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The map label for this gene is gcvPA

Identifier: 83590775

GI number: 83590775

Start: 2017167

End: 2018501

Strand: Reverse

Name: gcvPA

Synonym: Moth_1943

Alternate gene names: 83590775

Gene position: 2018501-2017167 (Counterclockwise)

Preceding gene: 83590776

Following gene: 83590774

Centisome position: 76.78

GC content: 60.45

Gene sequence:

>1335_bases
ATGACCTACATTCCCACCACGGCGGCGGAACAGCAGCAGATGCTGGCGGCCTGCGGTGCCCACCGGATGGAAGAGCTTTT
TAGTGATGTACCTGCCAGCGTACGCCTGGGCCGGGAGCTCAATCTCCCCCGGCCCATGGCGGAGGCTGAAGTATGGCGCC
ACCTGGAGGAACTGGCCGGGAAGAACAAAAAGCTGGTCTCCTTCCTGGGCGCCGGAGCCTACGAACACTACATTCCCAGC
GTGGTAGGACACCTCCTGGCCCGCTCCGAGTTTTACACGGCCTATACACCCTATCAACCGGAGATCAGTCAGGGGACCCT
CCAGGCTATCTTTGAATTTCAATCGTTAATCTGTGAGCTTACGGGCCTGGATGTAGCCACCGCTTCCCATTACGACGGGG
CCACGGCCATGGCCGAGGCGGCCCTGGTAGCTTGTAACGCCACCCGGCGGCAGAAAATTTTGGTCTCCCGCTCCGTGAAT
CCCCAGTACCGGACCGTCCTGAGCACCTATGCCAAGGGTCAGGGGGTAGAACTGGCGGAGGTGCCCCTGCAGGATGGTCG
GACGGACCTGGAGGCCCTGGAAAAACTGGCGGGCAAGGACGTCGCCGGGGTAATCCTGCAGAATCCCAATTTCTTCGGCC
AGATTGAAGCCATGGCCGAAGCAACTGATCTGGCTCACAAGGCCAGGGCTTTAGGTATTGCCGTCGTCGATCCCGTTTCC
CTGGGGCTGCTGGCGGCTCCGGGGGAATACGGCGCCGATCTGGCCGTAGGCGAGGGCCAGAGTCTGGGTAACCCCTTGAA
CTTCGGCGGTCCCTATTTGGGTTTTATCGCCGCCAGGGAAAAGCTGGTCCGGCGCTTGCCGGGCCGCATCGTCGGCCAGA
CCAAGGACGTGGACGGCAAACGCGCCTATGTCCTGACCCTCCAGGCCCGGGAGCAGCATATTCGCCGGGAAAAGGCGACG
TCCAATATTTGTTCCAATGAAGCCCTCTGCGCCCTGGCGGCCACCATCTACCTTGCCGCCATGGGCCGGGAAGGCCTGAA
GGAGGTGGCCAGCCAGTGCCTGTTGAAGGCCCATTATGCGCAAAAGAAGCTGGCCGCCCTACCAGGGGTAACGCCGGTTT
TTAACGGTCCTTTTTTCCATGAGTTTGTCCTGCAGACAAAGCTTTCACCGGCAACTGTAGCCCGGAGACTGGCGGAAAAT
GGTTTTGCCGCCGGTTTCGACCTGGGTCGCTTCTATCCCGAACTTAAAAATGCCCTGCTCTTTACCGTAACCGAAGTCCG
GACCAGGGAGGAAATAGACGCCCTGGTGGCGGCCATGAGGGGGATACTGGCATGA

Upstream 100 bases:

>100_bases
ATGATTGAACTGGAATTGAGCGATCCGAGTGAAGTAGAAAGCCTCATGGATGCCAGTGCTTACCTGGAACTGGTAAAGGA
GGAGAAGGGGGAGTAAGGGG

Downstream 100 bases:

>100_bases
AGACGGAACCCTTACTATTTGAACTCGGTGCCCCCGGAAGGCAAGGTTACACCCTGCCGGAATGTGATGTACCGGGGAAA
GTGGAGGATTACCTCCCCGA

Product: glycine dehydrogenase subunit 1

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 1; Glycine decarboxylase subunit 1

Number of amino acids: Translated: 444; Mature: 443

Protein sequence:

>444_residues
MTYIPTTAAEQQQMLAACGAHRMEELFSDVPASVRLGRELNLPRPMAEAEVWRHLEELAGKNKKLVSFLGAGAYEHYIPS
VVGHLLARSEFYTAYTPYQPEISQGTLQAIFEFQSLICELTGLDVATASHYDGATAMAEAALVACNATRRQKILVSRSVN
PQYRTVLSTYAKGQGVELAEVPLQDGRTDLEALEKLAGKDVAGVILQNPNFFGQIEAMAEATDLAHKARALGIAVVDPVS
LGLLAAPGEYGADLAVGEGQSLGNPLNFGGPYLGFIAAREKLVRRLPGRIVGQTKDVDGKRAYVLTLQAREQHIRREKAT
SNICSNEALCALAATIYLAAMGREGLKEVASQCLLKAHYAQKKLAALPGVTPVFNGPFFHEFVLQTKLSPATVARRLAEN
GFAAGFDLGRFYPELKNALLFTVTEVRTREEIDALVAAMRGILA

Sequences:

>Translated_444_residues
MTYIPTTAAEQQQMLAACGAHRMEELFSDVPASVRLGRELNLPRPMAEAEVWRHLEELAGKNKKLVSFLGAGAYEHYIPS
VVGHLLARSEFYTAYTPYQPEISQGTLQAIFEFQSLICELTGLDVATASHYDGATAMAEAALVACNATRRQKILVSRSVN
PQYRTVLSTYAKGQGVELAEVPLQDGRTDLEALEKLAGKDVAGVILQNPNFFGQIEAMAEATDLAHKARALGIAVVDPVS
LGLLAAPGEYGADLAVGEGQSLGNPLNFGGPYLGFIAAREKLVRRLPGRIVGQTKDVDGKRAYVLTLQAREQHIRREKAT
SNICSNEALCALAATIYLAAMGREGLKEVASQCLLKAHYAQKKLAALPGVTPVFNGPFFHEFVLQTKLSPATVARRLAEN
GFAAGFDLGRFYPELKNALLFTVTEVRTREEIDALVAAMRGILA
>Mature_443_residues
TYIPTTAAEQQQMLAACGAHRMEELFSDVPASVRLGRELNLPRPMAEAEVWRHLEELAGKNKKLVSFLGAGAYEHYIPSV
VGHLLARSEFYTAYTPYQPEISQGTLQAIFEFQSLICELTGLDVATASHYDGATAMAEAALVACNATRRQKILVSRSVNP
QYRTVLSTYAKGQGVELAEVPLQDGRTDLEALEKLAGKDVAGVILQNPNFFGQIEAMAEATDLAHKARALGIAVVDPVSL
GLLAAPGEYGADLAVGEGQSLGNPLNFGGPYLGFIAAREKLVRRLPGRIVGQTKDVDGKRAYVLTLQAREQHIRREKATS
NICSNEALCALAATIYLAAMGREGLKEVASQCLLKAHYAQKKLAALPGVTPVFNGPFFHEFVLQTKLSPATVARRLAENG
FAAGFDLGRFYPELKNALLFTVTEVRTREEIDALVAAMRGILA

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG0403

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. N-terminal subunit subfamily

Homologues:

Organism=Homo sapiens, GI108773801, Length=343, Percent_Identity=41.399416909621, Blast_Score=266, Evalue=2e-71,
Organism=Escherichia coli, GI1789269, Length=451, Percent_Identity=35.2549889135255, Blast_Score=211, Evalue=6e-56,
Organism=Caenorhabditis elegans, GI17535605, Length=349, Percent_Identity=41.8338108882521, Blast_Score=245, Evalue=4e-65,
Organism=Saccharomyces cerevisiae, GI6323843, Length=355, Percent_Identity=39.4366197183099, Blast_Score=247, Evalue=2e-66,
Organism=Drosophila melanogaster, GI24645648, Length=341, Percent_Identity=40.4692082111437, Blast_Score=265, Evalue=5e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCSPA_MOOTA (Q2RH48)

Other databases:

- EMBL:   CP000232
- RefSeq:   YP_430784.1
- ProteinModelPortal:   Q2RH48
- SMR:   Q2RH48
- STRING:   Q2RH48
- GeneID:   3832435
- GenomeReviews:   CP000232_GR
- KEGG:   mta:Moth_1943
- NMPDR:   fig|264732.9.peg.1952
- eggNOG:   COG0403
- HOGENOM:   HBG288345
- OMA:   VTEKRTK
- ProtClustDB:   PRK00451
- BioCyc:   MTHE264732:MOTH_1943-MONOMER
- HAMAP:   MF_00712
- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023010
- InterPro:   IPR015424
- InterPro:   IPR015421
- Gene3D:   G3DSA:3.40.640.10
- PANTHER:   PTHR11773

Pfam domain/function: PF02347 GDC-P; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =1.4.4.2

Molecular weight: Translated: 48031; Mature: 47900

Theoretical pI: Translated: 7.00; Mature: 7.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYIPTTAAEQQQMLAACGAHRMEELFSDVPASVRLGRELNLPRPMAEAEVWRHLEELAG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHC
KNKKLVSFLGAGAYEHYIPSVVGHLLARSEFYTAYTPYQPEISQGTLQAIFEFQSLICEL
CCHHHHHHHHCCHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCHHHHHHHHHHHHHHHHH
TGLDVATASHYDGATAMAEAALVACNATRRQKILVSRSVNPQYRTVLSTYAKGQGVELAE
HCCCEEECCCCCCHHHHHHHHHHHHCCHHHHHHHEECCCCHHHHHHHHHHHCCCCCEEEE
VPLQDGRTDLEALEKLAGKDVAGVILQNPNFFGQIEAMAEATDLAHKARALGIAVVDPVS
CCCCCCCCHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCEEEECHHH
LGLLAAPGEYGADLAVGEGQSLGNPLNFGGPYLGFIAAREKLVRRLPGRIVGQTKDVDGK
HCEEECCCCCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHCCCCCCCCCC
RAYVLTLQAREQHIRREKATSNICSNEALCALAATIYLAAMGREGLKEVASQCLLKAHYA
EEEEEEEHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHH
QKKLAALPGVTPVFNGPFFHEFVLQTKLSPATVARRLAENGFAAGFDLGRFYPELKNALL
HHHHHHCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHE
FTVTEVRTREEIDALVAAMRGILA
EHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TYIPTTAAEQQQMLAACGAHRMEELFSDVPASVRLGRELNLPRPMAEAEVWRHLEELAG
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHC
KNKKLVSFLGAGAYEHYIPSVVGHLLARSEFYTAYTPYQPEISQGTLQAIFEFQSLICEL
CCHHHHHHHHCCHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCHHHHHHHHHHHHHHHHH
TGLDVATASHYDGATAMAEAALVACNATRRQKILVSRSVNPQYRTVLSTYAKGQGVELAE
HCCCEEECCCCCCHHHHHHHHHHHHCCHHHHHHHEECCCCHHHHHHHHHHHCCCCCEEEE
VPLQDGRTDLEALEKLAGKDVAGVILQNPNFFGQIEAMAEATDLAHKARALGIAVVDPVS
CCCCCCCCHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCEEEECHHH
LGLLAAPGEYGADLAVGEGQSLGNPLNFGGPYLGFIAAREKLVRRLPGRIVGQTKDVDGK
HCEEECCCCCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHCCCCCCCCCC
RAYVLTLQAREQHIRREKATSNICSNEALCALAATIYLAAMGREGLKEVASQCLLKAHYA
EEEEEEEHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHH
QKKLAALPGVTPVFNGPFFHEFVLQTKLSPATVARRLAENGFAAGFDLGRFYPELKNALL
HHHHHHCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHE
FTVTEVRTREEIDALVAAMRGILA
EHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA