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The map label for this gene is pyrD [H]

Identifier: 83590953

GI number: 83590953

Start: 2225266

End: 2226324

Strand: Reverse

Name: pyrD [H]

Synonym: Moth_2127

Alternate gene names: 83590953

Gene position: 2226324-2225266 (Counterclockwise)

Preceding gene: 83590954

Following gene: 83590952

Centisome position: 84.69

GC content: 61.85

Gene sequence:

>1059_bases
ATGGAGCAGGCTGAGAAGAGGCCCGGAGTGAATCCTAAAGAAGAAGACGAGAAGTTGGGGGCCAGAGGTAAGGGACTTGC
AGGAACAGGCTGCGCCGGTTCCGGGCTAAAGTCACGATCTACTCCTCAAGAGCCGGAAACCGGTGCCGGGGTCAACCTGG
AGGTACAGCTTGGGGACCTGACCCTGCCGAACCCCGTCATGCCGGCCTCCGGTACCTTCGGCTTTGGCGAGGAATACGCA
CCTTTTCTGGACCTCAACCGCCTGGGGGCCCTGGTTGTGAAGACCATTACCCTGGAGCCGACCCCCGGCAACCCGCCGCC
GCGTTTAATGGAGACTCCCTCCGGTTTACTCAACTCCATCGGGCTCCAGAACCCGGGCCTGGAGGTTTTTCTCCGGGAGA
AACTGCCTTATTTGCGCCGGTTTACTCCCCCGCTGATTGTAAATATTGCCGGCAGGACGGTAGAGGAATACGGCGAGCTG
GCTGCCAGGCTAAGCGCGGCGGAGGGTATTGCCGCCCTGGAGGTCAACATCTCCTGCCCCAATGTCCGGGAGGGAGGTAT
TGTCTTCGGCACGGTGCCGGAAATGGCCGCCCGGGTGACGGCAACGGTAAAAGGGCAAACCCACCTGCCGGTGATAGTTA
AACTGACGCCCAATGTCACCGATATTACGGTCCTGGCCAGGGCGGTGGAGGACGCCGGGGCCGATGCCCTTTCCCTGATC
AATACCCTTCAGGGTATGGCCATCGACCTGGAGACCCGACGGCCGGCCCTGGCCAATATCGTCGGGGGCCTGAGCGGCCC
GGCCATTAAACCGGTGGCCCTCTGTGCCGTCTGGCGGGTGGCCCGGGCGGTAAAGATCCCGGTAATCGGCATGGGCGGTA
TCGTGACCGCCCGGGATGCCCTGGAGTTCCTCCTGGCCGGGGCCAGGGCCGTGGCGGTAGGCACAGCCGGCCTGGTGAAT
CCCCGGGCTATAATCGAAGTGATTGACGGGATTAAAGCCTACCTGCAGGAACAGGGTTTGCAGGATGTCAACGAACTGGT
AGGCGCCTTGCGAATTTAA

Upstream 100 bases:

>100_bases
GTCACCGCCCTCCGGGACAGCCGGGGGGAGAAGTATTACGAAAATGTCTGCACCGGCGGTCCGGTCTTCGATGCCGCTGC
CGTATGCTGGGAGGGTTAGT

Downstream 100 bases:

>100_bases
ACCTTGGGGTGAAAATATTTATGTTAAGTCGTGAAGAAGTCCTGGATATCTTCCGCCGCACCGGGGTCCTGTGGGAGGGG
CACTTCGTCTTGACCTCCGG

Product: dihydroorotate oxidase B, catalytic subunit

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 352; Mature: 352

Protein sequence:

>352_residues
MEQAEKRPGVNPKEEDEKLGARGKGLAGTGCAGSGLKSRSTPQEPETGAGVNLEVQLGDLTLPNPVMPASGTFGFGEEYA
PFLDLNRLGALVVKTITLEPTPGNPPPRLMETPSGLLNSIGLQNPGLEVFLREKLPYLRRFTPPLIVNIAGRTVEEYGEL
AARLSAAEGIAALEVNISCPNVREGGIVFGTVPEMAARVTATVKGQTHLPVIVKLTPNVTDITVLARAVEDAGADALSLI
NTLQGMAIDLETRRPALANIVGGLSGPAIKPVALCAVWRVARAVKIPVIGMGGIVTARDALEFLLAGARAVAVGTAGLVN
PRAIIEVIDGIKAYLQEQGLQDVNELVGALRI

Sequences:

>Translated_352_residues
MEQAEKRPGVNPKEEDEKLGARGKGLAGTGCAGSGLKSRSTPQEPETGAGVNLEVQLGDLTLPNPVMPASGTFGFGEEYA
PFLDLNRLGALVVKTITLEPTPGNPPPRLMETPSGLLNSIGLQNPGLEVFLREKLPYLRRFTPPLIVNIAGRTVEEYGEL
AARLSAAEGIAALEVNISCPNVREGGIVFGTVPEMAARVTATVKGQTHLPVIVKLTPNVTDITVLARAVEDAGADALSLI
NTLQGMAIDLETRRPALANIVGGLSGPAIKPVALCAVWRVARAVKIPVIGMGGIVTARDALEFLLAGARAVAVGTAGLVN
PRAIIEVIDGIKAYLQEQGLQDVNELVGALRI
>Mature_352_residues
MEQAEKRPGVNPKEEDEKLGARGKGLAGTGCAGSGLKSRSTPQEPETGAGVNLEVQLGDLTLPNPVMPASGTFGFGEEYA
PFLDLNRLGALVVKTITLEPTPGNPPPRLMETPSGLLNSIGLQNPGLEVFLREKLPYLRRFTPPLIVNIAGRTVEEYGEL
AARLSAAEGIAALEVNISCPNVREGGIVFGTVPEMAARVTATVKGQTHLPVIVKLTPNVTDITVLARAVEDAGADALSLI
NTLQGMAIDLETRRPALANIVGGLSGPAIKPVALCAVWRVARAVKIPVIGMGGIVTARDALEFLLAGARAVAVGTAGLVN
PRAIIEVIDGIKAYLQEQGLQDVNELVGALRI

Specific function: Unknown

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI119943098, Length=204, Percent_Identity=35.7843137254902, Blast_Score=105, Evalue=5e-23,
Organism=Homo sapiens, GI45006951, Length=322, Percent_Identity=28.5714285714286, Blast_Score=79, Evalue=8e-15,
Organism=Escherichia coli, GI87082059, Length=315, Percent_Identity=31.1111111111111, Blast_Score=115, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI71984108, Length=169, Percent_Identity=35.5029585798817, Blast_Score=87, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6322633, Length=313, Percent_Identity=28.7539936102236, Blast_Score=115, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24640763, Length=262, Percent_Identity=32.0610687022901, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI18858217, Length=262, Percent_Identity=32.0610687022901, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI281361352, Length=319, Percent_Identity=25.3918495297806, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI17137316, Length=319, Percent_Identity=25.3918495297806, Blast_Score=69, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005720
- InterPro:   IPR012135
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.3.1 [H]

Molecular weight: Translated: 36755; Mature: 36755

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQAEKRPGVNPKEEDEKLGARGKGLAGTGCAGSGLKSRSTPQEPETGAGVNLEVQLGDL
CCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCE
TLPNPVMPASGTFGFGEEYAPFLDLNRLGALVVKTITLEPTPGNPPPRLMETPSGLLNSI
ECCCCCCCCCCCCCCCCCCCCHHHHHHHCEEEEEEEEECCCCCCCCCHHHCCCHHHHHHC
GLQNPGLEVFLREKLPYLRRFTPPLIVNIAGRTVEEYGELAARLSAAEGIAALEVNISCP
CCCCCCCEEHHHHHCHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHCCEEEEEEEECCC
NVREGGIVFGTVPEMAARVTATVKGQTHLPVIVKLTPNVTDITVLARAVEDAGADALSLI
CCCCCCEEEECHHHHHHHEEEEECCCCCCCEEEEECCCCHHHHHHHHHHHHCCHHHHHHH
NTLQGMAIDLETRRPALANIVGGLSGPAIKPVALCAVWRVARAVKIPVIGMGGIVTARDA
HHHCCCEEEECCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHH
LEFLLAGARAVAVGTAGLVNPRAIIEVIDGIKAYLQEQGLQDVNELVGALRI
HHHHHHCCHHEEECCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCC
>Mature Secondary Structure
MEQAEKRPGVNPKEEDEKLGARGKGLAGTGCAGSGLKSRSTPQEPETGAGVNLEVQLGDL
CCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCE
TLPNPVMPASGTFGFGEEYAPFLDLNRLGALVVKTITLEPTPGNPPPRLMETPSGLLNSI
ECCCCCCCCCCCCCCCCCCCCHHHHHHHCEEEEEEEEECCCCCCCCCHHHCCCHHHHHHC
GLQNPGLEVFLREKLPYLRRFTPPLIVNIAGRTVEEYGELAARLSAAEGIAALEVNISCP
CCCCCCCEEHHHHHCHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHCCEEEEEEEECCC
NVREGGIVFGTVPEMAARVTATVKGQTHLPVIVKLTPNVTDITVLARAVEDAGADALSLI
CCCCCCEEEECHHHHHHHEEEEECCCCCCCEEEEECCCCHHHHHHHHHHHHCCHHHHHHH
NTLQGMAIDLETRRPALANIVGGLSGPAIKPVALCAVWRVARAVKIPVIGMGGIVTARDA
HHHCCCEEEECCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHH
LEFLLAGARAVAVGTAGLVNPRAIIEVIDGIKAYLQEQGLQDVNELVGALRI
HHHHHHCCHHEEECCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA