Click here to switch to the map view.

The map label for this gene is purR [H]

Identifier: 83590854

GI number: 83590854

Start: 2112161

End: 2113207

Strand: Reverse

Name: purR [H]

Synonym: Moth_2024

Alternate gene names: 83590854

Gene position: 2113207-2112161 (Counterclockwise)

Preceding gene: 83590855

Following gene: 83590853

Centisome position: 80.39

GC content: 54.82

Gene sequence:

>1047_bases
TTGCCAAATATCTCTGATGTTGCCAGAAGAGCCGGAGTATCACGAACTACGGTATCCAGGGTCCTCAACGGGAAAGACGA
CGTCAACGAAGAAACCCGGCGCCGGGTACTGGAGGCCATTAAGGAGCTAAACTACCGCCCCAGTGCCCTGGCCCGCAGCC
TGGTGAAACAAAAGACCGATACCATTGGCGTTATCCTGTCGGATATCACCGATCCCTTCTTTTCCCTTATTATCCAGGGG
GTGGAAGATGTAGCTCATAAATTCGGTTACGGCATAGTTTACGCCAGTATGCGCTGGGACCCGCAAATCAAGCATAACTA
TGTAAGTTTCTTGCGCAACGGGCGGGTGGACGGTCTCCTTATGATGGGCCATACAGTGGGCAATGAAGACTATGTACGGG
AGATGGTAGAGGATAAGTTTCCCCTGGTCCTGGTTGAATATTGGATTGAGAATCTCAAGGCCAACTTTATATCCATTGAT
AACAAAGGGGGGGGTTACCTGGCCACCAGGCACCTGCTGGGACTTGGGCACCGCCGCATTGCCCATGTAGCAGGGCATAA
AAACGCCCGGGTATCGCAAGAACGCCTGGCCGGTTACCGCCAGGCCCTGGAGGAAGCCGGCAGGCCCTACGACGAAAGCC
TGGTAGTTTACAGCGATTTTACCACCGAAGGAGCCATACCGGTTGCGAAAAAACTATTATCCCTGCCTGAGCGGCCGACA
GCCATCTTTGCGGCCAACGACCTGATGGCCTACGGCGTCATCCATGCGGCCCGCGAACTGGGATTAAGGGTTCCAAAGGA
TCTGGCGGTGGTCGGCTACGACGACATCGAGCTGGCTTCCCTAGTAACACCACCCTTAACAACCATCCATCAGCCCCGCT
ATGAAATCGGCTCCATGGCCGCCTGGTCCCTGATCCAGCAGATCGAGAATAAAGAAATGCAGCCGACGGTAACAGAGTTT
AAGACGAGCCTGGTAATTCGGGAATCCTGCGGCGCTGTTTTCCGGCGCGGCGACCAGGGGTATGTAGAAGGAGGCAAGCC
GGCATGA

Upstream 100 bases:

>100_bases
ACAGATGCCTACGATAGGCTGTATGAAATATATAAATCCCTTTATCCTCTCCTGCGCGACACGATGCACGATCTGACAAA
ATTTACGGAGTGAAAACGAT

Downstream 100 bases:

>100_bases
ATCCTTGCTGGTGGCGGGAAATAGATTTCCGTGGCTGGAATGGGGCTGTCGAGTTCGGAAATGACCTGATCCGGGTGGTT
ATGGTCCCGAACCTGGGTGG

Product: LacI family transcription regulator

Products: NA

Alternate protein names: Pur regulon repressor; Purine nucleotide synthesis repressor [H]

Number of amino acids: Translated: 348; Mature: 347

Protein sequence:

>348_residues
MPNISDVARRAGVSRTTVSRVLNGKDDVNEETRRRVLEAIKELNYRPSALARSLVKQKTDTIGVILSDITDPFFSLIIQG
VEDVAHKFGYGIVYASMRWDPQIKHNYVSFLRNGRVDGLLMMGHTVGNEDYVREMVEDKFPLVLVEYWIENLKANFISID
NKGGGYLATRHLLGLGHRRIAHVAGHKNARVSQERLAGYRQALEEAGRPYDESLVVYSDFTTEGAIPVAKKLLSLPERPT
AIFAANDLMAYGVIHAARELGLRVPKDLAVVGYDDIELASLVTPPLTTIHQPRYEIGSMAAWSLIQQIENKEMQPTVTEF
KTSLVIRESCGAVFRRGDQGYVEGGKPA

Sequences:

>Translated_348_residues
MPNISDVARRAGVSRTTVSRVLNGKDDVNEETRRRVLEAIKELNYRPSALARSLVKQKTDTIGVILSDITDPFFSLIIQG
VEDVAHKFGYGIVYASMRWDPQIKHNYVSFLRNGRVDGLLMMGHTVGNEDYVREMVEDKFPLVLVEYWIENLKANFISID
NKGGGYLATRHLLGLGHRRIAHVAGHKNARVSQERLAGYRQALEEAGRPYDESLVVYSDFTTEGAIPVAKKLLSLPERPT
AIFAANDLMAYGVIHAARELGLRVPKDLAVVGYDDIELASLVTPPLTTIHQPRYEIGSMAAWSLIQQIENKEMQPTVTEF
KTSLVIRESCGAVFRRGDQGYVEGGKPA
>Mature_347_residues
PNISDVARRAGVSRTTVSRVLNGKDDVNEETRRRVLEAIKELNYRPSALARSLVKQKTDTIGVILSDITDPFFSLIIQGV
EDVAHKFGYGIVYASMRWDPQIKHNYVSFLRNGRVDGLLMMGHTVGNEDYVREMVEDKFPLVLVEYWIENLKANFISIDN
KGGGYLATRHLLGLGHRRIAHVAGHKNARVSQERLAGYRQALEEAGRPYDESLVVYSDFTTEGAIPVAKKLLSLPERPTA
IFAANDLMAYGVIHAARELGLRVPKDLAVVGYDDIELASLVTPPLTTIHQPRYEIGSMAAWSLIQQIENKEMQPTVTEFK
TSLVIRESCGAVFRRGDQGYVEGGKPA

Specific function: Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression. PurR is allosterically activated to bind its cognate DNA by binding the purine corepre

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790194, Length=327, Percent_Identity=40.9785932721713, Blast_Score=227, Evalue=7e-61,
Organism=Escherichia coli, GI1787948, Length=334, Percent_Identity=40.4191616766467, Blast_Score=220, Evalue=1e-58,
Organism=Escherichia coli, GI1790369, Length=331, Percent_Identity=35.3474320241692, Blast_Score=218, Evalue=3e-58,
Organism=Escherichia coli, GI1789202, Length=330, Percent_Identity=31.2121212121212, Blast_Score=173, Evalue=2e-44,
Organism=Escherichia coli, GI1788474, Length=333, Percent_Identity=33.3333333333333, Blast_Score=166, Evalue=2e-42,
Organism=Escherichia coli, GI1787580, Length=324, Percent_Identity=30.8641975308642, Blast_Score=153, Evalue=2e-38,
Organism=Escherichia coli, GI1789068, Length=337, Percent_Identity=28.7833827893175, Blast_Score=151, Evalue=7e-38,
Organism=Escherichia coli, GI1786540, Length=304, Percent_Identity=32.8947368421053, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI48994940, Length=333, Percent_Identity=25.5255255255255, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1787906, Length=320, Percent_Identity=27.5, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1790715, Length=317, Percent_Identity=24.9211356466877, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1786268, Length=331, Percent_Identity=22.9607250755287, Blast_Score=98, Evalue=6e-22,
Organism=Escherichia coli, GI1789456, Length=351, Percent_Identity=25.9259259259259, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1790689, Length=310, Percent_Identity=24.5161290322581, Blast_Score=82, Evalue=7e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 38810; Mature: 38679

Theoretical pI: Translated: 7.83; Mature: 7.83

Prosite motif: PS00356 HTH_LACI_1 ; PS50932 HTH_LACI_2 ; PS00775 GLYCOSYL_HYDROL_F3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPNISDVARRAGVSRTTVSRVLNGKDDVNEETRRRVLEAIKELNYRPSALARSLVKQKTD
CCCHHHHHHHCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
TIGVILSDITDPFFSLIIQGVEDVAHKFGYGIVYASMRWDPQIKHNYVSFLRNGRVDGLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHCCCCCEEE
MMGHTVGNEDYVREMVEDKFPLVLVEYWIENLKANFISIDNKGGGYLATRHLLGLGHRRI
EECCCCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCHHHH
AHVAGHKNARVSQERLAGYRQALEEAGRPYDESLVVYSDFTTEGAIPVAKKLLSLPERPT
HHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHCCCCCCC
AIFAANDLMAYGVIHAARELGLRVPKDLAVVGYDDIELASLVTPPLTTIHQPRYEIGSMA
EEEEHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHCCCCHHHHCCCCHHHHHHH
AWSLIQQIENKEMQPTVTEFKTSLVIRESCGAVFRRGDQGYVEGGKPA
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
PNISDVARRAGVSRTTVSRVLNGKDDVNEETRRRVLEAIKELNYRPSALARSLVKQKTD
CCHHHHHHHCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
TIGVILSDITDPFFSLIIQGVEDVAHKFGYGIVYASMRWDPQIKHNYVSFLRNGRVDGLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHCCCCCEEE
MMGHTVGNEDYVREMVEDKFPLVLVEYWIENLKANFISIDNKGGGYLATRHLLGLGHRRI
EECCCCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCHHHH
AHVAGHKNARVSQERLAGYRQALEEAGRPYDESLVVYSDFTTEGAIPVAKKLLSLPERPT
HHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHCCCCCCC
AIFAANDLMAYGVIHAARELGLRVPKDLAVVGYDDIELASLVTPPLTTIHQPRYEIGSMA
EEEEHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHCCCCHHHHCCCCHHHHHHH
AWSLIQQIENKEMQPTVTEFKTSLVIRESCGAVFRRGDQGYVEGGKPA
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA