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The map label for this gene is ndhL [H]

Identifier: 83590074

GI number: 83590074

Start: 1263698

End: 1264978

Strand: Reverse

Name: ndhL [H]

Synonym: Moth_1226

Alternate gene names: 83590074

Gene position: 1264978-1263698 (Counterclockwise)

Preceding gene: 83590076

Following gene: 83590073

Centisome position: 48.12

GC content: 62.76

Gene sequence:

>1281_bases
ATGGGAGTGATCGGTGCTTCCCCCGCCAGAGGTGATGCCCGAGCCAAGGTCACCGGTGAGGCCATCTACCCGGCTGATAT
CGTCTTCCCGGGCATGATTTACGGCCAGGCTATTCGCAGCCCCCACCCCCACGCCAGGATTGTCAATATCGACACCGCCG
CAGCCCTGAAGGTACCCGGGGTCCTCTGCGTGCTTACCGCCCGGGATATTCCCGGACACAACGGCCAGGGTGTTCTTTTC
CAGGATATGCCCGTCCTCGCCGGAAACGAGGTGCGCTCGGTTAACGACGTCGTAGCCCTGGTGGGGGCTACCACCCCGGC
GGCGGCCCGGGAAGGGGCCGCTATGGTAAAGGTGGACTATGAGGAACTACCGGCCCTCCTGGACCCGGTGGCCGCGATGC
AACCGGGCGCGCCCCGGGTCCATCCCGACCGGGAGAATATTATTTACCACCTGCCCATCAGGAGGGGCGACGTGGCGGCC
GGTTTCGCCGCTGCCGACGTGGTTGTGGAAAACACCTACCGTACCCAGCTCCTGGACCACGCCTTCCTCCAACCGGAAGC
CGCAGTGGCCCGGCTGGACGAGCGCGGCCACCTTATAATCTATGTGGCCACCCAGTATGTCCACTGGGATCGGACGGAAG
TAGCACGGGTGCTGGGCTGGAACCAGGATCGCGTCCGCATTGTGGCTCCGGCGGTGGGGGGTGCCTTCGGCGGCCGGGAA
GATATGACCCTGCAGACCCTGGTGGCTTTGCTGGCCGTCCATACCCGCCGGCCGGCCAAAATGGTTCTCAGCAGGGAAGA
ATCCTTTTTCGCCCACAGCAAACGGCATCCCATGATTATGCGCTATAAGACCGGGGCTACACGCGAGGGGAAATTAACGG
CCCTGGAAGCCGAAATTATCGGCGACAGCGGCGCCTATTGTTCCTGGGCCCCCAATGTACTGCGTAAGGCGGCCATCCAT
GCCACCGGGCCTTATGTCATCCCCAACGTCAAGATCGATGCCTATGCCGTCTATACCAACAACCCCTTTACGGGGGCTAT
GCGCGGCTTTGGCGCCACCCAGCCGCCCCTGGCTTATGAAAGCCAGATGGACGAACTGGCTGCGCAGCTGGGCATTCACC
CCTTTACCATCCGCTGGCTCAACGCTTTCCGCCAGGGGGATGTAACCGCTACCGGCCAGGTCCTGGAAAGTAGCGTCGGT
CTTACGGAAACTATGCTCCAGGCAGCCCGGGCTGCCGGCTGGTCCCCTGACAATTTGCTACCGGGAGGGAAGCTAGGATG
A

Upstream 100 bases:

>100_bases
TACCAGGCAACCGCAAATTGCCCGGCTACGAAGGTATATCTTCGTTGCTGCGCGCCGGTTGCCTGGTTTTTTATAAACTC
TATATGAAGGAGTGATCCAC

Downstream 100 bases:

>100_bases
GTAAAAAACGTGGCACCGGCATGGCTTGCTTCTTCTACGGTACCGGCTACGGCAACGGGTTTCCCGATGTTTCCACGGCC
AACGTGGAAATCCACGATGA

Product: aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead

Products: NA

Alternate protein names: NDH; Nicotinic acid hydroxylase large molybdopterin subunit; NAH [H]

Number of amino acids: Translated: 426; Mature: 425

Protein sequence:

>426_residues
MGVIGASPARGDARAKVTGEAIYPADIVFPGMIYGQAIRSPHPHARIVNIDTAAALKVPGVLCVLTARDIPGHNGQGVLF
QDMPVLAGNEVRSVNDVVALVGATTPAAAREGAAMVKVDYEELPALLDPVAAMQPGAPRVHPDRENIIYHLPIRRGDVAA
GFAAADVVVENTYRTQLLDHAFLQPEAAVARLDERGHLIIYVATQYVHWDRTEVARVLGWNQDRVRIVAPAVGGAFGGRE
DMTLQTLVALLAVHTRRPAKMVLSREESFFAHSKRHPMIMRYKTGATREGKLTALEAEIIGDSGAYCSWAPNVLRKAAIH
ATGPYVIPNVKIDAYAVYTNNPFTGAMRGFGATQPPLAYESQMDELAAQLGIHPFTIRWLNAFRQGDVTATGQVLESSVG
LTETMLQAARAAGWSPDNLLPGGKLG

Sequences:

>Translated_426_residues
MGVIGASPARGDARAKVTGEAIYPADIVFPGMIYGQAIRSPHPHARIVNIDTAAALKVPGVLCVLTARDIPGHNGQGVLF
QDMPVLAGNEVRSVNDVVALVGATTPAAAREGAAMVKVDYEELPALLDPVAAMQPGAPRVHPDRENIIYHLPIRRGDVAA
GFAAADVVVENTYRTQLLDHAFLQPEAAVARLDERGHLIIYVATQYVHWDRTEVARVLGWNQDRVRIVAPAVGGAFGGRE
DMTLQTLVALLAVHTRRPAKMVLSREESFFAHSKRHPMIMRYKTGATREGKLTALEAEIIGDSGAYCSWAPNVLRKAAIH
ATGPYVIPNVKIDAYAVYTNNPFTGAMRGFGATQPPLAYESQMDELAAQLGIHPFTIRWLNAFRQGDVTATGQVLESSVG
LTETMLQAARAAGWSPDNLLPGGKLG
>Mature_425_residues
GVIGASPARGDARAKVTGEAIYPADIVFPGMIYGQAIRSPHPHARIVNIDTAAALKVPGVLCVLTARDIPGHNGQGVLFQ
DMPVLAGNEVRSVNDVVALVGATTPAAAREGAAMVKVDYEELPALLDPVAAMQPGAPRVHPDRENIIYHLPIRRGDVAAG
FAAADVVVENTYRTQLLDHAFLQPEAAVARLDERGHLIIYVATQYVHWDRTEVARVLGWNQDRVRIVAPAVGGAFGGRED
MTLQTLVALLAVHTRRPAKMVLSREESFFAHSKRHPMIMRYKTGATREGKLTALEAEIIGDSGAYCSWAPNVLRKAAIHA
TGPYVIPNVKIDAYAVYTNNPFTGAMRGFGATQPPLAYESQMDELAAQLGIHPFTIRWLNAFRQGDVTATGQVLESSVGL
TETMLQAARAAGWSPDNLLPGGKLG

Specific function: Catalyzes the hydroxylation of nicotinate to 6- hydroxynicotinate. Also active against 2-pyrazinecarboxylic acid, but inactive against other nicotinate analogs [H]

COG id: COG1529

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=390, Percent_Identity=32.8205128205128, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI71773480, Length=380, Percent_Identity=28.4210526315789, Blast_Score=148, Evalue=1e-35,
Organism=Escherichia coli, GI1789230, Length=418, Percent_Identity=32.2966507177034, Blast_Score=193, Evalue=2e-50,
Organism=Escherichia coli, GI1789246, Length=469, Percent_Identity=28.5714285714286, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI1786478, Length=433, Percent_Identity=29.7921478060046, Blast_Score=102, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17540638, Length=387, Percent_Identity=25.8397932816537, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17539860, Length=383, Percent_Identity=24.8041775456919, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI32566215, Length=372, Percent_Identity=23.1182795698925, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI17737937, Length=398, Percent_Identity=32.1608040201005, Blast_Score=179, Evalue=3e-45,
Organism=Drosophila melanogaster, GI24647193, Length=395, Percent_Identity=25.0632911392405, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24647199, Length=384, Percent_Identity=23.9583333333333, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24647201, Length=388, Percent_Identity=22.4226804123711, Blast_Score=85, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000674
- InterPro:   IPR008274 [H]

Pfam domain/function: PF01315 Ald_Xan_dh_C; PF02738 Ald_Xan_dh_C2 [H]

EC number: =1.17.1.5 [H]

Molecular weight: Translated: 45764; Mature: 45633

Theoretical pI: Translated: 7.47; Mature: 7.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGVIGASPARGDARAKVTGEAIYPADIVFPGMIYGQAIRSPHPHARIVNIDTAAALKVPG
CCCCCCCCCCCCCCEEEECCEECCHHHHCCCHHHHHHHCCCCCCEEEEEECCHHHHCCCC
VLCVLTARDIPGHNGQGVLFQDMPVLAGNEVRSVNDVVALVGATTPAAAREGAAMVKVDY
EEEEEEECCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHEECCCCCHHHHCCCEEEEECH
EELPALLDPVAAMQPGAPRVHPDRENIIYHLPIRRGDVAAGFAAADVVVENTYRTQLLDH
HHHHHHHCHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCCCHHHHHEEEECHHHHHHHHH
AFLQPEAAVARLDERGHLIIYVATQYVHWDRTEVARVLGWNQDRVRIVAPAVGGAFGGRE
HHCCCHHHHHHHCCCCCEEEEEEEEEEECCHHHHHHHHCCCCCCEEEEEEECCCCCCCCC
DMTLQTLVALLAVHTRRPAKMVLSREESFFAHSKRHPMIMRYKTGATREGKLTALEAEII
CCHHHHHHHHHHHHCCCCHHHHHHCCHHHHHHCCCCCEEEEEECCCCCCCCEEEEEEEEE
GDSGAYCSWAPNVLRKAAIHATGPYVIPNVKIDAYAVYTNNPFTGAMRGFGATQPPLAYE
CCCCCCCCCCHHHHHHHHHCCCCCEEECCEEEEEEEEEECCCCCHHHHCCCCCCCCCHHH
SQMDELAAQLGIHPFTIRWLNAFRQGDVTATGQVLESSVGLTETMLQAARAAGWSPDNLL
HHHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHHCCHHHHHHHHHHHCCCCCCCCC
PGGKLG
CCCCCC
>Mature Secondary Structure 
GVIGASPARGDARAKVTGEAIYPADIVFPGMIYGQAIRSPHPHARIVNIDTAAALKVPG
CCCCCCCCCCCCCEEEECCEECCHHHHCCCHHHHHHHCCCCCCEEEEEECCHHHHCCCC
VLCVLTARDIPGHNGQGVLFQDMPVLAGNEVRSVNDVVALVGATTPAAAREGAAMVKVDY
EEEEEEECCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHEECCCCCHHHHCCCEEEEECH
EELPALLDPVAAMQPGAPRVHPDRENIIYHLPIRRGDVAAGFAAADVVVENTYRTQLLDH
HHHHHHHCHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCCCHHHHHEEEECHHHHHHHHH
AFLQPEAAVARLDERGHLIIYVATQYVHWDRTEVARVLGWNQDRVRIVAPAVGGAFGGRE
HHCCCHHHHHHHCCCCCEEEEEEEEEEECCHHHHHHHHCCCCCCEEEEEEECCCCCCCCC
DMTLQTLVALLAVHTRRPAKMVLSREESFFAHSKRHPMIMRYKTGATREGKLTALEAEII
CCHHHHHHHHHHHHCCCCHHHHHHCCHHHHHHCCCCCEEEEEECCCCCCCCEEEEEEEEE
GDSGAYCSWAPNVLRKAAIHATGPYVIPNVKIDAYAVYTNNPFTGAMRGFGATQPPLAYE
CCCCCCCCCCHHHHHHHHHCCCCCEEECCEEEEEEEEEECCCCCHHHHCCCCCCCCCHHH
SQMDELAAQLGIHPFTIRWLNAFRQGDVTATGQVLESSVGLTETMLQAARAAGWSPDNLL
HHHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHHCCHHHHHHHHHHHCCCCCCCCC
PGGKLG
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA