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The map label for this gene is mutS2 [H]

Identifier: 83590547

GI number: 83590547

Start: 1749221

End: 1751626

Strand: Reverse

Name: mutS2 [H]

Synonym: Moth_1711

Alternate gene names: 83590547

Gene position: 1751626-1749221 (Counterclockwise)

Preceding gene: 83590548

Following gene: 83590545

Centisome position: 66.63

GC content: 63.55

Gene sequence:

>2406_bases
TTGGAAATGGGGGCCAAAGGTTTGAATAAGACGTACATTAAACTGGAACTGGATAAAATTCTGGCCCGGCTGGAGGGCTA
TTGCCTATCGCCCCTGGGAGCGGAGAGGGTGCGTGCTCTGGAACCGGTCCGGGACCTGGAACTGGTGCGCCGGCGCCAGG
AAGCAACGGGAGAAGGGGAACGGGTATTGCTGCGCTATCCGGATTTACCCCTGGGTAACTTCCAGGACATCCGGCCGGAG
ATCAACCGGGCGGCAGCCGGAGCCATCCTGGAGGGCCAGGAACTCCTCCGGGTGGCCACCACCCTGGCTGCCGGCCGGCG
CTTGCGCCAGTTCCTCCTGGGGCTGGAGGGCGAGTGGCCGGTTCTTAAAGGGCTGGCCGCCGGGATTGGCGACTTTCGCC
AGCTGGAAAGGGCGATTACGGCCGCCATCGGCCCCGACGGCCTGGTCCTGGACCAGGCCACGCCGCGCCTGGCGAGCCTG
CGGCAGCAGGTTCGCCAGGCCCAGGAGAGGATCAAAGAGCGCCTGGATAGCTACCTGCGTTCAACCGAGATGCAGAAATA
CCTCCAGGATAACCTGTTCACCATTCGCAATGATCGCTATGTCTTACCCGTCAAGCAGGAGTACCGCCACCAGGTACCGG
GGCTGGTTCACGATCAATCGGCCAGCGGGGCCACCCTCTTCATCGAACCCATGGCCCTGGTGGAGTTGAATAACGAACTA
CGCCGTCTCCAGACAGCCGAAGCCAGGGAAGTGGAGGCTATTCTCCTGCACTTGAGTAAACTCGTAGGCGGGCAGAAAGA
AGAAATCCTGGCCAGCCTGGCCGCCCTGGGGGAACTGGATTTTACCCTGGCCAAAGGACGCCTCAGCCAGGCCATGGCCG
CGGTGCCGCCGCGTCTCAATGCCGGGGGGCGCTGGCGTATCCGCCAGGGTCGTCATCCCCTCCTGGGCGGCCGGGTTGTA
CCCGTTAGCCTGACCCTGGGCGAGGATTTTGATACCCTGGTCATTACCGGACCCAACACCGGCGGCAAGACGGTTACTTT
GAAGACCATGGGCCTGTTTACCCTGATGGCCCAGTGCGGCCTGCACCTGCCGGCGGCTGACGGTACCGAAGTCGATGTCA
CGGCAGCCGTCTATGCCGACATCGGTGACGAACAGAGTATCGAGCAATCCCTGAGCACCTTCTCGGCCCACATGCGTCAG
ATTGTGGCCATTGTCAGGGAAGTGGAAGCGGGGAGCCTGGTCCTCCTGGACGAACTGGGAGCCGGTACCGACCCTACTGA
AGGAGCGGCCCTGGCCATGGCCATCCTGGACTACCTGACCGGGGTGGGGGCCCGGACGGTAGCTACCACCCACTTCAGCG
AACTCAAGGCCTACGCCTATGCCACGCCCCGGGTAGAAAACGCCGCCGTGGAGTTTGACAGCGAGACCCTGCAGCCGACT
TATAAGCTCCTCATCGGCACCCCCGGGGAGAGCAACGCCTTCGCCGTTGCCGGTCGTCTGGGACTGCCGCCGGCCCTCAT
CGAACAGGCCCGTGGCTTCCTGAGCGAGGAGAACCGGCGGGTCAGCCGTCTGATCGAGGGACTGACGGCCGACAGGCGGG
CCAGCGCCCGGGAACGGGCCGAGGCCGAATCCTTACGCCGCGAGGCGGAAGCCGCCCGGGAAGCCATGGAAAAGGAACGT
AGGGAGTGGCAGCAGCAGGCTGCCAGGCAATTGGAGAAGGCCCGGGAGGAAGCCCGGGCCATCCTCCGCCGGGCCCGTTA
TGAAGTCAGGGAGCTCATGGCCAGGGTGGAGAAGGCCCTGGCGGAGGAAAGCCTGCGCAGCCAGCAGCAGGTCCTCTCTA
GAGCCCGCCAGCGGTTAAAGGAACTGGAGGATGAGGTAGAAACCGGGATGGAACGCTACCAGCCGGTAGCAGGCGGCCAG
CCGCCGGAGCACCTCCGGGCGGGGGACAGGGTCTTCCTGGCTTCCTGGGGCCAGGTCGGAGAAGTTATCAGCCCTCCTAA
CGAGCAGGGAGAGGTCCTGGTCCAGGTTGGCGCTCTCAAAGTGAATGTGCCGGTAAAGGAGCTTCGCCTGGTTAATAACG
ACCATCACGAAAATAGAACTAAAACTAGAAGGAACGTCGCCGGTGCCGGCTGGACTGTCCAAGCGGCCGTCAATGACGAC
ATCCGGCCGGAAATCGACCTGCGGGGGCTAACCGTAGCCGAAGCCTGCCATCAAGTAGACGAATACCTGGACGACGCCGT
TCTGGCAGGTCTGAACCGGGTAAGTTTAATCCATGGCAAGGGTACCGGCGCCCTACGAGTGGCCCTGCAGGACTACCTGC
GCCAGCACCCCCTGGTCAAGGGCTTTCGCCTGGGCGGGGCCGGGGAAGGTGGCAGCGGGGTGACCATCGTCGATATCGGC
CGTTGA

Upstream 100 bases:

>100_bases
TTTCCGGGGAGTTATTGATGTTTAAATTAACTCCAGCCGGGTGCAACGTCGGCCTTTCCTGTTGACCGCGGCGGTAGATG
AAGTTATCATCAGGACGAGG

Downstream 100 bases:

>100_bases
CCTGGTGCCAGGGATAAAAAAGAGGGGTAGACCCCGGGGAAAATACTCCGGCGTTTACCCCTCTTTAGCCTCTCCCTTTA
TTTTTTGGGTATAGCTATGG

Product: MutS2 family protein

Products: ADP; phosphate; H+

Alternate protein names: NA

Number of amino acids: Translated: 801; Mature: 801

Protein sequence:

>801_residues
MEMGAKGLNKTYIKLELDKILARLEGYCLSPLGAERVRALEPVRDLELVRRRQEATGEGERVLLRYPDLPLGNFQDIRPE
INRAAAGAILEGQELLRVATTLAAGRRLRQFLLGLEGEWPVLKGLAAGIGDFRQLERAITAAIGPDGLVLDQATPRLASL
RQQVRQAQERIKERLDSYLRSTEMQKYLQDNLFTIRNDRYVLPVKQEYRHQVPGLVHDQSASGATLFIEPMALVELNNEL
RRLQTAEAREVEAILLHLSKLVGGQKEEILASLAALGELDFTLAKGRLSQAMAAVPPRLNAGGRWRIRQGRHPLLGGRVV
PVSLTLGEDFDTLVITGPNTGGKTVTLKTMGLFTLMAQCGLHLPAADGTEVDVTAAVYADIGDEQSIEQSLSTFSAHMRQ
IVAIVREVEAGSLVLLDELGAGTDPTEGAALAMAILDYLTGVGARTVATTHFSELKAYAYATPRVENAAVEFDSETLQPT
YKLLIGTPGESNAFAVAGRLGLPPALIEQARGFLSEENRRVSRLIEGLTADRRASARERAEAESLRREAEAAREAMEKER
REWQQQAARQLEKAREEARAILRRARYEVRELMARVEKALAEESLRSQQQVLSRARQRLKELEDEVETGMERYQPVAGGQ
PPEHLRAGDRVFLASWGQVGEVISPPNEQGEVLVQVGALKVNVPVKELRLVNNDHHENRTKTRRNVAGAGWTVQAAVNDD
IRPEIDLRGLTVAEACHQVDEYLDDAVLAGLNRVSLIHGKGTGALRVALQDYLRQHPLVKGFRLGGAGEGGSGVTIVDIG
R

Sequences:

>Translated_801_residues
MEMGAKGLNKTYIKLELDKILARLEGYCLSPLGAERVRALEPVRDLELVRRRQEATGEGERVLLRYPDLPLGNFQDIRPE
INRAAAGAILEGQELLRVATTLAAGRRLRQFLLGLEGEWPVLKGLAAGIGDFRQLERAITAAIGPDGLVLDQATPRLASL
RQQVRQAQERIKERLDSYLRSTEMQKYLQDNLFTIRNDRYVLPVKQEYRHQVPGLVHDQSASGATLFIEPMALVELNNEL
RRLQTAEAREVEAILLHLSKLVGGQKEEILASLAALGELDFTLAKGRLSQAMAAVPPRLNAGGRWRIRQGRHPLLGGRVV
PVSLTLGEDFDTLVITGPNTGGKTVTLKTMGLFTLMAQCGLHLPAADGTEVDVTAAVYADIGDEQSIEQSLSTFSAHMRQ
IVAIVREVEAGSLVLLDELGAGTDPTEGAALAMAILDYLTGVGARTVATTHFSELKAYAYATPRVENAAVEFDSETLQPT
YKLLIGTPGESNAFAVAGRLGLPPALIEQARGFLSEENRRVSRLIEGLTADRRASARERAEAESLRREAEAAREAMEKER
REWQQQAARQLEKAREEARAILRRARYEVRELMARVEKALAEESLRSQQQVLSRARQRLKELEDEVETGMERYQPVAGGQ
PPEHLRAGDRVFLASWGQVGEVISPPNEQGEVLVQVGALKVNVPVKELRLVNNDHHENRTKTRRNVAGAGWTVQAAVNDD
IRPEIDLRGLTVAEACHQVDEYLDDAVLAGLNRVSLIHGKGTGALRVALQDYLRQHPLVKGFRLGGAGEGGSGVTIVDIG
R
>Mature_801_residues
MEMGAKGLNKTYIKLELDKILARLEGYCLSPLGAERVRALEPVRDLELVRRRQEATGEGERVLLRYPDLPLGNFQDIRPE
INRAAAGAILEGQELLRVATTLAAGRRLRQFLLGLEGEWPVLKGLAAGIGDFRQLERAITAAIGPDGLVLDQATPRLASL
RQQVRQAQERIKERLDSYLRSTEMQKYLQDNLFTIRNDRYVLPVKQEYRHQVPGLVHDQSASGATLFIEPMALVELNNEL
RRLQTAEAREVEAILLHLSKLVGGQKEEILASLAALGELDFTLAKGRLSQAMAAVPPRLNAGGRWRIRQGRHPLLGGRVV
PVSLTLGEDFDTLVITGPNTGGKTVTLKTMGLFTLMAQCGLHLPAADGTEVDVTAAVYADIGDEQSIEQSLSTFSAHMRQ
IVAIVREVEAGSLVLLDELGAGTDPTEGAALAMAILDYLTGVGARTVATTHFSELKAYAYATPRVENAAVEFDSETLQPT
YKLLIGTPGESNAFAVAGRLGLPPALIEQARGFLSEENRRVSRLIEGLTADRRASARERAEAESLRREAEAAREAMEKER
REWQQQAARQLEKAREEARAILRRARYEVRELMARVEKALAEESLRSQQQVLSRARQRLKELEDEVETGMERYQPVAGGQ
PPEHLRAGDRVFLASWGQVGEVISPPNEQGEVLVQVGALKVNVPVKELRLVNNDHHENRTKTRRNVAGAGWTVQAAVNDD
IRPEIDLRGLTVAEACHQVDEYLDDAVLAGLNRVSLIHGKGTGALRVALQDYLRQHPLVKGFRLGGAGEGGSGVTIVDIG
R

Specific function: This Protein Is Involved In The Repair Of Mismatches In DNA. It Is Possible That It Carries Out The Mismatch Recognition Step. This Protein Has A Weak Atpase Activity. [C]

COG id: COG1193

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Smr domain [H]

Homologues:

Organism=Homo sapiens, GI36949366, Length=230, Percent_Identity=33.0434782608696, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI4557761, Length=292, Percent_Identity=30.4794520547945, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI284813531, Length=391, Percent_Identity=24.5524296675192, Blast_Score=103, Evalue=5e-22,
Organism=Homo sapiens, GI26638666, Length=231, Percent_Identity=35.4978354978355, Blast_Score=98, Evalue=3e-20,
Organism=Homo sapiens, GI4505253, Length=231, Percent_Identity=35.4978354978355, Blast_Score=98, Evalue=3e-20,
Organism=Homo sapiens, GI26638664, Length=232, Percent_Identity=36.2068965517241, Blast_Score=95, Evalue=3e-19,
Organism=Homo sapiens, GI4504191, Length=282, Percent_Identity=28.7234042553192, Blast_Score=91, Evalue=5e-18,
Organism=Homo sapiens, GI262231786, Length=157, Percent_Identity=40.1273885350318, Blast_Score=89, Evalue=2e-17,
Organism=Escherichia coli, GI1789089, Length=333, Percent_Identity=27.9279279279279, Blast_Score=99, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17508445, Length=407, Percent_Identity=23.8329238329238, Blast_Score=104, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17534743, Length=303, Percent_Identity=26.4026402640264, Blast_Score=98, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17539736, Length=393, Percent_Identity=22.3918575063613, Blast_Score=78, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17508447, Length=243, Percent_Identity=26.7489711934156, Blast_Score=69, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6324482, Length=294, Percent_Identity=27.2108843537415, Blast_Score=103, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6321912, Length=320, Percent_Identity=24.375, Blast_Score=88, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6319935, Length=377, Percent_Identity=25.4641909814324, Blast_Score=86, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6321109, Length=184, Percent_Identity=29.3478260869565, Blast_Score=84, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6320302, Length=284, Percent_Identity=25, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24664545, Length=323, Percent_Identity=26.625386996904, Blast_Score=107, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24584320, Length=238, Percent_Identity=28.5714285714286, Blast_Score=93, Evalue=8e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005747
- InterPro:   IPR000432
- InterPro:   IPR007696
- InterPro:   IPR002625 [H]

Pfam domain/function: PF00488 MutS_V; PF01713 Smr [H]

EC number: 3.6.3.14

Molecular weight: Translated: 88062; Mature: 88062

Theoretical pI: Translated: 6.48; Mature: 6.48

Prosite motif: PS50828 SMR ; PS00486 DNA_MISMATCH_REPAIR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEMGAKGLNKTYIKLELDKILARLEGYCLSPLGAERVRALEPVRDLELVRRRQEATGEGE
CCCCCCCCCCEEEEEEHHHHHHHHCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHCCCCCC
RVLLRYPDLPLGNFQDIRPEINRAAAGAILEGQELLRVATTLAAGRRLRQFLLGLEGEWP
EEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
VLKGLAAGIGDFRQLERAITAAIGPDGLVLDQATPRLASLRQQVRQAQERIKERLDSYLR
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
STEMQKYLQDNLFTIRNDRYVLPVKQEYRHQVPGLVHDQSASGATLFIEPMALVELNNEL
HHHHHHHHHCCCEEEECCCEEEECHHHHHHHCCCCEECCCCCCCEEEECCHHHHHHHHHH
RRLQTAEAREVEAILLHLSKLVGGQKEEILASLAALGELDFTLAKGRLSQAMAAVPPRLN
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCC
AGGRWRIRQGRHPLLGGRVVPVSLTLGEDFDTLVITGPNTGGKTVTLKTMGLFTLMAQCG
CCCCEEECCCCCCCCCCEEEEEEEEECCCCCEEEEECCCCCCCEEEEEHHHHHHHHHHCC
LHLPAADGTEVDVTAAVYADIGDEQSIEQSLSTFSAHMRQIVAIVREVEAGSLVLLDELG
CCCCCCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCC
AGTDPTEGAALAMAILDYLTGVGARTVATTHFSELKAYAYATPRVENAAVEFDSETLQPT
CCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEECCCHHCCCE
YKLLIGTPGESNAFAVAGRLGLPPALIEQARGFLSEENRRVSRLIEGLTADRRASARERA
EEEEEECCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHH
EAESLRREAEAAREAMEKERREWQQQAARQLEKAREEARAILRRARYEVRELMARVEKAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AEESLRSQQQVLSRARQRLKELEDEVETGMERYQPVAGGQPPEHLRAGDRVFLASWGQVG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCEEEEECCCCCC
EVISPPNEQGEVLVQVGALKVNVPVKELRLVNNDHHENRTKTRRNVAGAGWTVQAAVNDD
CCCCCCCCCCCEEEEECCEEECCCHHHHHHHCCCCCCHHHHHHHHCCCCCEEEEEECCCC
IRPEIDLRGLTVAEACHQVDEYLDDAVLAGLNRVSLIHGKGTGALRVALQDYLRQHPLVK
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHCCCCC
GFRLGGAGEGGSGVTIVDIGR
CEECCCCCCCCCCEEEEECCC
>Mature Secondary Structure
MEMGAKGLNKTYIKLELDKILARLEGYCLSPLGAERVRALEPVRDLELVRRRQEATGEGE
CCCCCCCCCCEEEEEEHHHHHHHHCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHCCCCCC
RVLLRYPDLPLGNFQDIRPEINRAAAGAILEGQELLRVATTLAAGRRLRQFLLGLEGEWP
EEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
VLKGLAAGIGDFRQLERAITAAIGPDGLVLDQATPRLASLRQQVRQAQERIKERLDSYLR
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
STEMQKYLQDNLFTIRNDRYVLPVKQEYRHQVPGLVHDQSASGATLFIEPMALVELNNEL
HHHHHHHHHCCCEEEECCCEEEECHHHHHHHCCCCEECCCCCCCEEEECCHHHHHHHHHH
RRLQTAEAREVEAILLHLSKLVGGQKEEILASLAALGELDFTLAKGRLSQAMAAVPPRLN
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCC
AGGRWRIRQGRHPLLGGRVVPVSLTLGEDFDTLVITGPNTGGKTVTLKTMGLFTLMAQCG
CCCCEEECCCCCCCCCCEEEEEEEEECCCCCEEEEECCCCCCCEEEEEHHHHHHHHHHCC
LHLPAADGTEVDVTAAVYADIGDEQSIEQSLSTFSAHMRQIVAIVREVEAGSLVLLDELG
CCCCCCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCC
AGTDPTEGAALAMAILDYLTGVGARTVATTHFSELKAYAYATPRVENAAVEFDSETLQPT
CCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEECCCHHCCCE
YKLLIGTPGESNAFAVAGRLGLPPALIEQARGFLSEENRRVSRLIEGLTADRRASARERA
EEEEEECCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHH
EAESLRREAEAAREAMEKERREWQQQAARQLEKAREEARAILRRARYEVRELMARVEKAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AEESLRSQQQVLSRARQRLKELEDEVETGMERYQPVAGGQPPEHLRAGDRVFLASWGQVG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCEEEEECCCCCC
EVISPPNEQGEVLVQVGALKVNVPVKELRLVNNDHHENRTKTRRNVAGAGWTVQAAVNDD
CCCCCCCCCCCEEEEECCEEECCCHHHHHHHCCCCCCHHHHHHHHCCCCCEEEEEECCCC
IRPEIDLRGLTVAEACHQVDEYLDDAVLAGLNRVSLIHGKGTGALRVALQDYLRQHPLVK
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHCCCCC
GFRLGGAGEGGSGVTIVDIGR
CEECCCCCCCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O; H+

Specific reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out)

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA