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The map label for this gene is trpF

Identifier: 83590185

GI number: 83590185

Start: 1384522

End: 1385193

Strand: Reverse

Name: trpF

Synonym: Moth_1338

Alternate gene names: 83590185

Gene position: 1385193-1384522 (Counterclockwise)

Preceding gene: 83590186

Following gene: 83590184

Centisome position: 52.69

GC content: 59.52

Gene sequence:

>672_bases
GTGGTCAGAGTAAAAATCTGCGGCATCCGGGATTGGGAAGAAGCCCGGATGGTTCTCGACGCGGGCGTAGACACCTTGGG
CTTTGTTTTCGCCAGGAGTCCCAGGGCGATCAAGCCGGAAGCCGCCCGGGAGATAATCACCAAGCTGCCACCCTTCACCA
CCACGGTTGGTGTATTTGTCAACGAACCACGCTATAGCCTAATGGAGATAGCCTCCTTTTGCCGCCTGGATGTCCTGCAG
CTCCACGGCGACGAGCCGCCCGAGTACTGTCACGGTCTTTCCCAGCGTTTGATTAAAGCCATTCGGGTACGTGACGCCGC
TTCCCTGGCCAGCCTGGAGGCTTACCGGGAGGTCCAGGGATTTCTCCTGGACGCCTGGGTCCCGGGAAAAGCCGGGGGTA
CCGGTACGACCTTTAATTGGGAACTGGTACGGGGGGCAGCAACGGGTGGTAAACCGGTAATTCTTGCCGGCGGCCTGACC
CCTGAGAATGTCGGCGCTGCCATTCAGTTGGTACACCCTTACGCCGTCGATGTCTCCAGCGGGGTAGAAGTGGACGGCCG
TAAAAACCCGGCCCGGATAGCCGCCTTTCTGGAGGCAGTGAGGAAAGCTGAGGAGCACCATGTGCGCCCAACCGCCAGCA
GTTGCTGTACGGGATTGAAGGGGGATTTTTGA

Upstream 100 bases:

>100_bases
TGGGCGAGGCCCTGATGACAGCCGGGGACGTTATGGCTAAGATGGCCGAACTACGGCTTGCTATCTAGCTCCGATCATTT
TTTGGGTGGAGGAAAAGAAT

Downstream 100 bases:

>100_bases
TGACATTACCAGATAAACAGGGTCATTTTGGCCCCTATGGCGGGCGGTTTGTACCCGAAACCCTCATGCCGGCCCTGGAA
GAGATAGAACAGGCTTACCG

Product: phosphoribosylanthranilate isomerase

Products: NA

Alternate protein names: PRAI

Number of amino acids: Translated: 223; Mature: 223

Protein sequence:

>223_residues
MVRVKICGIRDWEEARMVLDAGVDTLGFVFARSPRAIKPEAAREIITKLPPFTTTVGVFVNEPRYSLMEIASFCRLDVLQ
LHGDEPPEYCHGLSQRLIKAIRVRDAASLASLEAYREVQGFLLDAWVPGKAGGTGTTFNWELVRGAATGGKPVILAGGLT
PENVGAAIQLVHPYAVDVSSGVEVDGRKNPARIAAFLEAVRKAEEHHVRPTASSCCTGLKGDF

Sequences:

>Translated_223_residues
MVRVKICGIRDWEEARMVLDAGVDTLGFVFARSPRAIKPEAAREIITKLPPFTTTVGVFVNEPRYSLMEIASFCRLDVLQ
LHGDEPPEYCHGLSQRLIKAIRVRDAASLASLEAYREVQGFLLDAWVPGKAGGTGTTFNWELVRGAATGGKPVILAGGLT
PENVGAAIQLVHPYAVDVSSGVEVDGRKNPARIAAFLEAVRKAEEHHVRPTASSCCTGLKGDF
>Mature_223_residues
MVRVKICGIRDWEEARMVLDAGVDTLGFVFARSPRAIKPEAAREIITKLPPFTTTVGVFVNEPRYSLMEIASFCRLDVLQ
LHGDEPPEYCHGLSQRLIKAIRVRDAASLASLEAYREVQGFLLDAWVPGKAGGTGTTFNWELVRGAATGGKPVILAGGLT
PENVGAAIQLVHPYAVDVSSGVEVDGRKNPARIAAFLEAVRKAEEHHVRPTASSCCTGLKGDF

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0135

COG function: function code E; Phosphoribosylanthranilate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpF family

Homologues:

Organism=Escherichia coli, GI87081863, Length=200, Percent_Identity=32, Blast_Score=81, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6320210, Length=215, Percent_Identity=33.4883720930233, Blast_Score=103, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPF_MOOTA (Q2RIT8)

Other databases:

- EMBL:   CP000232
- RefSeq:   YP_430194.1
- ProteinModelPortal:   Q2RIT8
- SMR:   Q2RIT8
- STRING:   Q2RIT8
- GeneID:   3831895
- GenomeReviews:   CP000232_GR
- KEGG:   mta:Moth_1338
- NMPDR:   fig|264732.9.peg.1333
- eggNOG:   COG0135
- HOGENOM:   HBG554803
- OMA:   SKICGIT
- PhylomeDB:   Q2RIT8
- BioCyc:   MTHE264732:MOTH_1338-MONOMER
- HAMAP:   MF_00135_B
- InterPro:   IPR013785
- InterPro:   IPR001240
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00697 PRAI; SSF51366 RibP_bind_barrel

EC number: =5.3.1.24

Molecular weight: Translated: 24112; Mature: 24112

Theoretical pI: Translated: 7.46; Mature: 7.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVRVKICGIRDWEEARMVLDAGVDTLGFVFARSPRAIKPEAAREIITKLPPFTTTVGVFV
CEEEEEECCCCHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCEEEEEEE
NEPRYSLMEIASFCRLDVLQLHGDEPPEYCHGLSQRLIKAIRVRDAASLASLEAYREVQG
CCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLLDAWVPGKAGGTGTTFNWELVRGAATGGKPVILAGGLTPENVGAAIQLVHPYAVDVSS
HEEEEECCCCCCCCCCEEEEEEEEECCCCCCEEEEECCCCCCCCCCEEEEECCEEEECCC
GVEVDGRKNPARIAAFLEAVRKAEEHHVRPTASSCCTGLKGDF
CCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCC
>Mature Secondary Structure
MVRVKICGIRDWEEARMVLDAGVDTLGFVFARSPRAIKPEAAREIITKLPPFTTTVGVFV
CEEEEEECCCCHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCEEEEEEE
NEPRYSLMEIASFCRLDVLQLHGDEPPEYCHGLSQRLIKAIRVRDAASLASLEAYREVQG
CCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLLDAWVPGKAGGTGTTFNWELVRGAATGGKPVILAGGLTPENVGAAIQLVHPYAVDVSS
HEEEEECCCCCCCCCCEEEEEEEEECCCCCCEEEEECCCCCCCCCCEEEEECCEEEECCC
GVEVDGRKNPARIAAFLEAVRKAEEHHVRPTASSCCTGLKGDF
CCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA