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The map label for this gene is iscS [H]

Identifier: 83589068

GI number: 83589068

Start: 195342

End: 196490

Strand: Reverse

Name: iscS [H]

Synonym: Moth_0199

Alternate gene names: 83589068

Gene position: 196490-195342 (Counterclockwise)

Preceding gene: 83589070

Following gene: 83589067

Centisome position: 7.47

GC content: 65.88

Gene sequence:

>1149_bases
TTGGCCATTATTTACCTCGATAACAGCGCCACCACAGCGGCTTTACCCGAAGTAGCAATCGCCGTGAAGGAAATGCTGAC
GGAAAACTACGGCAACCCCTCTTCCCTCCACGGCCTGGGGATAAAGGCGGAAAAGGCCCTGGGCGAAGCCCGGCGCCAGG
TGGCCGGCCTCATCGGCGCCCGGCCCACGGAGATCTACTTCACCTCCGGCGGCACCGAGGCCAACAACTGGGCCCTGCTG
GGGATAGCCCGGGCACGGCGGCGCCAGGGCAGGCACCTGATCACCACGGCCATCGAACACCCCTCCATCCTGGCCACCTG
TCGGCGGCTGGAGGCCGACGGCTTTGAAGTAACCTACCTGCCGGCAGACGCCCGGGGGGTCATCCGCCTGGCCGACCTGG
AAGCGGCCCTGCGGGAGGACACCATCCTGGTGAGCGTCATGAGCGTTAACAACGAGGTGGGTTCCCGGCAACCTGTAGCT
GACATCGCCCGCCTGGTCCACAGCCGCAGCCGGGCCGTCCTGCACGTCGATCACATCCAGGGCTACGGCAAGATACCCTT
GAACTGCCATGAAGCCGGCATCGACCTGATGTCCTTAAGCGGCCATAAAATTCACGGGCCCAAGGGCGTGGGCGCCCTGT
ACATAAAGGAAGGTTTGCGGCTGGAGCCCCTGCTGACCGGCGGCGGTCAGGAGGCCGGCCAGCGCTCTGGTACCGAGAAC
ACTGCCGGCATCGCCGGTTTCGGCGTCGCCGCCCAACTGGCCGCAGCCGACTTTGCCCGGCGGACTGCCAGGATGCAGGA
GATAAAGCTCGAACTCGCCCGGCGGCTGGTGGCCGAGATCCCCGGCGCCGTCATCAACGGCCCGCCCCCCGAGGAAGGCG
CCCCTAACATCATAAACGTCTCCTTCCCGGGGGTGCGGGCCGAGGTCCTGGTCCACATGCTGGAGCAGCGGGGCATCTAC
GTCTCCACCGGCTCGGCCTGCCACTCCCGCAGGGAGAGCGCCAGCCACGTCCTCCAGGCCCTGCACCTGGAACGCTGGCG
CCAGGACGGCGCCATCCGCATCAGCCTGGGGGCCTTGAACCGGCTGGAAGAGGTGGAACCTACCGTGGAGGCCTTTAAGG
AATGCGTGCAAGAATTGTGGTCGTTATAG

Upstream 100 bases:

>100_bases
TGCAAAGGGCCTTTAAGGTAGTGCCTTTTGTTGTATAATACTAGCAGAGATCCCGCCGCGCCGGTATCAATATTGATATA
CCCCCTGGGAGGTATTGGTT

Downstream 100 bases:

>100_bases
ACAGGGCTGGCGGGTACAGCAGAGCAAACTCGAGCAGAGCCGAAGGCCTCGGCGGGCCCCTGATGGCGACACGCGCCGCA
ACGAAGCATGAAAATAGCAT

Product: aminotransferase, class V

Products: NA

Alternate protein names: NifS protein homolog [H]

Number of amino acids: Translated: 382; Mature: 381

Protein sequence:

>382_residues
MAIIYLDNSATTAALPEVAIAVKEMLTENYGNPSSLHGLGIKAEKALGEARRQVAGLIGARPTEIYFTSGGTEANNWALL
GIARARRRQGRHLITTAIEHPSILATCRRLEADGFEVTYLPADARGVIRLADLEAALREDTILVSVMSVNNEVGSRQPVA
DIARLVHSRSRAVLHVDHIQGYGKIPLNCHEAGIDLMSLSGHKIHGPKGVGALYIKEGLRLEPLLTGGGQEAGQRSGTEN
TAGIAGFGVAAQLAAADFARRTARMQEIKLELARRLVAEIPGAVINGPPPEEGAPNIINVSFPGVRAEVLVHMLEQRGIY
VSTGSACHSRRESASHVLQALHLERWRQDGAIRISLGALNRLEEVEPTVEAFKECVQELWSL

Sequences:

>Translated_382_residues
MAIIYLDNSATTAALPEVAIAVKEMLTENYGNPSSLHGLGIKAEKALGEARRQVAGLIGARPTEIYFTSGGTEANNWALL
GIARARRRQGRHLITTAIEHPSILATCRRLEADGFEVTYLPADARGVIRLADLEAALREDTILVSVMSVNNEVGSRQPVA
DIARLVHSRSRAVLHVDHIQGYGKIPLNCHEAGIDLMSLSGHKIHGPKGVGALYIKEGLRLEPLLTGGGQEAGQRSGTEN
TAGIAGFGVAAQLAAADFARRTARMQEIKLELARRLVAEIPGAVINGPPPEEGAPNIINVSFPGVRAEVLVHMLEQRGIY
VSTGSACHSRRESASHVLQALHLERWRQDGAIRISLGALNRLEEVEPTVEAFKECVQELWSL
>Mature_381_residues
AIIYLDNSATTAALPEVAIAVKEMLTENYGNPSSLHGLGIKAEKALGEARRQVAGLIGARPTEIYFTSGGTEANNWALLG
IARARRRQGRHLITTAIEHPSILATCRRLEADGFEVTYLPADARGVIRLADLEAALREDTILVSVMSVNNEVGSRQPVAD
IARLVHSRSRAVLHVDHIQGYGKIPLNCHEAGIDLMSLSGHKIHGPKGVGALYIKEGLRLEPLLTGGGQEAGQRSGTENT
AGIAGFGVAAQLAAADFARRTARMQEIKLELARRLVAEIPGAVINGPPPEEGAPNIINVSFPGVRAEVLVHMLEQRGIYV
STGSACHSRRESASHVLQALHLERWRQDGAIRISLGALNRLEEVEPTVEAFKECVQELWSL

Specific function: Catalyzes the removal of elemental sulfur from cysteine to produce alanine [H]

COG id: COG1104

COG function: function code E; Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=382, Percent_Identity=45.0261780104712, Blast_Score=307, Evalue=1e-83,
Organism=Homo sapiens, GI156713448, Length=411, Percent_Identity=33.5766423357664, Blast_Score=192, Evalue=6e-49,
Organism=Escherichia coli, GI48994898, Length=384, Percent_Identity=44.0104166666667, Blast_Score=291, Evalue=5e-80,
Organism=Escherichia coli, GI1787970, Length=394, Percent_Identity=26.9035532994924, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1789175, Length=397, Percent_Identity=26.9521410579345, Blast_Score=82, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI25143064, Length=379, Percent_Identity=40.1055408970976, Blast_Score=260, Evalue=7e-70,
Organism=Caenorhabditis elegans, GI17533177, Length=313, Percent_Identity=32.9073482428115, Blast_Score=164, Evalue=5e-41,
Organism=Saccharomyces cerevisiae, GI6319831, Length=382, Percent_Identity=42.1465968586387, Blast_Score=274, Evalue=2e-74,
Organism=Drosophila melanogaster, GI20129463, Length=379, Percent_Identity=43.0079155672823, Blast_Score=278, Evalue=4e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR010240
- InterPro:   IPR017772
- InterPro:   IPR016454
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 41137; Mature: 41005

Theoretical pI: Translated: 7.19; Mature: 7.19

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIIYLDNSATTAALPEVAIAVKEMLTENYGNPSSLHGLGIKAEKALGEARRQVAGLIGA
CEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCC
RPTEIYFTSGGTEANNWALLGIARARRRQGRHLITTAIEHPSILATCRRLEADGFEVTYL
CCCEEEEECCCCCCCCEEEEEEHHHHHHCCCEEEEEHHCCCHHHHHHHHHCCCCEEEEEE
PADARGVIRLADLEAALREDTILVSVMSVNNEVGSRQPVADIARLVHSRSRAVLHVDHIQ
CCCCCCEEEEEHHHHHHCCCEEEEEEEECCCCCCCCCCHHHHHHHHHCCCCEEEEEECCC
GYGKIPLNCHEAGIDLMSLSGHKIHGPKGVGALYIKEGLRLEPLLTGGGQEAGQRSGTEN
CCCCCCCCHHHHCCEEEECCCCEECCCCCCCEEEECCCCEEEEEECCCCHHHHCCCCCCC
TAGIAGFGVAAQLAAADFARRTARMQEIKLELARRLVAEIPGAVINGPPPEEGAPNIINV
CCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEE
SFPGVRAEVLVHMLEQRGIYVSTGSACHSRRESASHVLQALHLERWRQDGAIRISLGALN
ECCCHHHHHHHHHHHHCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHH
RLEEVEPTVEAFKECVQELWSL
HHHHCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AIIYLDNSATTAALPEVAIAVKEMLTENYGNPSSLHGLGIKAEKALGEARRQVAGLIGA
EEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCC
RPTEIYFTSGGTEANNWALLGIARARRRQGRHLITTAIEHPSILATCRRLEADGFEVTYL
CCCEEEEECCCCCCCCEEEEEEHHHHHHCCCEEEEEHHCCCHHHHHHHHHCCCCEEEEEE
PADARGVIRLADLEAALREDTILVSVMSVNNEVGSRQPVADIARLVHSRSRAVLHVDHIQ
CCCCCCEEEEEHHHHHHCCCEEEEEEEECCCCCCCCCCHHHHHHHHHCCCCEEEEEECCC
GYGKIPLNCHEAGIDLMSLSGHKIHGPKGVGALYIKEGLRLEPLLTGGGQEAGQRSGTEN
CCCCCCCCHHHHCCEEEECCCCEECCCCCCCEEEECCCCEEEEEECCCCHHHHCCCCCCC
TAGIAGFGVAAQLAAADFARRTARMQEIKLELARRLVAEIPGAVINGPPPEEGAPNIINV
CCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEE
SFPGVRAEVLVHMLEQRGIYVSTGSACHSRRESASHVLQALHLERWRQDGAIRISLGALN
ECCCHHHHHHHHHHHHCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHH
RLEEVEPTVEAFKECVQELWSL
HHHHCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10930739 [H]