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The map label for this gene is purQ

Identifier: 83590879

GI number: 83590879

Start: 2141635

End: 2142345

Strand: Reverse

Name: purQ

Synonym: Moth_2049

Alternate gene names: 83590879

Gene position: 2142345-2141635 (Counterclockwise)

Preceding gene: 83590880

Following gene: 83590878

Centisome position: 81.5

GC content: 60.9

Gene sequence:

>711_bases
ATGAAATTCGGCGTTATCGTCTTTCCCGGCTCCAACTGCGACCAGGACGTCCACTACGCCCTGGGTAGCGTCCTGGGCCA
GAACGTTGACTATCTATGGCACGGCGACACCAGCGTTTCCGGCTACGACTGCCTGATCCTGCCCGGCGGCTTCTCCTACG
GCGACTACCTGCGGGCCGGGGCCATTGCCCGCTTTGCCCCCATTATGCCGGCAGTCATTGATTTCGCTCGCTCCGGGGGT
CTGGTCCTGGGTATCTGCAACGGTTTCCAGATCCTCCTGGAGGCCGGCCTCCTACCGGGTGCCATGATGCGTAACGCCTG
CCTCCAGTTTCGCTGCCAGTGGACCTGTTTAAAAGTGGATAATAACGCTACACCCTTTACCAATCGCTTCCGGGAGGGGC
AGGTCGTCCGTATCCCCATCGCCCATGGTGAAGGCAATTACTACGCCGACGCAGCCACCCTGGCCCAACTGGAAGCCAAC
CGGCAAATTATCTTTCGCTACTGCTCCCCGGACGGTGAGGTGACGCCGGCGGCCAATCCCAATGGTTCGGTGGGCAATAT
CGCCGGCATCATCAACCGGGAAGGCAACGTTCTGGGAATGATGCCCCATCCGGAACGTTGTGCCGAAGGGATCCTGGGTG
GTAGCGACGGCCGGGAACTGCTGGCGTCCATTGTTGACTGGTGGGAGAGGGGAGAGCGCCTTGGAGCCTGA

Upstream 100 bases:

>100_bases
AAGCATCGCAGCGGTGAACGGAATGGTGATATTTTTGCAGGATCCCTCATGAGGGACCCTGCCCTCTCCAAGAACCCTGA
AAATTTATGGAGGAACAGCT

Downstream 100 bases:

>100_bases
AATCTACCGGAGAATGGGCCTCACTGATGCAGAATTTGAGAAAGTTAAGGCCATCCTGGGCCGGGAACCCAACTACGTCG
AACTGGGCATGTTTGCCGTT

Product: phosphoribosylformylglycinamidine synthase I

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase I; FGAM synthase I

Number of amino acids: Translated: 236; Mature: 236

Protein sequence:

>236_residues
MKFGVIVFPGSNCDQDVHYALGSVLGQNVDYLWHGDTSVSGYDCLILPGGFSYGDYLRAGAIARFAPIMPAVIDFARSGG
LVLGICNGFQILLEAGLLPGAMMRNACLQFRCQWTCLKVDNNATPFTNRFREGQVVRIPIAHGEGNYYADAATLAQLEAN
RQIIFRYCSPDGEVTPAANPNGSVGNIAGIINREGNVLGMMPHPERCAEGILGGSDGRELLASIVDWWERGERLGA

Sequences:

>Translated_236_residues
MKFGVIVFPGSNCDQDVHYALGSVLGQNVDYLWHGDTSVSGYDCLILPGGFSYGDYLRAGAIARFAPIMPAVIDFARSGG
LVLGICNGFQILLEAGLLPGAMMRNACLQFRCQWTCLKVDNNATPFTNRFREGQVVRIPIAHGEGNYYADAATLAQLEAN
RQIIFRYCSPDGEVTPAANPNGSVGNIAGIINREGNVLGMMPHPERCAEGILGGSDGRELLASIVDWWERGERLGA
>Mature_236_residues
MKFGVIVFPGSNCDQDVHYALGSVLGQNVDYLWHGDTSVSGYDCLILPGGFSYGDYLRAGAIARFAPIMPAVIDFARSGG
LVLGICNGFQILLEAGLLPGAMMRNACLQFRCQWTCLKVDNNATPFTNRFREGQVVRIPIAHGEGNYYADAATLAQLEAN
RQIIFRYCSPDGEVTPAANPNGSVGNIAGIINREGNVLGMMPHPERCAEGILGGSDGRELLASIVDWWERGERLGA

Specific function: Unknown

COG id: COG0047

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain

Homologues:

Organism=Homo sapiens, GI31657129, Length=238, Percent_Identity=28.5714285714286, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI48994899, Length=205, Percent_Identity=33.6585365853659, Blast_Score=87, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17553022, Length=233, Percent_Identity=26.6094420600858, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6321498, Length=182, Percent_Identity=34.0659340659341, Blast_Score=71, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24582111, Length=197, Percent_Identity=33.502538071066, Blast_Score=98, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24582109, Length=197, Percent_Identity=33.502538071066, Blast_Score=98, Evalue=5e-21,
Organism=Drosophila melanogaster, GI17137292, Length=197, Percent_Identity=33.502538071066, Blast_Score=98, Evalue=5e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PURQ_MOOTA (Q2RGU4)

Other databases:

- EMBL:   CP000232
- RefSeq:   YP_430888.1
- ProteinModelPortal:   Q2RGU4
- STRING:   Q2RGU4
- GeneID:   3831195
- GenomeReviews:   CP000232_GR
- KEGG:   mta:Moth_2049
- NMPDR:   fig|264732.9.peg.2071
- eggNOG:   COG0047
- HOGENOM:   HBG302712
- OMA:   FPGTNCD
- ProtClustDB:   PRK03619
- BioCyc:   MTHE264732:MOTH_2049-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00421
- InterPro:   IPR017926
- InterPro:   IPR010075
- InterPro:   IPR002818
- PIRSF:   PIRSF001586
- TIGRFAMs:   TIGR01737

Pfam domain/function: PF01965 DJ-1_PfpI

EC number: =6.3.5.3

Molecular weight: Translated: 25444; Mature: 25444

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS51273 GATASE_TYPE_1

Important sites: ACT_SITE 86-86 ACT_SITE 203-203 ACT_SITE 205-205

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
3.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFGVIVFPGSNCDQDVHYALGSVLGQNVDYLWHGDTSVSGYDCLILPGGFSYGDYLRAG
CCEEEEEECCCCCCHHHHHHHHHHHCCCCCEEECCCCCCCCEEEEEECCCCCHHHHHHHH
AIARFAPIMPAVIDFARSGGLVLGICNGFQILLEAGLLPGAMMRNACLQFRCQWTCLKVD
HHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHCCCCHHHHHHHHHEEEEEEEEEEEC
NNATPFTNRFREGQVVRIPIAHGEGNYYADAATLAQLEANRQIIFRYCSPDGEVTPAANP
CCCCCCHHHHCCCCEEEEEEEECCCCEEEHHHHHHHHHCCCEEEEEEECCCCCCCCCCCC
NGSVGNIAGIINREGNVLGMMPHPERCAEGILGGSDGRELLASIVDWWERGERLGA
CCCCCCEEEEEECCCCEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKFGVIVFPGSNCDQDVHYALGSVLGQNVDYLWHGDTSVSGYDCLILPGGFSYGDYLRAG
CCEEEEEECCCCCCHHHHHHHHHHHCCCCCEEECCCCCCCCEEEEEECCCCCHHHHHHHH
AIARFAPIMPAVIDFARSGGLVLGICNGFQILLEAGLLPGAMMRNACLQFRCQWTCLKVD
HHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHCCCCHHHHHHHHHEEEEEEEEEEEC
NNATPFTNRFREGQVVRIPIAHGEGNYYADAATLAQLEANRQIIFRYCSPDGEVTPAANP
CCCCCCHHHHCCCCEEEEEEEECCCCEEEHHHHHHHHHCCCEEEEEEECCCCCCCCCCCC
NGSVGNIAGIINREGNVLGMMPHPERCAEGILGGSDGRELLASIVDWWERGERLGA
CCCCCCEEEEEECCCCEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA