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The map label for this gene is cofH [H]

Identifier: 83590678

GI number: 83590678

Start: 1902337

End: 1903419

Strand: Reverse

Name: cofH [H]

Synonym: Moth_1844

Alternate gene names: 83590678

Gene position: 1903419-1902337 (Counterclockwise)

Preceding gene: 83590679

Following gene: 83590677

Centisome position: 72.41

GC content: 58.82

Gene sequence:

>1083_bases
ATGAAAGAAACTATCGCCTGCAAAGTGCTTGACGGTGAGCGTTTGAGTTTTCACGAAGCGGAGCGTCTTTATCAGGAGGC
CGGCCTGCTGGAACTGGGTTACCTGGCCAACCTGGTCCGCCAGAAGCTGCACCCCGAAGGGACGGTCACCTTTGTCGTGG
ACCGGAATATCAACTATACCAATATTTGCGTCAATGCCTGCCGTTTCTGTGCCTTTTATCGCCTGCCCGGGGATCCGGAA
GGCTACCTCCTCAGCCGGGAGGAAATCGGCCGTAAAATCGAGGCGACCCTGGCTGCAGGGGGAACCCAGATCCTGATGCA
GGGGGGCCTGCATCCCGATCTAGACCTGGCCTGGTTTGAGGACCTCTTCTCCTGGATTAAATCCCGCTATCCGGTCACCC
TTCATTCCCTATCTCCGGTAGAAATCGATGACCTGGCCCGGAAGGAAGGGCTGCCGGTGATAGAGGTTTTGCGGCGGCTG
AAGAAAGCAGGCCTCGATTCCCTGCCGGGCGGTGGGGCGGAGATCCTGGTCGACAGGGTTCGCGGCCGGGTTAGCCCCAA
AAAGACCGGTGCGGCCCGCTGGCTGGAAGTGATGCGCGCCGCCCATGCCCTGGGGATGAAATCAACCGCCACCATGGTTT
TCGGGTTGGGGGAAACTATGGCTGAGCGGATCGCTCACCTGGAGGCTATCCGGCAGCTCCAGGATGAAACGGGAGGTTTT
ACAGCCTTCATCCCCTGGAGTTTCCAGCCAGGCAATACCGAACTTGGCGGCGTGGAAGCTAGCACCACCGAATACCTGAA
ACTCCTGGCCCTTTCCCGGCTTTACCTGGATAATATCCCCAATATCCAGGTCTCCTGGGTAACCCAGGGAACCAAGGTGG
CTCAGGCGGCCCTTTTCTTTGGCGCCAACGATTTCGGTTCCACCATGCTGGAGGAAAACGTAGTCCGGGCGGCTGGTGCT
TCCTTCCGTGCCGATCGGGAGGAGATCCTTCGCTGCATCCAGGCGGCCGGTTTCCGGCCCGCCCAGCGCGATAATGAATA
TCATATTTTGCGCTACTACGAGGCAGGGCAGGTTAACCGGTGA

Upstream 100 bases:

>100_bases
GATTGGCCGCACCTGGAGGGGCTTTTAACCTTTTACGGCCTGGCCCATGGGGAAGGATTCCTCGCCCATCCGGTGGCTCT
GGAGATCTGGGGGGTAGACA

Downstream 100 bases:

>100_bases
ACCCATTTCCCTTCCGGCTTCGCCAGAACCCCGGCTTCCCGGGCCTGGGCACCGGTTCCGGGCCATGCCTACCGGTTCAC
CGTGATGGTGAGTGCCTCTA

Product: hypothetical protein

Products: NA

Alternate protein names: 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase subunit 2 [H]

Number of amino acids: Translated: 360; Mature: 360

Protein sequence:

>360_residues
MKETIACKVLDGERLSFHEAERLYQEAGLLELGYLANLVRQKLHPEGTVTFVVDRNINYTNICVNACRFCAFYRLPGDPE
GYLLSREEIGRKIEATLAAGGTQILMQGGLHPDLDLAWFEDLFSWIKSRYPVTLHSLSPVEIDDLARKEGLPVIEVLRRL
KKAGLDSLPGGGAEILVDRVRGRVSPKKTGAARWLEVMRAAHALGMKSTATMVFGLGETMAERIAHLEAIRQLQDETGGF
TAFIPWSFQPGNTELGGVEASTTEYLKLLALSRLYLDNIPNIQVSWVTQGTKVAQAALFFGANDFGSTMLEENVVRAAGA
SFRADREEILRCIQAAGFRPAQRDNEYHILRYYEAGQVNR

Sequences:

>Translated_360_residues
MKETIACKVLDGERLSFHEAERLYQEAGLLELGYLANLVRQKLHPEGTVTFVVDRNINYTNICVNACRFCAFYRLPGDPE
GYLLSREEIGRKIEATLAAGGTQILMQGGLHPDLDLAWFEDLFSWIKSRYPVTLHSLSPVEIDDLARKEGLPVIEVLRRL
KKAGLDSLPGGGAEILVDRVRGRVSPKKTGAARWLEVMRAAHALGMKSTATMVFGLGETMAERIAHLEAIRQLQDETGGF
TAFIPWSFQPGNTELGGVEASTTEYLKLLALSRLYLDNIPNIQVSWVTQGTKVAQAALFFGANDFGSTMLEENVVRAAGA
SFRADREEILRCIQAAGFRPAQRDNEYHILRYYEAGQVNR
>Mature_360_residues
MKETIACKVLDGERLSFHEAERLYQEAGLLELGYLANLVRQKLHPEGTVTFVVDRNINYTNICVNACRFCAFYRLPGDPE
GYLLSREEIGRKIEATLAAGGTQILMQGGLHPDLDLAWFEDLFSWIKSRYPVTLHSLSPVEIDDLARKEGLPVIEVLRRL
KKAGLDSLPGGGAEILVDRVRGRVSPKKTGAARWLEVMRAAHALGMKSTATMVFGLGETMAERIAHLEAIRQLQDETGGF
TAFIPWSFQPGNTELGGVEASTTEYLKLLALSRLYLDNIPNIQVSWVTQGTKVAQAALFFGANDFGSTMLEENVVRAAGA
SFRADREEILRCIQAAGFRPAQRDNEYHILRYYEAGQVNR

Specific function: Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) [H]

COG id: COG1060

COG function: function code HR; Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. CofH family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR019940
- InterPro:   IPR006638
- InterPro:   IPR020050
- InterPro:   IPR005244
- InterPro:   IPR007197 [H]

Pfam domain/function: PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 40049; Mature: 40049

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKETIACKVLDGERLSFHEAERLYQEAGLLELGYLANLVRQKLHPEGTVTFVVDRNINYT
CCCCEEEEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCHH
NICVNACRFCAFYRLPGDPEGYLLSREEIGRKIEATLAAGGTQILMQGGLHPDLDLAWFE
HHHHHHHHHHHHCCCCCCCCCCEECHHHHCCHHHHHHHCCCHHEEEECCCCCCCHHHHHH
DLFSWIKSRYPVTLHSLSPVEIDDLARKEGLPVIEVLRRLKKAGLDSLPGGGAEILVDRV
HHHHHHHCCCCEEEECCCCCCHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHH
RGRVSPKKTGAARWLEVMRAAHALGMKSTATMVFGLGETMAERIAHLEAIRQLQDETGGF
HCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHEEECCHHHHHHHHHHHHHHHHHHHCCCE
TAFIPWSFQPGNTELGGVEASTTEYLKLLALSRLYLDNIPNIQVSWVTQGTKVAQAALFF
EEEEECEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEECCHHHHHHHHHC
GANDFGSTMLEENVVRAAGASFRADREEILRCIQAAGFRPAQRDNEYHILRYYEAGQVNR
CCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCC
>Mature Secondary Structure
MKETIACKVLDGERLSFHEAERLYQEAGLLELGYLANLVRQKLHPEGTVTFVVDRNINYT
CCCCEEEEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCHH
NICVNACRFCAFYRLPGDPEGYLLSREEIGRKIEATLAAGGTQILMQGGLHPDLDLAWFE
HHHHHHHHHHHHCCCCCCCCCCEECHHHHCCHHHHHHHCCCHHEEEECCCCCCCHHHHHH
DLFSWIKSRYPVTLHSLSPVEIDDLARKEGLPVIEVLRRLKKAGLDSLPGGGAEILVDRV
HHHHHHHCCCCEEEECCCCCCHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHH
RGRVSPKKTGAARWLEVMRAAHALGMKSTATMVFGLGETMAERIAHLEAIRQLQDETGGF
HCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHEEECCHHHHHHHHHHHHHHHHHHHCCCE
TAFIPWSFQPGNTELGGVEASTTEYLKLLALSRLYLDNIPNIQVSWVTQGTKVAQAALFF
EEEEECEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEECCHHHHHHHHHC
GANDFGSTMLEENVVRAAGASFRADREEILRCIQAAGFRPAQRDNEYHILRYYEAGQVNR
CCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11930014 [H]