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The map label for this gene is tyrS

Identifier: 83590545

GI number: 83590545

Start: 1745040

End: 1746281

Strand: Reverse

Name: tyrS

Synonym: Moth_1709

Alternate gene names: 83590545

Gene position: 1746281-1745040 (Counterclockwise)

Preceding gene: 83590547

Following gene: 83590544

Centisome position: 66.43

GC content: 56.44

Gene sequence:

>1242_bases
TTGCATGATTATTTCGGAGGATGGTTTAAGTTGGAACAAGAAGTCGCACGGCAGTTAAGGATCCTCCGCCGGGGAGTGGC
TGAGATTGTGCCTGAGGAGGATTTGCAGGCCAAACTCAGAAAATCCCTGGCCACCGGTAAACCCTTAAAGGTTAAACTGG
GTTTAGACCCTACGGCCCCGGATATTCATCTGGGTCATACGGTGGTGCTCCAGAAACTGCGCCAGTTTCAGGAATTGGGC
CACCAGGTGATAATCATCATCGGCGATTTTACCGGGCGTATAGGCGATCCCACCGGTAAATCGGAAACCAGGCGCCAGCT
TACAGAAGCAGAAATCCTGGCCAATGCCGAAACCTATAAGGAACAGATTTTTAAAGTACTGGACCCAGAGCAAACCCGGG
TGACCTTTAACAGCCACTGGCTGGGCAAGCTTACCTTTGCCGAAGTCATTGAACTGGCAGCTAGGACGACGGTGGCCCGC
ATGCTGGAGCGGGACGATTTTGCCCGCCGGTTCCAGGAAAATCGTCCTATCAGCATCCATGAGTTTTTTTACCCCCTGAT
GCAGGGTTATGATTCCGTGGCCCTGGCTGCAGATGTCGAACTTGGGGGTACGGATCAGAAGTTTAACCTCCTTATGGGCC
GTCACCTGCAGCGTGAATATGGCCAGGAGCCCCAGGTGGCCATGATGATGCCCATCCTCCCCGGCCTGGACGGCGTACAG
AAGATGAGCAAGAGCCTGGGGAACTATATCGGTATCAAGGAATCCCCCCGGGAGATGTACGGTAAGACCATGTCCCTCCC
TGATGAACTCATGCTCACCTATTACGAGCTGGTGACGGCAGTGCCCCTGGAGGAGCTGGCAGCCATCAGGCAGGGCCTGG
CCAGCGGCAGCCTGCACCCCAGGGATGCCAAAATGCGCCTGGCCCGGGAGATAGTAGCCATGTATCACACTCCGGAAGCG
GCCCTGGAGGCGGAGAGGGAATTTCGCCAGGTCTTCCAGCAGCATGACCTGCCTGATGATATGCCGGAATTAACGATTAA
AGAAGACAGGGTGTGGCTGCCCCGGCTCATGGTCCAGGCCGGGCTGGCTCCCAGCACCAGCGAGGCCCGGCGCCTGATCC
GCCAGGGTGCAGTAAAGATCGACGGTGAACGGGTAACCGATCCTGACACCGAGGTTGAGGTCAGGGAGGGCCAGGTCCTC
CAGGCCGGTAAACGTAAATTTGCCCGGCTGCACACATTTTAA

Upstream 100 bases:

>100_bases
CCCGGCCGCCAGGGGAATGATGATACCTTGAAGGACGGCCGGGGCTTATGCTAAACTTAAGCAAGTGCTACTTAAAAATA
GACGTTGGGGCAGCAAAGAA

Downstream 100 bases:

>100_bases
TCACCCCCTGAGTATACTTCTTATATGGGGGTGATTGCCTTGCGGCGGCGGTGGCGGCGCCCTGGAAGGCGGCCGTGGGG
AGTGGCAGCGCTGGTCCTGG

Product: tyrosyl-tRNA synthetase

Products: NA

Alternate protein names: Tyrosine--tRNA ligase; TyrRS

Number of amino acids: Translated: 413; Mature: 413

Protein sequence:

>413_residues
MHDYFGGWFKLEQEVARQLRILRRGVAEIVPEEDLQAKLRKSLATGKPLKVKLGLDPTAPDIHLGHTVVLQKLRQFQELG
HQVIIIIGDFTGRIGDPTGKSETRRQLTEAEILANAETYKEQIFKVLDPEQTRVTFNSHWLGKLTFAEVIELAARTTVAR
MLERDDFARRFQENRPISIHEFFYPLMQGYDSVALAADVELGGTDQKFNLLMGRHLQREYGQEPQVAMMMPILPGLDGVQ
KMSKSLGNYIGIKESPREMYGKTMSLPDELMLTYYELVTAVPLEELAAIRQGLASGSLHPRDAKMRLAREIVAMYHTPEA
ALEAEREFRQVFQQHDLPDDMPELTIKEDRVWLPRLMVQAGLAPSTSEARRLIRQGAVKIDGERVTDPDTEVEVREGQVL
QAGKRKFARLHTF

Sequences:

>Translated_413_residues
MHDYFGGWFKLEQEVARQLRILRRGVAEIVPEEDLQAKLRKSLATGKPLKVKLGLDPTAPDIHLGHTVVLQKLRQFQELG
HQVIIIIGDFTGRIGDPTGKSETRRQLTEAEILANAETYKEQIFKVLDPEQTRVTFNSHWLGKLTFAEVIELAARTTVAR
MLERDDFARRFQENRPISIHEFFYPLMQGYDSVALAADVELGGTDQKFNLLMGRHLQREYGQEPQVAMMMPILPGLDGVQ
KMSKSLGNYIGIKESPREMYGKTMSLPDELMLTYYELVTAVPLEELAAIRQGLASGSLHPRDAKMRLAREIVAMYHTPEA
ALEAEREFRQVFQQHDLPDDMPELTIKEDRVWLPRLMVQAGLAPSTSEARRLIRQGAVKIDGERVTDPDTEVEVREGQVL
QAGKRKFARLHTF
>Mature_413_residues
MHDYFGGWFKLEQEVARQLRILRRGVAEIVPEEDLQAKLRKSLATGKPLKVKLGLDPTAPDIHLGHTVVLQKLRQFQELG
HQVIIIIGDFTGRIGDPTGKSETRRQLTEAEILANAETYKEQIFKVLDPEQTRVTFNSHWLGKLTFAEVIELAARTTVAR
MLERDDFARRFQENRPISIHEFFYPLMQGYDSVALAADVELGGTDQKFNLLMGRHLQREYGQEPQVAMMMPILPGLDGVQ
KMSKSLGNYIGIKESPREMYGKTMSLPDELMLTYYELVTAVPLEELAAIRQGLASGSLHPRDAKMRLAREIVAMYHTPEA
ALEAEREFRQVFQQHDLPDDMPELTIKEDRVWLPRLMVQAGLAPSTSEARRLIRQGAVKIDGERVTDPDTEVEVREGQVL
QAGKRKFARLHTF

Specific function: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction:tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)

COG id: COG0162

COG function: function code J; Tyrosyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S4 RNA-binding domain

Homologues:

Organism=Homo sapiens, GI94681057, Length=414, Percent_Identity=27.0531400966184, Blast_Score=120, Evalue=2e-27,
Organism=Escherichia coli, GI1787925, Length=387, Percent_Identity=27.6485788113695, Blast_Score=147, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI25145802, Length=387, Percent_Identity=27.906976744186, Blast_Score=110, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6325160, Length=397, Percent_Identity=25.6926952141058, Blast_Score=99, Evalue=1e-21,
Organism=Drosophila melanogaster, GI20130383, Length=427, Percent_Identity=26.2295081967213, Blast_Score=121, Evalue=8e-28,

Paralogues:

None

Copy number: 892 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYY_MOOTA (Q2RHS8)

Other databases:

- EMBL:   CP000232
- RefSeq:   YP_430554.1
- ProteinModelPortal:   Q2RHS8
- SMR:   Q2RHS8
- STRING:   Q2RHS8
- GeneID:   3833159
- GenomeReviews:   CP000232_GR
- KEGG:   mta:Moth_1709
- NMPDR:   fig|264732.9.peg.1709
- eggNOG:   COG0162
- HOGENOM:   HBG288125
- OMA:   YVVQVGK
- PhylomeDB:   Q2RHS8
- ProtClustDB:   PRK05912
- BioCyc:   MTHE264732:MOTH_1709-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_02007
- InterPro:   IPR001412
- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002942
- InterPro:   IPR002307
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR11766
- PRINTS:   PR01040
- SMART:   SM00363
- TIGRFAMs:   TIGR00234

Pfam domain/function: PF01479 S4; PF00579 tRNA-synt_1b

EC number: =6.1.1.1

Molecular weight: Translated: 47024; Mature: 47024

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: PS00178 AA_TRNA_LIGASE_I; PS50889 S4

Important sites: BINDING 244-244

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHDYFGGWFKLEQEVARQLRILRRGVAEIVPEEDLQAKLRKSLATGKPLKVKLGLDPTAP
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEEECCCCCCC
DIHLGHTVVLQKLRQFQELGHQVIIIIGDFTGRIGDPTGKSETRRQLTEAEILANAETYK
CCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
EQIFKVLDPEQTRVTFNSHWLGKLTFAEVIELAARTTVARMLERDDFARRFQENRPISIH
HHHHHHHCCCHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
EFFYPLMQGYDSVALAADVELGGTDQKFNLLMGRHLQREYGQEPQVAMMMPILPGLDGVQ
HHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHH
KMSKSLGNYIGIKESPREMYGKTMSLPDELMLTYYELVTAVPLEELAAIRQGLASGSLHP
HHHHHHHCCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCC
RDAKMRLAREIVAMYHTPEAALEAEREFRQVFQQHDLPDDMPELTIKEDRVWLPRLMVQA
CHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEECCCCHHHHHHHHHH
GLAPSTSEARRLIRQGAVKIDGERVTDPDTEVEVREGQVLQAGKRKFARLHTF
CCCCCHHHHHHHHHHCCEEECCCCCCCCCCCEEECCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MHDYFGGWFKLEQEVARQLRILRRGVAEIVPEEDLQAKLRKSLATGKPLKVKLGLDPTAP
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEEECCCCCCC
DIHLGHTVVLQKLRQFQELGHQVIIIIGDFTGRIGDPTGKSETRRQLTEAEILANAETYK
CCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
EQIFKVLDPEQTRVTFNSHWLGKLTFAEVIELAARTTVARMLERDDFARRFQENRPISIH
HHHHHHHCCCHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
EFFYPLMQGYDSVALAADVELGGTDQKFNLLMGRHLQREYGQEPQVAMMMPILPGLDGVQ
HHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHH
KMSKSLGNYIGIKESPREMYGKTMSLPDELMLTYYELVTAVPLEELAAIRQGLASGSLHP
HHHHHHHCCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCC
RDAKMRLAREIVAMYHTPEAALEAEREFRQVFQQHDLPDDMPELTIKEDRVWLPRLMVQA
CHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEECCCCHHHHHHHHHH
GLAPSTSEARRLIRQGAVKIDGERVTDPDTEVEVREGQVLQAGKRKFARLHTF
CCCCCHHHHHHHHHHCCEEECCCCCCCCCCCEEECCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA