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The map label for this gene is purL

Identifier: 83590878

GI number: 83590878

Start: 2139444

End: 2141645

Strand: Reverse

Name: purL

Synonym: Moth_2048

Alternate gene names: 83590878

Gene position: 2141645-2139444 (Counterclockwise)

Preceding gene: 83590879

Following gene: 83590877

Centisome position: 81.47

GC content: 63.35

Gene sequence:

>2202_bases
TTGGAGCCTGAAATCTACCGGAGAATGGGCCTCACTGATGCAGAATTTGAGAAAGTTAAGGCCATCCTGGGCCGGGAACC
CAACTACGTCGAACTGGGCATGTTTGCCGTTATGTGGTCAGAGCACTGCGGCTATAAAAGCTCCCGTTCGGTACTGAAGC
TGTTCCCGACGAAGGCCCCCTGGGTCCTCCAGGGCCCGGGGGAGAACGCCGGCATCGTGGACATCGGTGACGGCCAGGCC
GTGGTCTTTAAAATCGAAAGCCACAACCATCCCTCGGCCATAGAACCCTTCCAGGGGGCGGCCACCGGGGTGGGGGGCAT
CGTCCGCGACATCTTTGCCATGGGGGCGCGGCCCATTGCCGTCCTCAATTCCTTACGTTTCGGACCCCTGGACGACTCCC
GCACCCGGTACCTCATGGGCGGGGTGGTGGGCGGCATCGCCTTTTACGGCAACTGCCTGGGCCTGCCCACGGTGGCCGGG
GAGGTTTATTTTGAACCCTCGTATGCCTGTAACCCCCTGGTCAACGTCATGGCCGTGGGCTTAATCGAGCAAAAGAATAT
CCGCCGGGGTACGGCTGCCGGAGTGGGCAACGCCGTCATGCTAATAGGTGCTCGCACCGGCCGCGACGGCATCCACGGGG
CCACCTTCGCCTCCGAGGAATTGAGCGAGGCTTCCGAGGAGCGACGGCCCTCCGTCCAGGTAGGCGACCCCTTCCGGGAA
AAGCTCCTCATCGAAGCCTGCCTGGAAATAATAAATGAAGATTTAATCATCGGCATGCAGGATATGGGCGCCGCCGGTAT
TACCAGCTCCTCCTGCGAGATGGCGGCCCGGGCCGGCACCGGCATGGAGATTGACATCGCCCTGGTGCCGCGGCGGGAAG
AAGGTATGACCCCCTACGAGGTCATGCTGTCGGAATCCCAGGAACGGATGCTCTTGGTACCCAAAAAAGGCGCTGAAGAG
AGGATCCGGGCCATCTGCCGGCGCTGGGGCCTGGAAGCGGTAATCATCGGCCGGGTAACGGGCGACGGCCTGATGCGCAT
CATGGAGAACGGCCGGGTGGTGGCCGAGGTGCCGGCCAAGGCCCTGACGGACCAGTGCCCGGTCTATGAACGGGAACGCC
GCCGGCCGGCCTACCTGGATGAAGTACGGCAAAGGGACTTAAGCCGCCTGCCGGAACCGGAGGATTACGGCCGGGTGCTC
CTGGGGCTGCTGGCGGCGCCGAACCTGGCCAGTAAAGAGTGGGTTTACCGCCAGTATGATTATATGGTCCGGACGGATAC
GGTGGCCGGGCCCGGGGGAGACGCCGCGATCTTAAGGGTTAAAGGCACGAGCAAAGGCCTGGCCCTGACGGTGGACGGCA
ATGGTCGCTACTGTTACCTGGACCCGGAGCGGGGCGGGGCCATCGCCGTTGCCGAGGCGGCCCGGAACCTCGCCTGTGTG
GGGGCGCGGCCCCTGGCCATCACCGATTGCCTGAACTTCGGTAATCCCGAAAAGCCCGAGGTGGCCTGGCAGTTCTATCA
GGCCGTGAGCGGCATGAGCCGGGCCTGTGAGGTTTTGCGGACCCCGGTAACCGGCGGTAACGTCAGCTTTTATAACGAAA
CCGAAAGCGGAGCTATCTACCCCACCCCGGTGGTGGGCATGGTCGGCCTGCTGCCGGATATAGAAAAACGCTGTGGCATT
GGTTTCCGCCGGGAAGGCGACCTGTTGATCCTTATGGGCGAGACTTACCCGGAGATAGGCGGCAGCGAGTACCTGGCCAC
ATTCCATGGCCTGGTGGCCGGAGAACCGCCTGCCCTGGACCTGGAGCGGGAAAAGGCCGTCCAGGCCCTGGTCCGGGAGG
TTATCGCCGCCGGGCTAGCAACAGCAGCCCATGACTGCGCCGAAGGGGGTCTGGCCGTGGCCCTGGCGGAAAGCGCCCTG
GCCGGAGGCCTGGGGGCGGAGGTGGAACTGGCGAGCGACCTGCGGCCCGATTTTCTCCTCTTCAGTGAGAGCCAGTCCAG
GATACTGCTGGCGGTAGCACCTGAGGCCAGGGACAGGGTGCTGGATCTGGCCCGAGAAAAGGGCGTGCGGGCATCGGTCA
TTGGCCGGTGCGGGGGCCACAGCCTGGTGGTAAGGATAAACGGCAGGACATTGTTCAATCTAAGCCTTGAGGAGATGGGG
AAACAATGGCGGGAGAGCATACCGGTGCTGATGGCCCGGTAA

Upstream 100 bases:

>100_bases
ATGCCCCATCCGGAACGTTGTGCCGAAGGGATCCTGGGTGGTAGCGACGGCCGGGAACTGCTGGCGTCCATTGTTGACTG
GTGGGAGAGGGGAGAGCGCC

Downstream 100 bases:

>100_bases
GGATGTCGTCCTGGCACGAGGAGTGCGGTGTCTTTGGCATCTACGCTCCGGGCCAGGACGTGGCCCGGCTGGCCTACTAC
GGACTCTTTGCCCTCCAGCA

Product: phosphoribosylformylglycinamidine synthase II

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase II; FGAM synthase II

Number of amino acids: Translated: 733; Mature: 733

Protein sequence:

>733_residues
MEPEIYRRMGLTDAEFEKVKAILGREPNYVELGMFAVMWSEHCGYKSSRSVLKLFPTKAPWVLQGPGENAGIVDIGDGQA
VVFKIESHNHPSAIEPFQGAATGVGGIVRDIFAMGARPIAVLNSLRFGPLDDSRTRYLMGGVVGGIAFYGNCLGLPTVAG
EVYFEPSYACNPLVNVMAVGLIEQKNIRRGTAAGVGNAVMLIGARTGRDGIHGATFASEELSEASEERRPSVQVGDPFRE
KLLIEACLEIINEDLIIGMQDMGAAGITSSSCEMAARAGTGMEIDIALVPRREEGMTPYEVMLSESQERMLLVPKKGAEE
RIRAICRRWGLEAVIIGRVTGDGLMRIMENGRVVAEVPAKALTDQCPVYERERRRPAYLDEVRQRDLSRLPEPEDYGRVL
LGLLAAPNLASKEWVYRQYDYMVRTDTVAGPGGDAAILRVKGTSKGLALTVDGNGRYCYLDPERGGAIAVAEAARNLACV
GARPLAITDCLNFGNPEKPEVAWQFYQAVSGMSRACEVLRTPVTGGNVSFYNETESGAIYPTPVVGMVGLLPDIEKRCGI
GFRREGDLLILMGETYPEIGGSEYLATFHGLVAGEPPALDLEREKAVQALVREVIAAGLATAAHDCAEGGLAVALAESAL
AGGLGAEVELASDLRPDFLLFSESQSRILLAVAPEARDRVLDLAREKGVRASVIGRCGGHSLVVRINGRTLFNLSLEEMG
KQWRESIPVLMAR

Sequences:

>Translated_733_residues
MEPEIYRRMGLTDAEFEKVKAILGREPNYVELGMFAVMWSEHCGYKSSRSVLKLFPTKAPWVLQGPGENAGIVDIGDGQA
VVFKIESHNHPSAIEPFQGAATGVGGIVRDIFAMGARPIAVLNSLRFGPLDDSRTRYLMGGVVGGIAFYGNCLGLPTVAG
EVYFEPSYACNPLVNVMAVGLIEQKNIRRGTAAGVGNAVMLIGARTGRDGIHGATFASEELSEASEERRPSVQVGDPFRE
KLLIEACLEIINEDLIIGMQDMGAAGITSSSCEMAARAGTGMEIDIALVPRREEGMTPYEVMLSESQERMLLVPKKGAEE
RIRAICRRWGLEAVIIGRVTGDGLMRIMENGRVVAEVPAKALTDQCPVYERERRRPAYLDEVRQRDLSRLPEPEDYGRVL
LGLLAAPNLASKEWVYRQYDYMVRTDTVAGPGGDAAILRVKGTSKGLALTVDGNGRYCYLDPERGGAIAVAEAARNLACV
GARPLAITDCLNFGNPEKPEVAWQFYQAVSGMSRACEVLRTPVTGGNVSFYNETESGAIYPTPVVGMVGLLPDIEKRCGI
GFRREGDLLILMGETYPEIGGSEYLATFHGLVAGEPPALDLEREKAVQALVREVIAAGLATAAHDCAEGGLAVALAESAL
AGGLGAEVELASDLRPDFLLFSESQSRILLAVAPEARDRVLDLAREKGVRASVIGRCGGHSLVVRINGRTLFNLSLEEMG
KQWRESIPVLMAR
>Mature_733_residues
MEPEIYRRMGLTDAEFEKVKAILGREPNYVELGMFAVMWSEHCGYKSSRSVLKLFPTKAPWVLQGPGENAGIVDIGDGQA
VVFKIESHNHPSAIEPFQGAATGVGGIVRDIFAMGARPIAVLNSLRFGPLDDSRTRYLMGGVVGGIAFYGNCLGLPTVAG
EVYFEPSYACNPLVNVMAVGLIEQKNIRRGTAAGVGNAVMLIGARTGRDGIHGATFASEELSEASEERRPSVQVGDPFRE
KLLIEACLEIINEDLIIGMQDMGAAGITSSSCEMAARAGTGMEIDIALVPRREEGMTPYEVMLSESQERMLLVPKKGAEE
RIRAICRRWGLEAVIIGRVTGDGLMRIMENGRVVAEVPAKALTDQCPVYERERRRPAYLDEVRQRDLSRLPEPEDYGRVL
LGLLAAPNLASKEWVYRQYDYMVRTDTVAGPGGDAAILRVKGTSKGLALTVDGNGRYCYLDPERGGAIAVAEAARNLACV
GARPLAITDCLNFGNPEKPEVAWQFYQAVSGMSRACEVLRTPVTGGNVSFYNETESGAIYPTPVVGMVGLLPDIEKRCGI
GFRREGDLLILMGETYPEIGGSEYLATFHGLVAGEPPALDLEREKAVQALVREVIAAGLATAAHDCAEGGLAVALAESAL
AGGLGAEVELASDLRPDFLLFSESQSRILLAVAPEARDRVLDLAREKGVRASVIGRCGGHSLVVRINGRTLFNLSLEEMG
KQWRESIPVLMAR

Specific function: Unknown

COG id: COG0046

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGAMS family

Homologues:

Organism=Escherichia coli, GI48994899, Length=826, Percent_Identity=24.5762711864407, Blast_Score=130, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17553022, Length=742, Percent_Identity=22.6415094339623, Blast_Score=102, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6321498, Length=818, Percent_Identity=22.1271393643032, Blast_Score=112, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24582111, Length=748, Percent_Identity=24.4652406417112, Blast_Score=103, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24582109, Length=748, Percent_Identity=24.4652406417112, Blast_Score=103, Evalue=4e-22,
Organism=Drosophila melanogaster, GI17137292, Length=748, Percent_Identity=24.4652406417112, Blast_Score=103, Evalue=4e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PURL_MOOTA (Q2RGU5)

Other databases:

- EMBL:   CP000232
- RefSeq:   YP_430887.1
- ProteinModelPortal:   Q2RGU5
- SMR:   Q2RGU5
- STRING:   Q2RGU5
- GeneID:   3831194
- GenomeReviews:   CP000232_GR
- KEGG:   mta:Moth_2048
- NMPDR:   fig|264732.9.peg.2070
- eggNOG:   COG0046
- HOGENOM:   HBG311214
- OMA:   YGNSFGV
- ProtClustDB:   PRK01213
- BioCyc:   MTHE264732:MOTH_2048-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00420
- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR010074
- InterPro:   IPR016188
- TIGRFAMs:   TIGR01736

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C; SSF56042 AIR_synth_C; SSF55326 PurM_N-like

EC number: =6.3.5.3

Molecular weight: Translated: 79105; Mature: 79105

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEPEIYRRMGLTDAEFEKVKAILGREPNYVELGMFAVMWSEHCGYKSSRSVLKLFPTKAP
CCCHHHHHCCCCHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHCCCCCCCCHHEECCCCCC
WVLQGPGENAGIVDIGDGQAVVFKIESHNHPSAIEPFQGAATGVGGIVRDIFAMGARPIA
EEEECCCCCCCEEEECCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHH
VLNSLRFGPLDDSRTRYLMGGVVGGIAFYGNCLGLPTVAGEVYFEPSYACNPLVNVMAVG
HHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCHHHHHHHHH
LIEQKNIRRGTAAGVGNAVMLIGARTGRDGIHGATFASEELSEASEERRPSVQVGDPFRE
HHHHCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHH
KLLIEACLEIINEDLIIGMQDMGAAGITSSSCEMAARAGTGMEIDIALVPRREEGMTPYE
HHHHHHHHHHHCCCEEEEHHHCCCCCCCCCCHHHHHHCCCCCEEEEEEECCCCCCCCHHH
VMLSESQERMLLVPKKGAEERIRAICRRWGLEAVIIGRVTGDGLMRIMENGRVVAEVPAK
HHHCCCCCCEEEECCCCHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHCCCEEEECCHH
ALTDQCPVYERERRRPAYLDEVRQRDLSRLPEPEDYGRVLLGLLAAPNLASKEWVYRQYD
HHHCCCCCCHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHC
YMVRTDTVAGPGGDAAILRVKGTSKGLALTVDGNGRYCYLDPERGGAIAVAEAARNLACV
EEEEECCCCCCCCCEEEEEEECCCCCEEEEEECCCCEEEECCCCCCEEEEEHHHCCEEEE
GARPLAITDCLNFGNPEKPEVAWQFYQAVSGMSRACEVLRTPVTGGNVSFYNETESGAIY
CCCCEEHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCC
PTPVVGMVGLLPDIEKRCGIGFRREGDLLILMGETYPEIGGSEYLATFHGLVAGEPPALD
CCHHHHHHHHCCCHHHHCCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCC
LEREKAVQALVREVIAAGLATAAHDCAEGGLAVALAESALAGGLGAEVELASDLRPDFLL
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHCCCCCCCEEECCCCCCCEEE
FSESQSRILLAVAPEARDRVLDLAREKGVRASVIGRCGGHSLVVRINGRTLFNLSLEEMG
EECCCCEEEEEECCCHHHHHHHHHHHCCCEEEEEECCCCCEEEEEECCCEEEEECHHHHH
KQWRESIPVLMAR
HHHHHCCCEEECC
>Mature Secondary Structure
MEPEIYRRMGLTDAEFEKVKAILGREPNYVELGMFAVMWSEHCGYKSSRSVLKLFPTKAP
CCCHHHHHCCCCHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHCCCCCCCCHHEECCCCCC
WVLQGPGENAGIVDIGDGQAVVFKIESHNHPSAIEPFQGAATGVGGIVRDIFAMGARPIA
EEEECCCCCCCEEEECCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHH
VLNSLRFGPLDDSRTRYLMGGVVGGIAFYGNCLGLPTVAGEVYFEPSYACNPLVNVMAVG
HHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCHHHHHHHHH
LIEQKNIRRGTAAGVGNAVMLIGARTGRDGIHGATFASEELSEASEERRPSVQVGDPFRE
HHHHCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHH
KLLIEACLEIINEDLIIGMQDMGAAGITSSSCEMAARAGTGMEIDIALVPRREEGMTPYE
HHHHHHHHHHHCCCEEEEHHHCCCCCCCCCCHHHHHHCCCCCEEEEEEECCCCCCCCHHH
VMLSESQERMLLVPKKGAEERIRAICRRWGLEAVIIGRVTGDGLMRIMENGRVVAEVPAK
HHHCCCCCCEEEECCCCHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHCCCEEEECCHH
ALTDQCPVYERERRRPAYLDEVRQRDLSRLPEPEDYGRVLLGLLAAPNLASKEWVYRQYD
HHHCCCCCCHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHC
YMVRTDTVAGPGGDAAILRVKGTSKGLALTVDGNGRYCYLDPERGGAIAVAEAARNLACV
EEEEECCCCCCCCCEEEEEEECCCCCEEEEEECCCCEEEECCCCCCEEEEEHHHCCEEEE
GARPLAITDCLNFGNPEKPEVAWQFYQAVSGMSRACEVLRTPVTGGNVSFYNETESGAIY
CCCCEEHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCC
PTPVVGMVGLLPDIEKRCGIGFRREGDLLILMGETYPEIGGSEYLATFHGLVAGEPPALD
CCHHHHHHHHCCCHHHHCCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCC
LEREKAVQALVREVIAAGLATAAHDCAEGGLAVALAESALAGGLGAEVELASDLRPDFLL
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHCCCCCCCEEECCCCCCCEEE
FSESQSRILLAVAPEARDRVLDLAREKGVRASVIGRCGGHSLVVRINGRTLFNLSLEEMG
EECCCCEEEEEECCCHHHHHHHHHHHCCCEEEEEECCCCCEEEEEECCCEEEEECHHHHH
KQWRESIPVLMAR
HHHHHCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA