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The map label for this gene is hom [H]

Identifier: 83590154

GI number: 83590154

Start: 1350196

End: 1351494

Strand: Reverse

Name: hom [H]

Synonym: Moth_1307

Alternate gene names: 83590154

Gene position: 1351494-1350196 (Counterclockwise)

Preceding gene: 83590155

Following gene: 83590153

Centisome position: 51.41

GC content: 56.89

Gene sequence:

>1299_bases
GTGTTGGGACCAATCAATCTTGGCCTTCTGGGCCTGGGTACTGTTGGCAGCGGTGTGGTCCGGTTGCTGGAGCAGAACAA
AGCCATCATTACCCAGAAATTGGGCCAGCCTTTAAATATTAAACGCATCCTGGTCCGGGATTTAAACCGCCCTCGTCAGG
TGGCAGTCGATCCAGCCTTGCTGACAACCGACCCGGATACCATCCTGGGTGATCCAGATATCCCTATTATCGTCGAGGTC
ATGGGGGGTACCGGGACGGCCAGAGAGTACATCCTCCAGGCTCTAAGCCGGGGTAAAAGTGTGGTTACGGCCAACAAGGA
TCTCCTCGCCCTTTATGGCAAGGAGCTTTTTGATGCCGCCGACGCCCATGGGGCCGACCTCCTCTTTGAAGCCAGCGTAG
GAGGGGGGATACCCATTATTCGCCCCCTGAAGGAATGCCTGGCGGGTAACCGGATTCGTCAGGTCATGGGCATCATTAAT
GGTACCACCAACTATATCTTGACCAAGATGAGCCGCGAAGGCCGCGACTTTAACGACGTTCTAAAGGAAGCCCAGTCCTT
GGGTTACGCCGAAGCCGATCCTACGTCCGATATTGAAGGCGATGATGCCGCACGTAAAATGGCCATCCTCGCTTCCATAG
CCTTCGGTACCCGGATTACTTACCCGGAGGTTTACCGGGAGGGTATAGGCCGCCTGTCGTCCCATGACATCAACTACGCC
AGGGATATGGGCTATGCCGTCAAGCTCCTGGGCATCGCCCGGGAAGACGAGGACGGGATCGAGGTGCGGGTCCACCCGGC
TCTGGTACCCCTGAATCACCCCCTGGCCTCGGTTAGCGATGTTTTTAACGCCATCTTCGTGGAAGGCGACGCCGTGGGCG
AGACGATGTTTTACGGCCGCGGAGCCGGTTCCCTGCCGACTGCCAGCGCCGTTGTCGGGGACATTATTGAAGGGGCCCGT
AACCTCCAGCATCACGACCGGGGCCGGATATCCTGCACTTGTTTTTATGATAAACCCCTAAAACCGATAGGAGCAATTAT
TACTAAATATTACCTCCGCCTGGTAGTCGTCGACCGACCGGGAGTCCTGGCTACCATTGCCGGGATTTTCGGCGAGCGTG
AAGTCAGCCTGGCCTCGGTCATCCAGGAACGGATGCTTGGCGACCTGGCGGAACTGGTGCTTATTACCCACCGCGTCCGG
GAAAAGAATGTCCGGGAAGCCCTGGAGGTTTTAGGCAGCCTGCCGGTGGTCAAAGAGATAGCCAGCGTAATAAGGGTAGA
AGGAGGAGAAGCCAGGTGA

Upstream 100 bases:

>100_bases
AAGAAACAAGTCCATAGGACAGTGAATATGCCTGCTTAAAAAAGTATTGCCCATCTGACTGCTATACGGTAAAATTGAGG
GGTATAAGGGGAGTGAAACA

Downstream 100 bases:

>100_bases
ACTGGCCCGGAGTTATTCGTGCCTACCGGGAGTTCCTGCCGGTGACGGAGGCGACTCCCTTGATTACTTTAGAGGAGGGG
AATACCCCCCTGATTGCCGC

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 432; Mature: 432

Protein sequence:

>432_residues
MLGPINLGLLGLGTVGSGVVRLLEQNKAIITQKLGQPLNIKRILVRDLNRPRQVAVDPALLTTDPDTILGDPDIPIIVEV
MGGTGTAREYILQALSRGKSVVTANKDLLALYGKELFDAADAHGADLLFEASVGGGIPIIRPLKECLAGNRIRQVMGIIN
GTTNYILTKMSREGRDFNDVLKEAQSLGYAEADPTSDIEGDDAARKMAILASIAFGTRITYPEVYREGIGRLSSHDINYA
RDMGYAVKLLGIAREDEDGIEVRVHPALVPLNHPLASVSDVFNAIFVEGDAVGETMFYGRGAGSLPTASAVVGDIIEGAR
NLQHHDRGRISCTCFYDKPLKPIGAIITKYYLRLVVVDRPGVLATIAGIFGEREVSLASVIQERMLGDLAELVLITHRVR
EKNVREALEVLGSLPVVKEIASVIRVEGGEAR

Sequences:

>Translated_432_residues
MLGPINLGLLGLGTVGSGVVRLLEQNKAIITQKLGQPLNIKRILVRDLNRPRQVAVDPALLTTDPDTILGDPDIPIIVEV
MGGTGTAREYILQALSRGKSVVTANKDLLALYGKELFDAADAHGADLLFEASVGGGIPIIRPLKECLAGNRIRQVMGIIN
GTTNYILTKMSREGRDFNDVLKEAQSLGYAEADPTSDIEGDDAARKMAILASIAFGTRITYPEVYREGIGRLSSHDINYA
RDMGYAVKLLGIAREDEDGIEVRVHPALVPLNHPLASVSDVFNAIFVEGDAVGETMFYGRGAGSLPTASAVVGDIIEGAR
NLQHHDRGRISCTCFYDKPLKPIGAIITKYYLRLVVVDRPGVLATIAGIFGEREVSLASVIQERMLGDLAELVLITHRVR
EKNVREALEVLGSLPVVKEIASVIRVEGGEAR
>Mature_432_residues
MLGPINLGLLGLGTVGSGVVRLLEQNKAIITQKLGQPLNIKRILVRDLNRPRQVAVDPALLTTDPDTILGDPDIPIIVEV
MGGTGTAREYILQALSRGKSVVTANKDLLALYGKELFDAADAHGADLLFEASVGGGIPIIRPLKECLAGNRIRQVMGIIN
GTTNYILTKMSREGRDFNDVLKEAQSLGYAEADPTSDIEGDDAARKMAILASIAFGTRITYPEVYREGIGRLSSHDINYA
RDMGYAVKLLGIAREDEDGIEVRVHPALVPLNHPLASVSDVFNAIFVEGDAVGETMFYGRGAGSLPTASAVVGDIIEGAR
NLQHHDRGRISCTCFYDKPLKPIGAIITKYYLRLVVVDRPGVLATIAGIFGEREVSLASVIQERMLGDLAELVLITHRVR
EKNVREALEVLGSLPVVKEIASVIRVEGGEAR

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=268, Percent_Identity=31.3432835820896, Blast_Score=85, Evalue=9e-18,
Organism=Escherichia coli, GI1790376, Length=356, Percent_Identity=26.123595505618, Blast_Score=77, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6322599, Length=238, Percent_Identity=29.8319327731092, Blast_Score=84, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 46573; Mature: 46573

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLGPINLGLLGLGTVGSGVVRLLEQNKAIITQKLGQPLNIKRILVRDLNRPRQVAVDPAL
CCCCCCCCEEECCHHHHHHHHHHHHCHHHHHHHCCCCCCHHHHHHHHCCCCCEEEECCEE
LTTDPDTILGDPDIPIIVEVMGGTGTAREYILQALSRGKSVVTANKDLLALYGKELFDAA
EECCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHC
DAHGADLLFEASVGGGIPIIRPLKECLAGNRIRQVMGIINGTTNYILTKMSREGRDFNDV
CCCCCCEEEEECCCCCCHHHHHHHHHHCCHHHHHHHHHHCCCHHHHEEHHHHCCCCHHHH
LKEAQSLGYAEADPTSDIEGDDAARKMAILASIAFGTRITYPEVYREGIGRLSSHDINYA
HHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCHH
RDMGYAVKLLGIAREDEDGIEVRVHPALVPLNHPLASVSDVFNAIFVEGDAVGETMFYGR
HHHCHHHHEEEEECCCCCCCEEEEEEEEEECCCCHHHHHHHHHHHEECCCCCCCHHEECC
GAGSLPTASAVVGDIIEGARNLQHHDRGRISCTCFYDKPLKPIGAIITKYYLRLVVVDRP
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHEEEEECCC
GVLATIAGIFGEREVSLASVIQERMLGDLAELVLITHRVREKNVREALEVLGSLPVVKEI
CHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
ASVIRVEGGEAR
HHHHCCCCCCCC
>Mature Secondary Structure
MLGPINLGLLGLGTVGSGVVRLLEQNKAIITQKLGQPLNIKRILVRDLNRPRQVAVDPAL
CCCCCCCCEEECCHHHHHHHHHHHHCHHHHHHHCCCCCCHHHHHHHHCCCCCEEEECCEE
LTTDPDTILGDPDIPIIVEVMGGTGTAREYILQALSRGKSVVTANKDLLALYGKELFDAA
EECCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHC
DAHGADLLFEASVGGGIPIIRPLKECLAGNRIRQVMGIINGTTNYILTKMSREGRDFNDV
CCCCCCEEEEECCCCCCHHHHHHHHHHCCHHHHHHHHHHCCCHHHHEEHHHHCCCCHHHH
LKEAQSLGYAEADPTSDIEGDDAARKMAILASIAFGTRITYPEVYREGIGRLSSHDINYA
HHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCHH
RDMGYAVKLLGIAREDEDGIEVRVHPALVPLNHPLASVSDVFNAIFVEGDAVGETMFYGR
HHHCHHHHEEEEECCCCCCCEEEEEEEEEECCCCHHHHHHHHHHHEECCCCCCCHHEECC
GAGSLPTASAVVGDIIEGARNLQHHDRGRISCTCFYDKPLKPIGAIITKYYLRLVVVDRP
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHEEEEECCC
GVLATIAGIFGEREVSLASVIQERMLGDLAELVLITHRVREKNVREALEVLGSLPVVKEI
CHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
ASVIRVEGGEAR
HHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]