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The map label for this gene is dmsA [H]

Identifier: 83590233

GI number: 83590233

Start: 1431887

End: 1434286

Strand: Reverse

Name: dmsA [H]

Synonym: Moth_1386

Alternate gene names: 83590233

Gene position: 1434286-1431887 (Counterclockwise)

Preceding gene: 83590234

Following gene: 83590232

Centisome position: 54.56

GC content: 55.29

Gene sequence:

>2400_bases
ATGGCTGAGGACACCAAACTGTGGCTCAAGCCCATCTCCAGGCGTAAGTTTTTAACCCTTAGCGCGGCTGCTGCCGGTGG
GGTCGCAGCCCTGACGACATTGATGTGGGAGAAAAAGGCCGGGGCCGTCGCCAGCGGTGCTACCGGTGCGACCGGGGAAA
CTATTATCCCCACCAGTTGCGTGCATAACTGTGGTGGTCGCTGTCCCCTGTATGCCCATGTTAAAGACGGGGTGGTAACC
TGGTTTTCCCCTGATCAGGAGGGAAACGACAGCCCCGATTTCCCCCAGGTCCGCGCTTGCCTGAGGGGACGTTCCCAGAG
GAAACGCCTCTATCACCCCGACCGGTTAAAATACCCCATGAAGCGGGTAGGTAAACGGGGAGAAGGCAAATTTGAAAGGA
TCTCCTGGGATGAGGCTCTGGATACTATTGCCAGAGAGCTACAGCGAATCAAAAGCAACTATGGTAACGAAGCGATCTAT
ATCAATTATGCTACCGGCGTTTATGGCCAGGTCAGCCAGTCCTGGATTACGCCGGCCTTTGGTGGCGCCCTGCCACGTTT
CCTCAATATGTTCGGTGGATACCTGGGGTATTACAACACCTATAGCTCGGCCTGTTTCAGTTATGCCGCTCCATATACCT
TTGGTACGGTAGAAGGTAACAGCCCCGATGACCTTTTAAACTCCAAACTTATCGTTCTCTTTGCCGATAACCCTGGCGAG
ACTCGCCTGGGCGGGGCCAACGGCCATTATTACCTGCGCCTGGCCAAGGAGAAGGGGGCGCGGGTAATTGTTGTCGATCC
CCGTTATACCGACACGGCCGTGACCCTGGCCGACGAATGGATTCCCATTCGACCGACTACGGATAACGCCCTCATTGACG
CCCTGGCCTATGTAATGATTAATGAAAATCTCCATGACCAGGCCTTCCTGGATAAGTACTGCCTGGGTTTCGACGAGGAG
CATATGCCTCCTGGTATCCCGCCCGGCAACTCCTACAAGAGCTATGTCCTGGGTCAGGGCGAAGATAAAACTCCCAAAAC
GCCGGAATGGGCGGAAGCCATCACCGGTGTACCCCGGGACACCATTATCAAACTCGCCCGGCAGATTGCCAGCATAAAAC
CATGCTGTCTCCTGCAGGGCTTTGGCTGGCAACGCCATGCCTACGGTGAACAACCAGTACGGGGCCTGCCAGTCCTGGCG
GCAATGACAGGTAATATCGGCATTCGCGGCGGCGGACCCGGCCTCCGTAACGGCGGGCACGGGGTAGTAGTTGGCTGGAT
GCCGGCCGGGCAAAACCCTGTTAAAGCTTCGATCCCTTGCTTTATGTGGCCGGAGGCTATTGAACGCGGCCATGAACTGA
CTGCCGCCGATGGGGTCAAGGGCGTAGATAAGCTTTCGACGGATATCAAGATGATATGGAATTACGGCGGTAACACCCTT
ATTAACCAGCACTCGGATATTAATAAGACTGCTAAAATCCTGGCCGATGAGAAGAAATGTGAGTTCATCCTTGTTCATGA
TGTCTTCATGACGCCCAGTGCCAGGTTTGCCGATATCCTGCTGCCGGATGTAACCCACTTCGAGCGGGAAGACATTGTTA
CCTTCGCTTCTGGTATCGGTTATGCCATTTATCACCAGAAAGTTGTTGACCCCATGTACGAGTGCCGCAGCCTTTATGAT
GTTTGTAGCGAGCTGGCCAAACGCCTGGGCTTTGGCGACCAGTACACCGAGGGTAAAAGCGAGCAGGATTGGCTGCGGGA
AGCAGTTAACGTTGCCCGGCAAAAGGACCCCAACTTCCCAAGCTTTGAGGAGTTCCGGCGTAAGGGTATCTACAAAATAG
CACCCAAAGACCCCATTGTAGCCTATGAAAAACAGATTAAGGACCCGGCCAACAATCCCTTTCAGACACCTTCGGGTAAG
ATCGAAATTTTTTCAACGCGCTTGTGGGCTATGAACAACCCCAAGGAAATCCCGGCCATCCCCAAGTATATCCCGGCCTG
GGAAGGTCCCCAGGACCCCCTGCGGGCTAAATATCCCCTGCAGTGTATCGGACCCCACTACAAGCGACGGGTTCATTCAA
CCTTTGACAACGTGCCCTGGCTGGAAGAGGCATCCCCGCAGGAGATGTGGATTAACCCCCGGGATGCCGCCGAACGAGGC
CTGAAGGACGGCGATAAAGCGCGGGTTTTCAATGACCGCGGGGAGCTAATAATCCCGGTAAAGGTAACGCCACGGATTAT
GCCCGGGGTGGTGGCCATCCCCCAGGGTGCCTGGTGGACACCGGATAGTAACGGCGTGGACCAGCGGGGCTGCATCAACA
CCCTGACCAAATATCATCCCACGCCCCTGGCCCACGGCAACCCCCAGCATACCAACCTTGTGCAGGTGGCTAAAGCTTAA

Upstream 100 bases:

>100_bases
AATTTTGGTGCCCAGGCCAAAGGGAAAGAAGCGTGGCTGAAAGAATATATGGTCCTACGCTGTGATTGTTAACGCAGTTT
AAAAAAGGAGGAAAGGCAGT

Downstream 100 bases:

>100_bases
AGGGCAGGCCCTGCCTCCCTGGCGGTACCGGGAGAGGTAAGAAAGAGAACGGAGGAGAAAAATATGGCCGGTCAACTAGG
TTTTCATGTACAGCAGGACC

Product: anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE

Products: Reduced form of N-Oxide compounds [C]

Alternate protein names: DMSO reductase [H]

Number of amino acids: Translated: 799; Mature: 798

Protein sequence:

>799_residues
MAEDTKLWLKPISRRKFLTLSAAAAGGVAALTTLMWEKKAGAVASGATGATGETIIPTSCVHNCGGRCPLYAHVKDGVVT
WFSPDQEGNDSPDFPQVRACLRGRSQRKRLYHPDRLKYPMKRVGKRGEGKFERISWDEALDTIARELQRIKSNYGNEAIY
INYATGVYGQVSQSWITPAFGGALPRFLNMFGGYLGYYNTYSSACFSYAAPYTFGTVEGNSPDDLLNSKLIVLFADNPGE
TRLGGANGHYYLRLAKEKGARVIVVDPRYTDTAVTLADEWIPIRPTTDNALIDALAYVMINENLHDQAFLDKYCLGFDEE
HMPPGIPPGNSYKSYVLGQGEDKTPKTPEWAEAITGVPRDTIIKLARQIASIKPCCLLQGFGWQRHAYGEQPVRGLPVLA
AMTGNIGIRGGGPGLRNGGHGVVVGWMPAGQNPVKASIPCFMWPEAIERGHELTAADGVKGVDKLSTDIKMIWNYGGNTL
INQHSDINKTAKILADEKKCEFILVHDVFMTPSARFADILLPDVTHFEREDIVTFASGIGYAIYHQKVVDPMYECRSLYD
VCSELAKRLGFGDQYTEGKSEQDWLREAVNVARQKDPNFPSFEEFRRKGIYKIAPKDPIVAYEKQIKDPANNPFQTPSGK
IEIFSTRLWAMNNPKEIPAIPKYIPAWEGPQDPLRAKYPLQCIGPHYKRRVHSTFDNVPWLEEASPQEMWINPRDAAERG
LKDGDKARVFNDRGELIIPVKVTPRIMPGVVAIPQGAWWTPDSNGVDQRGCINTLTKYHPTPLAHGNPQHTNLVQVAKA

Sequences:

>Translated_799_residues
MAEDTKLWLKPISRRKFLTLSAAAAGGVAALTTLMWEKKAGAVASGATGATGETIIPTSCVHNCGGRCPLYAHVKDGVVT
WFSPDQEGNDSPDFPQVRACLRGRSQRKRLYHPDRLKYPMKRVGKRGEGKFERISWDEALDTIARELQRIKSNYGNEAIY
INYATGVYGQVSQSWITPAFGGALPRFLNMFGGYLGYYNTYSSACFSYAAPYTFGTVEGNSPDDLLNSKLIVLFADNPGE
TRLGGANGHYYLRLAKEKGARVIVVDPRYTDTAVTLADEWIPIRPTTDNALIDALAYVMINENLHDQAFLDKYCLGFDEE
HMPPGIPPGNSYKSYVLGQGEDKTPKTPEWAEAITGVPRDTIIKLARQIASIKPCCLLQGFGWQRHAYGEQPVRGLPVLA
AMTGNIGIRGGGPGLRNGGHGVVVGWMPAGQNPVKASIPCFMWPEAIERGHELTAADGVKGVDKLSTDIKMIWNYGGNTL
INQHSDINKTAKILADEKKCEFILVHDVFMTPSARFADILLPDVTHFEREDIVTFASGIGYAIYHQKVVDPMYECRSLYD
VCSELAKRLGFGDQYTEGKSEQDWLREAVNVARQKDPNFPSFEEFRRKGIYKIAPKDPIVAYEKQIKDPANNPFQTPSGK
IEIFSTRLWAMNNPKEIPAIPKYIPAWEGPQDPLRAKYPLQCIGPHYKRRVHSTFDNVPWLEEASPQEMWINPRDAAERG
LKDGDKARVFNDRGELIIPVKVTPRIMPGVVAIPQGAWWTPDSNGVDQRGCINTLTKYHPTPLAHGNPQHTNLVQVAKA
>Mature_798_residues
AEDTKLWLKPISRRKFLTLSAAAAGGVAALTTLMWEKKAGAVASGATGATGETIIPTSCVHNCGGRCPLYAHVKDGVVTW
FSPDQEGNDSPDFPQVRACLRGRSQRKRLYHPDRLKYPMKRVGKRGEGKFERISWDEALDTIARELQRIKSNYGNEAIYI
NYATGVYGQVSQSWITPAFGGALPRFLNMFGGYLGYYNTYSSACFSYAAPYTFGTVEGNSPDDLLNSKLIVLFADNPGET
RLGGANGHYYLRLAKEKGARVIVVDPRYTDTAVTLADEWIPIRPTTDNALIDALAYVMINENLHDQAFLDKYCLGFDEEH
MPPGIPPGNSYKSYVLGQGEDKTPKTPEWAEAITGVPRDTIIKLARQIASIKPCCLLQGFGWQRHAYGEQPVRGLPVLAA
MTGNIGIRGGGPGLRNGGHGVVVGWMPAGQNPVKASIPCFMWPEAIERGHELTAADGVKGVDKLSTDIKMIWNYGGNTLI
NQHSDINKTAKILADEKKCEFILVHDVFMTPSARFADILLPDVTHFEREDIVTFASGIGYAIYHQKVVDPMYECRSLYDV
CSELAKRLGFGDQYTEGKSEQDWLREAVNVARQKDPNFPSFEEFRRKGIYKIAPKDPIVAYEKQIKDPANNPFQTPSGKI
EIFSTRLWAMNNPKEIPAIPKYIPAWEGPQDPLRAKYPLQCIGPHYKRRVHSTFDNVPWLEEASPQEMWINPRDAAERGL
KDGDKARVFNDRGELIIPVKVTPRIMPGVVAIPQGAWWTPDSNGVDQRGCINTLTKYHPTPLAHGNPQHTNLVQVAKA

Specific function: Terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds. Allows E.coli to grow anaerobically on Me(2)SO as respiratory oxidant [H]

COG id: COG0243

COG function: function code C; Anaerobic dehydrogenases, typically selenocysteine-containing

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI87081797, Length=804, Percent_Identity=53.2338308457711, Blast_Score=831, Evalue=0.0,
Organism=Escherichia coli, GI1787870, Length=809, Percent_Identity=50.4326328800989, Blast_Score=793, Evalue=0.0,
Organism=Escherichia coli, GI171474008, Length=802, Percent_Identity=48.7531172069825, Blast_Score=764, Evalue=0.0,
Organism=Escherichia coli, GI145693196, Length=748, Percent_Identity=32.2192513368984, Blast_Score=307, Evalue=2e-84,
Organism=Escherichia coli, GI87081994, Length=847, Percent_Identity=30.6965761511216, Blast_Score=282, Evalue=7e-77,
Organism=Escherichia coli, GI1787231, Length=759, Percent_Identity=30.8300395256917, Blast_Score=268, Evalue=1e-72,
Organism=Escherichia coli, GI3868721, Length=677, Percent_Identity=26.1447562776957, Blast_Score=162, Evalue=9e-41,
Organism=Escherichia coli, GI3868720, Length=490, Percent_Identity=26.530612244898, Blast_Score=107, Evalue=4e-24,
Organism=Escherichia coli, GI3868719, Length=477, Percent_Identity=24.1090146750524, Blast_Score=94, Evalue=5e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011888
- InterPro:   IPR009010
- InterPro:   IPR006657
- InterPro:   IPR006656
- InterPro:   IPR006963
- InterPro:   IPR006655
- InterPro:   IPR006311 [H]

Pfam domain/function: PF04879 Molybdop_Fe4S4; PF00384 Molybdopterin; PF01568 Molydop_binding [H]

EC number: 1.8.99.- [C]

Molecular weight: Translated: 88760; Mature: 88629

Theoretical pI: Translated: 8.19; Mature: 8.19

Prosite motif: PS00551 MOLYBDOPTERIN_PROK_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEDTKLWLKPISRRKFLTLSAAAAGGVAALTTLMWEKKAGAVASGATGATGETIIPTSC
CCCCHHHHHHHCCCCEEEEEEHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHH
VHNCGGRCPLYAHVKDGVVTWFSPDQEGNDSPDFPQVRACLRGRSQRKRLYHPDRLKYPM
HHHCCCCCCEEEEECCCEEEEECCCCCCCCCCCHHHHHHHHCCCHHHHHCCCCHHCCCHH
KRVGKRGEGKFERISWDEALDTIARELQRIKSNYGNEAIYINYATGVYGQVSQSWITPAF
HHCCCCCCCCEEECCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHCCCHH
GGALPRFLNMFGGYLGYYNTYSSACFSYAAPYTFGTVEGNSPDDLLNSKLIVLFADNPGE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHCCCEEEEEECCCCC
TRLGGANGHYYLRLAKEKGARVIVVDPRYTDTAVTLADEWIPIRPTTDNALIDALAYVMI
CCCCCCCCEEEEEEECCCCCEEEEECCCCCCCEEEEECCCEECCCCCCHHHHHHHHHHHH
NENLHDQAFLDKYCLGFDEEHMPPGIPPGNSYKSYVLGQGEDKTPKTPEWAEAITGVPRD
CCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCHHHHHHCCCCHH
TIIKLARQIASIKPCCLLQGFGWQRHAYGEQPVRGLPVLAAMTGNIGIRGGGPGLRNGGH
HHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCEEEEEECCEEEECCCCCCCCCCC
GVVVGWMPAGQNPVKASIPCFMWPEAIERGHELTAADGVKGVDKLSTDIKMIWNYGGNTL
EEEEEEECCCCCCCCCCCCCEECHHHHHCCCCEECCCCCCHHHHHHHCCEEEEECCCCEE
INQHSDINKTAKILADEKKCEFILVHDVFMTPSARFADILLPDVTHFEREDIVTFASGIG
ECCCCCHHHHHHHHCCCCCCCEEEEEEEEECCCCHHHHHHCCCCHHCCHHHHHHHHHCCC
YAIYHQKVVDPMYECRSLYDVCSELAKRLGFGDQYTEGKSEQDWLREAVNVARQKDPNFP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCC
SFEEFRRKGIYKIAPKDPIVAYEKQIKDPANNPFQTPSGKIEIFSTRLWAMNNPKEIPAI
CHHHHHHCCCEEECCCCCCHHHHHHHCCCCCCCCCCCCCCEEEEEEEEEECCCCCCCCCC
PKYIPAWEGPQDPLRAKYPLQCIGPHYKRRVHSTFDNVPWLEEASPQEMWINPRDAAERG
CCCCCCCCCCCCCCCCCCCHHHCCHHHHHHHHHHHCCCCCCCCCCCHHEECCCHHHHHCC
LKDGDKARVFNDRGELIIPVKVTPRIMPGVVAIPQGAWWTPDSNGVDQRGCINTLTKYHP
CCCCCCEEEECCCCCEEEEEEECCCCCCCEEECCCCCEECCCCCCCCCHHHHHHHHHCCC
TPLAHGNPQHTNLVQVAKA
CCCCCCCCCCCCCEEEECC
>Mature Secondary Structure 
AEDTKLWLKPISRRKFLTLSAAAAGGVAALTTLMWEKKAGAVASGATGATGETIIPTSC
CCCHHHHHHHCCCCEEEEEEHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHH
VHNCGGRCPLYAHVKDGVVTWFSPDQEGNDSPDFPQVRACLRGRSQRKRLYHPDRLKYPM
HHHCCCCCCEEEEECCCEEEEECCCCCCCCCCCHHHHHHHHCCCHHHHHCCCCHHCCCHH
KRVGKRGEGKFERISWDEALDTIARELQRIKSNYGNEAIYINYATGVYGQVSQSWITPAF
HHCCCCCCCCEEECCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHCCCHH
GGALPRFLNMFGGYLGYYNTYSSACFSYAAPYTFGTVEGNSPDDLLNSKLIVLFADNPGE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHCCCEEEEEECCCCC
TRLGGANGHYYLRLAKEKGARVIVVDPRYTDTAVTLADEWIPIRPTTDNALIDALAYVMI
CCCCCCCCEEEEEEECCCCCEEEEECCCCCCCEEEEECCCEECCCCCCHHHHHHHHHHHH
NENLHDQAFLDKYCLGFDEEHMPPGIPPGNSYKSYVLGQGEDKTPKTPEWAEAITGVPRD
CCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCHHHHHHCCCCHH
TIIKLARQIASIKPCCLLQGFGWQRHAYGEQPVRGLPVLAAMTGNIGIRGGGPGLRNGGH
HHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCEEEEEECCEEEECCCCCCCCCCC
GVVVGWMPAGQNPVKASIPCFMWPEAIERGHELTAADGVKGVDKLSTDIKMIWNYGGNTL
EEEEEEECCCCCCCCCCCCCEECHHHHHCCCCEECCCCCCHHHHHHHCCEEEEECCCCEE
INQHSDINKTAKILADEKKCEFILVHDVFMTPSARFADILLPDVTHFEREDIVTFASGIG
ECCCCCHHHHHHHHCCCCCCCEEEEEEEEECCCCHHHHHHCCCCHHCCHHHHHHHHHCCC
YAIYHQKVVDPMYECRSLYDVCSELAKRLGFGDQYTEGKSEQDWLREAVNVARQKDPNFP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCC
SFEEFRRKGIYKIAPKDPIVAYEKQIKDPANNPFQTPSGKIEIFSTRLWAMNNPKEIPAI
CHHHHHHCCCEEECCCCCCHHHHHHHCCCCCCCCCCCCCCEEEEEEEEEECCCCCCCCCC
PKYIPAWEGPQDPLRAKYPLQCIGPHYKRRVHSTFDNVPWLEEASPQEMWINPRDAAERG
CCCCCCCCCCCCCCCCCCCHHHCCHHHHHHHHHHHCCCCCCCCCCCHHEECCCHHHHHCC
LKDGDKARVFNDRGELIIPVKVTPRIMPGVVAIPQGAWWTPDSNGVDQRGCINTLTKYHP
CCCCCCEEEECCCCCEEEEEEECCCCCCCEEECCCCCEECCCCCCCCCHHHHHHHHHCCC
TPLAHGNPQHTNLVQVAKA
CCCCCCCCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: May Bind 4Fe-4S Cluster. [C]

Metal ions: Fe; Mo [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: N-Oxide; Sulfoxide Compounds Including Trimethylamine N-Oxide. [C]

Specific reaction: Reduces Various N-Oxide And Sulfoxide Compounds Including Trimethylamine N-Oxide. [C]

General reaction: Oxidoreductases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3062312; 8905232; 9278503; 2170332; 8125918; 10801884 [H]