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The map label for this gene is gutB [H]

Identifier: 83591089

GI number: 83591089

Start: 2375283

End: 2376359

Strand: Reverse

Name: gutB [H]

Synonym: Moth_2268

Alternate gene names: 83591089

Gene position: 2376359-2375283 (Counterclockwise)

Preceding gene: 83591090

Following gene: 83591088

Centisome position: 90.4

GC content: 57.2

Gene sequence:

>1077_bases
ATGACTTATATGATCCCTGAAAAAATGAAAGCCCTGGTTCTCTTCGGCCCTAACGACGTGCGCCTGGTAGAAAAGCCGGT
GCCCAAACCCGGCCCCGGCGAGGTGCTGGTCAGGGTGGCGGCCTGCGGCATCTGCGGCACCGATGTAAAGATTATCACCA
AGGGCATGCCAAAGATGCCTCCCTACGGTGAATTTACCTTCGGCCATGAATGGGCCGGGACCATTGTCGCCCTGGGAGAA
ACAGTGGACGAATTCCAGGTCGGCGACCGGGTAGCCATCGAGGCTCACAAGGGTTGCGGCCGCTGTGAAAACTGCATCGA
CGGCAAGTACACTGCCTGCCTAAACTACGGCCGCCTGGACAAGGGCCACCGGGCCGCGGGCATGACGGTAGACGGTGGCT
TTGCCGAGTATGCCGTCCAGCATGTAAATTCAGTCTACAAGATTCCCGACAATATTACTTTCAACGAAGCCACCTATGTG
ACTACGGCCGGCTGTGCCCTCTACGCCATCGACAAGAGCGGCGGTTATATTGCCGGGGATACGGTCCTGGTCATCGGCCC
CGGCCCTATTGGTCTCTCTGTGGTCCAGGGAGCCCGGTCCCTGGGGGCCGAAAAGATCATCCTCATGGGAACCCGAGAAG
ACCGCCTGGTCAAGGGTCGTGAGCTCGGCGCCACCCATACCATTAATATTCGTGAGGTGGCCGATCCCGTTGCCGAAGTA
ATGGCCATCACCGGTGGTAAGGGCTGCGAGCGGGTTTTTGAGTGCGCCGGCAACTCTCAGTCCTTCGAGTACGGCATCAA
AGCGGCTAAAAAGGGCGGTGTCATGGTCCTGGTTTCCTTCTATAAGGAACCGGTAATGGCTAACCTGGATTATGTCGTCT
TAAACCAGATCAGCCTGCTCACCGTACGCGGTGAGGGCAACCAGAACTGTAAGCGCGCCCTGTCACTGATGGCCCAGGGT
AAGATTGACGCCAAACCAATTATGACCCACGCCTTCCCGTTAGAAGAGTTCCAGAAGGGCCTGGATTACTTCGTCAACCG
CAAAGACGGGGCCATGAAGGTGGTTATCAACCCCTAA

Upstream 100 bases:

>100_bases
AAAGCGCAATCGTAAAGCAAGCACCAAGGTGAAGGTTGAGTACCTGAACGCCGCCGACCTGGAGTTAATGTAGAGTGATT
TCCCAAGGAGGTCAAAAGCT

Downstream 100 bases:

>100_bases
AAAAGGCTAACGGCCCGGAGCAGGCCGTTAGCGACGGCGGGGAGCAGTGACGGATGGTAAGCTGTAACCTGCTCCCTGCT
CCTTATATCTTAATAATAAA

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: Glucitol dehydrogenase; L-iditol 2-dehydrogenase [H]

Number of amino acids: Translated: 358; Mature: 357

Protein sequence:

>358_residues
MTYMIPEKMKALVLFGPNDVRLVEKPVPKPGPGEVLVRVAACGICGTDVKIITKGMPKMPPYGEFTFGHEWAGTIVALGE
TVDEFQVGDRVAIEAHKGCGRCENCIDGKYTACLNYGRLDKGHRAAGMTVDGGFAEYAVQHVNSVYKIPDNITFNEATYV
TTAGCALYAIDKSGGYIAGDTVLVIGPGPIGLSVVQGARSLGAEKIILMGTREDRLVKGRELGATHTINIREVADPVAEV
MAITGGKGCERVFECAGNSQSFEYGIKAAKKGGVMVLVSFYKEPVMANLDYVVLNQISLLTVRGEGNQNCKRALSLMAQG
KIDAKPIMTHAFPLEEFQKGLDYFVNRKDGAMKVVINP

Sequences:

>Translated_358_residues
MTYMIPEKMKALVLFGPNDVRLVEKPVPKPGPGEVLVRVAACGICGTDVKIITKGMPKMPPYGEFTFGHEWAGTIVALGE
TVDEFQVGDRVAIEAHKGCGRCENCIDGKYTACLNYGRLDKGHRAAGMTVDGGFAEYAVQHVNSVYKIPDNITFNEATYV
TTAGCALYAIDKSGGYIAGDTVLVIGPGPIGLSVVQGARSLGAEKIILMGTREDRLVKGRELGATHTINIREVADPVAEV
MAITGGKGCERVFECAGNSQSFEYGIKAAKKGGVMVLVSFYKEPVMANLDYVVLNQISLLTVRGEGNQNCKRALSLMAQG
KIDAKPIMTHAFPLEEFQKGLDYFVNRKDGAMKVVINP
>Mature_357_residues
TYMIPEKMKALVLFGPNDVRLVEKPVPKPGPGEVLVRVAACGICGTDVKIITKGMPKMPPYGEFTFGHEWAGTIVALGET
VDEFQVGDRVAIEAHKGCGRCENCIDGKYTACLNYGRLDKGHRAAGMTVDGGFAEYAVQHVNSVYKIPDNITFNEATYVT
TAGCALYAIDKSGGYIAGDTVLVIGPGPIGLSVVQGARSLGAEKIILMGTREDRLVKGRELGATHTINIREVADPVAEVM
AITGGKGCERVFECAGNSQSFEYGIKAAKKGGVMVLVSFYKEPVMANLDYVVLNQISLLTVRGEGNQNCKRALSLMAQGK
IDAKPIMTHAFPLEEFQKGLDYFVNRKDGAMKVVINP

Specific function: Reduces glucitol to fructose [H]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=347, Percent_Identity=32.5648414985591, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI4501929, Length=377, Percent_Identity=28.6472148541114, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI156523966, Length=359, Percent_Identity=25.3481894150418, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI4501939, Length=359, Percent_Identity=25.3481894150418, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI34577061, Length=375, Percent_Identity=27.2, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI4501933, Length=373, Percent_Identity=26.8096514745308, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI71743840, Length=363, Percent_Identity=25.6198347107438, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI262073058, Length=363, Percent_Identity=25.6198347107438, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI71565154, Length=278, Percent_Identity=28.7769784172662, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI71565152, Length=271, Percent_Identity=26.1992619926199, Blast_Score=79, Evalue=5e-15,
Organism=Escherichia coli, GI1788075, Length=364, Percent_Identity=29.6703296703297, Blast_Score=152, Evalue=4e-38,
Organism=Escherichia coli, GI1788073, Length=352, Percent_Identity=30.1136363636364, Blast_Score=152, Evalue=4e-38,
Organism=Escherichia coli, GI1790045, Length=353, Percent_Identity=29.1784702549575, Blast_Score=146, Evalue=2e-36,
Organism=Escherichia coli, GI1787863, Length=350, Percent_Identity=29.4285714285714, Blast_Score=144, Evalue=8e-36,
Organism=Escherichia coli, GI87082125, Length=360, Percent_Identity=28.6111111111111, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI1788407, Length=342, Percent_Identity=26.3157894736842, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1786825, Length=392, Percent_Identity=27.0408163265306, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI226510992, Length=331, Percent_Identity=26.8882175226586, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI1786552, Length=365, Percent_Identity=29.041095890411, Blast_Score=105, Evalue=5e-24,
Organism=Escherichia coli, GI87081918, Length=318, Percent_Identity=27.3584905660377, Blast_Score=98, Evalue=7e-22,
Organism=Escherichia coli, GI1790718, Length=357, Percent_Identity=26.3305322128852, Blast_Score=92, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI17562876, Length=352, Percent_Identity=31.5340909090909, Blast_Score=161, Evalue=6e-40,
Organism=Caenorhabditis elegans, GI17562878, Length=356, Percent_Identity=32.3033707865169, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI71988145, Length=329, Percent_Identity=25.531914893617, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17562582, Length=311, Percent_Identity=28.2958199356913, Blast_Score=82, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17562584, Length=288, Percent_Identity=28.4722222222222, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI25146526, Length=281, Percent_Identity=28.8256227758007, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI71997431, Length=291, Percent_Identity=27.4914089347079, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17565904, Length=240, Percent_Identity=28.3333333333333, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6322619, Length=353, Percent_Identity=28.0453257790368, Blast_Score=143, Evalue=4e-35,
Organism=Saccharomyces cerevisiae, GI6319955, Length=353, Percent_Identity=28.0453257790368, Blast_Score=142, Evalue=8e-35,
Organism=Saccharomyces cerevisiae, GI6323099, Length=357, Percent_Identity=27.1708683473389, Blast_Score=134, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6319258, Length=384, Percent_Identity=24.7395833333333, Blast_Score=110, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6319257, Length=394, Percent_Identity=24.6192893401015, Blast_Score=107, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6319621, Length=334, Percent_Identity=30.8383233532934, Blast_Score=105, Evalue=9e-24,
Organism=Saccharomyces cerevisiae, GI6323961, Length=349, Percent_Identity=28.6532951289398, Blast_Score=100, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6324486, Length=350, Percent_Identity=27.4285714285714, Blast_Score=96, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6323729, Length=335, Percent_Identity=28.3582089552239, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6320033, Length=353, Percent_Identity=26.0623229461756, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6323980, Length=311, Percent_Identity=26.3665594855305, Blast_Score=71, Evalue=3e-13,
Organism=Drosophila melanogaster, GI17137530, Length=359, Percent_Identity=30.6406685236769, Blast_Score=153, Evalue=2e-37,
Organism=Drosophila melanogaster, GI17737897, Length=353, Percent_Identity=30.3116147308782, Blast_Score=147, Evalue=8e-36,
Organism=Drosophila melanogaster, GI221457811, Length=349, Percent_Identity=22.0630372492837, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI45550770, Length=349, Percent_Identity=22.0630372492837, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI45551930, Length=349, Percent_Identity=22.0630372492837, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI17737895, Length=269, Percent_Identity=29.7397769516729, Blast_Score=82, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.14 [H]

Molecular weight: Translated: 38490; Mature: 38359

Theoretical pI: Translated: 7.65; Mature: 7.65

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYMIPEKMKALVLFGPNDVRLVEKPVPKPGPGEVLVRVAACGICGTDVKIITKGMPKMP
CCCCCCCCCCEEEEECCCCEEEEECCCCCCCCHHHHEEEECCCCCCCCCEEEECCCCCCC
PYGEFTFGHEWAGTIVALGETVDEFQVGDRVAIEAHKGCGRCENCIDGKYTACLNYGRLD
CCCCCCCCCCCCCEEEEECCCHHHHHCCCEEEEEECCCCCCHHHHCCCCEEEEEECCCCC
KGHRAAGMTVDGGFAEYAVQHVNSVYKIPDNITFNEATYVTTAGCALYAIDKSGGYIAGD
CCCCCCCEEECCCHHHHHHHHHHHHEECCCCCEECCEEEEEECCEEEEEEECCCCEEECC
TVLVIGPGPIGLSVVQGARSLGAEKIILMGTREDRLVKGRELGATHTINIREVADPVAEV
EEEEECCCCCCHHHHHHHHHCCCCEEEEEECCCCHHCCCCCCCCEEEEEHHHHHHHHHHH
MAITGGKGCERVFECAGNSQSFEYGIKAAKKGGVMVLVSFYKEPVMANLDYVVLNQISLL
HEECCCCHHHHHHHHCCCCCCCHHHHHHHCCCCEEEEEEHHCCCHHHCCCEEEECCEEEE
TVRGEGNQNCKRALSLMAQGKIDAKPIMTHAFPLEEFQKGLDYFVNRKDGAMKVVINP
EEECCCCHHHHHHHHHHHCCCCCCCCCEEECCCHHHHHHHHHHHCCCCCCEEEEEECC
>Mature Secondary Structure 
TYMIPEKMKALVLFGPNDVRLVEKPVPKPGPGEVLVRVAACGICGTDVKIITKGMPKMP
CCCCCCCCCEEEEECCCCEEEEECCCCCCCCHHHHEEEECCCCCCCCCEEEECCCCCCC
PYGEFTFGHEWAGTIVALGETVDEFQVGDRVAIEAHKGCGRCENCIDGKYTACLNYGRLD
CCCCCCCCCCCCCEEEEECCCHHHHHCCCEEEEEECCCCCCHHHHCCCCEEEEEECCCCC
KGHRAAGMTVDGGFAEYAVQHVNSVYKIPDNITFNEATYVTTAGCALYAIDKSGGYIAGD
CCCCCCCEEECCCHHHHHHHHHHHHEECCCCCEECCEEEEEECCEEEEEEECCCCEEECC
TVLVIGPGPIGLSVVQGARSLGAEKIILMGTREDRLVKGRELGATHTINIREVADPVAEV
EEEEECCCCCCHHHHHHHHHCCCCEEEEEECCCCHHCCCCCCCCEEEEEHHHHHHHHHHH
MAITGGKGCERVFECAGNSQSFEYGIKAAKKGGVMVLVSFYKEPVMANLDYVVLNQISLL
HEECCCCHHHHHHHHCCCCCCCHHHHHHHCCCCEEEEEEHHCCCHHHCCCEEEECCEEEE
TVRGEGNQNCKRALSLMAQGKIDAKPIMTHAFPLEEFQKGLDYFVNRKDGAMKVVINP
EEECCCCHHHHHHHHHHHCCCCCCCCCEEECCCHHHHHHHHHHHCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1460002; 9384377; 8195086 [H]