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The map label for this gene is ndhM [H]

Identifier: 83590073

GI number: 83590073

Start: 1262697

End: 1263701

Strand: Reverse

Name: ndhM [H]

Synonym: Moth_1225

Alternate gene names: 83590073

Gene position: 1263701-1262697 (Counterclockwise)

Preceding gene: 83590074

Following gene: 83590072

Centisome position: 48.07

GC content: 58.81

Gene sequence:

>1005_bases
ATGAGTAAAAAACGTGGCACCGGCATGGCTTGCTTCTTCTACGGTACCGGCTACGGCAACGGGTTTCCCGATGTTTCCAC
GGCCAACGTGGAAATCCACGATGACGGTTCGGCCACCGTCCACACCGGGGCAGTAGACTGCGGCCAGGGCTCTAATACAG
TCCTAGCCCAGATCGCTGCTGAGGAACTCGGTATCCCATACAACTGGGTAACAGTGGTCAGCGCCGACACCGACACCACC
CCCGATGCCGGCACTACCGCGGCCACCCGCCAGACCTATGCCTCCGGCAACGCCGTGCAGGCCGCCTGCCGCCAGGCCCG
GGAAACCCTTTTTGAGTACACCCGCACCATCTTAGGAGTCAACACCATCGCCGGCCTGGTGGCCAGGGATGGAGTTATCT
ACGTTAAGGGTTACCCGGAAAAGCATATAACCTATCCCGAAGCAGCCGCCCGGGCCCGCCTGGCCGGTTACCGGCTGGTA
GGGCAGGGAACCTTCGTCACCCATACCACGGCCGTCGACCGGGAGACCGGCCAGGGAGCCCCCTACTGGCCCTATGCCTT
CGGTACCCAAATTGCTGAAGTGGAAGTAGATACAGAAACAGGGGAGGTACGGGTTCTAAAGCTCGTAGCCGCCCATGATG
TAGGCCGGGCCGTCAACCGTCAGGGGGTTGAAGGACAGATCGCCGGCGGCATCGGCCAAGGCGTTGGTATGGCCCTAATG
GAAAAGGTGCACCTAAAGGAGGGGCGAATTATCAACAATTCCTTTTCCACCTATCTAATACCCACTACCCTGGATATGCC
CGAGGTGCAGCCTTTAATCGTGGAATCCTATGAACCAACCGGCCCCTACGGTGCCAAAGGGGTGGGAGAACCGGCCACCA
TTCCCACTGTACCGGCCATAATTAACGCTATCTACGATGCTATCGGCGTCCGCATTACCGAGCTACCGGCTACACCGGAA
AAAATTTTGGCCGCACTGCGGGCAAAAGAAGGAGAGAGACAATGA

Upstream 100 bases:

>100_bases
AGGTCCTGGAAAGTAGCGTCGGTCTTACGGAAACTATGCTCCAGGCAGCCCGGGCTGCCGGCTGGTCCCCTGACAATTTG
CTACCGGGAGGGAAGCTAGG

Downstream 100 bases:

>100_bases
CTATATTAATCAAAAACGGCACCCTGGTCACCATGAACCCCCAGCGGGAGGTGTATCAGGGAAACATCTATATTGAAGAC
GATCGCATTGCCGCCATCGG

Product: aldehyde oxidase and xanthine dehydrogenase molybdopterin binding

Products: NA

Alternate protein names: NDH; Nicotinic acid hydroxylase medium molybdopterin subunit; NAH [H]

Number of amino acids: Translated: 334; Mature: 333

Protein sequence:

>334_residues
MSKKRGTGMACFFYGTGYGNGFPDVSTANVEIHDDGSATVHTGAVDCGQGSNTVLAQIAAEELGIPYNWVTVVSADTDTT
PDAGTTAATRQTYASGNAVQAACRQARETLFEYTRTILGVNTIAGLVARDGVIYVKGYPEKHITYPEAAARARLAGYRLV
GQGTFVTHTTAVDRETGQGAPYWPYAFGTQIAEVEVDTETGEVRVLKLVAAHDVGRAVNRQGVEGQIAGGIGQGVGMALM
EKVHLKEGRIINNSFSTYLIPTTLDMPEVQPLIVESYEPTGPYGAKGVGEPATIPTVPAIINAIYDAIGVRITELPATPE
KILAALRAKEGERQ

Sequences:

>Translated_334_residues
MSKKRGTGMACFFYGTGYGNGFPDVSTANVEIHDDGSATVHTGAVDCGQGSNTVLAQIAAEELGIPYNWVTVVSADTDTT
PDAGTTAATRQTYASGNAVQAACRQARETLFEYTRTILGVNTIAGLVARDGVIYVKGYPEKHITYPEAAARARLAGYRLV
GQGTFVTHTTAVDRETGQGAPYWPYAFGTQIAEVEVDTETGEVRVLKLVAAHDVGRAVNRQGVEGQIAGGIGQGVGMALM
EKVHLKEGRIINNSFSTYLIPTTLDMPEVQPLIVESYEPTGPYGAKGVGEPATIPTVPAIINAIYDAIGVRITELPATPE
KILAALRAKEGERQ
>Mature_333_residues
SKKRGTGMACFFYGTGYGNGFPDVSTANVEIHDDGSATVHTGAVDCGQGSNTVLAQIAAEELGIPYNWVTVVSADTDTTP
DAGTTAATRQTYASGNAVQAACRQARETLFEYTRTILGVNTIAGLVARDGVIYVKGYPEKHITYPEAAARARLAGYRLVG
QGTFVTHTTAVDRETGQGAPYWPYAFGTQIAEVEVDTETGEVRVLKLVAAHDVGRAVNRQGVEGQIAGGIGQGVGMALME
KVHLKEGRIINNSFSTYLIPTTLDMPEVQPLIVESYEPTGPYGAKGVGEPATIPTVPAIINAIYDAIGVRITELPATPEK
ILAALRAKEGERQ

Specific function: Catalyzes the hydroxylation of nicotinate to 6- hydroxynicotinate. Also active against 2-pyrazinecarboxylic acid, but inactive against other nicotinate analogs [H]

COG id: COG1529

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=343, Percent_Identity=28.2798833819242, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI71773480, Length=340, Percent_Identity=27.9411764705882, Blast_Score=108, Evalue=9e-24,
Organism=Escherichia coli, GI1789230, Length=328, Percent_Identity=31.4024390243902, Blast_Score=160, Evalue=9e-41,
Organism=Escherichia coli, GI1789246, Length=313, Percent_Identity=32.5878594249201, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI1786478, Length=313, Percent_Identity=31.629392971246, Blast_Score=125, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI17540638, Length=337, Percent_Identity=29.673590504451, Blast_Score=114, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI17539860, Length=312, Percent_Identity=29.1666666666667, Blast_Score=95, Evalue=5e-20,
Organism=Drosophila melanogaster, GI17737937, Length=293, Percent_Identity=27.3037542662116, Blast_Score=88, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008274 [H]

Pfam domain/function: PF02738 Ald_Xan_dh_C2 [H]

EC number: =1.17.1.5 [H]

Molecular weight: Translated: 35352; Mature: 35221

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKKRGTGMACFFYGTGYGNGFPDVSTANVEIHDDGSATVHTGAVDCGQGSNTVLAQIAA
CCCCCCCCEEEEEEECCCCCCCCCCEEEEEEEECCCCCEEEECCEECCCCCCHHHEEEHH
EELGIPYNWVTVVSADTDTTPDAGTTAATRQTYASGNAVQAACRQARETLFEYTRTILGV
HHHCCCEEEEEEEECCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
NTIAGLVARDGVIYVKGYPEKHITYPEAAARARLAGYRLVGQGTFVTHTTAVDRETGQGA
HHHHHHHHCCCEEEEECCCCCCCCCCHHHHHHHHHCEEEEECCEEEEEEEECCCCCCCCC
PYWPYAFGTQIAEVEVDTETGEVRVLKLVAAHDVGRAVNRQGVEGQIAGGIGQGVGMALM
CCCCHHHCCEEEEEEEECCCCCEEEEEEEHHHHHHHHHHCCCCCEEECCCCCCHHHHHHH
EKVHLKEGRIINNSFSTYLIPTTLDMPEVQPLIVESYEPTGPYGAKGVGEPATIPTVPAI
HHHHHCCCEEEECCCCEEEEEEECCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHH
INAIYDAIGVRITELPATPEKILAALRAKEGERQ
HHHHHHHHCCEEEECCCCHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SKKRGTGMACFFYGTGYGNGFPDVSTANVEIHDDGSATVHTGAVDCGQGSNTVLAQIAA
CCCCCCCEEEEEEECCCCCCCCCCEEEEEEEECCCCCEEEECCEECCCCCCHHHEEEHH
EELGIPYNWVTVVSADTDTTPDAGTTAATRQTYASGNAVQAACRQARETLFEYTRTILGV
HHHCCCEEEEEEEECCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
NTIAGLVARDGVIYVKGYPEKHITYPEAAARARLAGYRLVGQGTFVTHTTAVDRETGQGA
HHHHHHHHCCCEEEEECCCCCCCCCCHHHHHHHHHCEEEEECCEEEEEEEECCCCCCCCC
PYWPYAFGTQIAEVEVDTETGEVRVLKLVAAHDVGRAVNRQGVEGQIAGGIGQGVGMALM
CCCCHHHCCEEEEEEEECCCCCEEEEEEEHHHHHHHHHHCCCCCEEECCCCCCHHHHHHH
EKVHLKEGRIINNSFSTYLIPTTLDMPEVQPLIVESYEPTGPYGAKGVGEPATIPTVPAI
HHHHHCCCEEEECCCCEEEEEEECCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHH
INAIYDAIGVRITELPATPEKILAALRAKEGERQ
HHHHHHHHCCEEEECCCCHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA