAGCCGTCACCAACAACATCAAAGAAGCGGCCGAAGGCGCCGATATCCTTTATACCGACGTCTGGGCGAGTATGGGCCAG
GAGGACGAAGCCGAGAAGCGGCGCCAGGCCTTTCGCAAATACCAGATCAACAGCGAGCTCCTCAAGCTGGCCAAGCCGGA
CGCCATGGTTCTCCACTGCCTGCCCGCCCACCGGGGCGAGGAGATCACTGACGAGGTCATGGACGGACCCCAGTCGGCCG
TTTTTGACGAGGCCGAGAATCGCCTTCACGCCCACAAGGCCATCATGGTAGCCTTGATGGGTTGA

Upstream 100 bases:

>100_bases
ATAGTTTTTGGTTTTAGGTACGGCGGGAAAATATAGTGGCAAAAATTACGGGTTTTCAAGTAAAATAAGGAATGTAAATA
AGGAAAGGAGCGAAGGTATA

Downstream 100 bases:

>100_bases
AGATGTCTCAGCCCGCAGCCATCTTTGCCGATCCGGTCTCCTGCACCGGGACGCAGTATGTTTCCGGTCCATGGGGCCAG
GTAAACATTTTGGATATGAA

Product: ornithine carbamoyltransferase

Products: NA

Alternate protein names: OTCase [H]

Number of amino acids: Translated: 314; Mature: 314

Protein sequence:

>314_residues
MNDLAGSLKGRDFLSLKDFSREEIFYLLDLADDLKAKLKKREPHPLLAGKTLGMIFTKRSTRTRVSFEVGMYQLGGYPLF
LTKDDLQLGRGETIADTARVLSRYLDGIMIRTYSHREVEELAEYASIPVINGLTDFLHPTQALADIMTIREWKGKLQGLN
LTFIGDGNNVAHSLMYGGAKVGLNVTIACPSGYEPMPQVVEEARRIAAGNGCQIAVTNNIKEAAEGADILYTDVWASMGQ
EDEAEKRRQAFRKYQINSELLKLAKPDAMVLHCLPAHRGEEITDEVMDGPQSAVFDEAENRLHAHKAIMVALMG

Sequences:

>Translated_314_residues
MNDLAGSLKGRDFLSLKDFSREEIFYLLDLADDLKAKLKKREPHPLLAGKTLGMIFTKRSTRTRVSFEVGMYQLGGYPLF
LTKDDLQLGRGETIADTARVLSRYLDGIMIRTYSHREVEELAEYASIPVINGLTDFLHPTQALADIMTIREWKGKLQGLN
LTFIGDGNNVAHSLMYGGAKVGLNVTIACPSGYEPMPQVVEEARRIAAGNGCQIAVTNNIKEAAEGADILYTDVWASMGQ
EDEAEKRRQAFRKYQINSELLKLAKPDAMVLHCLPAHRGEEITDEVMDGPQSAVFDEAENRLHAHKAIMVALMG
>Mature_314_residues
MNDLAGSLKGRDFLSLKDFSREEIFYLLDLADDLKAKLKKREPHPLLAGKTLGMIFTKRSTRTRVSFEVGMYQLGGYPLF
LTKDDLQLGRGETIADTARVLSRYLDGIMIRTYSHREVEELAEYASIPVINGLTDFLHPTQALADIMTIREWKGKLQGLN
LTFIGDGNNVAHSLMYGGAKVGLNVTIACPSGYEPMPQVVEEARRIAAGNGCQIAVTNNIKEAAEGADILYTDVWASMGQ
EDEAEKRRQAFRKYQINSELLKLAKPDAMVLHCLPAHRGEEITDEVMDGPQSAVFDEAENRLHAHKAIMVALMG

Specific function: Arginine biosynthesis; sixth step. [C]

COG id: COG0078

COG function: function code E; Ornithine carbamoyltransferase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATCase/OTCase family [H]

Homologues:

Organism=Homo sapiens, GI38788445, Length=307, Percent_Identity=50.814332247557, Blast_Score=310, Evalue=2e-84,
Organism=Homo sapiens, GI18105007, Length=321, Percent_Identity=31.1526479750779, Blast_Score=135, Evalue=7e-32,
Organism=Escherichia coli, GI1790703, Length=326, Percent_Identity=43.2515337423313, Blast_Score=247, Evalue=7e-67,
Organism=Escherichia coli, GI1786469, Length=330, Percent_Identity=40.6060606060606, Blast_Score=231, Evalue=6e-62,
Organism=Escherichia coli, GI2367364, Length=321, Percent_Identity=31.7757009345794, Blast_Score=117, Evalue=7e-28,
Organism=Escherichia coli, GI48994908, Length=366, Percent_Identity=26.5027322404372, Blast_Score=101, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI193204318, Length=333, Percent_Identity=29.7297297297297, Blast_Score=106, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6322373, Length=309, Percent_Identity=38.5113268608414, Blast_Score=225, Evalue=8e-60,
Organism=Saccharomyces cerevisiae, GI6322331, Length=315, Percent_Identity=30.7936507936508, Blast_Score=120, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24642586, Length=319, Percent_Identity=30.0940438871473, Blast_Score=126, Evalue=2e-29,

Paralogues:

None

Copy number: 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2066 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006132
- InterPro:   IPR006130
- InterPro:   IPR006131
- InterPro:   IPR002292 [H]

Pfam domain/function: PF00185 OTCace; PF02729 OTCace_N [H]

EC number: =2.1.3.3 [H]

Molecular weight: Translated: 34889; Mature: 34889

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: PS00097 CARBAMOYLTRANSFERASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDLAGSLKGRDFLSLKDFSREEIFYLLDLADDLKAKLKKREPHPLLAGKTLGMIFTKRS
CCCCCCCCCCCEEEEHHCCCCCCEEEEEECHHHHHHHHHCCCCCCEECCCCEEEEEECCC
TRTRVSFEVGMYQLGGYPLFLTKDDLQLGRGETIADTARVLSRYLDGIMIRTYSHREVEE
CCEEEEEEECEEEECCEEEEEECCCHHCCCCCHHHHHHHHHHHHHCCEEEEECCCHHHHH
LAEYASIPVINGLTDFLHPTQALADIMTIREWKGKLQGLNLTFIGDGNNVAHSLMYGGAK
HHHHHCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHCCEE
VGLNVTIACPSGYEPMPQVVEEARRIAAGNGCQIAVTNNIKEAAEGADILYTDVWASMGQ
ECEEEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEEECCHHHHHCCCCEEEHHHHHHCCC
EDEAEKRRQAFRKYQINSELLKLAKPDAMVLHCLPAHRGEEITDEVMDGPQSAVFDEAEN
CHHHHHHHHHHHHHCCCHHHHHHCCCCEEEEEEECCCCCCHHHHHHHCCCHHHHHHHHHH
RLHAHKAIMVALMG
HHHHHHHHEEEECC
>Mature Secondary Structure
MNDLAGSLKGRDFLSLKDFSREEIFYLLDLADDLKAKLKKREPHPLLAGKTLGMIFTKRS
CCCCCCCCCCCEEEEHHCCCCCCEEEEEECHHHHHHHHHCCCCCCEECCCCEEEEEECCC
TRTRVSFEVGMYQLGGYPLFLTKDDLQLGRGETIADTARVLSRYLDGIMIRTYSHREVEE
CCEEEEEEECEEEECCEEEEEECCCHHCCCCCHHHHHHHHHHHHHCCEEEEECCCHHHHH
LAEYASIPVINGLTDFLHPTQALADIMTIREWKGKLQGLNLTFIGDGNNVAHSLMYGGAK
HHHHHCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHCCEE
VGLNVTIACPSGYEPMPQVVEEARRIAAGNGCQIAVTNNIKEAAEGADILYTDVWASMGQ
ECEEEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEEECCHHHHHCCCCEEEHHHHHHCCC
EDEAEKRRQAFRKYQINSELLKLAKPDAMVLHCLPAHRGEEITDEVMDGPQSAVFDEAEN
CHHHHHHHHHHHHHCCCHHHHHHCCCCEEEEEEECCCCCCHHHHHHHCCCHHHHHHHHHH
RLHAHKAIMVALMG
HHHHHHHHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA