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The map label for this gene is pyrE

Identifier: 83590952

GI number: 83590952

Start: 2224664

End: 2225245

Strand: Reverse

Name: pyrE

Synonym: Moth_2126

Alternate gene names: 83590952

Gene position: 2225245-2224664 (Counterclockwise)

Preceding gene: 83590953

Following gene: 83590951

Centisome position: 84.65

GC content: 62.54

Gene sequence:

>582_bases
ATGTTAAGTCGTGAAGAAGTCCTGGATATCTTCCGCCGCACCGGGGTCCTGTGGGAGGGGCACTTCGTCTTGACCTCCGG
TCTCCACAGCGGTCGTTATCTCCAGTGCGCCCGGGTGCAGCAGTTCCCGGAGGAAAATACCCTTCTCTGCCACGAGCTGG
CCGCCAGGTTTAAGGACCGGGGTATTACCACGGTCATCGGCCCGGCCATCGGCGCTATTATCATGGCTTATGAAATGGCC
CGCCAGCTGGGGGCCCGGTGCCTCTTTACCGAGCGGGAAAACGGCGTCATGACCCTGCGCCGCAGCTTCACCCTGGAACC
CGGGGAAAAGGTTCTGGTGGTAGAAGACGTCATTACCACCGGCGGGTCGGTGCGGGAAGTAATCGAGGTAGTGAAACAGC
ACGGAGCCGTGCCGGTGGGAGTCGGGGTGCTGGTGGACCGCAGCGGCGGCCGGGCCGACGTCGGCGCGCCCGTGGAGCCT
CTGATTACCTTTGATATTGAGACGTATCAGCCCGGGGATTGCCCCTTATGCCGGCAGGGGGTGCCGGTGGTTAAACCGGG
GAGCAGGCAGCTTAAGCCTTAG

Upstream 100 bases:

>100_bases
TGATTGACGGGATTAAAGCCTACCTGCAGGAACAGGGTTTGCAGGATGTCAACGAACTGGTAGGCGCCTTGCGAATTTAA
ACCTTGGGGTGAAAATATTT

Downstream 100 bases:

>100_bases
AGCGGGGACGGGGTGGCAGCCAGGAGAAGCCGCCCCGTCTTTAGTTCTCCCGGCAAGGACTATGACTTGGCGGTGAAAGT
CCGCTACTGGCGAAGCAGAA

Product: orotate phosphoribosyltransferase

Products: NA

Alternate protein names: OPRT; OPRTase [H]

Number of amino acids: Translated: 193; Mature: 193

Protein sequence:

>193_residues
MLSREEVLDIFRRTGVLWEGHFVLTSGLHSGRYLQCARVQQFPEENTLLCHELAARFKDRGITTVIGPAIGAIIMAYEMA
RQLGARCLFTERENGVMTLRRSFTLEPGEKVLVVEDVITTGGSVREVIEVVKQHGAVPVGVGVLVDRSGGRADVGAPVEP
LITFDIETYQPGDCPLCRQGVPVVKPGSRQLKP

Sequences:

>Translated_193_residues
MLSREEVLDIFRRTGVLWEGHFVLTSGLHSGRYLQCARVQQFPEENTLLCHELAARFKDRGITTVIGPAIGAIIMAYEMA
RQLGARCLFTERENGVMTLRRSFTLEPGEKVLVVEDVITTGGSVREVIEVVKQHGAVPVGVGVLVDRSGGRADVGAPVEP
LITFDIETYQPGDCPLCRQGVPVVKPGSRQLKP
>Mature_193_residues
MLSREEVLDIFRRTGVLWEGHFVLTSGLHSGRYLQCARVQQFPEENTLLCHELAARFKDRGITTVIGPAIGAIIMAYEMA
RQLGARCLFTERENGVMTLRRSFTLEPGEKVLVVEDVITTGGSVREVIEVVKQHGAVPVGVGVLVDRSGGRADVGAPVEP
LITFDIETYQPGDCPLCRQGVPVVKPGSRQLKP

Specific function: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) [H]

COG id: COG0461

COG function: function code F; Orotate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023031
- InterPro:   IPR006273
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.10 [H]

Molecular weight: Translated: 21153; Mature: 21153

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSREEVLDIFRRTGVLWEGHFVLTSGLHSGRYLQCARVQQFPEENTLLCHELAARFKDR
CCCHHHHHHHHHHCCCEECCCEEEECCCCCCCEEEHHHHHHCCCCCCHHHHHHHHHHHHC
GITTVIGPAIGAIIMAYEMARQLGARCLFTERENGVMTLRRSFTLEPGEKVLVVEDVITT
CCEEEHHHHHHHHHHHHHHHHHHCCEEEEEECCCCEEEEEEEECCCCCCEEEEEEHHHHC
GGSVREVIEVVKQHGAVPVGVGVLVDRSGGRADVGAPVEPLITFDIETYQPGDCPLCRQG
CCCHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCCCCCEEEEEECCCCCCCCCHHHCC
VPVVKPGSRQLKP
CCEECCCCCCCCC
>Mature Secondary Structure
MLSREEVLDIFRRTGVLWEGHFVLTSGLHSGRYLQCARVQQFPEENTLLCHELAARFKDR
CCCHHHHHHHHHHCCCEECCCEEEECCCCCCCEEEHHHHHHCCCCCCHHHHHHHHHHHHC
GITTVIGPAIGAIIMAYEMARQLGARCLFTERENGVMTLRRSFTLEPGEKVLVVEDVITT
CCEEEHHHHHHHHHHHHHHHHHHCCEEEEEECCCCEEEEEEEECCCCCCEEEEEEHHHHC
GGSVREVIEVVKQHGAVPVGVGVLVDRSGGRADVGAPVEPLITFDIETYQPGDCPLCRQG
CCCHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCCCCCEEEEEECCCCCCCCCHHHCC
VPVVKPGSRQLKP
CCEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA