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The map label for this gene is hemL

Identifier: 83590092

GI number: 83590092

Start: 1284613

End: 1285926

Strand: Reverse

Name: hemL

Synonym: Moth_1244

Alternate gene names: 83590092

Gene position: 1285926-1284613 (Counterclockwise)

Preceding gene: 83590093

Following gene: 83590088

Centisome position: 48.92

GC content: 60.81

Gene sequence:

>1314_bases
TTGACTGATTCGGAAGCCTGGCCCCGCTCGGCAGCCGCCTTTGCCGAGGCTGTCAAACTCATGCCAGGCGGCGTCAACAG
CCCGGTACGGGCTTTTAAATCCGTAGGCCTGACCCCGCCCTTTATCCAGCGGGGAGAGGGGGCCTATCTCTATGATATAG
ACGGCCATAAGTATATCGACTACGTTTCTTCCTGGGGTCCCCTGATCCTGGGGCACCGCCATCCGGAGGTCGTAGACGCC
CTGGAAAAAACCCTGCGCGAGATGGGGACCAGCTTCGGCGCCCCTACGGAATTGGAAAACGAGCTGGCCCGGGAAATCAC
TACCGCCATGCCGGCCGTAGAGATGGTCCGCCTGGTAAATTCCGGTACGGAGGCGACCATGAGCGCCCTGCGCCTGGCCC
GGGGTTATACCGGCCGGGAAAAGGTCGTCAAGTTTGCCGGTTGTTACCACGGCCATGCCGACTACTTCCTCATCCAGGCC
GGTTCCGGAGCCCTGACCTTCGGCATTCCCAACAGCCCTGGCGTCCCGGCAACCGTAGCCGCCAACACCATCGTCGCCCC
CTATAACGACCTGGCGGCCGTGGAGGATATCTTCCAGAAGGCAGGGGAAGAGATTGCCGCCGTGATCGTTGAGCCTGTAG
CCGGTAACATGGGTTGTGTGCCACCCCTGACGGGTTTCCTGGCCGGGTTAAGGACCATAACGAAAGAATACGGCAGCCTG
TTAATCTTCGATGAAGTAATGACCGGTTTCCGCGTTGCCTTTGGCGGCGCCCAGGCCCTCTATGGCATTAGACCTGATCT
CACCTGCCTGGGCAAGATTATCGGCGGCGGCCTACCGGTAGGAGCCTACGGCGGCCGGCGGGAGATCATGGAGAGGGTGG
CCCCGTCGGGGCCGATCTACCAGGCCGGCACCCTGTCCGGCAACCCCCTGGCCGTAAGCGCCGGTCTGGCCACCCTGAAG
GTATTAAAAAAACCAGGCACTTACGAACGCCTGGAAAGTCTCTCCGCCCGCCTGGAAAAGGGACTTAAGGAAGCTGCTGC
AGAGGCCGGGGTGCCGGTAACCTTCAACCGAGTGGGAGCCATGTTCACTACCTTCTTCAACCCGGGACCGGTAACGGATT
ATGCCACAGCCACAGCCAGCGACACCAGGGCCTTTGCCGCCTTTTTCCGGGCTATGTTGCGTCAGGGCATTTACCTGGCC
CCCTCCCAGTTTGAGGCTGCCTTCATGTCCCTGGCCCATAGGGAGGATGACATCGACTGCACCATCGCCGCCGCCCGTGA
GGCTTTTAAAGGGATTGCCATTGGTGATAGCTAA

Upstream 100 bases:

>100_bases
CTGGTGCCTCTACCAGGGCCGGCAGGACGCGGCGGCGCACGACAATTAAATCCCGCCGTGCGATAATCGGAGAATAAATA
TTGGGAAGGTGGGATCATCC

Downstream 100 bases:

>100_bases
CCGTTGGTGCAATGATAACACCAATCGCTGCCCCCGAATCGGTTTATAAAAAATTTTTCTGGTAACCATGTATAACATTT
ACCGGGGAGGTTATACTAGG

Product: glutamate-1-semialdehyde 2,1-aminomutase

Products: NA

Alternate protein names: GSA; Glutamate-1-semialdehyde aminotransferase; GSA-AT

Number of amino acids: Translated: 437; Mature: 436

Protein sequence:

>437_residues
MTDSEAWPRSAAAFAEAVKLMPGGVNSPVRAFKSVGLTPPFIQRGEGAYLYDIDGHKYIDYVSSWGPLILGHRHPEVVDA
LEKTLREMGTSFGAPTELENELAREITTAMPAVEMVRLVNSGTEATMSALRLARGYTGREKVVKFAGCYHGHADYFLIQA
GSGALTFGIPNSPGVPATVAANTIVAPYNDLAAVEDIFQKAGEEIAAVIVEPVAGNMGCVPPLTGFLAGLRTITKEYGSL
LIFDEVMTGFRVAFGGAQALYGIRPDLTCLGKIIGGGLPVGAYGGRREIMERVAPSGPIYQAGTLSGNPLAVSAGLATLK
VLKKPGTYERLESLSARLEKGLKEAAAEAGVPVTFNRVGAMFTTFFNPGPVTDYATATASDTRAFAAFFRAMLRQGIYLA
PSQFEAAFMSLAHREDDIDCTIAAAREAFKGIAIGDS

Sequences:

>Translated_437_residues
MTDSEAWPRSAAAFAEAVKLMPGGVNSPVRAFKSVGLTPPFIQRGEGAYLYDIDGHKYIDYVSSWGPLILGHRHPEVVDA
LEKTLREMGTSFGAPTELENELAREITTAMPAVEMVRLVNSGTEATMSALRLARGYTGREKVVKFAGCYHGHADYFLIQA
GSGALTFGIPNSPGVPATVAANTIVAPYNDLAAVEDIFQKAGEEIAAVIVEPVAGNMGCVPPLTGFLAGLRTITKEYGSL
LIFDEVMTGFRVAFGGAQALYGIRPDLTCLGKIIGGGLPVGAYGGRREIMERVAPSGPIYQAGTLSGNPLAVSAGLATLK
VLKKPGTYERLESLSARLEKGLKEAAAEAGVPVTFNRVGAMFTTFFNPGPVTDYATATASDTRAFAAFFRAMLRQGIYLA
PSQFEAAFMSLAHREDDIDCTIAAAREAFKGIAIGDS
>Mature_436_residues
TDSEAWPRSAAAFAEAVKLMPGGVNSPVRAFKSVGLTPPFIQRGEGAYLYDIDGHKYIDYVSSWGPLILGHRHPEVVDAL
EKTLREMGTSFGAPTELENELAREITTAMPAVEMVRLVNSGTEATMSALRLARGYTGREKVVKFAGCYHGHADYFLIQAG
SGALTFGIPNSPGVPATVAANTIVAPYNDLAAVEDIFQKAGEEIAAVIVEPVAGNMGCVPPLTGFLAGLRTITKEYGSLL
IFDEVMTGFRVAFGGAQALYGIRPDLTCLGKIIGGGLPVGAYGGRREIMERVAPSGPIYQAGTLSGNPLAVSAGLATLKV
LKKPGTYERLESLSARLEKGLKEAAAEAGVPVTFNRVGAMFTTFFNPGPVTDYATATASDTRAFAAFFRAMLRQGIYLAP
SQFEAAFMSLAHREDDIDCTIAAAREAFKGIAIGDS

Specific function: Porphyrin biosynthesis by the C5 pathway; second step. [C]

COG id: COG0001

COG function: function code H; Glutamate-1-semialdehyde aminotransferase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily

Homologues:

Organism=Homo sapiens, GI4557809, Length=321, Percent_Identity=33.0218068535826, Blast_Score=129, Evalue=6e-30,
Organism=Homo sapiens, GI13994255, Length=332, Percent_Identity=27.4096385542169, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI37574042, Length=329, Percent_Identity=27.9635258358663, Blast_Score=105, Evalue=7e-23,
Organism=Homo sapiens, GI24119277, Length=326, Percent_Identity=29.1411042944785, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI226442705, Length=329, Percent_Identity=27.0516717325228, Blast_Score=94, Evalue=4e-19,
Organism=Homo sapiens, GI226442709, Length=298, Percent_Identity=28.1879194630872, Blast_Score=92, Evalue=7e-19,
Organism=Homo sapiens, GI284507298, Length=243, Percent_Identity=32.5102880658436, Blast_Score=89, Evalue=1e-17,
Organism=Escherichia coli, GI1786349, Length=422, Percent_Identity=59.9526066350711, Blast_Score=526, Evalue=1e-150,
Organism=Escherichia coli, GI1789016, Length=323, Percent_Identity=33.7461300309598, Blast_Score=150, Evalue=2e-37,
Organism=Escherichia coli, GI1787560, Length=341, Percent_Identity=32.5513196480938, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1788044, Length=313, Percent_Identity=35.1437699680511, Blast_Score=135, Evalue=5e-33,
Organism=Escherichia coli, GI1789759, Length=311, Percent_Identity=30.5466237942122, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI145693181, Length=316, Percent_Identity=31.3291139240506, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1786991, Length=387, Percent_Identity=28.4237726098191, Blast_Score=94, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI25144271, Length=320, Percent_Identity=30.9375, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI71992977, Length=357, Percent_Identity=28.5714285714286, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI32564660, Length=347, Percent_Identity=29.971181556196, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI25144274, Length=160, Percent_Identity=35.625, Blast_Score=85, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6323470, Length=331, Percent_Identity=26.8882175226586, Blast_Score=102, Evalue=8e-23,
Organism=Saccharomyces cerevisiae, GI6324432, Length=344, Percent_Identity=25, Blast_Score=91, Evalue=3e-19,
Organism=Drosophila melanogaster, GI21356575, Length=337, Percent_Identity=28.7833827893175, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI21357415, Length=295, Percent_Identity=27.4576271186441, Blast_Score=105, Evalue=7e-23,
Organism=Drosophila melanogaster, GI161085790, Length=343, Percent_Identity=27.1137026239067, Blast_Score=99, Evalue=8e-21,
Organism=Drosophila melanogaster, GI28574759, Length=343, Percent_Identity=27.1137026239067, Blast_Score=98, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GSA_MOOTA (Q2RJ31)

Other databases:

- EMBL:   CP000232
- RefSeq:   YP_430101.1
- ProteinModelPortal:   Q2RJ31
- SMR:   Q2RJ31
- STRING:   Q2RJ31
- GeneID:   3833039
- GenomeReviews:   CP000232_GR
- KEGG:   mta:Moth_1244
- NMPDR:   fig|264732.9.peg.1236
- eggNOG:   COG0001
- HOGENOM:   HBG725944
- OMA:   DKVIKFE
- PhylomeDB:   Q2RJ31
- BioCyc:   MTHE264732:MOTH_1244-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00375
- InterPro:   IPR004639
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11986
- TIGRFAMs:   TIGR00713

Pfam domain/function: PF00202 Aminotran_3; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =5.4.3.8

Molecular weight: Translated: 46262; Mature: 46131

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDSEAWPRSAAAFAEAVKLMPGGVNSPVRAFKSVGLTPPFIQRGEGAYLYDIDGHKYID
CCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHHCCCCCEEEECCCCHHHH
YVSSWGPLILGHRHPEVVDALEKTLREMGTSFGAPTELENELAREITTAMPAVEMVRLVN
HHHCCCCEEECCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
SGTEATMSALRLARGYTGREKVVKFAGCYHGHADYFLIQAGSGALTFGIPNSPGVPATVA
CCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEEEECCCEEEECCCCCCCCCCCCC
ANTIVAPYNDLAAVEDIFQKAGEEIAAVIVEPVAGNMGCVPPLTGFLAGLRTITKEYGSL
CCEEECCCHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCE
LIFDEVMTGFRVAFGGAQALYGIRPDLTCLGKIIGGGLPVGAYGGRREIMERVAPSGPIY
EEHHHHHHHHHHHHCCHHHHCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCE
QAGTLSGNPLAVSAGLATLKVLKKPGTYERLESLSARLEKGLKEAAAEAGVPVTFNRVGA
ECCCCCCCCEEEHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHH
MFTTFFNPGPVTDYATATASDTRAFAAFFRAMLRQGIYLAPSQFEAAFMSLAHREDDIDC
HHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCEEECCHHHHHHHHHHHHCCCCCCH
TIAAAREAFKGIAIGDS
HHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
TDSEAWPRSAAAFAEAVKLMPGGVNSPVRAFKSVGLTPPFIQRGEGAYLYDIDGHKYID
CCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHHCCCCCEEEECCCCHHHH
YVSSWGPLILGHRHPEVVDALEKTLREMGTSFGAPTELENELAREITTAMPAVEMVRLVN
HHHCCCCEEECCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
SGTEATMSALRLARGYTGREKVVKFAGCYHGHADYFLIQAGSGALTFGIPNSPGVPATVA
CCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEEEECCCEEEECCCCCCCCCCCCC
ANTIVAPYNDLAAVEDIFQKAGEEIAAVIVEPVAGNMGCVPPLTGFLAGLRTITKEYGSL
CCEEECCCHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCE
LIFDEVMTGFRVAFGGAQALYGIRPDLTCLGKIIGGGLPVGAYGGRREIMERVAPSGPIY
EEHHHHHHHHHHHHCCHHHHCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCE
QAGTLSGNPLAVSAGLATLKVLKKPGTYERLESLSARLEKGLKEAAAEAGVPVTFNRVGA
ECCCCCCCCEEEHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHH
MFTTFFNPGPVTDYATATASDTRAFAAFFRAMLRQGIYLAPSQFEAAFMSLAHREDDIDC
HHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCEEECCHHHHHHHHHHHHCCCCCCH
TIAAAREAFKGIAIGDS
HHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA