Click here to switch to the map view.

The map label for this gene is lytS [H]

Identifier: 83590797

GI number: 83590797

Start: 2045578

End: 2047308

Strand: Reverse

Name: lytS [H]

Synonym: Moth_1965

Alternate gene names: 83590797

Gene position: 2047308-2045578 (Counterclockwise)

Preceding gene: 83590798

Following gene: 83590796

Centisome position: 77.88

GC content: 57.42

Gene sequence:

>1731_bases
ATGGACTGGTCAATGGGCCTGCATCTTGCGGAAAGATTGAGTATGGTTGCCACAGCGGCTTTTATCCTATCTCGTACCCC
GGCCCTGGGACGCATCTTATCCCGGCAGCTTACCAATCGGGACAGGCTATTGCTGGTCCTTGTCCTTGGCGGGATGGGGA
TAGTTGGAACCTATGCCGGTATCCCCATTCACGATGCCCTGGCCAACTCCCGGGTGGTGGGAGTGATGGTAGCTGGCCTG
CTGGGCGGTCCCTTCGTAGGGGCGGGAGCCGGCCTGATCGCCGGCATCCATCGCTATTTAATGGGGGGCTTTACCGCCTT
CGCCTGCGGCCTGGCGGCAGTAGCGGAGGGGACCCTCGGGGGACTGGTACAGCAGTGTTACCGTCGTTCACCGGTGCCCT
GGCCTATGGCCTTCGCCGCGGGCCTGGTAGGGGAAACCATGCAGATGGTCATCATCCTCCTGACAGCCCGCCCCTTTACT
GAGGCCTGGGCTCTGGTTCAGATTATCGGCCCCCCGATGATTATTGTCAATTCTATTGGCGTGGCCATTTTCATGTTTAT
TGTTAAAACTGCCGCCGAACAGCAGGACCACATCGCCGCCTGTCAGGCCCAGCGGGCTCTGGATATTGCCAACCAGACAT
TACCTTTCCTGCGCCATGGCTTGAACCGGGAGTCGGCCGAAGAGGCGGCAAGGATTATCTTTAATTCCATTAAAGTGGCC
GCCGTAGCTATTACCGACAGGCAGGAAATTCTGGCCCATGTGGGAATGGGCAGTGACCACCATCACCCGGGTATGCCTAT
CATGACCAGCGCCACCCTCCAGGCCATAGCCACCGGAGAGTTGCAGCTGGCCCGGAGCCGGGGTGAAATCGGCTGCCGGG
AGAAGGACTGTCGTTTGGCTTCGGCGGTGGTGGTGCCTCTCAAGAGGCGGGAAGCAACCATTGGCACGTTAAAGCTTTAT
CACGAGCGGGAGAATAGCATTACCACGGTGGACCTGGAACTGGCCCGGGGGCTGGCCCACCTGTTTTCTACCCAGCTGGA
ACTGGCAGAGGTGAAATACCAGGCTCAGCTACGTTCCCAGGCAGAACTAAAGGTCCTGCAGGCTCAGATACACCCCCACT
TCCTCTTTAATGCCTTGAATACCATTAGTTCCCTGATCCGTACCAGACCCGAAAAAGCAAGGGAATTGCTGGCGAAACTG
GCCAGTTTCTTCCGCTATAGTTTAAGAAGGGACGATAACCCCATTCCCCTGGCCGAAGAGCTGGCCCACGTAGATTCTTA
CCTGGCTATAGAGGAAGCGCGTTTTGGTAATAAGCTGGAGGTTATCCGCCAGGTGGACCCCGCCACCCTGGCTTTCCCTG
TCCCTGCCTTCACCCTGCAACCGGTAGTGGAAAACGCCATCAAACATGGATTACAACCCAGAACTCAAGGGGGCAGGGTG
ATATTGAACGCCAGCGATCGGGGAGCGGATGTAGAGGTCAGGGTAACGGACGACGGGGTGGGTATTGCCCCGGAAGAAAT
GAATAAAATTTTTCTCCCTGGCTACGGTCGCGGCCACGGCCTGGGCCTGTCTATTGTTAACGAGCGTTTAAAGGCCCTTT
ACGGGCCGGAATACGCCGTCCGGGTGAAGAGTGTCCCCGGCCAGGGTACCGAGGTGGTCCTGCGTTTTCCTAAAAAAGTT
GAGCACCGGGAGGTGAAGGAGGAAGATGACCTTTACCGCCGTTGTGGTTGA

Upstream 100 bases:

>100_bases
GGGGTTCATGGAAGGGGGCGTTAGGGCTACTCCGGGCTGTTACTGACTAACCATGGCCATTTTGATATAATATAAAATGT
AATAGAAAGGGGGCGAGTCT

Downstream 100 bases:

>100_bases
TGACCAGCCCCTGGCTCGGGATGAACTAAAATACCTGCTGTCTGCCTACGAAGAATGCCAGGTCATCGGCGAAGCTGAAG
ACGGGGGGGAAGCCCTGCAA

Product: histidine kinase internal region

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 576; Mature: 576

Protein sequence:

>576_residues
MDWSMGLHLAERLSMVATAAFILSRTPALGRILSRQLTNRDRLLLVLVLGGMGIVGTYAGIPIHDALANSRVVGVMVAGL
LGGPFVGAGAGLIAGIHRYLMGGFTAFACGLAAVAEGTLGGLVQQCYRRSPVPWPMAFAAGLVGETMQMVIILLTARPFT
EAWALVQIIGPPMIIVNSIGVAIFMFIVKTAAEQQDHIAACQAQRALDIANQTLPFLRHGLNRESAEEAARIIFNSIKVA
AVAITDRQEILAHVGMGSDHHHPGMPIMTSATLQAIATGELQLARSRGEIGCREKDCRLASAVVVPLKRREATIGTLKLY
HERENSITTVDLELARGLAHLFSTQLELAEVKYQAQLRSQAELKVLQAQIHPHFLFNALNTISSLIRTRPEKARELLAKL
ASFFRYSLRRDDNPIPLAEELAHVDSYLAIEEARFGNKLEVIRQVDPATLAFPVPAFTLQPVVENAIKHGLQPRTQGGRV
ILNASDRGADVEVRVTDDGVGIAPEEMNKIFLPGYGRGHGLGLSIVNERLKALYGPEYAVRVKSVPGQGTEVVLRFPKKV
EHREVKEEDDLYRRCG

Sequences:

>Translated_576_residues
MDWSMGLHLAERLSMVATAAFILSRTPALGRILSRQLTNRDRLLLVLVLGGMGIVGTYAGIPIHDALANSRVVGVMVAGL
LGGPFVGAGAGLIAGIHRYLMGGFTAFACGLAAVAEGTLGGLVQQCYRRSPVPWPMAFAAGLVGETMQMVIILLTARPFT
EAWALVQIIGPPMIIVNSIGVAIFMFIVKTAAEQQDHIAACQAQRALDIANQTLPFLRHGLNRESAEEAARIIFNSIKVA
AVAITDRQEILAHVGMGSDHHHPGMPIMTSATLQAIATGELQLARSRGEIGCREKDCRLASAVVVPLKRREATIGTLKLY
HERENSITTVDLELARGLAHLFSTQLELAEVKYQAQLRSQAELKVLQAQIHPHFLFNALNTISSLIRTRPEKARELLAKL
ASFFRYSLRRDDNPIPLAEELAHVDSYLAIEEARFGNKLEVIRQVDPATLAFPVPAFTLQPVVENAIKHGLQPRTQGGRV
ILNASDRGADVEVRVTDDGVGIAPEEMNKIFLPGYGRGHGLGLSIVNERLKALYGPEYAVRVKSVPGQGTEVVLRFPKKV
EHREVKEEDDLYRRCG
>Mature_576_residues
MDWSMGLHLAERLSMVATAAFILSRTPALGRILSRQLTNRDRLLLVLVLGGMGIVGTYAGIPIHDALANSRVVGVMVAGL
LGGPFVGAGAGLIAGIHRYLMGGFTAFACGLAAVAEGTLGGLVQQCYRRSPVPWPMAFAAGLVGETMQMVIILLTARPFT
EAWALVQIIGPPMIIVNSIGVAIFMFIVKTAAEQQDHIAACQAQRALDIANQTLPFLRHGLNRESAEEAARIIFNSIKVA
AVAITDRQEILAHVGMGSDHHHPGMPIMTSATLQAIATGELQLARSRGEIGCREKDCRLASAVVVPLKRREATIGTLKLY
HERENSITTVDLELARGLAHLFSTQLELAEVKYQAQLRSQAELKVLQAQIHPHFLFNALNTISSLIRTRPEKARELLAKL
ASFFRYSLRRDDNPIPLAEELAHVDSYLAIEEARFGNKLEVIRQVDPATLAFPVPAFTLQPVVENAIKHGLQPRTQGGRV
ILNASDRGADVEVRVTDDGVGIAPEEMNKIFLPGYGRGHGLGLSIVNERLKALYGPEYAVRVKSVPGQGTEVVLRFPKKV
EHREVKEEDDLYRRCG

Specific function: Member of the two-component regulatory system lytS/lytT that probably regulates genes involved in cell wall metabolism [H]

COG id: COG3275

COG function: function code T; Putative regulator of cell autolysis

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788446, Length=569, Percent_Identity=36.5553602811951, Blast_Score=345, Evalue=3e-96,
Organism=Escherichia coli, GI1788723, Length=564, Percent_Identity=34.3971631205674, Blast_Score=320, Evalue=2e-88,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003018
- InterPro:   IPR010559
- InterPro:   IPR005467
- InterPro:   IPR011620 [H]

Pfam domain/function: PF07694 5TM-5TMR_LYT; PF01590 GAF; PF02518 HATPase_c; PF06580 His_kinase [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 62719; Mature: 62719

Theoretical pI: Translated: 8.76; Mature: 8.76

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDWSMGLHLAERLSMVATAAFILSRTPALGRILSRQLTNRDRLLLVLVLGGMGIVGTYAG
CCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEEECCCCCHHHHCCC
IPIHDALANSRVVGVMVAGLLGGPFVGAGAGLIAGIHRYLMGGFTAFACGLAAVAEGTLG
CCHHHHHCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
GLVQQCYRRSPVPWPMAFAAGLVGETMQMVIILLTARPFTEAWALVQIIGPPMIIVNSIG
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEEHHHHH
VAIFMFIVKTAAEQQDHIAACQAQRALDIANQTLPFLRHGLNRESAEEAARIIFNSIKVA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHEE
AVAITDRQEILAHVGMGSDHHHPGMPIMTSATLQAIATGELQLARSRGEIGCREKDCRLA
EEEECCHHHHHHHHCCCCCCCCCCCCEEHHHHHHHHHCCHHHEECCCCCCCCCCHHHHHH
SAVVVPLKRREATIGTLKLYHERENSITTVDLELARGLAHLFSTQLELAEVKYQAQLRSQ
HHHEEEHHHCCCHHHHEEEEEECCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AELKVLQAQIHPHFLFNALNTISSLIRTRPEKARELLAKLASFFRYSLRRDDNPIPLAEE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
LAHVDSYLAIEEARFGNKLEVIRQVDPATLAFPVPAFTLQPVVENAIKHGLQPRTQGGRV
HHHHHHHHHHHHHHCCCHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHCCCCCCCCCEE
ILNASDRGADVEVRVTDDGVGIAPEEMNKIFLPGYGRGHGLGLSIVNERLKALYGPEYAV
EEECCCCCCEEEEEEECCCCCCCHHHCCEEECCCCCCCCCCHHHHHHHHHHHHHCCCEEE
RVKSVPGQGTEVVLRFPKKVEHREVKEEDDLYRRCG
EEECCCCCCCEEEEECCHHHHHHHCCCHHHHHHHCC
>Mature Secondary Structure
MDWSMGLHLAERLSMVATAAFILSRTPALGRILSRQLTNRDRLLLVLVLGGMGIVGTYAG
CCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEEECCCCCHHHHCCC
IPIHDALANSRVVGVMVAGLLGGPFVGAGAGLIAGIHRYLMGGFTAFACGLAAVAEGTLG
CCHHHHHCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
GLVQQCYRRSPVPWPMAFAAGLVGETMQMVIILLTARPFTEAWALVQIIGPPMIIVNSIG
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEEHHHHH
VAIFMFIVKTAAEQQDHIAACQAQRALDIANQTLPFLRHGLNRESAEEAARIIFNSIKVA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHEE
AVAITDRQEILAHVGMGSDHHHPGMPIMTSATLQAIATGELQLARSRGEIGCREKDCRLA
EEEECCHHHHHHHHCCCCCCCCCCCCEEHHHHHHHHHCCHHHEECCCCCCCCCCHHHHHH
SAVVVPLKRREATIGTLKLYHERENSITTVDLELARGLAHLFSTQLELAEVKYQAQLRSQ
HHHEEEHHHCCCHHHHEEEEEECCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AELKVLQAQIHPHFLFNALNTISSLIRTRPEKARELLAKLASFFRYSLRRDDNPIPLAEE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
LAHVDSYLAIEEARFGNKLEVIRQVDPATLAFPVPAFTLQPVVENAIKHGLQPRTQGGRV
HHHHHHHHHHHHHHCCCHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHCCCCCCCCCEE
ILNASDRGADVEVRVTDDGVGIAPEEMNKIFLPGYGRGHGLGLSIVNERLKALYGPEYAV
EEECCCCCCEEEEEEECCCCCCCHHHCCEEECCCCCCCCCCHHHHHHHHHHHHHCCCEEE
RVKSVPGQGTEVVLRFPKKVEHREVKEEDDLYRRCG
EEECCCCCCCEEEEECCHHHHHHHCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377 [H]