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The map label for this gene is 83590035

Identifier: 83590035

GI number: 83590035

Start: 1218622

End: 1220232

Strand: Reverse

Name: 83590035

Synonym: Moth_1187

Alternate gene names: NA

Gene position: 1220232-1218622 (Counterclockwise)

Preceding gene: 83590036

Following gene: 83590033

Centisome position: 46.42

GC content: 57.05

Gene sequence:

>1611_bases
ATGATTAAATTACAGTTTTGCGGCGCTGCTGGAACGGTTACCGGTTCCTGTTACCTCCTTGATACCGGCCGCTACCGCTT
ACTAATTGACTGTGGCCTGTTTCAAGGCTCCAAAGCCATCAAGGAGCGTAACTACGGTCCCTTTCCCTTCAATCCCGGCG
CGATCGACGCCCTGATCCTGACCCATGCCCATATCGACCACTGTGGCCTCATACCCAAGCTCTACCTCCAGGGGTTCAAG
GGGCCTATCTTCACAACTCCGGTTACCGCCGAGCTGGCCCGGGTCCTTCTACCAGATTGCGGGCATATCCAGGAGATGGA
GGTCGAACGCAAAAACCGCAAGAACAAACGCGCCGGCCTGCCTATATTAACACCTATTTATACTGCGGCCCAGGCGGCTG
CCTGCCTGGATTTCTTCCGGACCCTGGACTATCGGGAAGAGCAGGAGATCCTGCCCGGTGTCCGCCTGCGTCTCCAGGAC
GCCGGCCATATCCTGGGCTCGGCTATAGTCGAGCTCTGGGTCAAGGACATGGCTGGTGAAATTAAGATTACCTTTTCCGG
TGACCTGGGTAATCCTGGCCAGCCCATCGTCAATGACCCAACTCCTATCGCAAGCACCGATTACCTGGTGATAGAATCCA
CCTACGGTAATCGCCGTCATAATATCCAGGGAGATAAAATCGAGCTCCTCAAAGAGGTTATCCTGGCGACCATGAAAAAG
GGAGGTAACCTGATTATCCCGGCCTTTGCCGTGGAACGTACCCAGGACCTCCTGTACGCCCTGAATGTCATCCTGCAACA
GGGTGCCGTCAAGGTAGACAAAATCTACCTGGATAGTCCCCTGGCGGTTGCCGCTACGGAGATCTTTTGCCGCCACCAGG
ATTACTTTGATGCTGAAACCAAAGATCTAAGCCATAACGGCAGTACTTGCCCCTTTTATTTACCTGGTATGCACCTCAGC
CGGACGGCGGAAGAATCCATGGCTATTAATAAAATCCACGGCGGGGCCATTATAATCTCTGCCAGCGGCATGGCCGACGC
CGGCCGGATTAAACACCACCTGAAGCACAACCTCTGGCGGCCGGAGGCTACCGTTCTCCTGGTTGGTTACCAGGCGGCAG
GTACCCTGGGACGGCGCCTGCTGGAAGGGGAGAAACGGGTCCGTATCCACGGCGAGGAAATCGCTGTCCGGGCGGATATT
GTCAGTATCGACGGCTTCTCGGCCCACGCCGACCAGGCCGGCCTCCTCAACTGGGTAAAATCCTTCCGCCAGCCGCCGCG
AAAAGTATTTGTGACCCATGGTGAAAAAGAAGCAGCTGAGGATTTTGCCCGCCTGCTGACTACCGAACTGGGCCTGGCCA
CGGAAGTGCCGGGATGGCTGGATACCGTCCAGCTACTCCCAATAGCGGCAGAGCTTGCCCCGGCACCGGCAGCTGCCCTC
AGAGATACCAGTACAGCTGCAGAGGCAGAGGCTGCCTACCAGCGACTCCTGGTCCAACTCAAGGCGCTGGTGGAGGCCGG
TTTTGCCCGCCAGGACTATGCCGGTACCAAACGCAGGCTGGAACAAATAGCGGCCCTGGTAAACCAGGGCCTGGACGAAA
AAGCCGGCTAG

Upstream 100 bases:

>100_bases
CCATGAATCGCATGGAACGCTTTGTCGCCCGGCGTCTGGCCTTTAACCAGCGGGCCGTAGCCCAGGCTTAAAAGAAAAAA
TTATTTCCGGGAGAGGAATT

Downstream 100 bases:

>100_bases
AAAACCTTCAGGTTTCTTTACCCTCCAGTTTAAGACCGCTTACAGTAATGTTGACAGCCACAACTTCCAGGGCTGTCATA
TTTGTAATATTTGTCATCAC

Product: RNA-metabolising metallo-beta-lactamase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 536; Mature: 536

Protein sequence:

>536_residues
MIKLQFCGAAGTVTGSCYLLDTGRYRLLIDCGLFQGSKAIKERNYGPFPFNPGAIDALILTHAHIDHCGLIPKLYLQGFK
GPIFTTPVTAELARVLLPDCGHIQEMEVERKNRKNKRAGLPILTPIYTAAQAAACLDFFRTLDYREEQEILPGVRLRLQD
AGHILGSAIVELWVKDMAGEIKITFSGDLGNPGQPIVNDPTPIASTDYLVIESTYGNRRHNIQGDKIELLKEVILATMKK
GGNLIIPAFAVERTQDLLYALNVILQQGAVKVDKIYLDSPLAVAATEIFCRHQDYFDAETKDLSHNGSTCPFYLPGMHLS
RTAEESMAINKIHGGAIIISASGMADAGRIKHHLKHNLWRPEATVLLVGYQAAGTLGRRLLEGEKRVRIHGEEIAVRADI
VSIDGFSAHADQAGLLNWVKSFRQPPRKVFVTHGEKEAAEDFARLLTTELGLATEVPGWLDTVQLLPIAAELAPAPAAAL
RDTSTAAEAEAAYQRLLVQLKALVEAGFARQDYAGTKRRLEQIAALVNQGLDEKAG

Sequences:

>Translated_536_residues
MIKLQFCGAAGTVTGSCYLLDTGRYRLLIDCGLFQGSKAIKERNYGPFPFNPGAIDALILTHAHIDHCGLIPKLYLQGFK
GPIFTTPVTAELARVLLPDCGHIQEMEVERKNRKNKRAGLPILTPIYTAAQAAACLDFFRTLDYREEQEILPGVRLRLQD
AGHILGSAIVELWVKDMAGEIKITFSGDLGNPGQPIVNDPTPIASTDYLVIESTYGNRRHNIQGDKIELLKEVILATMKK
GGNLIIPAFAVERTQDLLYALNVILQQGAVKVDKIYLDSPLAVAATEIFCRHQDYFDAETKDLSHNGSTCPFYLPGMHLS
RTAEESMAINKIHGGAIIISASGMADAGRIKHHLKHNLWRPEATVLLVGYQAAGTLGRRLLEGEKRVRIHGEEIAVRADI
VSIDGFSAHADQAGLLNWVKSFRQPPRKVFVTHGEKEAAEDFARLLTTELGLATEVPGWLDTVQLLPIAAELAPAPAAAL
RDTSTAAEAEAAYQRLLVQLKALVEAGFARQDYAGTKRRLEQIAALVNQGLDEKAG
>Mature_536_residues
MIKLQFCGAAGTVTGSCYLLDTGRYRLLIDCGLFQGSKAIKERNYGPFPFNPGAIDALILTHAHIDHCGLIPKLYLQGFK
GPIFTTPVTAELARVLLPDCGHIQEMEVERKNRKNKRAGLPILTPIYTAAQAAACLDFFRTLDYREEQEILPGVRLRLQD
AGHILGSAIVELWVKDMAGEIKITFSGDLGNPGQPIVNDPTPIASTDYLVIESTYGNRRHNIQGDKIELLKEVILATMKK
GGNLIIPAFAVERTQDLLYALNVILQQGAVKVDKIYLDSPLAVAATEIFCRHQDYFDAETKDLSHNGSTCPFYLPGMHLS
RTAEESMAINKIHGGAIIISASGMADAGRIKHHLKHNLWRPEATVLLVGYQAAGTLGRRLLEGEKRVRIHGEEIAVRADI
VSIDGFSAHADQAGLLNWVKSFRQPPRKVFVTHGEKEAAEDFARLLTTELGLATEVPGWLDTVQLLPIAAELAPAPAAAL
RDTSTAAEAEAAYQRLLVQLKALVEAGFARQDYAGTKRRLEQIAALVNQGLDEKAG

Specific function: Has endoribonuclease activity towards 23S and 16S rRNA (in vitro) [H]

COG id: COG1236

COG function: function code J; Predicted exonuclease of the beta-lactamase fold involved in RNA processing

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family [H]

Homologues:

Organism=Homo sapiens, GI7706427, Length=444, Percent_Identity=26.1261261261261, Blast_Score=137, Evalue=3e-32,
Organism=Homo sapiens, GI33300633, Length=507, Percent_Identity=23.6686390532544, Blast_Score=130, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI32566029, Length=435, Percent_Identity=26.2068965517241, Blast_Score=132, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI32564696, Length=479, Percent_Identity=25.2609603340292, Blast_Score=129, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6323307, Length=444, Percent_Identity=24.5495495495495, Blast_Score=128, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24648013, Length=443, Percent_Identity=26.410835214447, Blast_Score=144, Evalue=2e-34,
Organism=Drosophila melanogaster, GI21358523, Length=468, Percent_Identity=26.0683760683761, Blast_Score=136, Evalue=4e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022712
- InterPro:   IPR001279
- InterPro:   IPR011108 [H]

Pfam domain/function: PF10996 Beta-Casp; PF00753 Lactamase_B; PF07521 RMMBL [H]

EC number: NA

Molecular weight: Translated: 58619; Mature: 58619

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKLQFCGAAGTVTGSCYLLDTGRYRLLIDCGLFQGSKAIKERNYGPFPFNPGAIDALIL
CEEEEEECCCCCCCCEEEEEECCCEEEEEEECCCCCCHHHHHCCCCCCCCCCCCHHHHHH
THAHIDHCGLIPKLYLQGFKGPIFTTPVTAELARVLLPDCGHIQEMEVERKNRKNKRAGL
HHHHHHHHCCHHHHHHCCCCCCEECCCHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHCCC
PILTPIYTAAQAAACLDFFRTLDYREEQEILPGVRLRLQDAGHILGSAIVELWVKDMAGE
CCHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCEEEECHHHHHHHHHHHHHHHHHCCCE
IKITFSGDLGNPGQPIVNDPTPIASTDYLVIESTYGNRRHNIQGDKIELLKEVILATMKK
EEEEEECCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHC
GGNLIIPAFAVERTQDLLYALNVILQQGAVKVDKIYLDSPLAVAATEIFCRHQDYFDAET
CCCEEEEHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCHHHHHHHHHHHCCCCCCCCC
KDLSHNGSTCPFYLPGMHLSRTAEESMAINKIHGGAIIISASGMADAGRIKHHLKHNLWR
CCCCCCCCCCCEECCCCCHHHHHHHHHHHEEECCCEEEEEECCCCCHHHHHHHHHHCCCC
PEATVLLVGYQAAGTLGRRLLEGEKRVRIHGEEIAVRADIVSIDGFSAHADQAGLLNWVK
CCEEEEEEEEHHHHHHHHHHHCCCCEEEEECCEEEEEEEEEEECCCCCCCCHHHHHHHHH
SFRQPPRKVFVTHGEKEAAEDFARLLTTELGLATEVPGWLDTVQLLPIAAELAPAPAAAL
HHCCCCCEEEEECCCHHHHHHHHHHHHHHHCCHHCCCCHHHHHHHHHHHHHHCCCCHHHH
RDTSTAAEAEAAYQRLLVQLKALVEAGFARQDYAGTKRRLEQIAALVNQGLDEKAG
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MIKLQFCGAAGTVTGSCYLLDTGRYRLLIDCGLFQGSKAIKERNYGPFPFNPGAIDALIL
CEEEEEECCCCCCCCEEEEEECCCEEEEEEECCCCCCHHHHHCCCCCCCCCCCCHHHHHH
THAHIDHCGLIPKLYLQGFKGPIFTTPVTAELARVLLPDCGHIQEMEVERKNRKNKRAGL
HHHHHHHHCCHHHHHHCCCCCCEECCCHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHCCC
PILTPIYTAAQAAACLDFFRTLDYREEQEILPGVRLRLQDAGHILGSAIVELWVKDMAGE
CCHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCEEEECHHHHHHHHHHHHHHHHHCCCE
IKITFSGDLGNPGQPIVNDPTPIASTDYLVIESTYGNRRHNIQGDKIELLKEVILATMKK
EEEEEECCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHC
GGNLIIPAFAVERTQDLLYALNVILQQGAVKVDKIYLDSPLAVAATEIFCRHQDYFDAET
CCCEEEEHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCHHHHHHHHHHHCCCCCCCCC
KDLSHNGSTCPFYLPGMHLSRTAEESMAINKIHGGAIIISASGMADAGRIKHHLKHNLWR
CCCCCCCCCCCEECCCCCHHHHHHHHHHHEEECCCEEEEEECCCCCHHHHHHHHHHCCCC
PEATVLLVGYQAAGTLGRRLLEGEKRVRIHGEEIAVRADIVSIDGFSAHADQAGLLNWVK
CCEEEEEEEEHHHHHHHHHHHCCCCEEEEECCEEEEEEEEEEECCCCCCCCHHHHHHHHH
SFRQPPRKVFVTHGEKEAAEDFARLLTTELGLATEVPGWLDTVQLLPIAAELAPAPAAAL
HHCCCCCEEEEECCCHHHHHHHHHHHHHHHCCHHCCCCHHHHHHHHHHHHHHCCCCHHHH
RDTSTAAEAEAAYQRLLVQLKALVEAGFARQDYAGTKRRLEQIAALVNQGLDEKAG
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA