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The map label for this gene is thrB

Identifier: 83590152

GI number: 83590152

Start: 1348229

End: 1349119

Strand: Reverse

Name: thrB

Synonym: Moth_1305

Alternate gene names: 83590152

Gene position: 1349119-1348229 (Counterclockwise)

Preceding gene: 83590153

Following gene: 83590151

Centisome position: 51.32

GC content: 60.94

Gene sequence:

>891_bases
ATGCCGCTGGTACGGGTACCAGCTACGACGGCCAACTTGGGACCGGGGTTTGATACCCTGGGCATGGCCCTTAATCTTTT
TGATGAGCTTAAAATTGAAGAATCCAGTTCACCGGAGATTATCATCACCGGCGAGGGGGAGGGTACCATACCCCGGGGCC
AGGAGAATATTGCCTACCGGGCCGCCCGGGCCGTCTTTGCCAAGGTGGGGCGGCCGCCAGTACCCCTGAAGCTGGAAATG
CACAACTCCATCCCGGTGGCCAGGGGCCTGGGGTCCAGCGCCGCTGCTCTGGTCGGGGCTATCGTAGGAACCAATGCCAT
ACTGGGAGGACCTTTGGGCCCGGCTGAGCTGGTAAATCTGGCCACAACCCTCGAGGGGCATCCTGATAACGTGGCCCCGG
CTATTTTAGGCGGCCTGGTAGCCTCCGCCAGGGACGGGGAACAGGTCATATGCCGGCGCCTGGAACTACCGCCAGGTTTA
GTCACCGTAGTTGCAATACCCCAATTCACCCTTTCCACCCGGATCTCTAGGGGCGTACTGCCGGCTAAAGTAGACCTGGA
AGACGCGGTATTTAACATCAGCCGGGTAGCCGTGCTCCTGGCCGCCGTTGCTACCGGAGACCTGGACCTCATGGGCAGGA
TGATGGTCGACAAACTGCATCAGCCGTACCGGTTACCCCTAATACCCGGGATGGCCGAGGTCTTTGCAGCTGCCCGGGAA
GCCGGCGCCCTGGCTGTTACCCTGAGCGGTTCCGGCCCCACGGTAATTGCCTTTTGCCGCGGCCGGCAACCGAAGGTGGG
ACCGGCTATGGCCGCGGCCTTCGCCCGTAAGGGGGTAAAATGTACCGTCAAAGAACTGGCCCCTTGTAACCACGGGGCAG
TAGTCATTTGA

Upstream 100 bases:

>100_bases
CAAACAGGTAGGCGAGCCCATCTCCCTGCCGGTGGATGAAGCCAGGGTTCTGGAGATCGTACTATAAAAAAGTCATAAAA
AATAAAGGGGCATGGGAAAT

Downstream 100 bases:

>100_bases
GATTCCGGAGGAGGTTACTATGGCCCTCATCGTCCAAAAGTACGGCGGCACTTCCGTTAACGGCCCGGAACGGGTCAAAA
ACGTAGCCCGCCGGGTAGTA

Product: homoserine kinase

Products: NA

Alternate protein names: HK; HSK

Number of amino acids: Translated: 296; Mature: 295

Protein sequence:

>296_residues
MPLVRVPATTANLGPGFDTLGMALNLFDELKIEESSSPEIIITGEGEGTIPRGQENIAYRAARAVFAKVGRPPVPLKLEM
HNSIPVARGLGSSAAALVGAIVGTNAILGGPLGPAELVNLATTLEGHPDNVAPAILGGLVASARDGEQVICRRLELPPGL
VTVVAIPQFTLSTRISRGVLPAKVDLEDAVFNISRVAVLLAAVATGDLDLMGRMMVDKLHQPYRLPLIPGMAEVFAAARE
AGALAVTLSGSGPTVIAFCRGRQPKVGPAMAAAFARKGVKCTVKELAPCNHGAVVI

Sequences:

>Translated_296_residues
MPLVRVPATTANLGPGFDTLGMALNLFDELKIEESSSPEIIITGEGEGTIPRGQENIAYRAARAVFAKVGRPPVPLKLEM
HNSIPVARGLGSSAAALVGAIVGTNAILGGPLGPAELVNLATTLEGHPDNVAPAILGGLVASARDGEQVICRRLELPPGL
VTVVAIPQFTLSTRISRGVLPAKVDLEDAVFNISRVAVLLAAVATGDLDLMGRMMVDKLHQPYRLPLIPGMAEVFAAARE
AGALAVTLSGSGPTVIAFCRGRQPKVGPAMAAAFARKGVKCTVKELAPCNHGAVVI
>Mature_295_residues
PLVRVPATTANLGPGFDTLGMALNLFDELKIEESSSPEIIITGEGEGTIPRGQENIAYRAARAVFAKVGRPPVPLKLEMH
NSIPVARGLGSSAAALVGAIVGTNAILGGPLGPAELVNLATTLEGHPDNVAPAILGGLVASARDGEQVICRRLELPPGLV
TVVAIPQFTLSTRISRGVLPAKVDLEDAVFNISRVAVLLAAVATGDLDLMGRMMVDKLHQPYRLPLIPGMAEVFAAAREA
GALAVTLSGSGPTVIAFCRGRQPKVGPAMAAAFARKGVKCTVKELAPCNHGAVVI

Specific function: Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate

COG id: COG0083

COG function: function code E; Homoserine kinase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Homoserine kinase subfamily

Homologues:

Organism=Escherichia coli, GI1786184, Length=272, Percent_Identity=31.25, Blast_Score=128, Evalue=4e-31,
Organism=Saccharomyces cerevisiae, GI6321814, Length=348, Percent_Identity=33.0459770114943, Blast_Score=167, Evalue=2e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KHSE_MOOTA (Q2RIX1)

Other databases:

- EMBL:   CP000232
- RefSeq:   YP_430161.1
- HSSP:   Q58504
- ProteinModelPortal:   Q2RIX1
- SMR:   Q2RIX1
- STRING:   Q2RIX1
- GeneID:   3831791
- GenomeReviews:   CP000232_GR
- KEGG:   mta:Moth_1305
- NMPDR:   fig|264732.9.peg.1299
- eggNOG:   COG0083
- HOGENOM:   HBG646290
- OMA:   FDCLGAA
- PhylomeDB:   Q2RIX1
- ProtClustDB:   PRK01212
- BioCyc:   MTHE264732:MOTH_1305-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00384
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR000870
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.230.10
- PIRSF:   PIRSF000676
- PRINTS:   PR00958
- TIGRFAMs:   TIGR00191

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =2.7.1.39

Molecular weight: Translated: 30545; Mature: 30414

Theoretical pI: Translated: 8.34; Mature: 8.34

Prosite motif: PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLVRVPATTANLGPGFDTLGMALNLFDELKIEESSSPEIIITGEGEGTIPRGQENIAYR
CCEEECCCCCCCCCCCHHHHHHHHHHHHHHEECCCCCCCEEEECCCCCCCCCCCHHHHHH
AARAVFAKVGRPPVPLKLEMHNSIPVARGLGSSAAALVGAIVGTNAILGGPLGPAELVNL
HHHHHHHHCCCCCCCEEEEECCCCCHHHCCCCHHHHHHHHHHHCCCEECCCCCHHHHHHH
ATTLEGHPDNVAPAILGGLVASARDGEQVICRRLELPPGLVTVVAIPQFTLSTRISRGVL
HHHCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHCCCCCEEEEEECCCHHHHHHHHCCCC
PAKVDLEDAVFNISRVAVLLAAVATGDLDLMGRMMVDKLHQPYRLPLIPGMAEVFAAARE
CCEECHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEECCCCCCHHHHHHHHHC
AGALAVTLSGSGPTVIAFCRGRQPKVGPAMAAAFARKGVKCTVKELAPCNHGAVVI
CCEEEEEECCCCCEEEEEECCCCCCCCHHHHHHHHHCCCEEEHHHCCCCCCCCEEC
>Mature Secondary Structure 
PLVRVPATTANLGPGFDTLGMALNLFDELKIEESSSPEIIITGEGEGTIPRGQENIAYR
CEEECCCCCCCCCCCHHHHHHHHHHHHHHEECCCCCCCEEEECCCCCCCCCCCHHHHHH
AARAVFAKVGRPPVPLKLEMHNSIPVARGLGSSAAALVGAIVGTNAILGGPLGPAELVNL
HHHHHHHHCCCCCCCEEEEECCCCCHHHCCCCHHHHHHHHHHHCCCEECCCCCHHHHHHH
ATTLEGHPDNVAPAILGGLVASARDGEQVICRRLELPPGLVTVVAIPQFTLSTRISRGVL
HHHCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHCCCCCEEEEEECCCHHHHHHHHCCCC
PAKVDLEDAVFNISRVAVLLAAVATGDLDLMGRMMVDKLHQPYRLPLIPGMAEVFAAARE
CCEECHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEECCCCCCHHHHHHHHHC
AGALAVTLSGSGPTVIAFCRGRQPKVGPAMAAAFARKGVKCTVKELAPCNHGAVVI
CCEEEEEECCCCCEEEEEECCCCCCCCHHHHHHHHHCCCEEEHHHCCCCCCCCEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA