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The map label for this gene is thrC [H]

Identifier: 83590153

GI number: 83590153

Start: 1349153

End: 1350199

Strand: Reverse

Name: thrC [H]

Synonym: Moth_1306

Alternate gene names: 83590153

Gene position: 1350199-1349153 (Counterclockwise)

Preceding gene: 83590154

Following gene: 83590152

Centisome position: 51.36

GC content: 57.88

Gene sequence:

>1047_bases
GTGAACTGGCCCGGAGTTATTCGTGCCTACCGGGAGTTCCTGCCGGTGACGGAGGCGACTCCCTTGATTACTTTAGAGGA
GGGGAATACCCCCCTGATTGCCGCCGGGAACCTTTCCCGGGAACTGGGGCTAAAACTATACTTCAAGTATGAAGGCCTCA
ACCCGAGCGGTTCCTTTAAGGATCGGGGCATGGTCATGGCTGTCGCCAAGGCCATGGAGAACGGTTCCAAGGCCATAATG
TGCGCTTCCACGGGCAACACCTCGGCTTCGGCAGCGGCCTATGCCGCAAGATGTGGTTTAAAATGCAGCGTCCTGATCCC
TGAGGGCAATATCGCCCTGGGAAAACTCGCCCAGGCCCTTTTTTATGGGGCCAGGGTCATAGCTATCCAGGGCAATTTTG
ACGATGCCCTGACCCTGGTGCGCAACATCACCTCCCGTTACCCCATTACTCTGGTTAATTCCATCAATCCCTTCCGCATT
GAAGGGCAAAAAACGGCCGCCTTCGAGATCTGCGACGTGCTGGGGGAGGCTCCGGATTACCTGGCCATTCCTGTAGGTAA
CGCCGGCAATATCACTGCCTATTGGAAGGGCTTTAACGAGTATTACCAGGCCGGCCGTAGCCATACCCTGCCGAAGATGA
TCGGCTTCCAGGCCGAAGGCGCAGCACCCATTGTGCGGGGAGAAGTAGTGCCGAACCCGGAAACCGTAGCCACGGCCATC
CGCATCGGCAACCCGGCCAGCTGGCAACCGGCCGTCCGGGCAGCTAAAGACTCTGGCGGGTTTATCGATTGCGTGAGTGA
TGACGAAATCCTGGCAGCCCAGCGCCTGCTGGCAACGGCGGAAGGCATCTTCGCCGAACCGGCTTCCGCCGCCTCCCTGG
CCGGGGTGCTCAAGTATGCTAAAAAGGGTTATTTCCATAAGGATGATAGGGTGGTGTGCGTCCTCACCGGGCATGGCCTT
AAAGATCCCAACATCGCCATCAAACAGGTAGGCGAGCCCATCTCCCTGCCGGTGGATGAAGCCAGGGTTCTGGAGATCGT
ACTATAA

Upstream 100 bases:

>100_bases
TCCGGGAAAAGAATGTCCGGGAAGCCCTGGAGGTTTTAGGCAGCCTGCCGGTGGTCAAAGAGATAGCCAGCGTAATAAGG
GTAGAAGGAGGAGAAGCCAG

Downstream 100 bases:

>100_bases
AAAAGTCATAAAAAATAAAGGGGCATGGGAAATATGCCGCTGGTACGGGTACCAGCTACGACGGCCAACTTGGGACCGGG
GTTTGATACCCTGGGCATGG

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 348; Mature: 348

Protein sequence:

>348_residues
MNWPGVIRAYREFLPVTEATPLITLEEGNTPLIAAGNLSRELGLKLYFKYEGLNPSGSFKDRGMVMAVAKAMENGSKAIM
CASTGNTSASAAAYAARCGLKCSVLIPEGNIALGKLAQALFYGARVIAIQGNFDDALTLVRNITSRYPITLVNSINPFRI
EGQKTAAFEICDVLGEAPDYLAIPVGNAGNITAYWKGFNEYYQAGRSHTLPKMIGFQAEGAAPIVRGEVVPNPETVATAI
RIGNPASWQPAVRAAKDSGGFIDCVSDDEILAAQRLLATAEGIFAEPASAASLAGVLKYAKKGYFHKDDRVVCVLTGHGL
KDPNIAIKQVGEPISLPVDEARVLEIVL

Sequences:

>Translated_348_residues
MNWPGVIRAYREFLPVTEATPLITLEEGNTPLIAAGNLSRELGLKLYFKYEGLNPSGSFKDRGMVMAVAKAMENGSKAIM
CASTGNTSASAAAYAARCGLKCSVLIPEGNIALGKLAQALFYGARVIAIQGNFDDALTLVRNITSRYPITLVNSINPFRI
EGQKTAAFEICDVLGEAPDYLAIPVGNAGNITAYWKGFNEYYQAGRSHTLPKMIGFQAEGAAPIVRGEVVPNPETVATAI
RIGNPASWQPAVRAAKDSGGFIDCVSDDEILAAQRLLATAEGIFAEPASAASLAGVLKYAKKGYFHKDDRVVCVLTGHGL
KDPNIAIKQVGEPISLPVDEARVLEIVL
>Mature_348_residues
MNWPGVIRAYREFLPVTEATPLITLEEGNTPLIAAGNLSRELGLKLYFKYEGLNPSGSFKDRGMVMAVAKAMENGSKAIM
CASTGNTSASAAAYAARCGLKCSVLIPEGNIALGKLAQALFYGARVIAIQGNFDDALTLVRNITSRYPITLVNSINPFRI
EGQKTAAFEICDVLGEAPDYLAIPVGNAGNITAYWKGFNEYYQAGRSHTLPKMIGFQAEGAAPIVRGEVVPNPETVATAI
RIGNPASWQPAVRAAKDSGGFIDCVSDDEILAAQRLLATAEGIFAEPASAASLAGVLKYAKKGYFHKDDRVVCVLTGHGL
KDPNIAIKQVGEPISLPVDEARVLEIVL

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=303, Percent_Identity=27.3927392739274, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI33469958, Length=273, Percent_Identity=26.007326007326, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI2367138, Length=314, Percent_Identity=27.3885350318471, Blast_Score=72, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17508781, Length=313, Percent_Identity=24.9201277955272, Blast_Score=68, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6322631, Length=294, Percent_Identity=26.530612244898, Blast_Score=71, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 37034; Mature: 37034

Theoretical pI: Translated: 6.76; Mature: 6.76

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNWPGVIRAYREFLPVTEATPLITLEEGNTPLIAAGNLSRELGLKLYFKYEGLNPSGSFK
CCCHHHHHHHHHHCCCCCCCCEEEEECCCCCEEEECCCCCCCCEEEEEEEECCCCCCCCC
DRGMVMAVAKAMENGSKAIMCASTGNTSASAAAYAARCGLKCSVLIPEGNIALGKLAQAL
CCCHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHH
FYGARVIAIQGNFDDALTLVRNITSRYPITLVNSINPFRIEGQKTAAFEICDVLGEAPDY
HCCEEEEEEECCCHHHHHHHHHHHCCCCEEEECCCCCEEECCCCHHHHHHHHHHCCCCCE
LAIPVGNAGNITAYWKGFNEYYQAGRSHTLPKMIGFQAEGAAPIVRGEVVPNPETVATAI
EEEEECCCCCEEEEECCHHHHHHCCCCCCCHHHHCCCCCCCCCEEECCCCCCCHHEEEEE
RIGNPASWQPAVRAAKDSGGFIDCVSDDEILAAQRLLATAEGIFAEPASAASLAGVLKYA
EECCCCCCCHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
KKGYFHKDDRVVCVLTGHGLKDPNIAIKQVGEPISLPVDEARVLEIVL
HCCCCCCCCCEEEEEECCCCCCCCHHHHHCCCCCCCCCCCCEEEEEEC
>Mature Secondary Structure
MNWPGVIRAYREFLPVTEATPLITLEEGNTPLIAAGNLSRELGLKLYFKYEGLNPSGSFK
CCCHHHHHHHHHHCCCCCCCCEEEEECCCCCEEEECCCCCCCCEEEEEEEECCCCCCCCC
DRGMVMAVAKAMENGSKAIMCASTGNTSASAAAYAARCGLKCSVLIPEGNIALGKLAQAL
CCCHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHH
FYGARVIAIQGNFDDALTLVRNITSRYPITLVNSINPFRIEGQKTAAFEICDVLGEAPDY
HCCEEEEEEECCCHHHHHHHHHHHCCCCEEEECCCCCEEECCCCHHHHHHHHHHCCCCCE
LAIPVGNAGNITAYWKGFNEYYQAGRSHTLPKMIGFQAEGAAPIVRGEVVPNPETVATAI
EEEEECCCCCEEEEECCHHHHHHCCCCCCCHHHHCCCCCCCCCEEECCCCCCCHHEEEEE
RIGNPASWQPAVRAAKDSGGFIDCVSDDEILAAQRLLATAEGIFAEPASAASLAGVLKYA
EECCCCCCCHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
KKGYFHKDDRVVCVLTGHGLKDPNIAIKQVGEPISLPVDEARVLEIVL
HCCCCCCCCCEEEEEECCCCCCCCHHHHHCCCCCCCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3098560; 9384377; 3139660 [H]