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The map label for this gene is gcvPB [H]

Identifier: 83590774

GI number: 83590774

Start: 2015713

End: 2017170

Strand: Reverse

Name: gcvPB [H]

Synonym: Moth_1942

Alternate gene names: 83590774

Gene position: 2017170-2015713 (Counterclockwise)

Preceding gene: 83590775

Following gene: 83590773

Centisome position: 76.73

GC content: 61.73

Gene sequence:

>1458_bases
ATGAAGACGGAACCCTTACTATTTGAACTCGGTGCCCCCGGAAGGCAAGGTTACACCCTGCCGGAATGTGATGTACCGGG
GAAAGTGGAGGATTACCTCCCCGAAGCAACACGCCGCCGGTCCGATGCTGCCCTGCCGGAATTGAGCGAAGTAGAGGTCG
TCCGCCATTTTACCCATTTATCCACTATGAACTATGGCGTCGATACCGGTTTCTACCCCTTAGGTTCCTGTACCATGAAG
TATAACCCCAAGATCAATGAAGCGACGGCCAACTTGCCAGGCTTTACGGGACTGCACCCGCTGGTGCCGGTTGAGGCGGC
CCAGGGGGCCCTGGAACTCATGTACAACCTGCAGGAGTATCTCGCGGAAATCACCGGCATGGATGCCATCACCCTGCAGC
CGGCCGCCGGCGCCCACGGAGAGTATACCGGCCTGGCTGTCATCGCCGCCTATCATCAGAGCCGCGGTGACCGGGAACGG
CGCCAGGTGCTGGTGCCGGATTCCGCCCATGGCACCAACCCGGCCAGTGCCGCCATGGCCGGCCTGGAGGTAGTCCAGAT
ACCCTCCGACGAGGGGGGGCTAGTGGATCTTGAAGCCCTGAAGGCTGCCGTCGGCCCCAGGACGGCGGCCCTGATGCTGA
CCAACCCCAACACCCTGGGCCTCTTTGAGAGCAATATCGAGGCCATGGCAGCCATCGTCCATGCAGCCGGCGGCCTCCTC
TATTATGACGGCGCCAACCTGAACGCCATCATGGGCCTCACCAGGCCGGGAGATATGGGCTTTGACGTAGTTCACTTAAA
CCTCCACAAGACCTTCTCCACCCCCCACGGCGGCGGTGGTCCCGGCAGCGGCCCGGTGGGGGTGAAGGAGCACCTGGCTG
CCTTCCTGCCGGTGCCGGTGGTGGCTCGCCGGGAGGACGGCCAGTATTACCTGGATTACGACCGGCCCCAGAGCATCGGC
CAGGTACGTTCCTTCTATGGTAATTTCGGCGTCATGGTCAAGGCCTACACCTATATCCGCTCCCTGGGGGCCCCGGGCCT
GAAGAGGGTCAGCCAACAGGCGGTTTTGAATGCCAACTACATGCTGGCGCGCCTCAGGCCCTACTTCAAGGTGCCCTTCG
ACCGGCTGTGCAAGCACGAGTTTGTCATCGCACCGTCCCAGGAGGTAACTGATGCCGGCGTTCATACCCTGGATATAGCC
AAACGCCTCCTGGACTACGGTTTCCATGCGCCTACCATCTACTTCCCCCTCATTGTCCGCGAGGCCATGATGATCGAACC
GACGGAAACGGAGCCCCGGGAGAACCTGGACGCCTTCTGCGACGCTTTGATTGCTATTGCTAAAGAGGCAGTTGAGAACC
CGGAGGCTCTGCACCAGGCGCCCCATAACACCCCAGTGCGGCGCCTGGACGAGGTGGGCGCTGCCAGGAACCCGGTTTTA
CGCTGGCGGGGCAGGTAG

Upstream 100 bases:

>100_bases
TCTATCCCGAACTTAAAAATGCCCTGCTCTTTACCGTAACCGAAGTCCGGACCAGGGAGGAAATAGACGCCCTGGTGGCG
GCCATGAGGGGGATACTGGC

Downstream 100 bases:

>100_bases
TAAAAGACAGGAAGACGATTACTTTTACTATTGGCAGGCTTAAAGCCTGCCGGCTTTTTTATCAGCGTTTTGGCGAACCT
GTACGGCACACCCTCGGTTA

Product: glycine dehydrogenase subunit 2

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 2; Glycine decarboxylase subunit 2 [H]

Number of amino acids: Translated: 485; Mature: 485

Protein sequence:

>485_residues
MKTEPLLFELGAPGRQGYTLPECDVPGKVEDYLPEATRRRSDAALPELSEVEVVRHFTHLSTMNYGVDTGFYPLGSCTMK
YNPKINEATANLPGFTGLHPLVPVEAAQGALELMYNLQEYLAEITGMDAITLQPAAGAHGEYTGLAVIAAYHQSRGDRER
RQVLVPDSAHGTNPASAAMAGLEVVQIPSDEGGLVDLEALKAAVGPRTAALMLTNPNTLGLFESNIEAMAAIVHAAGGLL
YYDGANLNAIMGLTRPGDMGFDVVHLNLHKTFSTPHGGGGPGSGPVGVKEHLAAFLPVPVVARREDGQYYLDYDRPQSIG
QVRSFYGNFGVMVKAYTYIRSLGAPGLKRVSQQAVLNANYMLARLRPYFKVPFDRLCKHEFVIAPSQEVTDAGVHTLDIA
KRLLDYGFHAPTIYFPLIVREAMMIEPTETEPRENLDAFCDALIAIAKEAVENPEALHQAPHNTPVRRLDEVGAARNPVL
RWRGR

Sequences:

>Translated_485_residues
MKTEPLLFELGAPGRQGYTLPECDVPGKVEDYLPEATRRRSDAALPELSEVEVVRHFTHLSTMNYGVDTGFYPLGSCTMK
YNPKINEATANLPGFTGLHPLVPVEAAQGALELMYNLQEYLAEITGMDAITLQPAAGAHGEYTGLAVIAAYHQSRGDRER
RQVLVPDSAHGTNPASAAMAGLEVVQIPSDEGGLVDLEALKAAVGPRTAALMLTNPNTLGLFESNIEAMAAIVHAAGGLL
YYDGANLNAIMGLTRPGDMGFDVVHLNLHKTFSTPHGGGGPGSGPVGVKEHLAAFLPVPVVARREDGQYYLDYDRPQSIG
QVRSFYGNFGVMVKAYTYIRSLGAPGLKRVSQQAVLNANYMLARLRPYFKVPFDRLCKHEFVIAPSQEVTDAGVHTLDIA
KRLLDYGFHAPTIYFPLIVREAMMIEPTETEPRENLDAFCDALIAIAKEAVENPEALHQAPHNTPVRRLDEVGAARNPVL
RWRGR
>Mature_485_residues
MKTEPLLFELGAPGRQGYTLPECDVPGKVEDYLPEATRRRSDAALPELSEVEVVRHFTHLSTMNYGVDTGFYPLGSCTMK
YNPKINEATANLPGFTGLHPLVPVEAAQGALELMYNLQEYLAEITGMDAITLQPAAGAHGEYTGLAVIAAYHQSRGDRER
RQVLVPDSAHGTNPASAAMAGLEVVQIPSDEGGLVDLEALKAAVGPRTAALMLTNPNTLGLFESNIEAMAAIVHAAGGLL
YYDGANLNAIMGLTRPGDMGFDVVHLNLHKTFSTPHGGGGPGSGPVGVKEHLAAFLPVPVVARREDGQYYLDYDRPQSIG
QVRSFYGNFGVMVKAYTYIRSLGAPGLKRVSQQAVLNANYMLARLRPYFKVPFDRLCKHEFVIAPSQEVTDAGVHTLDIA
KRLLDYGFHAPTIYFPLIVREAMMIEPTETEPRENLDAFCDALIAIAKEAVENPEALHQAPHNTPVRRLDEVGAARNPVL
RWRGR

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG1003

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. C-terminal subunit subfamily [H]

Homologues:

Organism=Homo sapiens, GI108773801, Length=433, Percent_Identity=42.7251732101617, Blast_Score=311, Evalue=9e-85,
Organism=Escherichia coli, GI1789269, Length=409, Percent_Identity=44.7432762836186, Blast_Score=303, Evalue=1e-83,
Organism=Caenorhabditis elegans, GI17535605, Length=418, Percent_Identity=44.0191387559809, Blast_Score=300, Evalue=1e-81,
Organism=Caenorhabditis elegans, GI32564013, Length=375, Percent_Identity=45.3333333333333, Blast_Score=277, Evalue=7e-75,
Organism=Saccharomyces cerevisiae, GI6323843, Length=411, Percent_Identity=46.7153284671533, Blast_Score=329, Evalue=7e-91,
Organism=Drosophila melanogaster, GI24645648, Length=413, Percent_Identity=44.5520581113801, Blast_Score=316, Evalue=2e-86,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023012
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF02347 GDC-P [H]

EC number: =1.4.4.2 [H]

Molecular weight: Translated: 52752; Mature: 52752

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTEPLLFELGAPGRQGYTLPECDVPGKVEDYLPEATRRRSDAALPELSEVEVVRHFTHL
CCCCCEEEECCCCCCCCCCCCCCCCCCCHHHHCCHHHHCCCCCCCCCHHHHHHHHHHHHH
STMNYGVDTGFYPLGSCTMKYNPKINEATANLPGFTGLHPLVPVEAAQGALELMYNLQEY
HHHCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
LAEITGMDAITLQPAAGAHGEYTGLAVIAAYHQSRGDRERRQVLVPDSAHGTNPASAAMA
HHHHCCCCEEEECCCCCCCCCCHHHHHHHHHHHCCCCHHHCEEECCCCCCCCCHHHHHHH
GLEVVQIPSDEGGLVDLEALKAAVGPRTAALMLTNPNTLGLFESNIEAMAAIVHAAGGLL
CCEEEEECCCCCCEEEHHHHHHHCCCCEEEEEEECCCCCEEEHHHHHHHHHHHHHCCCEE
YYDGANLNAIMGLTRPGDMGFDVVHLNLHKTFSTPHGGGGPGSGPVGVKEHLAAFLPVPV
EECCCCCEEEEEECCCCCCCEEEEEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHCCCCE
VARREDGQYYLDYDRPQSIGQVRSFYGNFGVMVKAYTYIRSLGAPGLKRVSQQAVLNANY
EEEECCCCEEECCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCHHH
MLARLRPYFKVPFDRLCKHEFVIAPSQEVTDAGVHTLDIAKRLLDYGFHAPTIYFPLIVR
HHHHHCCHHCCCHHHHCCCCEEECCCCHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHH
EAMMIEPTETEPRENLDAFCDALIAIAKEAVENPEALHQAPHNTPVRRLDEVGAARNPVL
HHHEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCHHHHHHHHCCCCCCCE
RWRGR
EECCC
>Mature Secondary Structure
MKTEPLLFELGAPGRQGYTLPECDVPGKVEDYLPEATRRRSDAALPELSEVEVVRHFTHL
CCCCCEEEECCCCCCCCCCCCCCCCCCCHHHHCCHHHHCCCCCCCCCHHHHHHHHHHHHH
STMNYGVDTGFYPLGSCTMKYNPKINEATANLPGFTGLHPLVPVEAAQGALELMYNLQEY
HHHCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
LAEITGMDAITLQPAAGAHGEYTGLAVIAAYHQSRGDRERRQVLVPDSAHGTNPASAAMA
HHHHCCCCEEEECCCCCCCCCCHHHHHHHHHHHCCCCHHHCEEECCCCCCCCCHHHHHHH
GLEVVQIPSDEGGLVDLEALKAAVGPRTAALMLTNPNTLGLFESNIEAMAAIVHAAGGLL
CCEEEEECCCCCCEEEHHHHHHHCCCCEEEEEEECCCCCEEEHHHHHHHHHHHHHCCCEE
YYDGANLNAIMGLTRPGDMGFDVVHLNLHKTFSTPHGGGGPGSGPVGVKEHLAAFLPVPV
EECCCCCEEEEEECCCCCCCEEEEEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHCCCCE
VARREDGQYYLDYDRPQSIGQVRSFYGNFGVMVKAYTYIRSLGAPGLKRVSQQAVLNANY
EEEECCCCEEECCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCHHH
MLARLRPYFKVPFDRLCKHEFVIAPSQEVTDAGVHTLDIAKRLLDYGFHAPTIYFPLIVR
HHHHHCCHHCCCHHHHCCCCEEECCCCHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHH
EAMMIEPTETEPRENLDAFCDALIAIAKEAVENPEALHQAPHNTPVRRLDEVGAARNPVL
HHHEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCHHHHHHHHCCCCCCCE
RWRGR
EECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]