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The map label for this gene is folE [H]

Identifier: 83589276

GI number: 83589276

Start: 412946

End: 413503

Strand: Reverse

Name: folE [H]

Synonym: Moth_0408

Alternate gene names: 83589276

Gene position: 413503-412946 (Counterclockwise)

Preceding gene: 83589277

Following gene: 83589275

Centisome position: 15.73

GC content: 55.2

Gene sequence:

>558_bases
ATGGATAAGGAAAAGATCCGCCAGGCGGTACGCATGATTATTGAAGCTGTCGGTGAGGACCCGGACCGGGAAGGCCTGCG
GGAGACGCCCCGCCGTATAGCTGATATGTATGAGGAAATCTTTGCCGGTATTAACCGTGACCCCGGCGAGGAATTGACGG
TTGTCTTCGACGAACACCACGAGGAAATGGTACTGGTAAAGGATATACCTCTCTATTCTATCTGCGAACACCACTTCCTA
CCCTTCCTGGGCAGGGCCCATGTAGCTTACATTCCCCGGGGTAAAATTACCGGTTTAAGCAAACTGGCCCGGGTAGTGGA
CATCGCCGCCCGCCGGCCCCAGGTCCAGGAGCGTTTAACCTCCCAGATAGCCGATATTATCATGGAAAAGTTAAATCCCT
ACGGCGTAGTCGTTGTCATTGAAGCCGAACACCTTTGCATGAGCATGCGCGGCATAAAAAAACCAGGCTCCCTGACCATT
ACCTCCGCCGTCCGGGGTCTTTTCCGCCGCGACCAGGCCGCCCGGGCGGAAGCTATGTCCCTTATCCAGGGTCGCTAA

Upstream 100 bases:

>100_bases
TTACCATTTTATATCGCTACGGGGCAGGAAAATTTATAATCCTGGGGGAATTATTATGTAATGCGCCAAGCAACCAGAAG
TATAACCGGGGGGTACAACT

Downstream 100 bases:

>100_bases
GCAGAAAGGGGGTCAACTCTTTGGGTCAGGATAAGATTATTTTAGCCGGGCTGGAGTTTTATGGCTTCCACGGCAACCAT
CCGGCAGAGCAGCAGTTGGG

Product: GTP cyclohydrolase

Products: NA

Alternate protein names: GTP cyclohydrolase I; GTP-CH-I [H]

Number of amino acids: Translated: 185; Mature: 185

Protein sequence:

>185_residues
MDKEKIRQAVRMIIEAVGEDPDREGLRETPRRIADMYEEIFAGINRDPGEELTVVFDEHHEEMVLVKDIPLYSICEHHFL
PFLGRAHVAYIPRGKITGLSKLARVVDIAARRPQVQERLTSQIADIIMEKLNPYGVVVVIEAEHLCMSMRGIKKPGSLTI
TSAVRGLFRRDQAARAEAMSLIQGR

Sequences:

>Translated_185_residues
MDKEKIRQAVRMIIEAVGEDPDREGLRETPRRIADMYEEIFAGINRDPGEELTVVFDEHHEEMVLVKDIPLYSICEHHFL
PFLGRAHVAYIPRGKITGLSKLARVVDIAARRPQVQERLTSQIADIIMEKLNPYGVVVVIEAEHLCMSMRGIKKPGSLTI
TSAVRGLFRRDQAARAEAMSLIQGR
>Mature_185_residues
MDKEKIRQAVRMIIEAVGEDPDREGLRETPRRIADMYEEIFAGINRDPGEELTVVFDEHHEEMVLVKDIPLYSICEHHFL
PFLGRAHVAYIPRGKITGLSKLARVVDIAARRPQVQERLTSQIADIIMEKLNPYGVVVVIEAEHLCMSMRGIKKPGSLTI
TSAVRGLFRRDQAARAEAMSLIQGR

Specific function: Tetrahydrofolate biosynthesis; first step. [C]

COG id: COG0302

COG function: function code H; GTP cyclohydrolase I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase I family [H]

Homologues:

Organism=Homo sapiens, GI66932968, Length=176, Percent_Identity=48.8636363636364, Blast_Score=176, Evalue=8e-45,
Organism=Homo sapiens, GI4503949, Length=176, Percent_Identity=48.8636363636364, Blast_Score=176, Evalue=8e-45,
Organism=Homo sapiens, GI66932970, Length=145, Percent_Identity=46.8965517241379, Blast_Score=136, Evalue=8e-33,
Organism=Homo sapiens, GI66932972, Length=135, Percent_Identity=49.6296296296296, Blast_Score=135, Evalue=2e-32,
Organism=Escherichia coli, GI1788476, Length=169, Percent_Identity=43.1952662721894, Blast_Score=127, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI17560486, Length=179, Percent_Identity=49.7206703910614, Blast_Score=182, Evalue=9e-47,
Organism=Saccharomyces cerevisiae, GI6321706, Length=184, Percent_Identity=46.7391304347826, Blast_Score=169, Evalue=2e-43,
Organism=Drosophila melanogaster, GI24656782, Length=178, Percent_Identity=46.6292134831461, Blast_Score=162, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24656796, Length=179, Percent_Identity=46.3687150837989, Blast_Score=161, Evalue=3e-40,
Organism=Drosophila melanogaster, GI24656791, Length=179, Percent_Identity=46.3687150837989, Blast_Score=160, Evalue=3e-40,

Paralogues:

None

Copy number: 420 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001474
- InterPro:   IPR020602
- InterPro:   IPR018234 [H]

Pfam domain/function: PF01227 GTP_cyclohydroI [H]

EC number: =3.5.4.16 [H]

Molecular weight: Translated: 20971; Mature: 20971

Theoretical pI: Translated: 7.15; Mature: 7.15

Prosite motif: PS00859 GTP_CYCLOHYDROL_1_1 ; PS00860 GTP_CYCLOHYDROL_1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKEKIRQAVRMIIEAVGEDPDREGLRETPRRIADMYEEIFAGINRDPGEELTVVFDEHH
CCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCC
EEMVLVKDIPLYSICEHHFLPFLGRAHVAYIPRGKITGLSKLARVVDIAARRPQVQERLT
CCEEEEECCCHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHCCHHHHHHHH
SQIADIIMEKLNPYGVVVVIEAEHLCMSMRGIKKPGSLTITSAVRGLFRRDQAARAEAMS
HHHHHHHHHHCCCCCEEEEEEHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHH
LIQGR
HHCCC
>Mature Secondary Structure
MDKEKIRQAVRMIIEAVGEDPDREGLRETPRRIADMYEEIFAGINRDPGEELTVVFDEHH
CCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCC
EEMVLVKDIPLYSICEHHFLPFLGRAHVAYIPRGKITGLSKLARVVDIAARRPQVQERLT
CCEEEEECCCHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHCCHHHHHHHH
SQIADIIMEKLNPYGVVVVIEAEHLCMSMRGIKKPGSLTITSAVRGLFRRDQAARAEAMS
HHHHHHHHHHCCCCCEEEEEEHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHH
LIQGR
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA